Prognostic and Predictive Values of the Immunoscore in Patients with Rectal Cancer

1Department of Surgery, University of Medicine and Pharmacy “Gr T Popa”; Departments of 2Pathology and 3Surgical Oncology, Regional Institute of Oncology; 4Department of Pathology St. Spiridon Hospital, Iasi, Romania; 5Department of General and Digestive Surgery of the Georges Pompidou European Hospital and 6Department of Pathology of the Georges Pompidou European Hospital, 7Laboratory of Immunology, Immunomonitoring platform of the Georges Pompidou European Hospital, AP-HP; 8Laboratory of Integrative Cancer Immunology, Institut national de la santé et de la recherche medicale (INSERM) U872, Cordeliers Research Center; 9Paris-Descartes University; 10Pierre et Marie Curie-Paris 6 University, Paris; and 11Department of Pathology, Avicenne Hospital, Bobigny, France

1Department of Surgery, University of Medicine and Pharmacy “Gr T Popa”; Departments of 2Pathology and 3Surgical Oncology, Regional Institute of Oncology; 4Department of Pathology St. Spiridon Hospital, Iasi, Romania; 5Department of General and Digestive Surgery of the Georges Pompidou European Hospital and 6Department of Pathology of the Georges Pompidou European Hospital, 7Laboratory of Immunology, Immunomonitoring platform of the Georges Pompidou European Hospital, AP-HP; 8Laboratory of Integrative Cancer Immunology, Institut national de la santé et de la recherche medicale (INSERM) U872, Cordeliers Research Center; 9Paris-Descartes University; 10Pierre et Marie Curie-Paris 6 University, Paris; and 11Department of Pathology, Avicenne Hospital, Bobigny, France

1Department of Surgery, University of Medicine and Pharmacy “Gr T Popa”; Departments of 2Pathology and 3Surgical Oncology, Regional Institute of Oncology; 4Department of Pathology St. Spiridon Hospital, Iasi, Romania; 5Department of General and Digestive Surgery of the Georges Pompidou European Hospital and 6Department of Pathology of the Georges Pompidou European Hospital, 7Laboratory of Immunology, Immunomonitoring platform of the Georges Pompidou European Hospital, AP-HP; 8Laboratory of Integrative Cancer Immunology, Institut national de la santé et de la recherche medicale (INSERM) U872, Cordeliers Research Center; 9Paris-Descartes University; 10Pierre et Marie Curie-Paris 6 University, Paris; and 11Department of Pathology, Avicenne Hospital, Bobigny, France

1Department of Surgery, University of Medicine and Pharmacy “Gr T Popa”; Departments of 2Pathology and 3Surgical Oncology, Regional Institute of Oncology; 4Department of Pathology St. Spiridon Hospital, Iasi, Romania; 5Department of General and Digestive Surgery of the Georges Pompidou European Hospital and 6Department of Pathology of the Georges Pompidou European Hospital, 7Laboratory of Immunology, Immunomonitoring platform of the Georges Pompidou European Hospital, AP-HP; 8Laboratory of Integrative Cancer Immunology, Institut national de la santé et de la recherche medicale (INSERM) U872, Cordeliers Research Center; 9Paris-Descartes University; 10Pierre et Marie Curie-Paris 6 University, Paris; and 11Department of Pathology, Avicenne Hospital, Bobigny, France

1Department of Surgery, University of Medicine and Pharmacy “Gr T Popa”; Departments of 2Pathology and 3Surgical Oncology, Regional Institute of Oncology; 4Department of Pathology St. Spiridon Hospital, Iasi, Romania; 5Department of General and Digestive Surgery of the Georges Pompidou European Hospital and 6Department of Pathology of the Georges Pompidou European Hospital, 7Laboratory of Immunology, Immunomonitoring platform of the Georges Pompidou European Hospital, AP-HP; 8Laboratory of Integrative Cancer Immunology, Institut national de la santé et de la recherche medicale (INSERM) U872, Cordeliers Research Center; 9Paris-Descartes University; 10Pierre et Marie Curie-Paris 6 University, Paris; and 11Department of Pathology, Avicenne Hospital, Bobigny, France

1Department of Surgery, University of Medicine and Pharmacy “Gr T Popa”; Departments of 2Pathology and 3Surgical Oncology, Regional Institute of Oncology; 4Department of Pathology St. Spiridon Hospital, Iasi, Romania; 5Department of General and Digestive Surgery of the Georges Pompidou European Hospital and 6Department of Pathology of the Georges Pompidou European Hospital, 7Laboratory of Immunology, Immunomonitoring platform of the Georges Pompidou European Hospital, AP-HP; 8Laboratory of Integrative Cancer Immunology, Institut national de la santé et de la recherche medicale (INSERM) U872, Cordeliers Research Center; 9Paris-Descartes University; 10Pierre et Marie Curie-Paris 6 University, Paris; and 11Department of Pathology, Avicenne Hospital, Bobigny, France

1Department of Surgery, University of Medicine and Pharmacy “Gr T Popa”; Departments of 2Pathology and 3Surgical Oncology, Regional Institute of Oncology; 4Department of Pathology St. Spiridon Hospital, Iasi, Romania; 5Department of General and Digestive Surgery of the Georges Pompidou European Hospital and 6Department of Pathology of the Georges Pompidou European Hospital, 7Laboratory of Immunology, Immunomonitoring platform of the Georges Pompidou European Hospital, AP-HP; 8Laboratory of Integrative Cancer Immunology, Institut national de la santé et de la recherche medicale (INSERM) U872, Cordeliers Research Center; 9Paris-Descartes University; 10Pierre et Marie Curie-Paris 6 University, Paris; and 11Department of Pathology, Avicenne Hospital, Bobigny, France

1Department of Surgery, University of Medicine and Pharmacy “Gr T Popa”; Departments of 2Pathology and 3Surgical Oncology, Regional Institute of Oncology; 4Department of Pathology St. Spiridon Hospital, Iasi, Romania; 5Department of General and Digestive Surgery of the Georges Pompidou European Hospital and 6Department of Pathology of the Georges Pompidou European Hospital, 7Laboratory of Immunology, Immunomonitoring platform of the Georges Pompidou European Hospital, AP-HP; 8Laboratory of Integrative Cancer Immunology, Institut national de la santé et de la recherche medicale (INSERM) U872, Cordeliers Research Center; 9Paris-Descartes University; 10Pierre et Marie Curie-Paris 6 University, Paris; and 11Department of Pathology, Avicenne Hospital, Bobigny, France

1Department of Surgery, University of Medicine and Pharmacy “Gr T Popa”; Departments of 2Pathology and 3Surgical Oncology, Regional Institute of Oncology; 4Department of Pathology St. Spiridon Hospital, Iasi, Romania; 5Department of General and Digestive Surgery of the Georges Pompidou European Hospital and 6Department of Pathology of the Georges Pompidou European Hospital, 7Laboratory of Immunology, Immunomonitoring platform of the Georges Pompidou European Hospital, AP-HP; 8Laboratory of Integrative Cancer Immunology, Institut national de la santé et de la recherche medicale (INSERM) U872, Cordeliers Research Center; 9Paris-Descartes University; 10Pierre et Marie Curie-Paris 6 University, Paris; and 11Department of Pathology, Avicenne Hospital, Bobigny, France

1Department of Surgery, University of Medicine and Pharmacy “Gr T Popa”; Departments of 2Pathology and 3Surgical Oncology, Regional Institute of Oncology; 4Department of Pathology St. Spiridon Hospital, Iasi, Romania; 5Department of General and Digestive Surgery of the Georges Pompidou European Hospital and 6Department of Pathology of the Georges Pompidou European Hospital, 7Laboratory of Immunology, Immunomonitoring platform of the Georges Pompidou European Hospital, AP-HP; 8Laboratory of Integrative Cancer Immunology, Institut national de la santé et de la recherche medicale (INSERM) U872, Cordeliers Research Center; 9Paris-Descartes University; 10Pierre et Marie Curie-Paris 6 University, Paris; and 11Department of Pathology, Avicenne Hospital, Bobigny, France

1Department of Surgery, University of Medicine and Pharmacy “Gr T Popa”; Departments of 2Pathology and 3Surgical Oncology, Regional Institute of Oncology; 4Department of Pathology St. Spiridon Hospital, Iasi, Romania; 5Department of General and Digestive Surgery of the Georges Pompidou European Hospital and 6Department of Pathology of the Georges Pompidou European Hospital, 7Laboratory of Immunology, Immunomonitoring platform of the Georges Pompidou European Hospital, AP-HP; 8Laboratory of Integrative Cancer Immunology, Institut national de la santé et de la recherche medicale (INSERM) U872, Cordeliers Research Center; 9Paris-Descartes University; 10Pierre et Marie Curie-Paris 6 University, Paris; and 11Department of Pathology, Avicenne Hospital, Bobigny, France

1Department of Surgery, University of Medicine and Pharmacy “Gr T Popa”; Departments of 2Pathology and 3Surgical Oncology, Regional Institute of Oncology; 4Department of Pathology St. Spiridon Hospital, Iasi, Romania; 5Department of General and Digestive Surgery of the Georges Pompidou European Hospital and 6Department of Pathology of the Georges Pompidou European Hospital, 7Laboratory of Immunology, Immunomonitoring platform of the Georges Pompidou European Hospital, AP-HP; 8Laboratory of Integrative Cancer Immunology, Institut national de la santé et de la recherche medicale (INSERM) U872, Cordeliers Research Center; 9Paris-Descartes University; 10Pierre et Marie Curie-Paris 6 University, Paris; and 11Department of Pathology, Avicenne Hospital, Bobigny, France

1Department of Surgery, University of Medicine and Pharmacy “Gr T Popa”; Departments of 2Pathology and 3Surgical Oncology, Regional Institute of Oncology; 4Department of Pathology St. Spiridon Hospital, Iasi, Romania; 5Department of General and Digestive Surgery of the Georges Pompidou European Hospital and 6Department of Pathology of the Georges Pompidou European Hospital, 7Laboratory of Immunology, Immunomonitoring platform of the Georges Pompidou European Hospital, AP-HP; 8Laboratory of Integrative Cancer Immunology, Institut national de la santé et de la recherche medicale (INSERM) U872, Cordeliers Research Center; 9Paris-Descartes University; 10Pierre et Marie Curie-Paris 6 University, Paris; and 11Department of Pathology, Avicenne Hospital, Bobigny, France

1Department of Surgery, University of Medicine and Pharmacy “Gr T Popa”; Departments of 2Pathology and 3Surgical Oncology, Regional Institute of Oncology; 4Department of Pathology St. Spiridon Hospital, Iasi, Romania; 5Department of General and Digestive Surgery of the Georges Pompidou European Hospital and 6Department of Pathology of the Georges Pompidou European Hospital, 7Laboratory of Immunology, Immunomonitoring platform of the Georges Pompidou European Hospital, AP-HP; 8Laboratory of Integrative Cancer Immunology, Institut national de la santé et de la recherche medicale (INSERM) U872, Cordeliers Research Center; 9Paris-Descartes University; 10Pierre et Marie Curie-Paris 6 University, Paris; and 11Department of Pathology, Avicenne Hospital, Bobigny, France

1Department of Surgery, University of Medicine and Pharmacy “Gr T Popa”; Departments of 2Pathology and 3Surgical Oncology, Regional Institute of Oncology; 4Department of Pathology St. Spiridon Hospital, Iasi, Romania; 5Department of General and Digestive Surgery of the Georges Pompidou European Hospital and 6Department of Pathology of the Georges Pompidou European Hospital, 7Laboratory of Immunology, Immunomonitoring platform of the Georges Pompidou European Hospital, AP-HP; 8Laboratory of Integrative Cancer Immunology, Institut national de la santé et de la recherche medicale (INSERM) U872, Cordeliers Research Center; 9Paris-Descartes University; 10Pierre et Marie Curie-Paris 6 University, Paris; and 11Department of Pathology, Avicenne Hospital, Bobigny, France

1Department of Surgery, University of Medicine and Pharmacy “Gr T Popa”; Departments of 2Pathology and 3Surgical Oncology, Regional Institute of Oncology; 4Department of Pathology St. Spiridon Hospital, Iasi, Romania; 5Department of General and Digestive Surgery of the Georges Pompidou European Hospital and 6Department of Pathology of the Georges Pompidou European Hospital, 7Laboratory of Immunology, Immunomonitoring platform of the Georges Pompidou European Hospital, AP-HP; 8Laboratory of Integrative Cancer Immunology, Institut national de la santé et de la recherche medicale (INSERM) U872, Cordeliers Research Center; 9Paris-Descartes University; 10Pierre et Marie Curie-Paris 6 University, Paris; and 11Department of Pathology, Avicenne Hospital, Bobigny, France

1Department of Surgery, University of Medicine and Pharmacy “Gr T Popa”; Departments of 2Pathology and 3Surgical Oncology, Regional Institute of Oncology; 4Department of Pathology St. Spiridon Hospital, Iasi, Romania; 5Department of General and Digestive Surgery of the Georges Pompidou European Hospital and 6Department of Pathology of the Georges Pompidou European Hospital, 7Laboratory of Immunology, Immunomonitoring platform of the Georges Pompidou European Hospital, AP-HP; 8Laboratory of Integrative Cancer Immunology, Institut national de la santé et de la recherche medicale (INSERM) U872, Cordeliers Research Center; 9Paris-Descartes University; 10Pierre et Marie Curie-Paris 6 University, Paris; and 11Department of Pathology, Avicenne Hospital, Bobigny, France

1Department of Surgery, University of Medicine and Pharmacy “Gr T Popa”; Departments of 2Pathology and 3Surgical Oncology, Regional Institute of Oncology; 4Department of Pathology St. Spiridon Hospital, Iasi, Romania; 5Department of General and Digestive Surgery of the Georges Pompidou European Hospital and 6Department of Pathology of the Georges Pompidou European Hospital, 7Laboratory of Immunology, Immunomonitoring platform of the Georges Pompidou European Hospital, AP-HP; 8Laboratory of Integrative Cancer Immunology, Institut national de la santé et de la recherche medicale (INSERM) U872, Cordeliers Research Center; 9Paris-Descartes University; 10Pierre et Marie Curie-Paris 6 University, Paris; and 11Department of Pathology, Avicenne Hospital, Bobigny, France

1Department of Surgery, University of Medicine and Pharmacy “Gr T Popa”; Departments of 2Pathology and 3Surgical Oncology, Regional Institute of Oncology; 4Department of Pathology St. Spiridon Hospital, Iasi, Romania; 5Department of General and Digestive Surgery of the Georges Pompidou European Hospital and 6Department of Pathology of the Georges Pompidou European Hospital, 7Laboratory of Immunology, Immunomonitoring platform of the Georges Pompidou European Hospital, AP-HP; 8Laboratory of Integrative Cancer Immunology, Institut national de la santé et de la recherche medicale (INSERM) U872, Cordeliers Research Center; 9Paris-Descartes University; 10Pierre et Marie Curie-Paris 6 University, Paris; and 11Department of Pathology, Avicenne Hospital, Bobigny, France

1Department of Surgery, University of Medicine and Pharmacy “Gr T Popa”; Departments of 2Pathology and 3Surgical Oncology, Regional Institute of Oncology; 4Department of Pathology St. Spiridon Hospital, Iasi, Romania; 5Department of General and Digestive Surgery of the Georges Pompidou European Hospital and 6Department of Pathology of the Georges Pompidou European Hospital, 7Laboratory of Immunology, Immunomonitoring platform of the Georges Pompidou European Hospital, AP-HP; 8Laboratory of Integrative Cancer Immunology, Institut national de la santé et de la recherche medicale (INSERM) U872, Cordeliers Research Center; 9Paris-Descartes University; 10Pierre et Marie Curie-Paris 6 University, Paris; and 11Department of Pathology, Avicenne Hospital, Bobigny, France

1Department of Surgery, University of Medicine and Pharmacy “Gr T Popa”; Departments of 2Pathology and 3Surgical Oncology, Regional Institute of Oncology; 4Department of Pathology St. Spiridon Hospital, Iasi, Romania; 5Department of General and Digestive Surgery of the Georges Pompidou European Hospital and 6Department of Pathology of the Georges Pompidou European Hospital, 7Laboratory of Immunology, Immunomonitoring platform of the Georges Pompidou European Hospital, AP-HP; 8Laboratory of Integrative Cancer Immunology, Institut national de la santé et de la recherche medicale (INSERM) U872, Cordeliers Research Center; 9Paris-Descartes University; 10Pierre et Marie Curie-Paris 6 University, Paris; and 11Department of Pathology, Avicenne Hospital, Bobigny, France

1Department of Surgery, University of Medicine and Pharmacy “Gr T Popa”; Departments of 2Pathology and 3Surgical Oncology, Regional Institute of Oncology; 4Department of Pathology St. Spiridon Hospital, Iasi, Romania; 5Department of General and Digestive Surgery of the Georges Pompidou European Hospital and 6Department of Pathology of the Georges Pompidou European Hospital, 7Laboratory of Immunology, Immunomonitoring platform of the Georges Pompidou European Hospital, AP-HP; 8Laboratory of Integrative Cancer Immunology, Institut national de la santé et de la recherche medicale (INSERM) U872, Cordeliers Research Center; 9Paris-Descartes University; 10Pierre et Marie Curie-Paris 6 University, Paris; and 11Department of Pathology, Avicenne Hospital, Bobigny, France

1Department of Surgery, University of Medicine and Pharmacy “Gr T Popa”; Departments of 2Pathology and 3Surgical Oncology, Regional Institute of Oncology; 4Department of Pathology St. Spiridon Hospital, Iasi, Romania; 5Department of General and Digestive Surgery of the Georges Pompidou European Hospital and 6Department of Pathology of the Georges Pompidou European Hospital, 7Laboratory of Immunology, Immunomonitoring platform of the Georges Pompidou European Hospital, AP-HP; 8Laboratory of Integrative Cancer Immunology, Institut national de la santé et de la recherche medicale (INSERM) U872, Cordeliers Research Center; 9Paris-Descartes University; 10Pierre et Marie Curie-Paris 6 University, Paris; and 11Department of Pathology, Avicenne Hospital, Bobigny, France

1Department of Surgery, University of Medicine and Pharmacy “Gr T Popa”; Departments of 2Pathology and 3Surgical Oncology, Regional Institute of Oncology; 4Department of Pathology St. Spiridon Hospital, Iasi, Romania; 5Department of General and Digestive Surgery of the Georges Pompidou European Hospital and 6Department of Pathology of the Georges Pompidou European Hospital, 7Laboratory of Immunology, Immunomonitoring platform of the Georges Pompidou European Hospital, AP-HP; 8Laboratory of Integrative Cancer Immunology, Institut national de la santé et de la recherche medicale (INSERM) U872, Cordeliers Research Center; 9Paris-Descartes University; 10Pierre et Marie Curie-Paris 6 University, Paris; and 11Department of Pathology, Avicenne Hospital, Bobigny, France

1Department of Surgery, University of Medicine and Pharmacy “Gr T Popa”; Departments of 2Pathology and 3Surgical Oncology, Regional Institute of Oncology; 4Department of Pathology St. Spiridon Hospital, Iasi, Romania; 5Department of General and Digestive Surgery of the Georges Pompidou European Hospital and 6Department of Pathology of the Georges Pompidou European Hospital, 7Laboratory of Immunology, Immunomonitoring platform of the Georges Pompidou European Hospital, AP-HP; 8Laboratory of Integrative Cancer Immunology, Institut national de la santé et de la recherche medicale (INSERM) U872, Cordeliers Research Center; 9Paris-Descartes University; 10Pierre et Marie Curie-Paris 6 University, Paris; and 11Department of Pathology, Avicenne Hospital, Bobigny, France

1Department of Surgery, University of Medicine and Pharmacy “Gr T Popa”; Departments of 2Pathology and 3Surgical Oncology, Regional Institute of Oncology; 4Department of Pathology St. Spiridon Hospital, Iasi, Romania; 5Department of General and Digestive Surgery of the Georges Pompidou European Hospital and 6Department of Pathology of the Georges Pompidou European Hospital, 7Laboratory of Immunology, Immunomonitoring platform of the Georges Pompidou European Hospital, AP-HP; 8Laboratory of Integrative Cancer Immunology, Institut national de la santé et de la recherche medicale (INSERM) U872, Cordeliers Research Center; 9Paris-Descartes University; 10Pierre et Marie Curie-Paris 6 University, Paris; and 11Department of Pathology, Avicenne Hospital, Bobigny, France

1Department of Surgery, University of Medicine and Pharmacy “Gr T Popa”; Departments of 2Pathology and 3Surgical Oncology, Regional Institute of Oncology; 4Department of Pathology St. Spiridon Hospital, Iasi, Romania; 5Department of General and Digestive Surgery of the Georges Pompidou European Hospital and 6Department of Pathology of the Georges Pompidou European Hospital, 7Laboratory of Immunology, Immunomonitoring platform of the Georges Pompidou European Hospital, AP-HP; 8Laboratory of Integrative Cancer Immunology, Institut national de la santé et de la recherche medicale (INSERM) U872, Cordeliers Research Center; 9Paris-Descartes University; 10Pierre et Marie Curie-Paris 6 University, Paris; and 11Department of Pathology, Avicenne Hospital, Bobigny, France

1Department of Surgery, University of Medicine and Pharmacy “Gr T Popa”; Departments of 2Pathology and 3Surgical Oncology, Regional Institute of Oncology; 4Department of Pathology St. Spiridon Hospital, Iasi, Romania; 5Department of General and Digestive Surgery of the Georges Pompidou European Hospital and 6Department of Pathology of the Georges Pompidou European Hospital, 7Laboratory of Immunology, Immunomonitoring platform of the Georges Pompidou European Hospital, AP-HP; 8Laboratory of Integrative Cancer Immunology, Institut national de la santé et de la recherche medicale (INSERM) U872, Cordeliers Research Center; 9Paris-Descartes University; 10Pierre et Marie Curie-Paris 6 University, Paris; and 11Department of Pathology, Avicenne Hospital, Bobigny, France

1Department of Surgery, University of Medicine and Pharmacy “Gr T Popa”; Departments of 2Pathology and 3Surgical Oncology, Regional Institute of Oncology; 4Department of Pathology St. Spiridon Hospital, Iasi, Romania; 5Department of General and Digestive Surgery of the Georges Pompidou European Hospital and 6Department of Pathology of the Georges Pompidou European Hospital, 7Laboratory of Immunology, Immunomonitoring platform of the Georges Pompidou European Hospital, AP-HP; 8Laboratory of Integrative Cancer Immunology, Institut national de la santé et de la recherche medicale (INSERM) U872, Cordeliers Research Center; 9Paris-Descartes University; 10Pierre et Marie Curie-Paris 6 University, Paris; and 11Department of Pathology, Avicenne Hospital, Bobigny, France

1Department of Surgery, University of Medicine and Pharmacy “Gr T Popa”; Departments of 2Pathology and 3Surgical Oncology, Regional Institute of Oncology; 4Department of Pathology St. Spiridon Hospital, Iasi, Romania; 5Department of General and Digestive Surgery of the Georges Pompidou European Hospital and 6Department of Pathology of the Georges Pompidou European Hospital, 7Laboratory of Immunology, Immunomonitoring platform of the Georges Pompidou European Hospital, AP-HP; 8Laboratory of Integrative Cancer Immunology, Institut national de la santé et de la recherche medicale (INSERM) U872, Cordeliers Research Center; 9Paris-Descartes University; 10Pierre et Marie Curie-Paris 6 University, Paris; and 11Department of Pathology, Avicenne Hospital, Bobigny, France