Clinical Cancer Research: 20 (9)

Highlights

Highlights

Highlights of This Issue

Clin Cancer Res May 1 2014 20 (9) 2239-2239;

CCR Translations

CCR Translations

Vitamin D Status: Ready for Guiding Prostate Cancer Diagnosis and Treatment?

William B. Grant

Clin Cancer Res May 1 2014 20 (9) 2241-2243; DOI:10.1158/1078-0432.CCR-14-0369

CCR New Strategies

CCR New Strategies

New Strategies in Lung Cancer: Epigenetic Therapy for Non–Small Cell Lung Cancer

Patrick M. Forde, Julie R. Brahmer and Ronan J. Kelly

Clin Cancer Res May 1 2014 20 (9) 2244-2248; DOI:10.1158/1078-0432.CCR-13-2088

Molecular Pathways

Molecular Pathways

Molecular Pathways: Resistance to Kinase Inhibitors and Implications for Therapeutic Strategies

Christine M. Lovly and Alice T. Shaw

Clin Cancer Res May 1 2014 20 (9) 2249-2256; DOI:10.1158/1078-0432.CCR-13-1610
Molecular Pathways

Molecular Pathways: BRAF Induces Bioenergetic Adaptation by Attenuating Oxidative Phosphorylation

Rizwan Haq, David E. Fisher and Hans R. Widlund

Clin Cancer Res May 1 2014 20 (9) 2257-2263; DOI:10.1158/1078-0432.CCR-13-0898

Review

Review

Beyond Histology: Translating Tumor Genotypes into Clinically Effective Targeted Therapies

Catherine B. Meador, Christine M. Micheel, Mia A. Levy, Christine M. Lovly, Leora Horn, Jeremy L. Warner, Douglas B. Johnson, Zhongming Zhao, Ingrid A. Anderson, Jeffrey A. Sosman, Cindy L. Vnencak-Jones, Kimberly B. Dahlman and William Pao

Clin Cancer Res May 1 2014 20 (9) 2264-2275; DOI:10.1158/1078-0432.CCR-13-1591

Human Cancer Biology

Human Cancer Biology

Interleukin-32 Increases Human Gastric Cancer Cell Invasion Associated with Tumor Progression and Metastasis

Chung-Ying Tsai, Chia-Siu Wang, Ming-Ming Tsai, Hsiang-Cheng Chi, Wan-Li Cheng, Yi-Hsin Tseng, Cheng-Yi Chen, Crystal D. Lin, Jun-I. Wu, Lu-Hai Wang and Kwang-Huei Lin

Clin Cancer Res May 1 2014 20 (9) 2276-2288; DOI:10.1158/1078-0432.CCR-13-1221
Human Cancer Biology

Vitamin D Deficiency Predicts Prostate Biopsy Outcomes

Adam B. Murphy, Yaw Nyame, Iman K. Martin, William J. Catalona, Courtney M.P. Hollowell, Robert B. Nadler, James M. Kozlowski, Kent T. Perry, Andre Kajdacsy-Balla and Rick Kittles

Clin Cancer Res May 1 2014 20 (9) 2289-2299; DOI:10.1158/1078-0432.CCR-13-3085
Human Cancer Biology | AuthorChoice

Reverse-Phase Protein Array Profiling of Oropharyngeal Cancer and Significance of PIK3CA Mutations in HPV-Associated Head and Neck Cancer

Andrew Sewell, Brandee Brown, Asel Biktasova, Gordon B. Mills, Yiling Lu, Darren R. Tyson, Natalia Issaeva and Wendell G. Yarbrough

Clin Cancer Res May 1 2014 20 (9) 2300-2311; DOI:10.1158/1078-0432.CCR-13-2585
Human Cancer Biology

Identification of miR-133b and RB1CC1 as Independent Predictors for Biochemical Recurrence and Potential Therapeutic Targets for Prostate Cancer

Xia Li, Xuechao Wan, Hongbing Chen, Shu Yang, Yiyang Liu, Wenjuan Mo, Delong Meng, Wenting Du, Yan Huang, Hai Wu, Jingqiang Wang, Tao Li and Yao Li

Clin Cancer Res May 1 2014 20 (9) 2312-2325; DOI:10.1158/1078-0432.CCR-13-1588
Human Cancer Biology

PI3K Pathway Activation in High-Grade Ductal Carcinoma In Situ—Implications for Progression to Invasive Breast Carcinoma

Rita A. Sakr, Britta Weigelt, Sarat Chandarlapaty, Victor P. Andrade, Elena Guerini-Rocco, Dilip Giri, Charlotte K.Y. Ng, Catherine F. Cowell, Neal Rosen, Jorge S. Reis-Filho and Tari A. King

Clin Cancer Res May 1 2014 20 (9) 2326-2337; DOI:10.1158/1078-0432.CCR-13-2267
Human Cancer Biology

Prevalence and Clinical Implications of Epstein–Barr Virus Infection in De Novo Diffuse Large B-Cell Lymphoma in Western Countries

Chi Young Ok, Ling Li, Zijun Y. Xu-Monette, Carlo Visco, Alexander Tzankov, Ganiraju C. Manyam, Santiago Montes-Moreno, Karen Dybaer, April Chiu, Attilio Orazi, Youli Zu, Govind Bhagat, Jiayu Chen, Kristy L. Richards, Eric D. Hsi, William W. L. Choi, J. Han van Krieken, Jooryung Huh, Weiyun Ai, Maurilio Ponzoni, Andrés J.M. Ferreri, John P. Farnen, Michael B. Møller, Carlo E. Bueso-Ramos, Roberto N. Miranda, Jane N. Winter, Miguel A. Piris, L. Jeffrey Medeiros and Ken H. Young

Clin Cancer Res May 1 2014 20 (9) 2338-2349; DOI:10.1158/1078-0432.CCR-13-3157

Cancer Therapy: Preclinical

Cancer Therapy: Preclinical | AuthorChoice

Increased KIT Inhibition Enhances Therapeutic Efficacy in Gastrointestinal Stromal Tumor

Teresa S. Kim, Michael J. Cavnar, Noah A. Cohen, Eric C. Sorenson, Jonathan B. Greer, Adrian M. Seifert, Megan H. Crawley, Benjamin L. Green, Rachel Popow, Nagavarakishore Pillarsetty, Darren R. Veach, Anson T. Ku, Ferdinand Rossi, Peter Besmer, Cristina R. Antonescu, Shan Zeng and Ronald P. DeMatteo

Clin Cancer Res May 1 2014 20 (9) 2350-2362; DOI:10.1158/1078-0432.CCR-13-3033
Cancer Therapy: Preclinical

Reversal of Acquired Drug Resistance in FLT3-Mutated Acute Myeloid Leukemia Cells via Distinct Drug Combination Strategies

Weiguo Zhang, Chen Gao, Marina Konopleva, Ye Chen, Rodrigo O. Jacamo, Gautam Borthakur, Jorge E. Cortes, Farhad Ravandi, Abhijit Ramachandran and Michael Andreeff

Clin Cancer Res May 1 2014 20 (9) 2363-2374; DOI:10.1158/1078-0432.CCR-13-2052
Cancer Therapy: Preclinical

Mesenchymal Stem Cells from Human Fat Engineered to Secrete BMP4 Are Nononcogenic, Suppress Brain Cancer, and Prolong Survival

Qian Li, Olindi Wijesekera, Sussan J. Salas, Joanna Y. Wang, Mingxin Zhu, Colette Aprhys, Kaisorn L. Chaichana, David A. Chesler, Hao Zhang, Christopher L. Smith, Hugo Guerrero-Cazares, Andre Levchenko and Alfredo Quinones-Hinojosa

Clin Cancer Res May 1 2014 20 (9) 2375-2387; DOI:10.1158/1078-0432.CCR-13-1415
Cancer Therapy: Preclinical

CD133⁺ Tumor Initiating Cells in a Syngenic Murine Model of Pancreatic Cancer Respond to Minnelide

Sulagna Banerjee, Alice Nomura, Veena Sangwan, Rohit Chugh, Vikas Dudeja, Selwyn M. Vickers and Ashok Saluja

Clin Cancer Res May 1 2014 20 (9) 2388-2399; DOI:10.1158/1078-0432.CCR-13-2947
Cancer Therapy: Preclinical

Autophagy Is a Survival Mechanism of Acute Myelogenous Leukemia Precursors during Dual mTORC2/mTORC1 Targeting

Jessica K. Altman, Amy Szilard, Dennis J. Goussetis, Antonella Sassano, Marco Colamonici, Elias Gounaris, Olga Frankfurt, Francis J. Giles, Elizabeth A. Eklund, Elspeth M. Beauchamp and Leonidas C. Platanias

Clin Cancer Res May 1 2014 20 (9) 2400-2409; DOI:10.1158/1078-0432.CCR-13-3218
Cancer Therapy: Preclinical

BRaf and MEK Inhibitors Differentially Regulate Cell Fate and Microenvironment in Human Hepatocellular Carcinoma

Christian Breunig, Bernadett J. Mueller, Ludmila Umansky, Kristin Wahl, Katrin Hoffmann, Frank Lehner, Michael P. Manns, Heike Bantel and Christine S. Falk

Clin Cancer Res May 1 2014 20 (9) 2410-2423; DOI:10.1158/1078-0432.CCR-13-1635

Cancer Therapy: Clinical

Cancer Therapy: Clinical | Free Article

CTLA4 Blockade Broadens the Peripheral T-Cell Receptor Repertoire

Lidia Robert, Jennifer Tsoi, Xiaoyan Wang, Ryan Emerson, Blanca Homet, Thinle Chodon, Stephen Mok, Rong Rong Huang, Alistair J. Cochran, Begoña Comin-Anduix, Richard C. Koya, Thomas G. Graeber, Harlan Robins and Antoni Ribas

Clin Cancer Res May 1 2014 20 (9) 2424-2432; DOI:10.1158/1078-0432.CCR-13-2648
Cancer Therapy: Clinical

Phase I Dendritic Cell p53 Peptide Vaccine for Head and Neck Cancer

Patrick J. Schuler, Malgorzata Harasymczuk, Carmen Visus, Albert DeLeo, Sumita Trivedi, Yu Lei, Athanassios Argiris, William Gooding, Lisa H. Butterfield, Theresa L. Whiteside and Robert L. Ferris

Clin Cancer Res May 1 2014 20 (9) 2433-2444; DOI:10.1158/1078-0432.CCR-13-2617
Cancer Therapy: Clinical | AuthorChoice

Phase I Safety, Pharmacokinetic, and Pharmacodynamic Study of SAR245409 (XL765), a Novel, Orally Administered PI3K/mTOR Inhibitor in Patients with Advanced Solid Tumors

Kyriakos P. Papadopoulos, Josep Tabernero, Ben Markman, Amita Patnaik, Anthony W. Tolcher, José Baselga, Weiliang Shi, Coumaran Egile, Rodrigo Ruiz-Soto, A. Douglas Laird, Dale Miles and Patricia M. LoRusso

Clin Cancer Res May 1 2014 20 (9) 2445-2456; DOI:10.1158/1078-0432.CCR-13-2403
Cancer Therapy: Clinical

Adoptive Transfer of MART-1 T-Cell Receptor Transgenic Lymphocytes and Dendritic Cell Vaccination in Patients with Metastatic Melanoma

Thinle Chodon, Begoña Comin-Anduix, Bartosz Chmielowski, Richard C. Koya, Zhongqi Wu, Martin Auerbach, Charles Ng, Earl Avramis, Elizabeth Seja, Arturo Villanueva, Tara A. McCannel, Akira Ishiyama, Johannes Czernin, Caius G. Radu, Xiaoyan Wang, David W. Gjertson, Alistair J. Cochran, Kenneth Cornetta, Deborah J.L. Wong, Paula Kaplan-Lefko, Omid Hamid, Wolfram Samlowski, Peter A. Cohen, Gregory A. Daniels, Bijay Mukherji, Lili Yang, Jerome A. Zack, Donald B. Kohn, James R. Heath, John A. Glaspy, Owen N. Witte, David Baltimore, James S. Economou and Antoni Ribas

Clin Cancer Res May 1 2014 20 (9) 2457-2465; DOI:10.1158/1078-0432.CCR-13-3017

Predictive Biomarkers and Personalized Medicine

Predictive Biomarkers and Personalized Medicine | AuthorChoice

Replication of Genetic Polymorphisms Reported to Be Associated with Taxane-Related Sensory Neuropathy in Patients with Early Breast Cancer Treated with Paclitaxel

Jean E. Abraham, Qi Guo, Leila Dorling, Jonathan Tyrer, Susan Ingle, Richard Hardy, Anne-Laure Vallier, Louise Hiller, Russell Burns, Linda Jones, Sarah J. Bowden, Janet A. Dunn, Christopher J. Poole, Carlos Caldas, Paul P.D. Pharoah and Helena M. Earl

Clin Cancer Res May 1 2014 20 (9) 2466-2475; DOI:10.1158/1078-0432.CCR-13-3232
Predictive Biomarkers and Personalized Medicine

Integrated Next-Generation Sequencing and Avatar Mouse Models for Personalized Cancer Treatment

Elena Garralda, Keren Paz, Pedro P. López-Casas, Siân Jones, Amanda Katz, Lisa M. Kann, Fernando López-Rios, Francesca Sarno, Fátima Al-Shahrour, David Vasquez, Elizabeth Bruckheimer, Samuel V. Angiuoli, Antonio Calles, Luis A. Diaz, Victor E. Velculescu, Alfonso Valencia, David Sidransky and Manuel Hidalgo

Clin Cancer Res May 1 2014 20 (9) 2476-2484; DOI:10.1158/1078-0432.CCR-13-3047
Predictive Biomarkers and Personalized Medicine | AuthorChoice

Effect of Aromatase Inhibition on Functional Gene Modules in Estrogen Receptor–Positive Breast Cancer and Their Relationship with Antiproliferative Response

Qiong Gao, Neill Patani, Anita K. Dunbier, Zara Ghazoui, Marketa Zvelebil, Lesley-Ann Martin and Mitch Dowsett

Clin Cancer Res May 1 2014 20 (9) 2485-2494; DOI:10.1158/1078-0432.CCR-13-2602

Letters to the Editor

Letters to the Editor

TGR Analysis in Phase I Clinical Trials—Letter

Rodrigo Dienstmann and Josep Tabernero

Clin Cancer Res May 1 2014 20 (9) 2495-2496; DOI:10.1158/1078-0432.CCR-13-3455
Letters to the Editor

TGR Analysis in Phase I Clinical Trials—Response

Charles Ferté, Serge Koscielny and Jean-Charles Soria

Clin Cancer Res May 1 2014 20 (9) 2497-2497; DOI:10.1158/1078-0432.CCR-14-0366
Letters to the Editor

Efficacy of Vemurafenib in a Trametinib-Resistant Stage IV Melanoma Patient—Letter

Mathias Bernhardt, Elias Orouji, Lionel Larribere, Christoffer Gebhardt and Jochen Utikal

Clin Cancer Res May 1 2014 20 (9) 2498-2499; DOI:10.1158/1078-0432.CCR-13-2349

Corrections

Corrections

Correction: Genomic Estimates of Aneuploid Content in Glioblastoma Multiforme and Improved Classification

Clin Cancer Res May 1 2014 20 (9) 2500-2500; DOI:10.1158/1078-0432.CCR-14-0562
Corrections

Correction: hERG1 Channels Regulate VEGF-A Secretion in Human Gastric Cancer: Clinicopathological Correlations and Therapeutical Implications

Clin Cancer Res May 1 2014 20 (9) 2501-2501; DOI:10.1158/1078-0432.CCR-14-0637

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Table of Contents

Highlights

CCR Translations

CCR New Strategies

Molecular Pathways

Review

Human Cancer Biology

Cancer Therapy: Preclinical

Cancer Therapy: Clinical

Predictive Biomarkers and Personalized Medicine

Letters to the Editor

Corrections

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