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Table of Contents

Highlights

  • Highlights
    Highlights of This Issue
    Clin Cancer Res May 1 2014 20 (9) 2239-2239;

CCR Translations

  • CCR Translations
    Vitamin D Status: Ready for Guiding Prostate Cancer Diagnosis and Treatment?
    William B. Grant
    Clin Cancer Res May 1 2014 20 (9) 2241-2243; DOI:10.1158/1078-0432.CCR-14-0369

CCR New Strategies

  • CCR New Strategies
    New Strategies in Lung Cancer: Epigenetic Therapy for Non–Small Cell Lung Cancer
    Patrick M. Forde, Julie R. Brahmer and Ronan J. Kelly
    Clin Cancer Res May 1 2014 20 (9) 2244-2248; DOI:10.1158/1078-0432.CCR-13-2088

Molecular Pathways

  • Molecular Pathways
    Molecular Pathways: Resistance to Kinase Inhibitors and Implications for Therapeutic Strategies
    Christine M. Lovly and Alice T. Shaw
    Clin Cancer Res May 1 2014 20 (9) 2249-2256; DOI:10.1158/1078-0432.CCR-13-1610

  • Molecular Pathways
    Molecular Pathways: BRAF Induces Bioenergetic Adaptation by Attenuating Oxidative Phosphorylation
    Rizwan Haq, David E. Fisher and Hans R. Widlund
    Clin Cancer Res May 1 2014 20 (9) 2257-2263; DOI:10.1158/1078-0432.CCR-13-0898

Review

  • Review
    Beyond Histology: Translating Tumor Genotypes into Clinically Effective Targeted Therapies
    Catherine B. Meador, Christine M. Micheel, Mia A. Levy, Christine M. Lovly, Leora Horn, Jeremy L. Warner, Douglas B. Johnson, Zhongming Zhao, Ingrid A. Anderson, Jeffrey A. Sosman, Cindy L. Vnencak-Jones, Kimberly B. Dahlman and William Pao
    Clin Cancer Res May 1 2014 20 (9) 2264-2275; DOI:10.1158/1078-0432.CCR-13-1591

Human Cancer Biology

  • Human Cancer Biology
    Interleukin-32 Increases Human Gastric Cancer Cell Invasion Associated with Tumor Progression and Metastasis
    Chung-Ying Tsai, Chia-Siu Wang, Ming-Ming Tsai, Hsiang-Cheng Chi, Wan-Li Cheng, Yi-Hsin Tseng, Cheng-Yi Chen, Crystal D. Lin, Jun-I. Wu, Lu-Hai Wang and Kwang-Huei Lin
    Clin Cancer Res May 1 2014 20 (9) 2276-2288; DOI:10.1158/1078-0432.CCR-13-1221

  • Human Cancer Biology
    Vitamin D Deficiency Predicts Prostate Biopsy Outcomes
    Adam B. Murphy, Yaw Nyame, Iman K. Martin, William J. Catalona, Courtney M.P. Hollowell, Robert B. Nadler, James M. Kozlowski, Kent T. Perry, Andre Kajdacsy-Balla and Rick Kittles
    Clin Cancer Res May 1 2014 20 (9) 2289-2299; DOI:10.1158/1078-0432.CCR-13-3085

  • Human Cancer Biology | AuthorChoice
    Reverse-Phase Protein Array Profiling of Oropharyngeal Cancer and Significance of PIK3CA Mutations in HPV-Associated Head and Neck Cancer
    Andrew Sewell, Brandee Brown, Asel Biktasova, Gordon B. Mills, Yiling Lu, Darren R. Tyson, Natalia Issaeva and Wendell G. Yarbrough
    Clin Cancer Res May 1 2014 20 (9) 2300-2311; DOI:10.1158/1078-0432.CCR-13-2585

  • Human Cancer Biology
    Identification of miR-133b and RB1CC1 as Independent Predictors for Biochemical Recurrence and Potential Therapeutic Targets for Prostate Cancer
    Xia Li, Xuechao Wan, Hongbing Chen, Shu Yang, Yiyang Liu, Wenjuan Mo, Delong Meng, Wenting Du, Yan Huang, Hai Wu, Jingqiang Wang, Tao Li and Yao Li
    Clin Cancer Res May 1 2014 20 (9) 2312-2325; DOI:10.1158/1078-0432.CCR-13-1588

  • Human Cancer Biology
    PI3K Pathway Activation in High-Grade Ductal Carcinoma In Situ—Implications for Progression to Invasive Breast Carcinoma
    Rita A. Sakr, Britta Weigelt, Sarat Chandarlapaty, Victor P. Andrade, Elena Guerini-Rocco, Dilip Giri, Charlotte K.Y. Ng, Catherine F. Cowell, Neal Rosen, Jorge S. Reis-Filho and Tari A. King
    Clin Cancer Res May 1 2014 20 (9) 2326-2337; DOI:10.1158/1078-0432.CCR-13-2267

  • Human Cancer Biology
    Prevalence and Clinical Implications of Epstein–Barr Virus Infection in De Novo Diffuse Large B-Cell Lymphoma in Western Countries
    Chi Young Ok, Ling Li, Zijun Y. Xu-Monette, Carlo Visco, Alexander Tzankov, Ganiraju C. Manyam, Santiago Montes-Moreno, Karen Dybaer, April Chiu, Attilio Orazi, Youli Zu, Govind Bhagat, Jiayu Chen, Kristy L. Richards, Eric D. Hsi, William W. L. Choi, J. Han van Krieken, Jooryung Huh, Weiyun Ai, Maurilio Ponzoni, Andrés J.M. Ferreri, John P. Farnen, Michael B. Møller, Carlo E. Bueso-Ramos, Roberto N. Miranda, Jane N. Winter, Miguel A. Piris, L. Jeffrey Medeiros and Ken H. Young
    Clin Cancer Res May 1 2014 20 (9) 2338-2349; DOI:10.1158/1078-0432.CCR-13-3157

Cancer Therapy: Preclinical

  • Cancer Therapy: Preclinical | AuthorChoice
    Increased KIT Inhibition Enhances Therapeutic Efficacy in Gastrointestinal Stromal Tumor
    Teresa S. Kim, Michael J. Cavnar, Noah A. Cohen, Eric C. Sorenson, Jonathan B. Greer, Adrian M. Seifert, Megan H. Crawley, Benjamin L. Green, Rachel Popow, Nagavarakishore Pillarsetty, Darren R. Veach, Anson T. Ku, Ferdinand Rossi, Peter Besmer, Cristina R. Antonescu, Shan Zeng and Ronald P. DeMatteo
    Clin Cancer Res May 1 2014 20 (9) 2350-2362; DOI:10.1158/1078-0432.CCR-13-3033

  • Cancer Therapy: Preclinical
    Reversal of Acquired Drug Resistance in FLT3-Mutated Acute Myeloid Leukemia Cells via Distinct Drug Combination Strategies
    Weiguo Zhang, Chen Gao, Marina Konopleva, Ye Chen, Rodrigo O. Jacamo, Gautam Borthakur, Jorge E. Cortes, Farhad Ravandi, Abhijit Ramachandran and Michael Andreeff
    Clin Cancer Res May 1 2014 20 (9) 2363-2374; DOI:10.1158/1078-0432.CCR-13-2052

  • Cancer Therapy: Preclinical
    Mesenchymal Stem Cells from Human Fat Engineered to Secrete BMP4 Are Nononcogenic, Suppress Brain Cancer, and Prolong Survival
    Qian Li, Olindi Wijesekera, Sussan J. Salas, Joanna Y. Wang, Mingxin Zhu, Colette Aprhys, Kaisorn L. Chaichana, David A. Chesler, Hao Zhang, Christopher L. Smith, Hugo Guerrero-Cazares, Andre Levchenko and Alfredo Quinones-Hinojosa
    Clin Cancer Res May 1 2014 20 (9) 2375-2387; DOI:10.1158/1078-0432.CCR-13-1415

  • Cancer Therapy: Preclinical
    CD133+ Tumor Initiating Cells in a Syngenic Murine Model of Pancreatic Cancer Respond to Minnelide
    Sulagna Banerjee, Alice Nomura, Veena Sangwan, Rohit Chugh, Vikas Dudeja, Selwyn M. Vickers and Ashok Saluja
    Clin Cancer Res May 1 2014 20 (9) 2388-2399; DOI:10.1158/1078-0432.CCR-13-2947

  • Cancer Therapy: Preclinical
    Autophagy Is a Survival Mechanism of Acute Myelogenous Leukemia Precursors during Dual mTORC2/mTORC1 Targeting
    Jessica K. Altman, Amy Szilard, Dennis J. Goussetis, Antonella Sassano, Marco Colamonici, Elias Gounaris, Olga Frankfurt, Francis J. Giles, Elizabeth A. Eklund, Elspeth M. Beauchamp and Leonidas C. Platanias
    Clin Cancer Res May 1 2014 20 (9) 2400-2409; DOI:10.1158/1078-0432.CCR-13-3218

  • Cancer Therapy: Preclinical
    BRaf and MEK Inhibitors Differentially Regulate Cell Fate and Microenvironment in Human Hepatocellular Carcinoma
    Christian Breunig, Bernadett J. Mueller, Ludmila Umansky, Kristin Wahl, Katrin Hoffmann, Frank Lehner, Michael P. Manns, Heike Bantel and Christine S. Falk
    Clin Cancer Res May 1 2014 20 (9) 2410-2423; DOI:10.1158/1078-0432.CCR-13-1635

Cancer Therapy: Clinical

  • Cancer Therapy: Clinical | Free Article
    CTLA4 Blockade Broadens the Peripheral T-Cell Receptor Repertoire
    Lidia Robert, Jennifer Tsoi, Xiaoyan Wang, Ryan Emerson, Blanca Homet, Thinle Chodon, Stephen Mok, Rong Rong Huang, Alistair J. Cochran, Begoña Comin-Anduix, Richard C. Koya, Thomas G. Graeber, Harlan Robins and Antoni Ribas
    Clin Cancer Res May 1 2014 20 (9) 2424-2432; DOI:10.1158/1078-0432.CCR-13-2648

  • Cancer Therapy: Clinical
    Phase I Dendritic Cell p53 Peptide Vaccine for Head and Neck Cancer
    Patrick J. Schuler, Malgorzata Harasymczuk, Carmen Visus, Albert DeLeo, Sumita Trivedi, Yu Lei, Athanassios Argiris, William Gooding, Lisa H. Butterfield, Theresa L. Whiteside and Robert L. Ferris
    Clin Cancer Res May 1 2014 20 (9) 2433-2444; DOI:10.1158/1078-0432.CCR-13-2617

  • Cancer Therapy: Clinical | AuthorChoice
    Phase I Safety, Pharmacokinetic, and Pharmacodynamic Study of SAR245409 (XL765), a Novel, Orally Administered PI3K/mTOR Inhibitor in Patients with Advanced Solid Tumors
    Kyriakos P. Papadopoulos, Josep Tabernero, Ben Markman, Amita Patnaik, Anthony W. Tolcher, José Baselga, Weiliang Shi, Coumaran Egile, Rodrigo Ruiz-Soto, A. Douglas Laird, Dale Miles and Patricia M. LoRusso
    Clin Cancer Res May 1 2014 20 (9) 2445-2456; DOI:10.1158/1078-0432.CCR-13-2403

  • Cancer Therapy: Clinical
    Adoptive Transfer of MART-1 T-Cell Receptor Transgenic Lymphocytes and Dendritic Cell Vaccination in Patients with Metastatic Melanoma
    Thinle Chodon, Begoña Comin-Anduix, Bartosz Chmielowski, Richard C. Koya, Zhongqi Wu, Martin Auerbach, Charles Ng, Earl Avramis, Elizabeth Seja, Arturo Villanueva, Tara A. McCannel, Akira Ishiyama, Johannes Czernin, Caius G. Radu, Xiaoyan Wang, David W. Gjertson, Alistair J. Cochran, Kenneth Cornetta, Deborah J.L. Wong, Paula Kaplan-Lefko, Omid Hamid, Wolfram Samlowski, Peter A. Cohen, Gregory A. Daniels, Bijay Mukherji, Lili Yang, Jerome A. Zack, Donald B. Kohn, James R. Heath, John A. Glaspy, Owen N. Witte, David Baltimore, James S. Economou and Antoni Ribas
    Clin Cancer Res May 1 2014 20 (9) 2457-2465; DOI:10.1158/1078-0432.CCR-13-3017

Predictive Biomarkers and Personalized Medicine

  • Predictive Biomarkers and Personalized Medicine | AuthorChoice
    Replication of Genetic Polymorphisms Reported to Be Associated with Taxane-Related Sensory Neuropathy in Patients with Early Breast Cancer Treated with Paclitaxel
    Jean E. Abraham, Qi Guo, Leila Dorling, Jonathan Tyrer, Susan Ingle, Richard Hardy, Anne-Laure Vallier, Louise Hiller, Russell Burns, Linda Jones, Sarah J. Bowden, Janet A. Dunn, Christopher J. Poole, Carlos Caldas, Paul P.D. Pharoah and Helena M. Earl
    Clin Cancer Res May 1 2014 20 (9) 2466-2475; DOI:10.1158/1078-0432.CCR-13-3232

  • Predictive Biomarkers and Personalized Medicine
    Integrated Next-Generation Sequencing and Avatar Mouse Models for Personalized Cancer Treatment
    Elena Garralda, Keren Paz, Pedro P. López-Casas, Siân Jones, Amanda Katz, Lisa M. Kann, Fernando López-Rios, Francesca Sarno, Fátima Al-Shahrour, David Vasquez, Elizabeth Bruckheimer, Samuel V. Angiuoli, Antonio Calles, Luis A. Diaz, Victor E. Velculescu, Alfonso Valencia, David Sidransky and Manuel Hidalgo
    Clin Cancer Res May 1 2014 20 (9) 2476-2484; DOI:10.1158/1078-0432.CCR-13-3047

  • Predictive Biomarkers and Personalized Medicine | AuthorChoice
    Effect of Aromatase Inhibition on Functional Gene Modules in Estrogen Receptor–Positive Breast Cancer and Their Relationship with Antiproliferative Response
    Qiong Gao, Neill Patani, Anita K. Dunbier, Zara Ghazoui, Marketa Zvelebil, Lesley-Ann Martin and Mitch Dowsett
    Clin Cancer Res May 1 2014 20 (9) 2485-2494; DOI:10.1158/1078-0432.CCR-13-2602

Letters to the Editor

  • Letters to the Editor
    TGR Analysis in Phase I Clinical Trials—Letter
    Rodrigo Dienstmann and Josep Tabernero
    Clin Cancer Res May 1 2014 20 (9) 2495-2496; DOI:10.1158/1078-0432.CCR-13-3455

  • Letters to the Editor
    TGR Analysis in Phase I Clinical Trials—Response
    Charles Ferté, Serge Koscielny and Jean-Charles Soria
    Clin Cancer Res May 1 2014 20 (9) 2497-2497; DOI:10.1158/1078-0432.CCR-14-0366

  • Letters to the Editor
    Efficacy of Vemurafenib in a Trametinib-Resistant Stage IV Melanoma Patient—Letter
    Mathias Bernhardt, Elias Orouji, Lionel Larribere, Christoffer Gebhardt and Jochen Utikal
    Clin Cancer Res May 1 2014 20 (9) 2498-2499; DOI:10.1158/1078-0432.CCR-13-2349

Corrections

  • Corrections
    Correction: Genomic Estimates of Aneuploid Content in Glioblastoma Multiforme and Improved Classification
    Clin Cancer Res May 1 2014 20 (9) 2500-2500; DOI:10.1158/1078-0432.CCR-14-0562

  • Corrections
    Correction: hERG1 Channels Regulate VEGF-A Secretion in Human Gastric Cancer: Clinicopathological Correlations and Therapeutical Implications
    Clin Cancer Res May 1 2014 20 (9) 2501-2501; DOI:10.1158/1078-0432.CCR-14-0637

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Clinical Cancer Research: 20 (9)
May 2014
Volume 20, Issue 9
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Issue Highlights

  • Mesenchymal Stem Cells from Human Fat Engineered to Secrete BMP4 Are Nononcogenic, Suppress Brain Cancer, and Prolong Survival
  • Phase I Safety, Pharmacokinetic, and Pharmacodynamic Study of SAR245409 (XL765), a Novel, Orally Administered PI3K/mTOR Inhibitor in Patients with Advanced Solid Tumors
  • Increased KIT Inhibition Enhances Therapeutic Efficacy in Gastrointestinal Stromal Tumor
  • CD133+ Tumor Initiating Cells in a Syngenic Murine Model of Pancreatic Cancer Respond to Minnelide

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Clinical Cancer Research
eISSN: 1557-3265
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