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Cancer Therapy: Preclinical

An Antibody–Drug Conjugate Directed against Lymphocyte Antigen 6 Complex, Locus E (LY6E) Provides Robust Tumor Killing in a Wide Range of Solid Tumor Malignancies

Jyoti Asundi, Lisa Crocker, Jarrod Tremayne, Peter Chang, Chie Sakanaka, Josh Tanguay, Susan Spencer, Sreedevi Chalasani, Elizabeth Luis, Karen Gascoigne, Rupal Desai, Rajiv Raja, Brad A. Friedman, Peter M. Haverty, Paul Polakis and Ron Firestein
Jyoti Asundi
1Department of Molecular Oncology, Genentech Research, South San Francisco, California.
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  • For correspondence: ronf@gene.com jasundi@gene.com
Lisa Crocker
2Department of Translational Oncology, Genentech Research, South San Francisco, California.
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Jarrod Tremayne
2Department of Translational Oncology, Genentech Research, South San Francisco, California.
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Peter Chang
3Touro University, California College of Pharmacy, California.
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Chie Sakanaka
4Pharmaceuticals and Medical Devices Agency, Tokyo, Japan.
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Josh Tanguay
2Department of Translational Oncology, Genentech Research, South San Francisco, California.
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Susan Spencer
2Department of Translational Oncology, Genentech Research, South San Francisco, California.
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Sreedevi Chalasani
5Department of Pathology, Genentech Research, South San Francisco, California.
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Elizabeth Luis
6Department of Protein Chemistry, Genentech Research, South San Francisco, California.
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Karen Gascoigne
7Department of Discovery Oncology, Genentech Research, South San Francisco, California.
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Rupal Desai
8Department of Oncology Biomarker Development, Genentech Research, South San Francisco, California.
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Rajiv Raja
8Department of Oncology Biomarker Development, Genentech Research, South San Francisco, California.
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Brad A. Friedman
9Department of Bioinformatics, Genentech Research, South San Francisco, California.
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Peter M. Haverty
9Department of Bioinformatics, Genentech Research, South San Francisco, California.
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Paul Polakis
1Department of Molecular Oncology, Genentech Research, South San Francisco, California.
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Ron Firestein
5Department of Pathology, Genentech Research, South San Francisco, California.
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  • For correspondence: ronf@gene.com jasundi@gene.com
DOI: 10.1158/1078-0432.CCR-15-0156 Published July 2015
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Article Information

Volume 21, Issue 14, pp. 3252-3262

DOI 
https://doi.org/10.1158/1078-0432.CCR-15-0156
PubMed 
25862760

Published By 
American Association for Cancer Research
Print ISSN 
1078-0432
Online ISSN 
1557-3265
History 
  • Received January 21, 2015
  • Revision received March 17, 2015
  • Accepted March 19, 2015
  • Published first April 10, 2015.

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  • Previous version (April 10, 2015 - 09:11).
  • Previous version (June 1, 2015 - 09:27).
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Copyright & Usage 
©2015 American Association for Cancer Research.

Author Information

  1. Jyoti Asundi1,*,
  2. Lisa Crocker2,
  3. Jarrod Tremayne2,
  4. Peter Chang3,
  5. Chie Sakanaka4,
  6. Josh Tanguay2,
  7. Susan Spencer2,
  8. Sreedevi Chalasani5,
  9. Elizabeth Luis6,
  10. Karen Gascoigne7,
  11. Rupal Desai8,
  12. Rajiv Raja8,
  13. Brad A. Friedman9,
  14. Peter M. Haverty9,
  15. Paul Polakis1, and
  16. Ron Firestein5,*
  1. 1Department of Molecular Oncology, Genentech Research, South San Francisco, California.
  2. 2Department of Translational Oncology, Genentech Research, South San Francisco, California.
  3. 3Touro University, California College of Pharmacy, California.
  4. 4Pharmaceuticals and Medical Devices Agency, Tokyo, Japan.
  5. 5Department of Pathology, Genentech Research, South San Francisco, California.
  6. 6Department of Protein Chemistry, Genentech Research, South San Francisco, California.
  7. 7Department of Discovery Oncology, Genentech Research, South San Francisco, California.
  8. 8Department of Oncology Biomarker Development, Genentech Research, South San Francisco, California.
  9. 9Department of Bioinformatics, Genentech Research, South San Francisco, California.
  1. ↵*Corresponding Authors:
    Ron Firestein, Genentech, 1 DNA Way, South San Francisco, CA 94080. Phone: 650-225-8441; Fax: 650-225-8440; E-mail: ronf{at}gene.com; and Jyoti Asundi, E-mail: jasundi{at}gene.com
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Clinical Cancer Research: 21 (14)
July 2015
Volume 21, Issue 14
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An Antibody–Drug Conjugate Directed against Lymphocyte Antigen 6 Complex, Locus E (LY6E) Provides Robust Tumor Killing in a Wide Range of Solid Tumor Malignancies
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An Antibody–Drug Conjugate Directed against Lymphocyte Antigen 6 Complex, Locus E (LY6E) Provides Robust Tumor Killing in a Wide Range of Solid Tumor Malignancies
Jyoti Asundi, Lisa Crocker, Jarrod Tremayne, Peter Chang, Chie Sakanaka, Josh Tanguay, Susan Spencer, Sreedevi Chalasani, Elizabeth Luis, Karen Gascoigne, Rupal Desai, Rajiv Raja, Brad A. Friedman, Peter M. Haverty, Paul Polakis and Ron Firestein
Clin Cancer Res July 15 2015 (21) (14) 3252-3262; DOI: 10.1158/1078-0432.CCR-15-0156

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An Antibody–Drug Conjugate Directed against Lymphocyte Antigen 6 Complex, Locus E (LY6E) Provides Robust Tumor Killing in a Wide Range of Solid Tumor Malignancies
Jyoti Asundi, Lisa Crocker, Jarrod Tremayne, Peter Chang, Chie Sakanaka, Josh Tanguay, Susan Spencer, Sreedevi Chalasani, Elizabeth Luis, Karen Gascoigne, Rupal Desai, Rajiv Raja, Brad A. Friedman, Peter M. Haverty, Paul Polakis and Ron Firestein
Clin Cancer Res July 15 2015 (21) (14) 3252-3262; DOI: 10.1158/1078-0432.CCR-15-0156
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