Clinical Cancer Research: 21 (17)

Highlights

Highlights

Highlights of This Issue

Clin Cancer Res September 1 2015 21 (17) 3811-3811;

CCR 20th Anniversary Commentary

CCR 20th Anniversary Commentary | Free Article

CCR 20^th Anniversary Commentary: Triple-Negative Breast Cancer in 2015—Still in the Ballpark

Steven A. Narod, Rebecca A. Dent and William D. Foulkes

Clin Cancer Res September 1 2015 21 (17) 3813-3814; DOI:10.1158/1078-0432.CCR-14-3122

CCR Translations

CCR Translations

Moving Beyond “Lumpology”: PET/CT Imaging of Pheochromocytoma and Paraganglioma

Michael S. Hofman and Rodney J. Hicks

Clin Cancer Res September 1 2015 21 (17) 3815-3817; DOI:10.1158/1078-0432.CCR-15-1073
CCR Translations

Emerging Agents and New Mutations in EGFR-Mutant Lung Cancer

Deborah Ayeni, Katerina Politi and Sarah B. Goldberg

Clin Cancer Res September 1 2015 21 (17) 3818-3820; DOI:10.1158/1078-0432.CCR-15-1211

CCR New Strategies

CCR New Strategies

New Strategies in Human Papillomavirus–Related Oropharynx Cancer: Effecting Advances in Treatment for a Growing Epidemic

Erminia Massarelli, Renata Ferrarotto and Bonnie S. Glisson

Clin Cancer Res September 1 2015 21 (17) 3821-3828; DOI:10.1158/1078-0432.CCR-14-1329

CCR Drug Updates

CCR Drug Updates

Development of Olaparib for BRCA-Deficient Recurrent Epithelial Ovarian Cancer

Krishnansu S. Tewari, Ramez N. Eskander and Bradley J. Monk

Clin Cancer Res September 1 2015 21 (17) 3829-3835; DOI:10.1158/1078-0432.CCR-15-0088

Molecular Pathways

Molecular Pathways

Molecular Pathways: Is AMPK a Friend or a Foe in Cancer?

D. Grahame Hardie

Clin Cancer Res September 1 2015 21 (17) 3836-3840; DOI:10.1158/1078-0432.CCR-14-3300

Reviews

Reviews

Using CellMiner 1.6 for Systems Pharmacology and Genomic Analysis of the NCI-60

William C. Reinhold, Margot Sunshine, Sudhir Varma, James H. Doroshow and Yves Pommier

Clin Cancer Res September 1 2015 21 (17) 3841-3852; DOI:10.1158/1078-0432.CCR-15-0335
Reviews | AuthorChoice

Refining the Mantle Cell Lymphoma Paradigm: Impact of Novel Therapies on Current Practice

Irit Avivi and Andre Goy

Clin Cancer Res September 1 2015 21 (17) 3853-3861; DOI:10.1158/1078-0432.CCR-15-0488

Cancer Therapy: Clinical

Cancer Therapy: Clinical | AuthorChoice

A Randomized Phase II Trial of Sipuleucel-T with Concurrent versus Sequential Abiraterone Acetate plus Prednisone in Metastatic Castration-Resistant Prostate Cancer

Eric J. Small, Raymond S. Lance, Thomas A. Gardner, Lawrence I. Karsh, Lawrence Fong, Candice McCoy, Todd DeVries, Nadeem A. Sheikh, Debraj GuhaThakurta, Nancy Chang, Charles H. Redfern and Neal D. Shore

Clin Cancer Res September 1 2015 21 (17) 3862-3869; DOI:10.1158/1078-0432.CCR-15-0079
Cancer Therapy: Clinical

First-in-Human Trial of a Novel Anti-Trop-2 Antibody-SN-38 Conjugate, Sacituzumab Govitecan, for the Treatment of Diverse Metastatic Solid Tumors

Alexander N. Starodub, Allyson J. Ocean, Manish A. Shah, Michael J. Guarino, Vincent J. Picozzi Jr, Linda T. Vahdat, Sajeve S. Thomas, Serengulam V. Govindan, Pius P. Maliakal, William A. Wegener, Steven A. Hamburger, Robert M. Sharkey and David M. Goldenberg

Clin Cancer Res September 1 2015 21 (17) 3870-3878; DOI:10.1158/1078-0432.CCR-14-3321
Cancer Therapy: Clinical

Vaccination with Melanoma Helper Peptides Induces Antibody Responses Associated with Improved Overall Survival

Caroline M. Reed, Nicole D. Cresce, Ileana S. Mauldin, Craig L. Slingluff Jr and Walter C. Olson

Clin Cancer Res September 1 2015 21 (17) 3879-3887; DOI:10.1158/1078-0432.CCR-15-0233

Personalized Medicine and Imaging

Personalized Medicine and Imaging

Superiority of [⁶⁸Ga]-DOTATATE PET/CT to Other Functional Imaging Modalities in the Localization of SDHB-Associated Metastatic Pheochromocytoma and Paraganglioma

Ingo Janssen, Elise M. Blanchet, Karen Adams, Clara C. Chen, Corina M. Millo, Peter Herscovitch, David Taieb, Electron Kebebew, Hendrik Lehnert, Antonio T. Fojo and Karel Pacak

Clin Cancer Res September 1 2015 21 (17) 3888-3895; DOI:10.1158/1078-0432.CCR-14-2751
Personalized Medicine and Imaging

A Systematic Comparison of ¹⁸F-C-SNAT to Established Radiotracer Imaging Agents for the Detection of Tumor Response to Treatment

Timothy H. Witney, Aileen Hoehne, Robert E. Reeves, Ohad Ilovich, Mohammad Namavari, Bin Shen, Frederick T. Chin, Jianghong Rao and Sanjiv S. Gambhir

Clin Cancer Res September 1 2015 21 (17) 3896-3905; DOI:10.1158/1078-0432.CCR-14-3176
Personalized Medicine and Imaging

MR-Guided Near-Infrared Spectral Tomography Increases Diagnostic Performance of Breast MRI

Michael A. Mastanduno, Junqing Xu, Fadi El-Ghussein, Shudong Jiang, Hong Yin, Yan Zhao, Ke Wang, Fang Ren, Jiang Gui, Brian W. Pogue and Keith D. Paulsen

Clin Cancer Res September 1 2015 21 (17) 3906-3912; DOI:10.1158/1078-0432.CCR-14-2546

Cancer Therapy: Preclinical

Cancer Therapy: Preclinical

EGFR Mutations and Resistance to Irreversible Pyrimidine-Based EGFR Inhibitors

Dalia Ercan, Hwan Geun Choi, Cai-Hong Yun, Marzia Capelletti, Ting Xie, Michael J. Eck, Nathanael S. Gray and Pasi A. Jänne

Clin Cancer Res September 1 2015 21 (17) 3913-3923; DOI:10.1158/1078-0432.CCR-14-2789
Cancer Therapy: Preclinical | AuthorChoice

The Allelic Context of the C797S Mutation Acquired upon Treatment with Third-Generation EGFR Inhibitors Impacts Sensitivity to Subsequent Treatment Strategies

Matthew J. Niederst, Haichuan Hu, Hillary E. Mulvey, Elizabeth L. Lockerman, Angel R. Garcia, Zofia Piotrowska, Lecia V. Sequist and Jeffrey A. Engelman

Clin Cancer Res September 1 2015 21 (17) 3924-3933; DOI:10.1158/1078-0432.CCR-15-0560
Cancer Therapy: Preclinical

APO866 Increases Antitumor Activity of Cyclosporin-A by Inducing Mitochondrial and Endoplasmic Reticulum Stress in Leukemia Cells

Antonia Cagnetta, Irene Caffa, Chirag Acharya, Debora Soncini, Prakrati Acharya, Sophia Adamia, Ivana Pierri, Micaela Bergamaschi, Anna Garuti, Giulio Fraternali, Luca Mastracci, Alessandro Provenzani, Chiara Zucal, Gianluca Damonte, Annalisa Salis, Fabrizio Montecucco, Franco Patrone, Alberto Ballestrero, Santina Bruzzone, Marco Gobbi, Alessio Nencioni and Michele Cea

Clin Cancer Res September 1 2015 21 (17) 3934-3945; DOI:10.1158/1078-0432.CCR-14-3023
Cancer Therapy: Preclinical

MEK Inhibitor PD-0325901 Overcomes Resistance to PI3K/mTOR Inhibitor PF-5212384 and Potentiates Antitumor Effects in Human Head and Neck Squamous Cell Carcinoma

Suresh Mohan, Robert Vander Broek, Sujay Shah, Danielle F. Eytan, Matthew L. Pierce, Sophie G. Carlson, Jamie F. Coupar, Jialing Zhang, Hui Cheng, Zhong Chen and Carter Van Waes

Clin Cancer Res September 1 2015 21 (17) 3946-3956; DOI:10.1158/1078-0432.CCR-14-3377
Cancer Therapy: Preclinical

Untouched GMP-Ready Purified Engineered Immune Cells to Treat Cancer

Trudy Straetemans, Cordula Gründer, Sabine Heijhuurs, Samantha Hol, Ineke Slaper-Cortenbach, Halvard Bönig, Zsolt Sebestyen and Jürgen Kuball

Clin Cancer Res September 1 2015 21 (17) 3957-3968; DOI:10.1158/1078-0432.CCR-14-2860

Biology of Human Tumors

Biology of Human Tumors | AuthorChoice

Differential Expression of Immune-Regulatory Genes Associated with PD-L1 Display in Melanoma: Implications for PD-1 Pathway Blockade

Janis M. Taube, Geoffrey D. Young, Tracee L. McMiller, Shuming Chen, January T. Salas, Theresa S. Pritchard, Haiying Xu, Alan K. Meeker, Jinshui Fan, Chris Cheadle, Alan E. Berger, Drew M. Pardoll and Suzanne L. Topalian

Clin Cancer Res September 1 2015 21 (17) 3969-3976; DOI:10.1158/1078-0432.CCR-15-0244
Biology of Human Tumors

A Leukemia-Associated CD34/CD123/CD25/CD99⁺ Immunophenotype Identifies FLT3-Mutated Clones in Acute Myeloid Leukemia

Daniela F. Angelini, Tiziana Ottone, Gisella Guerrera, Serena Lavorgna, Michela Cittadini, Francesco Buccisano, Marco De Bardi, Francesca Gargano, Luca Maurillo, Mariadomenica Divona, Nélida I. Noguera, Maria Irno Consalvo, Giovanna Borsellino, Giorgio Bernardi, Sergio Amadori, Adriano Venditti, Luca Battistini and Francesco Lo-Coco

Clin Cancer Res September 1 2015 21 (17) 3977-3985; DOI:10.1158/1078-0432.CCR-14-3186
Biology of Human Tumors

Genome-Wide Analysis Uncovers Novel Recurrent Alterations in Primary Central Nervous System Lymphomas

Esteban Braggio, Scott Van Wier, Juhi Ojha, Ellen McPhail, Yan W. Asmann, Jan Egan, Jackline Ayres da Silva, David Schiff, M. Beatriz Lopes, Paul A. Decker, Riccardo Valdez, Raoul Tibes, Bruce Eckloff, Thomas E. Witzig, A. Keith Stewart, Rafael Fonseca and Brian Patrick O'Neill

Clin Cancer Res September 1 2015 21 (17) 3986-3994; DOI:10.1158/1078-0432.CCR-14-2116
Biology of Human Tumors | Free Article

Upregulation of ER Signaling as an Adaptive Mechanism of Cell Survival in HER2-Positive Breast Tumors Treated with Anti-HER2 Therapy

Mario Giuliano, Huizhong Hu, Yen-Chao Wang, Xiaoyong Fu, Agostina Nardone, Sabrina Herrera, Sufeng Mao, Alejandro Contreras, Carolina Gutierrez, Tao Wang, Susan G. Hilsenbeck, Carmine De Angelis, Nicholas J. Wang, Laura M. Heiser, Joe W. Gray, Sara Lopez-Tarruella, Anne C. Pavlick, Meghana V. Trivedi, Gary C. Chamness, Jenny C. Chang, C. Kent Osborne, Mothaffar F. Rimawi and Rachel Schiff

Clin Cancer Res September 1 2015 21 (17) 3995-4003; DOI:10.1158/1078-0432.CCR-14-2728
Biology of Human Tumors

miR-663 Suppresses Oncogenic Function of CXCR4 in Glioblastoma

Yu Shi, Cong Chen, Shi-Zhu Yu, Qing Liu, Jun Rao, Hua-Rong Zhang, Hua-Liang Xiao, Ti-Wei Fu, Hua Long, Zhi-Cheng He, Kai Zhou, Xiao-Hong Yao, You-Hong Cui, Xia Zhang, Yi-Fang Ping and Xiu-Wu Bian

Clin Cancer Res September 1 2015 21 (17) 4004-4013; DOI:10.1158/1078-0432.CCR-14-2807
Biology of Human Tumors

Induction of PD-L1 Expression by the EML4–ALK Oncoprotein and Downstream Signaling Pathways in Non–Small Cell Lung Cancer

Keiichi Ota, Koichi Azuma, Akihiko Kawahara, Satoshi Hattori, Eiji Iwama, Junko Tanizaki, Taishi Harada, Koichiro Matsumoto, Koichi Takayama, Shinzo Takamori, Masayoshi Kage, Tomoaki Hoshino, Yoichi Nakanishi and Isamu Okamoto

Clin Cancer Res September 1 2015 21 (17) 4014-4021; DOI:10.1158/1078-0432.CCR-15-0016

Letters to the Editor

Letters to the Editor

To B(MP-2) or Not To B(MP-2): Cytokines and Tumor Surgery—Letter

David S. Geller, Jonathan Gill, Michael Roth and Richard Gorlick

Clin Cancer Res September 1 2015 21 (17) 4022-4022; DOI:10.1158/1078-0432.CCR-15-0470
Letters to the Editor

To B(MP-2) or Not To B(MP-2): Cytokines and Tumor Surgery—Response

Kurt R. Weiss

Clin Cancer Res September 1 2015 21 (17) 4023-4023; DOI:10.1158/1078-0432.CCR-15-0875

Correction

Correction

Correction: “Vertical” Inhibition of HER2 Yields Horizontal Gains in the Clinic

Clin Cancer Res September 1 2015 21 (17) 4024-4024; DOI:10.1158/1078-0432.CCR-15-1662

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Table of Contents

Highlights

CCR 20th Anniversary Commentary

CCR Translations

CCR New Strategies

CCR Drug Updates

Molecular Pathways

Reviews

Cancer Therapy: Clinical

Personalized Medicine and Imaging

Cancer Therapy: Preclinical

Biology of Human Tumors

Letters to the Editor

Correction

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