Clinical Cancer Research: 21 (18)

Highlights

Highlights

Highlights of This Issue

Clin Cancer Res September 15 2015 21 (18) 4025-4025;

CCR 20th Anniversary Commentary

CCR 20th Anniversary Commentary | Free Article

CCR 20^th Anniversary Commentary: Simpson's Paradox and Neoadjuvant Trials

Lisa A. Carey

Clin Cancer Res September 15 2015 21 (18) 4027-4029; DOI:10.1158/1078-0432.CCR-14-3124

CCR Translations

CCR Translations

Cancer Immunotherapy: More Is (Much) Better

Yosef Yarden and Michael Sela

Clin Cancer Res September 15 2015 21 (18) 4030-4032; DOI:10.1158/1078-0432.CCR-15-0996
CCR Translations

SLFN11: Achilles' Heel or Troublemaker

Heinrich Kovar

Clin Cancer Res September 15 2015 21 (18) 4033-4034; DOI:10.1158/1078-0432.CCR-15-0883

CCR Perspectives in Drug Approval

CCR Perspectives in Drug Approval

FDA Approval: Blinatumomab

Donna Przepiorka, Chia-Wen Ko, Albert Deisseroth, Carolyn L. Yancey, Reyes Candau-Chacon, Haw-Jyh Chiu, Brenda J. Gehrke, Candace Gomez-Broughton, Robert C. Kane, Susan Kirshner, Nitin Mehrotra, Tiffany K. Ricks, Deborah Schmiel, Pengfei Song, Ping Zhao, Qing Zhou, Ann T. Farrell and Richard Pazdur

Clin Cancer Res September 15 2015 21 (18) 4035-4039; DOI:10.1158/1078-0432.CCR-15-0612

Molecular Pathways

Molecular Pathways

Molecular Pathways: At the Crossroads of Cancer Epigenetics and Immunotherapy

Michele Maio, Alessia Covre, Elisabetta Fratta, Anna Maria Di Giacomo, Pietro Taverna, Pier Giorgio Natali, Sandra Coral and Luca Sigalotti

Clin Cancer Res September 15 2015 21 (18) 4040-4047; DOI:10.1158/1078-0432.CCR-14-2914

Cancer Therapy: Clinical

Cancer Therapy: Clinical

Effects of Adjuvant Sorafenib and Sunitinib on Cardiac Function in Renal Cell Carcinoma Patients without Overt Metastases: Results from ASSURE, ECOG 2805

Naomi B. Haas, Judith Manola, Bonnie Ky, Keith T. Flaherty, Robert G. Uzzo, Christopher J. Kane, Michael Jewett, Lori Wood, Christopher G. Wood, Michael B. Atkins, Janice J. Dutcher, George Wilding and Robert S. DiPaola

Clin Cancer Res September 15 2015 21 (18) 4048-4054; DOI:10.1158/1078-0432.CCR-15-0215
Cancer Therapy: Clinical

A Phase I Trial of the Anti-KIR Antibody IPH2101 and Lenalidomide in Patients with Relapsed/Refractory Multiple Myeloma

Don M. Benson Jr, Adam D. Cohen, Sundar Jagannath, Nikhil C. Munshi, Gary Spitzer, Craig C. Hofmeister, Yvonne A. Efebera, Pascale Andre, Robert Zerbib and Michael A. Caligiuri

Clin Cancer Res September 15 2015 21 (18) 4055-4061; DOI:10.1158/1078-0432.CCR-15-0304
Cancer Therapy: Clinical

Bioactivity and Safety of IL13Rα2-Redirected Chimeric Antigen Receptor CD8⁺ T Cells in Patients with Recurrent Glioblastoma

Christine E. Brown, Behnam Badie, Michael E. Barish, Lihong Weng, Julie R. Ostberg, Wen-Chung Chang, Araceli Naranjo, Renate Starr, Jamie Wagner, Christine Wright, Yubo Zhai, James R. Bading, Julie A. Ressler, Jana Portnow, Massimo D'Apuzzo, Stephen J. Forman and Michael C. Jensen

Clin Cancer Res September 15 2015 21 (18) 4062-4072; DOI:10.1158/1078-0432.CCR-15-0428

Personalized Medicine and Imaging

Personalized Medicine and Imaging

Myeloid-Derived Suppressor Cells as an Immune Parameter in Patients with Concurrent Sunitinib and Stereotactic Body Radiotherapy

Hui-Ming Chen, Ge Ma, Neil Gildener-Leapman, Samuel Eisenstein, Brian A. Coakley, Junko Ozao, John Mandeli, Celia Divino, Myron Schwartz, Max Sung, Robert Ferris, Johnny Kao, Lu-Hai Wang, Ping-Ying Pan, Eric C. Ko and Shu-Hsia Chen

Clin Cancer Res September 15 2015 21 (18) 4073-4085; DOI:10.1158/1078-0432.CCR-14-2742
Personalized Medicine and Imaging

Polymorphism at 19q13.41 Predicts Breast Cancer Survival Specifically after Endocrine Therapy

Sofia Khan, Rainer Fagerholm, Sajjad Rafiq, William Tapper, Kristiina Aittomäki, Jianjun Liu, Carl Blomqvist, Diana Eccles and Heli Nevanlinna

Clin Cancer Res September 15 2015 21 (18) 4086-4096; DOI:10.1158/1078-0432.CCR-15-0296

Cancer Therapy: Preclinical

Cancer Therapy: Preclinical

Aurora A Kinase Inhibition Selectively Synergizes with Histone Deacetylase Inhibitor through Cytokinesis Failure in T-cell Lymphoma

Kelly M. Zullo, Yige Guo, Laurence Cooke, Xavier Jirau-Serrano, Michael Mangone, Luigi Scotto, Jennifer E. Amengual, Yinghui Mao, Renu Nandakumar, Serge Cremers, Jimmy Duong, Daruka Mahadevan and Owen A. O'Connor

Clin Cancer Res September 15 2015 21 (18) 4097-4109; DOI:10.1158/1078-0432.CCR-15-0033
Cancer Therapy: Preclinical

Pan-HER, an Antibody Mixture Simultaneously Targeting EGFR, HER2, and HER3, Effectively Overcomes Tumor Heterogeneity and Plasticity

Helle J. Jacobsen, Thomas T. Poulsen, Anna Dahlman, Ida Kjær, Klaus Koefoed, Jette W. Sen, Dietmar Weilguny, Bolette Bjerregaard, Christina R. Andersen, Ivan D. Horak, Mikkel W. Pedersen, Michael Kragh and Johan Lantto

Clin Cancer Res September 15 2015 21 (18) 4110-4122; DOI:10.1158/1078-0432.CCR-14-3312
Cancer Therapy: Preclinical

Inhibition of Survivin with YM155 Induces Durable Tumor Response in Anaplastic Thyroid Cancer

Amit Mehta, Lisa Zhang, Myriem Boufraqech, Yi Liu-Chittenden, Yaqin Zhang, Dhaval Patel, Sean Davis, Avi Rosenberg, Kris Ylaya, Rachel Aufforth, Zhuyin Li, Min Shen and Electron Kebebew

Clin Cancer Res September 15 2015 21 (18) 4123-4132; DOI:10.1158/1078-0432.CCR-14-3251
Cancer Therapy: Preclinical

Antiandrogens Inhibit ABCB1 Efflux and ATPase Activity and Reverse Docetaxel Resistance in Advanced Prostate Cancer

Yezi Zhu, Chengfei Liu, Cameron Armstrong, Wei Lou, Amandeep Sandher and Allen C. Gao

Clin Cancer Res September 15 2015 21 (18) 4133-4142; DOI:10.1158/1078-0432.CCR-15-0269
Cancer Therapy: Preclinical

Inhibition of JNK Sensitizes Hypoxic Colon Cancer Cells to DNA-Damaging Agents

Irina A. Vasilevskaya, Muthu Selvakumaran, Lucia Cabal Hierro, Sara R. Goldstein, Jeffrey D. Winkler and Peter J. O'Dwyer

Clin Cancer Res September 15 2015 21 (18) 4143-4152; DOI:10.1158/1078-0432.CCR-15-0352
Cancer Therapy: Preclinical

Maintenance Treatment with Cetuximab and BAY86-9766 Increases Antitumor Efficacy of Irinotecan plus Cetuximab in Human Colorectal Cancer Xenograft Models

Teresa Troiani, Stefania Napolitano, Giulia Martini, Erika Martinelli, Claudia Cardone, Nicola Normanno, Donata Vitagliano, Floriana Morgillo, Francesca Fenizia, Matilde Lambiase, Luigi Formisano, Roberto Bianco, Davide Ciardiello and Fortunato Ciardiello

Clin Cancer Res September 15 2015 21 (18) 4153-4164; DOI:10.1158/1078-0432.CCR-15-0211
Cancer Therapy: Preclinical | AuthorChoice

Anti-EFNA4 Calicheamicin Conjugates Effectively Target Triple-Negative Breast and Ovarian Tumor-Initiating Cells to Result in Sustained Tumor Regressions

Marc Damelin, Alexander Bankovich, Albert Park, Jorge Aguilar, Wade Anderson, Marianne Santaguida, Monette Aujay, Sarah Fong, Kiran Khandke, Virginia Pulito, Elana Ernstoff, Paul Escarpe, Jeffrey Bernstein, Marybeth Pysz, Wenyan Zhong, Erik Upeslacis, Judy Lucas, Justin Lucas, Timothy Nichols, Kathryn Loving, Orit Foord, Johannes Hampl, Robert Stull, Frank Barletta, Hadi Falahatpisheh, Puja Sapra, Hans-Peter Gerber and Scott J. Dylla

Clin Cancer Res September 15 2015 21 (18) 4165-4173; DOI:10.1158/1078-0432.CCR-15-0695

Biology of Human Tumors

Biology of Human Tumors

Genetics and Prognostication in Splenic Marginal Zone Lymphoma: Revelations from Deep Sequencing

Marina Parry, Matthew J.J. Rose-Zerilli, Viktor Ljungström, Jane Gibson, Jun Wang, Renata Walewska, Helen Parker, Anton Parker, Zadie Davis, Anne Gardiner, Neil McIver-Brown, Christina Kalpadakis, Aliki Xochelli, Achilles Anagnostopoulos, Claudia Fazi, David Gonzalez de Castro, Claire Dearden, Guy Pratt, Richard Rosenquist, Margaret Ashton-Key, Francesco Forconi, Andrew Collins, Paolo Ghia, Estella Matutes, Gerassimos Pangalis, Kostas Stamatopoulos, David Oscier and Jonathan C. Strefford

Clin Cancer Res September 15 2015 21 (18) 4174-4183; DOI:10.1158/1078-0432.CCR-14-2759
Biology of Human Tumors

SLFN11 Is a Transcriptional Target of EWS-FLI1 and a Determinant of Drug Response in Ewing Sarcoma

Sai-Wen Tang, Sven Bilke, Liang Cao, Junko Murai, Fabricio G. Sousa, Mihoko Yamade, Vinodh Rajapakse, Sudhir Varma, Lee J. Helman, Javed Khan, Paul S. Meltzer and Yves Pommier

Clin Cancer Res September 15 2015 21 (18) 4184-4193; DOI:10.1158/1078-0432.CCR-14-2112
Biology of Human Tumors | AuthorChoice

Gene Expression Profiling of Desmoid Tumors by cDNA Microarrays and Correlation with Progression-Free Survival

Sébastien Salas, Celine Brulard, Philippe Terrier, Dominique Ranchere-Vince, Agnes Neuville, Louis Guillou, Marick Lae, Agnes Leroux, Olivier Verola, Kurtz Jean-Emmanuel, Sylvie Bonvalot, Jean-Yves Blay, Axel Le Cesne, Alain Aurias, Jean-Michel Coindre and Frederic Chibon

Clin Cancer Res September 15 2015 21 (18) 4194-4200; DOI:10.1158/1078-0432.CCR-14-2910
Biology of Human Tumors

Whole Exome Sequencing Reveals the Order of Genetic Changes during Malignant Transformation and Metastasis in a Single Patient with NF1-plexiform Neurofibroma

Angela C. Hirbe, Sonika Dahiya, Christopher A. Miller, Tiandao Li, Robert S. Fulton, Xiaochun Zhang, Sandra McDonald, Katherine DeSchryver, Eric J. Duncavage, Jessica Walrath, Karlyne M. Reilly, Haley J. Abel, Melike Pekmezci, Arie Perry, Timothy J. Ley and David H. Gutmann

Clin Cancer Res September 15 2015 21 (18) 4201-4211; DOI:10.1158/1078-0432.CCR-14-3049
Biology of Human Tumors

Sunitinib Treatment Exacerbates Intratumoral Heterogeneity in Metastatic Renal Cancer

Grant D. Stewart, Fiach C. O'Mahony, Alexander Laird, Lel Eory, Alexander L.R. Lubbock, Alan Mackay, Jyoti Nanda, Marie O'Donnell, Peter Mullen, S. Alan McNeill, Antony C.P. Riddick, Daniel Berney, Axel Bex, Michael Aitchison, Ian M. Overton, David J. Harrison and Thomas Powles

Clin Cancer Res September 15 2015 21 (18) 4212-4223; DOI:10.1158/1078-0432.CCR-15-0207
Biology of Human Tumors

Intratumoral CD14⁺ Cells and Circulating CD14⁺HLA-DR^lo/neg Monocytes Correlate with Decreased Survival in Patients with Clear Cell Renal Cell Carcinoma

Michael P. Gustafson, Yi Lin, Jonathan S. Bleeker, Deepti Warad, Matthew K. Tollefson, Paul L. Crispen, Peggy A. Bulur, Susan M. Harrington, Rebecca R. Laborde, Dennis A. Gastineau, Bradley C. Leibovich, John C. Cheville, Eugene D. Kwon and Allan B. Dietz

Clin Cancer Res September 15 2015 21 (18) 4224-4233; DOI:10.1158/1078-0432.CCR-15-0260
Biology of Human Tumors

Serum miR-21, miR-29a, and miR-125b Are Promising Biomarkers for the Early Detection of Colorectal Neoplasia

Atsushi Yamada, Takahiro Horimatsu, Yoshinaga Okugawa, Naoshi Nishida, Hajime Honjo, Hiroshi Ida, Tadayuki Kou, Toshihiro Kusaka, Yu Sasaki, Makato Yagi, Takuma Higurashi, Norio Yukawa, Yusuke Amanuma, Osamu Kikuchi, Manabu Muto, Yoshiyuki Ueno, Atsushi Nakajima, Tsutomu Chiba, C. Richard Boland and Ajay Goel

Clin Cancer Res September 15 2015 21 (18) 4234-4242; DOI:10.1158/1078-0432.CCR-14-2793

Corrections

Corrections

Correction: PID1 (NYGGF4), a New Growth-Inhibitory Gene in Embryonal Brain Tumors and Gliomas

Clin Cancer Res September 15 2015 21 (18) 4243-4243; DOI:10.1158/1078-0432.CCR-15-1523
Corrections

Correction: Replication of Genetic Polymorphisms Reported to Be Associated with Taxane-Related Sensory Neuropathy in Patients with Early Breast Cancer Treated with Paclitaxel—Letter

Clin Cancer Res September 15 2015 21 (18) 4244-4244; DOI:10.1158/1078-0432.CCR-15-1693

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Table of Contents

Highlights

CCR 20th Anniversary Commentary

CCR Translations

CCR Perspectives in Drug Approval

Molecular Pathways

Cancer Therapy: Clinical

Personalized Medicine and Imaging

Cancer Therapy: Preclinical

Biology of Human Tumors

Corrections

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