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Cancer Therapy: Preclinical

Anti-EFNA4 Calicheamicin Conjugates Effectively Target Triple-Negative Breast and Ovarian Tumor-Initiating Cells to Result in Sustained Tumor Regressions

Marc Damelin, Alexander Bankovich, Albert Park, Jorge Aguilar, Wade Anderson, Marianne Santaguida, Monette Aujay, Sarah Fong, Kiran Khandke, Virginia Pulito, Elana Ernstoff, Paul Escarpe, Jeffrey Bernstein, Marybeth Pysz, Wenyan Zhong, Erik Upeslacis, Judy Lucas, Justin Lucas, Timothy Nichols, Kathryn Loving, Orit Foord, Johannes Hampl, Robert Stull, Frank Barletta, Hadi Falahatpisheh, Puja Sapra, Hans-Peter Gerber and Scott J. Dylla
Marc Damelin
1Pfizer, Inc., Pearl River, New York.
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  • For correspondence: scott.dylla@stemcentrx.com marc.damelin@pfizer.com
Alexander Bankovich
2Stemcentrx, Inc., South San Francisco, California.
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Albert Park
2Stemcentrx, Inc., South San Francisco, California.
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Jorge Aguilar
2Stemcentrx, Inc., South San Francisco, California.
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Wade Anderson
2Stemcentrx, Inc., South San Francisco, California.
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Marianne Santaguida
2Stemcentrx, Inc., South San Francisco, California.
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Monette Aujay
2Stemcentrx, Inc., South San Francisco, California.
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Sarah Fong
2Stemcentrx, Inc., South San Francisco, California.
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Kiran Khandke
1Pfizer, Inc., Pearl River, New York.
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Virginia Pulito
1Pfizer, Inc., Pearl River, New York.
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Elana Ernstoff
1Pfizer, Inc., Pearl River, New York.
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Paul Escarpe
2Stemcentrx, Inc., South San Francisco, California.
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Jeffrey Bernstein
2Stemcentrx, Inc., South San Francisco, California.
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Marybeth Pysz
2Stemcentrx, Inc., South San Francisco, California.
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Wenyan Zhong
1Pfizer, Inc., Pearl River, New York.
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Erik Upeslacis
1Pfizer, Inc., Pearl River, New York.
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Judy Lucas
1Pfizer, Inc., Pearl River, New York.
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Justin Lucas
1Pfizer, Inc., Pearl River, New York.
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Timothy Nichols
1Pfizer, Inc., Pearl River, New York.
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Kathryn Loving
2Stemcentrx, Inc., South San Francisco, California.
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Orit Foord
2Stemcentrx, Inc., South San Francisco, California.
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Johannes Hampl
2Stemcentrx, Inc., South San Francisco, California.
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Robert Stull
2Stemcentrx, Inc., South San Francisco, California.
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Frank Barletta
1Pfizer, Inc., Pearl River, New York.
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Hadi Falahatpisheh
1Pfizer, Inc., Pearl River, New York.
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Puja Sapra
1Pfizer, Inc., Pearl River, New York.
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Hans-Peter Gerber
1Pfizer, Inc., Pearl River, New York.
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Scott J. Dylla
2Stemcentrx, Inc., South San Francisco, California.
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  • For correspondence: scott.dylla@stemcentrx.com marc.damelin@pfizer.com
DOI: 10.1158/1078-0432.CCR-15-0695 Published September 2015
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ARTICLE USAGE: May 2015 to April 2021

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Total626438856935

Cited By

Article Information

Volume 21, Issue 18, pp. 4165-4173

DOI 
https://doi.org/10.1158/1078-0432.CCR-15-0695
PubMed 
26015513

Published By 
American Association for Cancer Research
Print ISSN 
1078-0432
Online ISSN 
1557-3265
History 
  • Received March 22, 2015
  • Revision received May 18, 2015
  • Accepted May 19, 2015
  • Published first May 26, 2015.

Article Versions

  • Previous version (May 26, 2015 - 06:25).
  • Previous version (July 21, 2015 - 09:10).
  • You are viewing the most recent version of this article.
Copyright & Usage 
©2015 American Association for Cancer Research.

Author Information

  1. Marc Damelin1,*,
  2. Alexander Bankovich2,
  3. Albert Park2,
  4. Jorge Aguilar2,
  5. Wade Anderson2,
  6. Marianne Santaguida2,
  7. Monette Aujay2,
  8. Sarah Fong2,
  9. Kiran Khandke1,
  10. Virginia Pulito1,
  11. Elana Ernstoff1,
  12. Paul Escarpe2,
  13. Jeffrey Bernstein2,
  14. Marybeth Pysz2,
  15. Wenyan Zhong1,
  16. Erik Upeslacis1,
  17. Judy Lucas1,
  18. Justin Lucas1,
  19. Timothy Nichols1,
  20. Kathryn Loving2,
  21. Orit Foord2,
  22. Johannes Hampl2,
  23. Robert Stull2,
  24. Frank Barletta1,
  25. Hadi Falahatpisheh1,
  26. Puja Sapra1,
  27. Hans-Peter Gerber1, and
  28. Scott J. Dylla2,*
  1. 1Pfizer, Inc., Pearl River, New York.
  2. 2Stemcentrx, Inc., South San Francisco, California.
  1. ↵*Corresponding Authors:
    Scott J. Dylla, Stemcentrx, Inc., 450 East Jamie Court, South San Francisco, CA 94080. Phone: 650-488-8547; Fax: 650-491-0116; E-mail: scott.dylla{at}stemcentrx.com; or Marc Damelin, Pfizer, Inc., 401 North Middletown Road, 200-4611, Pearl River, NY 10965. Phone: 845-602-7985; E-mail: marc.damelin{at}pfizer.com
  1. M. Damelin and A. Bankovich share first authorship.

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Clinical Cancer Research: 21 (18)
September 2015
Volume 21, Issue 18
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Anti-EFNA4 Calicheamicin Conjugates Effectively Target Triple-Negative Breast and Ovarian Tumor-Initiating Cells to Result in Sustained Tumor Regressions
Marc Damelin, Alexander Bankovich, Albert Park, Jorge Aguilar, Wade Anderson, Marianne Santaguida, Monette Aujay, Sarah Fong, Kiran Khandke, Virginia Pulito, Elana Ernstoff, Paul Escarpe, Jeffrey Bernstein, Marybeth Pysz, Wenyan Zhong, Erik Upeslacis, Judy Lucas, Justin Lucas, Timothy Nichols, Kathryn Loving, Orit Foord, Johannes Hampl, Robert Stull, Frank Barletta, Hadi Falahatpisheh, Puja Sapra, Hans-Peter Gerber and Scott J. Dylla
Clin Cancer Res September 15 2015 (21) (18) 4165-4173; DOI: 10.1158/1078-0432.CCR-15-0695

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Anti-EFNA4 Calicheamicin Conjugates Effectively Target Triple-Negative Breast and Ovarian Tumor-Initiating Cells to Result in Sustained Tumor Regressions
Marc Damelin, Alexander Bankovich, Albert Park, Jorge Aguilar, Wade Anderson, Marianne Santaguida, Monette Aujay, Sarah Fong, Kiran Khandke, Virginia Pulito, Elana Ernstoff, Paul Escarpe, Jeffrey Bernstein, Marybeth Pysz, Wenyan Zhong, Erik Upeslacis, Judy Lucas, Justin Lucas, Timothy Nichols, Kathryn Loving, Orit Foord, Johannes Hampl, Robert Stull, Frank Barletta, Hadi Falahatpisheh, Puja Sapra, Hans-Peter Gerber and Scott J. Dylla
Clin Cancer Res September 15 2015 (21) (18) 4165-4173; DOI: 10.1158/1078-0432.CCR-15-0695
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