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Clinical Cancer Research
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Table of Contents

Highlights

  • Highlights
    Highlights of This Issue
    Clin Cancer Res December 1 2015 21 (23) 5183-5183;

CCR 20th Anniversary Commentary

  • CCR 20th Anniversary Commentary | Free Article
    CCR 20th Anniversary Commentary: Molecular Pathology of ALK-Rearranged Lung Tumors
    A. John Iafrate
    Clin Cancer Res December 1 2015 21 (23) 5185-5187; DOI:10.1158/1078-0432.CCR-14-3130

CCR Translations

  • CCR Translations
    Can the Lung Cancer Pie Be Divided into Angiogenic Slices?
    Tina Cascone and John V. Heymach
    Clin Cancer Res December 1 2015 21 (23) 5188-5190; DOI:10.1158/1078-0432.CCR-15-1180

CCR New Strategies

  • CCR New Strategies
    New Strategies in Engineering T-cell Receptor Gene-Modified T cells to More Effectively Target Malignancies
    Thomas M. Schmitt, Ingunn M. Stromnes, Aude G. Chapuis and Philip D. Greenberg
    Clin Cancer Res December 1 2015 21 (23) 5191-5197; DOI:10.1158/1078-0432.CCR-15-0860

  • CCR New Strategies
    New Strategies in Stereotactic Radiotherapy for Oligometastases
    David A. Palma, Alexander V. Louie and George B. Rodrigues
    Clin Cancer Res December 1 2015 21 (23) 5198-5204; DOI:10.1158/1078-0432.CCR-15-0822

CCR Perspectives in Drug Approval

  • CCR Perspectives in Drug Approval
    FDA Approval Summary: Lenvatinib for Progressive, Radio-iodine–Refractory Differentiated Thyroid Cancer
    Abhilasha Nair, Steven J. Lemery, Jun Yang, Anshu Marathe, Liang Zhao, Hong Zhao, Xiaoping Jiang, Kun He, Gaetan Ladouceur, Amit K. Mitra, Liang Zhou, Emily Fox, Stephanie Aungst, Whitney Helms, Patricia Keegan and Richard Pazdur
    Clin Cancer Res December 1 2015 21 (23) 5205-5208; DOI:10.1158/1078-0432.CCR-15-1377

Molecular Pathways

  • Molecular Pathways | AuthorChoice
    Molecular Pathways: New Signaling Considerations When Targeting Cytoskeletal Balance to Reduce Tumor Growth
    Kristi R. Chakrabarti, Lindsay Hessler, Lekhana Bhandary and Stuart S. Martin
    Clin Cancer Res December 1 2015 21 (23) 5209-5214; DOI:10.1158/1078-0432.CCR-15-0328

Cancer Therapy: Clinical

  • Cancer Therapy: Clinical
    Multiple Gastrointestinal Polyps in Patients Treated with BRAF Inhibitors
    Ravi K. Amaravadi, Kathryn E. Hamilton, Xiaohong Ma, Shengfu Piao, Armando Del Portillo, Katherine L. Nathanson, Matteo S. Carlino, Georgina V. Long, Igor Puzanov, Xiaowei Xu, Jennifer J.D. Morrissette, Kenneth Y. Tsai, Keith T. Flaherty, Jeffrey A. Sosman, Grant R. Goodman, Grant A. McArthur, Anil K. Rustgi, David C. Metz, Lynn M. Schuchter, Paul B. Chapman and Antonia R. Sepulveda
    Clin Cancer Res December 1 2015 21 (23) 5215-5221; DOI:10.1158/1078-0432.CCR-15-0469

  • Cancer Therapy: Clinical
    Cellular Mechanisms Underlying Complete Hematological Response of Chronic Myeloid Leukemia to BRAF and MEK1/2 Inhibition in a Patient with Concomitant Metastatic Melanoma
    Miles C. Andrews, Natalie Turner, Janis Boyd, Andrew W. Roberts, Andrew P. Grigg, Andreas Behren and Jonathan Cebon
    Clin Cancer Res December 1 2015 21 (23) 5222-5234; DOI:10.1158/1078-0432.CCR-15-0393

  • Cancer Therapy: Clinical
    A Phase I Trial of Combined Ridaforolimus and MK-2206 in Patients with Advanced Malignancies
    Shilpa Gupta, Guillem Argilés, Pamela N. Munster, Antoine Hollebecque, Olav Dajani, Jonathan D. Cheng, Ruixue Wang, Ann Swift, Alessandra Tosolini and Sarina A. Piha-Paul
    Clin Cancer Res December 1 2015 21 (23) 5235-5244; DOI:10.1158/1078-0432.CCR-15-0180

  • Cancer Therapy: Clinical
    Randomized Phase II Study of Adjuvant Chemotherapy with Long-term S-1 versus Cisplatin+S-1 in Completely Resected Stage II–IIIA Non–Small Cell Lung Cancer
    Yasuo Iwamoto, Tetsuya Mitsudomi, Kazuko Sakai, Takeharu Yamanaka, Hiroshige Yoshioka, Makoto Takahama, Masahiro Yoshimura, Ichiro Yoshino, Masayuki Takeda, Shunichi Sugawara, Tomoya Kawaguchi, Toshiaki Takahashi, Mitsunori Ohta, Yukito Ichinose, Shinji Atagi, Morihito Okada, Hideo Saka, Kazuhiko Nakagawa, Yoichi Nakanishi and Kazuto Nishio
    Clin Cancer Res December 1 2015 21 (23) 5245-5252; DOI:10.1158/1078-0432.CCR-14-3160

Personalized Medicine and Imaging

  • Personalized Medicine and Imaging
    Gene Expression Signatures Predictive of Bevacizumab/Erlotinib Therapeutic Benefit in Advanced Nonsquamous Non–Small Cell Lung Cancer Patients (SAKK 19/05 trial)
    Anca Franzini, Florent Baty, Ina I. Macovei, Oliver Dürr, Cornelia Droege, Daniel Betticher, Bogdan D. Grigoriu, Dirk Klingbiel, Francesco Zappa and Martin H. Brutsche
    Clin Cancer Res December 1 2015 21 (23) 5253-5263; DOI:10.1158/1078-0432.CCR-14-3135

  • Personalized Medicine and Imaging
    Genome-wide Analysis Identifies Novel Loci Associated with Ovarian Cancer Outcomes: Findings from the Ovarian Cancer Association Consortium
    Sharon E. Johnatty, Jonathan P. Tyrer, Siddhartha Kar, Jonathan Beesley, Yi Lu, Bo Gao, Peter A. Fasching, Alexander Hein, Arif B. Ekici, Matthias W. Beckmann, Diether Lambrechts, Els Van Nieuwenhuysen, Ignace Vergote, Sandrina Lambrechts, Mary Anne Rossing, Jennifer A. Doherty, Jenny Chang-Claude, Francesmary Modugno, Roberta B. Ness, Kirsten B. Moysich, Douglas A. Levine, Lambertus A. Kiemeney, Leon F.A.G. Massuger, Jacek Gronwald, Jan Lubiński, Anna Jakubowska, Cezary Cybulski, Louise Brinton, Jolanta Lissowska, Nicolas Wentzensen, Honglin Song, Valerie Rhenius, Ian Campbell, Diana Eccles, Weiva Sieh, Alice S. Whittemore, Valerie McGuire, Joseph H. Rothstein, Rebecca Sutphen, Hoda Anton-Culver, Argyrios Ziogas, Simon A. Gayther, Aleksandra Gentry-Maharaj, Usha Menon, Susan J. Ramus, Celeste L. Pearce, Malcolm C. Pike, Daniel O. Stram, Anna H. Wu, Jolanta Kupryjanczyk, Agnieszka Dansonka-Mieszkowska, Iwona K. Rzepecka, Beata Spiewankiewicz, Marc T. Goodman, Lynne R. Wilkens, Michael E. Carney, Pamela J. Thompson, Florian Heitz, Andreas du Bois, Ira Schwaab, Philipp Harter, Jacobus Pisterer, Peter Hillemanns, on behalf of the AGO Study Group, Beth Y. Karlan, Christine Walsh, Jenny Lester, Sandra Orsulic, Stacey J. Winham, Madalene Earp, Melissa C. Larson, Zachary C. Fogarty, Estrid Høgdall, Allan Jensen, Susanne Kruger Kjaer, Brooke L. Fridley, Julie M. Cunningham, Robert A. Vierkant, Joellen M. Schildkraut, Edwin S. Iversen, Kathryn L. Terry, Daniel W. Cramer, Elisa V. Bandera, Irene Orlow, Tanja Pejovic, Yukie Bean, Claus Høgdall, Lene Lundvall, Ian McNeish, James Paul, Karen Carty, Nadeem Siddiqui, Rosalind Glasspool, Thomas Sellers, Catherine Kennedy, Yoke-Eng Chiew, Andrew Berchuck, Stuart MacGregor, Paul D.P. Pharoah, Ellen L. Goode, Anna deFazio, Penelope M. Webb and Georgia Chenevix-Trench
    Clin Cancer Res December 1 2015 21 (23) 5264-5276; DOI:10.1158/1078-0432.CCR-15-0632

  • Personalized Medicine and Imaging
    A Phase I/II Study for Analytic Validation of 89Zr-J591 ImmunoPET as a Molecular Imaging Agent for Metastatic Prostate Cancer
    Neeta Pandit-Taskar, Joseph A. O'Donoghue, Jeremy C. Durack, Serge K. Lyashchenko, Sarah M. Cheal, Volkan Beylergil, Robert A. Lefkowitz, Jorge A. Carrasquillo, Danny F. Martinez, Alex Mak Fung, Stephen B. Solomon, Mithat Gönen, Glenn Heller, Massimo Loda, David M. Nanus, Scott T. Tagawa, Jarett L. Feldman, Joseph R. Osborne, Jason S. Lewis, Victor E. Reuter, Wolfgang A. Weber, Neil H. Bander, Howard I. Scher, Steven M. Larson and Michael J. Morris
    Clin Cancer Res December 1 2015 21 (23) 5277-5285; DOI:10.1158/1078-0432.CCR-15-0552

  • Personalized Medicine and Imaging
    Stool Bacteriomic Profiling in Patients with Metastatic Renal Cell Carcinoma Receiving Vascular Endothelial Growth Factor–Tyrosine Kinase Inhibitors
    Sumanta K. Pal, Sierra M. Li, Xiwei Wu, Hanjun Qin, Marcin Kortylewski, JoAnn Hsu, Courtney Carmichael and Paul Frankel
    Clin Cancer Res December 1 2015 21 (23) 5286-5293; DOI:10.1158/1078-0432.CCR-15-0724

  • Personalized Medicine and Imaging
    Analysis of Molecular Markers by Anatomic Tumor Site in Stage III Colon Carcinomas from Adjuvant Chemotherapy Trial NCCTG N0147 (Alliance)
    Frank A. Sinicrope, Michelle R. Mahoney, Harry H. Yoon, Thomas C. Smyrk, Stephen N. Thibodeau, Richard M. Goldberg, Garth D. Nelson, Daniel J. Sargent and Steven R. Alberts
    Clin Cancer Res December 1 2015 21 (23) 5294-5304; DOI:10.1158/1078-0432.CCR-15-0527

  • Personalized Medicine and Imaging
    EGFR Exon 18 Mutations in Lung Cancer: Molecular Predictors of Augmented Sensitivity to Afatinib or Neratinib as Compared with First- or Third-Generation TKIs
    Yoshihisa Kobayashi, Yosuke Togashi, Yasushi Yatabe, Hiroshi Mizuuchi, Park Jangchul, Chiaki Kondo, Masaki Shimoji, Katsuaki Sato, Kenichi Suda, Kenji Tomizawa, Toshiki Takemoto, Toyoaki Hida, Kazuto Nishio and Tetsuya Mitsudomi
    Clin Cancer Res December 1 2015 21 (23) 5305-5313; DOI:10.1158/1078-0432.CCR-15-1046

Cancer Therapy: Preclinical

  • Cancer Therapy: Preclinical | AuthorChoice
    Phase I Clinical Pharmacology Study of F14512, a New Polyamine-Vectorized Anticancer Drug, in Naturally Occurring Canine Lymphoma
    Dominique Tierny, François Serres, Zacharie Segaoula, Ingrid Bemelmans, Emmanuel Bouchaert, Aurélie Pétain, Viviane Brel, Stéphane Couffin, Thierry Marchal, Laurent Nguyen, Xavier Thuru, Pierre Ferré, Nicolas Guilbaud and Bruno Gomes
    Clin Cancer Res December 1 2015 21 (23) 5314-5323; DOI:10.1158/1078-0432.CCR-14-3174

  • Cancer Therapy: Preclinical
    Pyrvinium Targets CD133 in Human Glioblastoma Brain Tumor–Initiating Cells
    Chitra Venugopal, Robin Hallett, Parvez Vora, Branavan Manoranjan, Sujeivan Mahendram, Maleeha A. Qazi, Nicole McFarlane, Minomi Subapanditha, Sara M. Nolte, Mohini Singh, David Bakhshinyan, Neha Garg, Thusyanth Vijayakumar, Boleslaw Lach, John P. Provias, Kesava Reddy, Naresh K. Murty, Bradley W. Doble, Mickie Bhatia, John A. Hassell and Sheila K. Singh
    Clin Cancer Res December 1 2015 21 (23) 5324-5337; DOI:10.1158/1078-0432.CCR-14-3147

  • Cancer Therapy: Preclinical
    Combining an Aurora Kinase Inhibitor and a Death Receptor Ligand/Agonist Antibody Triggers Apoptosis in Melanoma Cells and Prevents Tumor Growth in Preclinical Mouse Models
    Yan Liu, Oriana E. Hawkins, Anna E. Vilgelm, Jeffrey S. Pawlikowski, Jeffrey A. Ecsedy, Jeffrey A. Sosman, Mark C. Kelley and Ann Richmond
    Clin Cancer Res December 1 2015 21 (23) 5338-5348; DOI:10.1158/1078-0432.CCR-15-0293

  • Cancer Therapy: Preclinical | AuthorChoice
    Aspirin Suppresses the Growth and Metastasis of Osteosarcoma through the NF-κB Pathway
    Dan Liao, Li Zhong, Tingmei Duan, Ru-Hua Zhang, Xin Wang, Gang Wang, Kaishun Hu, Xiaobin Lv and Tiebang Kang
    Clin Cancer Res December 1 2015 21 (23) 5349-5359; DOI:10.1158/1078-0432.CCR-15-0198

Biology of Human Tumors

  • Biology of Human Tumors
    Genome Analysis of Latin American Cervical Cancer: Frequent Activation of the PIK3CA Pathway
    Hong Lou, Guillermo Villagran, Joseph F. Boland, Kate M. Im, Sarita Polo, Weiyin Zhou, Ushie Odey, Eligia Juárez-Torres, Ingrid Medina-Martínez, Edgar Roman-Basaure, Jason Mitchell, David Roberson, Julie Sawitzke, Lisa Garland, Maria Rodríguez-Herrera, David Wells, Jennifer Troyer, Francisco Castillo Pinto, Sara Bass, Xijun Zhang, Miriam Castillo, Bert Gold, Hesler Morales, Meredith Yeager, Jaime Berumen, Enrique Alvirez, Eduardo Gharzouzi and Michael Dean
    Clin Cancer Res December 1 2015 21 (23) 5360-5370; DOI:10.1158/1078-0432.CCR-14-1837

  • Biology of Human Tumors | AuthorChoice
    Transcriptomic Profiling of Sequential Tumors from Breast Cancer Patients Provides a Global View of Metastatic Expression Changes Following Endocrine Therapy
    Jean McBryan, Ailís Fagan, Damian McCartan, Fiona T. Bane, Damir Varešlija, Sinéad Cocchiglia, Christopher Byrne, Jarlath Bolger, Marie McIlroy, Lance Hudson, Paul Tibbitts, Peadar Ó Gaora, Arnold D. Hill and Leonie S. Young
    Clin Cancer Res December 1 2015 21 (23) 5371-5379; DOI:10.1158/1078-0432.CCR-14-2155

  • Biology of Human Tumors
    Dysfunctional Antibodies in the Tumor Microenvironment Associate with Impaired Anticancer Immunity
    Ningyan Zhang, Hui Deng, Xuejun Fan, Anneliese Gonzalez, Songlin Zhang, Randall J. Brezski, Byung-Kwon Choi, Michael Rycyzyn, William Strohl, Robert Jordan and Zhiqiang An
    Clin Cancer Res December 1 2015 21 (23) 5380-5390; DOI:10.1158/1078-0432.CCR-15-1057

  • Biology of Human Tumors
    Activation of EZH2 and SUZ12 Regulated by E2F1 Predicts the Disease Progression and Aggressive Characteristics of Bladder Cancer
    Se-Ra Lee, Yun-Gil Roh, Seon-Kyu Kim, Ju-Seog Lee, So-Young Seol, Hyun-Hee Lee, Won-Tae Kim, Wun-Jae Kim, Jeonghoon Heo, Hee-Jae Cha, Tae-Hong Kang, Jin Woong Chung, In-Sun Chu and Sun-Hee Leem
    Clin Cancer Res December 1 2015 21 (23) 5391-5403; DOI:10.1158/1078-0432.CCR-14-2680

Letter to the Editor

  • Letter to the Editor
    Missed Opportunities and Lost Lives: Consequences of Some Proposed Changes to Regulations on Research with Human Tissues—Letter
    William E. Grizzle
    Clin Cancer Res December 1 2015 21 (23) 5404-5405; DOI:10.1158/1078-0432.CCR-15-2513

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Clinical Cancer Research: 21 (23)
December 2015
Volume 21, Issue 23
  • Table of Contents
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Issue Highlights

  • EGFR Exon 18 Mutations in Lung Cancer: Molecular Predictors of Augmented Sensitivity to Afatinib or Neratinib as Compared with First- or Third-Generation TKIs
  • Phase I Clinical Pharmacology Study of F14512, a New Polyamine-Vectorized Anticancer Drug, in Naturally Occurring Canine Lymphoma
  • Multiple Gastrointestinal Polyps in Patients Treated with BRAF Inhibitors
  • Genome Analysis of Latin American Cervical Cancer: Frequent Activation of the PIK3CA Pathway
  • Transcriptomic Profiling of Sequential Tumors from Breast Cancer Patients Provides a Global View of Metastatic Expression Changes Following Endocrine Therapy

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Clinical Cancer Research
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