Clinical Cancer Research: 21 (3)

Highlights

Highlights

Highlights of This Issue

Clin Cancer Res February 1 2015 21 (3) 491-491;

CCR 20th Anniversary Commentary

CCR 20th Anniversary Commentary | Free Article

CCR 20^th Anniversary Commentary: Radioactive Drones for B-cell Lymphoma

Susan J. Knox and Ronald Levy

Clin Cancer Res February 1 2015 21 (3) 493-494; DOI:10.1158/1078-0432.CCR-14-2547

CCR Translations

CCR Translations

Novel Targets in Head and Neck Cancer: Should We Be Optimistic?

Gabriel S. Krigsfeld and Christine H. Chung

Clin Cancer Res February 1 2015 21 (3) 495-497; DOI:10.1158/1078-0432.CCR-14-1776

Molecular Pathways

Molecular Pathways

Molecular Pathways: Autophagy in Cancer—A Matter of Timing and Context

Michelle Cicchini, Vassiliki Karantza and Bing Xia

Clin Cancer Res February 1 2015 21 (3) 498-504; DOI:10.1158/1078-0432.CCR-13-2438
Molecular Pathways

Molecular Pathways: Novel Approaches for Improved Therapeutic Targeting of Hedgehog Signaling in Cancer Stem Cells

Verline Justilien and Alan P. Fields

Clin Cancer Res February 1 2015 21 (3) 505-513; DOI:10.1158/1078-0432.CCR-14-0507

Special Report

Special Report | Free Article

Electronic Nicotine Delivery Systems: A Policy Statement from the American Association for Cancer Research and the American Society of Clinical Oncology

Thomas H. Brandon, Maciej L. Goniewicz, Nasser H. Hanna, Dorothy K. Hatsukami, Roy S. Herbst, Jennifer A. Hobin, Jamie S. Ostroff, Peter G. Shields, Benjamin A. Toll, Courtney A. Tyne, Kasisomayajula Viswanath and Graham W. Warren

Clin Cancer Res February 1 2015 21 (3) 514-525; DOI:10.1158/1078-0432.CCR-14-2544

Review

Review

HER2 as a Therapeutic Target in Head and Neck Squamous Cell Carcinoma

Netanya I. Pollock and Jennifer R. Grandis

Clin Cancer Res February 1 2015 21 (3) 526-533; DOI:10.1158/1078-0432.CCR-14-1432

Cancer Therapy: Clinical

Cancer Therapy: Clinical

Persistence of CTL Clones Targeting Melanocyte Differentiation Antigens Was Insufficient to Mediate Significant Melanoma Regression in Humans

Smita S. Chandran, Biman C. Paria, Abhishek K. Srivastava, Luke D. Rothermel, Daniel J. Stephens, Mark E. Dudley, Robert Somerville, John R. Wunderlich, Richard M. Sherry, James C. Yang, Steven A. Rosenberg and Udai S. Kammula

Clin Cancer Res February 1 2015 21 (3) 534-543; DOI:10.1158/1078-0432.CCR-14-2208
Cancer Therapy: Clinical

Phase II Clinical and Exploratory Biomarker Study of Dacomitinib in Patients with Recurrent and/or Metastatic Squamous Cell Carcinoma of Head and Neck

Han Sang Kim, Hyeong Ju Kwon, Inkyung Jung, Mi Ran Yun, Myung-Ju Ahn, Byung Woog Kang, Jong-Mu Sun, Sung Bae Kim, Dok-Hyun Yoon, Keon Uk Park, Se-Hoon Lee, Yoon Woo Koh, Se Hun Kim, Eun Chang Choi, Dong Hoe Koo, Jin Hee Sohn, Bomi Kim, Nak-Jung Kwon, Hwan Jung Yun, Min Goo Lee, Ji Hyun Lee, Tae-Min Kim, Hye Ryun Kim, Joo Hang Kim, Soonmyung Paik and Byoung Chul Cho

Clin Cancer Res February 1 2015 21 (3) 544-552; DOI:10.1158/1078-0432.CCR-14-1756
Cancer Therapy: Clinical | AuthorChoice

First-in-Human Dose Study of the Novel Transforming Growth Factor-β Receptor I Kinase Inhibitor LY2157299 Monohydrate in Patients with Advanced Cancer and Glioma

Jordi Rodon, Michael A. Carducci, Juan M Sepulveda-Sánchez, Analia Azaro, Emiliano Calvo, Joan Seoane, Irene Braña, Elisabet Sicart, Ivelina Gueorguieva, Ann L. Cleverly, N. Sokalingum Pillay, Durisala Desaiah, Shawn T. Estrem, Luis Paz-Ares, Matthias Holdhoff, Jaishri Blakeley, Michael M. Lahn and Jose Baselga

Clin Cancer Res February 1 2015 21 (3) 553-560; DOI:10.1158/1078-0432.CCR-14-1380

Personalized Medicine and Imaging

Personalized Medicine and Imaging | AuthorChoice

The High-Dose Aldesleukin “Select” Trial: A Trial to Prospectively Validate Predictive Models of Response to Treatment in Patients with Metastatic Renal Cell Carcinoma

David F. McDermott, Su-Chun Cheng, Sabina Signoretti, Kim A. Margolin, Joseph I. Clark, Jeffrey A. Sosman, Janice P. Dutcher, Theodore F. Logan, Brendan D. Curti, Marc S. Ernstoff, Leonard Appleman, Michael K.K. Wong, Nikhil I. Khushalani, Leslie Oleksowicz, Ulka N. Vaishampayan, James W. Mier, David J. Panka, Rupal S. Bhatt, Alexandra S. Bailey, Bradley C. Leibovich, Eugene D. Kwon, Fairooz F. Kabbinavar, Arie S. Belldegrun, Robert A. Figlin, Allan J. Pantuck, Meredith M. Regan and Michael B. Atkins

Clin Cancer Res February 1 2015 21 (3) 561-568; DOI:10.1158/1078-0432.CCR-14-1520
Personalized Medicine and Imaging | AuthorChoice

High HER2 Expression Correlates with Response to the Combination of Lapatinib and Trastuzumab

Maurizio Scaltriti, Paolo Nuciforo, Ian Bradbury, Jeff Sperinde, Dominique Agbor-Tarh, Christine Campbell, Ahmed Chenna, John Winslow, Violeta Serra, Josep Lluis Parra, Ludmila Prudkin, José Jimenez, Claudia Aura, Nadia Harbeck, Lajos Pusztai, Catherine Ellis, Holger Eidtmann, Joaquin Arribas, Javier Cortes, Evandro de Azambuja, Martine Piccart and José Baselga

Clin Cancer Res February 1 2015 21 (3) 569-576; DOI:10.1158/1078-0432.CCR-14-1824
Personalized Medicine and Imaging

Optical Mammography Using Diffuse Optical Spectroscopy for Monitoring Tumor Response to Neoadjuvant Chemotherapy in Women with Locally Advanced Breast Cancer

Boudewijn E. Schaafsma, Martijn van de Giessen, Ayoub Charehbili, Vincent T.H.B.M. Smit, Judith R. Kroep, Boudewijn P.F. Lelieveldt, Gerrit-Jan Liefers, Alan Chan, Clemens W.G.M. Löwik, Jouke Dijkstra, Cornelis J.H. van de Velde, Martin N.J.M. Wasser and Alexander L. Vahrmeijer

Clin Cancer Res February 1 2015 21 (3) 577-584; DOI:10.1158/1078-0432.CCR-14-0736
Personalized Medicine and Imaging

A Five-Gene Hedgehog Signature Developed as a Patient Preselection Tool for Hedgehog Inhibitor Therapy in Medulloblastoma

Yaping Shou, Douglas M. Robinson, Dereck D. Amakye, Kristine L. Rose, Yoon-Jae Cho, Keith L. Ligon, Thad Sharp, Asifa S. Haider, Raj Bandaru, Yuichi Ando, Birgit Geoerger, François Doz, David M. Ashley, Darren R. Hargrave, Michela Casanova, Hussein A. Tawbi, Jordi Rodon, Anne L. Thomas, Alain C. Mita, Tobey J. MacDonald and Mark W. Kieran

Clin Cancer Res February 1 2015 21 (3) 585-593; DOI:10.1158/1078-0432.CCR-13-1711
Personalized Medicine and Imaging

Interobserver Agreement in Describing the Ultrasound Appearance of Adnexal Masses and in Calculating the Risk of Malignancy Using Logistic Regression Models

Povilas Sladkevicius and Lil Valentin

Clin Cancer Res February 1 2015 21 (3) 594-601; DOI:10.1158/1078-0432.CCR-14-0906
Personalized Medicine and Imaging

Differential Platelet Levels Affect Response to Taxane-Based Therapy in Ovarian Cancer

Justin Bottsford-Miller, Hyun-Jin Choi, Heather J. Dalton, Rebecca L. Stone, Min Soon Cho, Monika Haemmerle, Alpa M. Nick, Sunila Pradeep, Behrouz Zand, Rebecca A. Previs, Chad V. Pecot, Erin King Crane, Wei Hu, Susan K. Lutgendorf, Vahid Afshar-Kharghan and Anil K. Sood

Clin Cancer Res February 1 2015 21 (3) 602-610; DOI:10.1158/1078-0432.CCR-14-0870

Cancer Therapy: Preclinical

Cancer Therapy: Preclinical | AuthorChoice

Manipulating the Tumor Microenvironment Ex Vivo for Enhanced Expansion of Tumor-Infiltrating Lymphocytes for Adoptive Cell Therapy

Jessica Ann Chacon, Amod A. Sarnaik, Jie Qing Chen, Caitlin Creasy, Charuta Kale, John Robinson, Jeffrey Weber, Patrick Hwu, Shari Pilon-Thomas and Laszlo Radvanyi

Clin Cancer Res February 1 2015 21 (3) 611-621; DOI:10.1158/1078-0432.CCR-14-1934

Biology of Human Tumors

Biology of Human Tumors

Serum CA19-9 Is Significantly Upregulated up to 2 Years before Diagnosis with Pancreatic Cancer: Implications for Early Disease Detection

Darragh P. O'Brien, Neomal S. Sandanayake, Claire Jenkinson, Aleksandra Gentry-Maharaj, Sophia Apostolidou, Evangelia-Ourania Fourkala, Stephane Camuzeaux, Oleg Blyuss, Richard Gunu, Anne Dawnay, Alexey Zaikin, Ross C. Smith, Ian J. Jacobs, Usha Menon, Eithne Costello, Stephen P. Pereira and John F. Timms

Clin Cancer Res February 1 2015 21 (3) 622-631; DOI:10.1158/1078-0432.CCR-14-0365
Biology of Human Tumors

Integrative and Comparative Genomic Analysis of HPV-Positive and HPV-Negative Head and Neck Squamous Cell Carcinomas

Tanguy Y. Seiwert, Zhixiang Zuo, Michaela K. Keck, Arun Khattri, Chandra S. Pedamallu, Thomas Stricker, Christopher Brown, Trevor J. Pugh, Petar Stojanov, Juok Cho, Michael S. Lawrence, Gad Getz, Johannes Brägelmann, Rebecca DeBoer, Ralph R. Weichselbaum, Alexander Langerman, Louis Portugal, Elizabeth Blair, Kerstin Stenson, Mark W. Lingen, Ezra E.W. Cohen, Everett E. Vokes, Kevin P. White and Peter S. Hammerman

Clin Cancer Res February 1 2015 21 (3) 632-641; DOI:10.1158/1078-0432.CCR-13-3310
Biology of Human Tumors

Podoplanin-Positive Cancer-Associated Fibroblasts in the Tumor Microenvironment Induce Primary Resistance to EGFR-TKIs in Lung Adenocarcinoma with EGFR Mutation

Tatsuya Yoshida, Genichiro Ishii, Koichi Goto, Shinya Neri, Hiroko Hashimoto, Kiyotaka Yoh, Seiji Niho, Shigeki Umemura, Shingo Matsumoto, Hironobu Ohmatsu, Shinsuke Iida, Akio Niimi, Kanji Nagai, Yuichiro Ohe and Atsushi Ochiai

Clin Cancer Res February 1 2015 21 (3) 642-651; DOI:10.1158/1078-0432.CCR-14-0846
Biology of Human Tumors

Germline Mutation in BRCA1 or BRCA2 and Ten-Year Survival for Women Diagnosed with Epithelial Ovarian Cancer

Francisco J. Candido-dos-Reis, Honglin Song, Ellen L. Goode, Julie M. Cunningham, Brooke L. Fridley, Melissa C. Larson, Kathryn Alsop, Ed Dicks, Patricia Harrington, Susan J. Ramus, Anna de Fazio, Gillian Mitchell, Sian Fereday, Kelly L. Bolton, Charlie Gourley, Caroline Michie, Beth Karlan, Jenny Lester, Christine Walsh, Ilana Cass, Håkan Olsson, Martin Gore, Javier J. Benitez, Maria J. Garcia, Irene Andrulis, Anna Marie Mulligan, Gord Glendon, Ignacio Blanco, Conxi Lazaro, Alice S. Whittemore, Valerie McGuire, Weiva Sieh, Marco Montagna, Elisa Alducci, Siegal Sadetzki, Angela Chetrit, Ava Kwong, Susanne K. Kjaer, Allan Jensen, Estrid Høgdall, Susan Neuhausen, Robert Nussbaum, Mary Daly, Mark H. Greene, Phuong L. Mai, Jennifer T. Loud, Kirsten Moysich, Amanda E. Toland, Diether Lambrechts, Steve Ellis, Debra Frost, James D. Brenton, Marc Tischkowitz, Douglas F. Easton, Antonis Antoniou, Georgia Chenevix-Trench, Simon A. Gayther, David Bowtell and Paul D.P. Pharoah; for EMBRACE; for kConFab Investigators; for The Australian Ovarian Cancer Study Group

Clin Cancer Res February 1 2015 21 (3) 652-657; DOI:10.1158/1078-0432.CCR-14-2497

Letters to the Editor

Letters to the Editor

DNA Repair Mutations and Outcomes in Ovarian Cancer—Letter

Robert A. Soslow

Clin Cancer Res February 1 2015 21 (3) 658-658; DOI:10.1158/1078-0432.CCR-14-2436
Letters to the Editor

DNA Repair Mutations and Outcomes in Ovarian Cancer—Response

Elizabeth M. Swisher, Barbara M. Norquist, Kathryn P. Pennington, Mara H. Rendi and Rochelle L. Garcia

Clin Cancer Res February 1 2015 21 (3) 659-659; DOI:10.1158/1078-0432.CCR-14-2805

Corrections

Corrections

Correction: First-in-Human Study of CH5132799, an Oral Class I PI3K Inhibitor, Studying Toxicity, Pharmacokinetics, and Pharmacodynamics, in Patients with Metastatic Cancer

Clin Cancer Res February 1 2015 21 (3) 660-660; DOI:10.1158/1078-0432.CCR-14-3188
Corrections

Correction: HDM2 Regulation by AURKA Promotes Cell Survival in Gastric Cancer

Clin Cancer Res February 1 2015 21 (3) 661-661; DOI:10.1158/1078-0432.CCR-14-3207
Corrections

Correction: Durable Therapeutic Efficacy Utilizing Combinatorial Blockade against IDO, CTLA-4, and PD-L1 in Mice with Brain Tumors

Clin Cancer Res February 1 2015 21 (3) 662-662; DOI:10.1158/1078-0432.CCR-14-3211

Main menu

User menu

Search

Table of Contents

Highlights

CCR 20th Anniversary Commentary

CCR Translations

Molecular Pathways

Special Report

Review

Cancer Therapy: Clinical

Personalized Medicine and Imaging

Cancer Therapy: Preclinical

Biology of Human Tumors

Letters to the Editor

Corrections

Issue Highlights

Jump to

Articles

Info for

About Clinical Cancer Research