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Table of Contents

Highlights

  • Highlights
    Highlights of This Issue
    Clin Cancer Res February 1 2015 21 (3) 491-491;

CCR 20th Anniversary Commentary

  • CCR 20th Anniversary Commentary | Free Article
    CCR 20th Anniversary Commentary: Radioactive Drones for B-cell Lymphoma
    Susan J. Knox and Ronald Levy
    Clin Cancer Res February 1 2015 21 (3) 493-494; DOI:10.1158/1078-0432.CCR-14-2547

CCR Translations

  • CCR Translations
    Novel Targets in Head and Neck Cancer: Should We Be Optimistic?
    Gabriel S. Krigsfeld and Christine H. Chung
    Clin Cancer Res February 1 2015 21 (3) 495-497; DOI:10.1158/1078-0432.CCR-14-1776

Molecular Pathways

  • Molecular Pathways
    Molecular Pathways: Autophagy in Cancer—A Matter of Timing and Context
    Michelle Cicchini, Vassiliki Karantza and Bing Xia
    Clin Cancer Res February 1 2015 21 (3) 498-504; DOI:10.1158/1078-0432.CCR-13-2438

  • Molecular Pathways
    Molecular Pathways: Novel Approaches for Improved Therapeutic Targeting of Hedgehog Signaling in Cancer Stem Cells
    Verline Justilien and Alan P. Fields
    Clin Cancer Res February 1 2015 21 (3) 505-513; DOI:10.1158/1078-0432.CCR-14-0507

Special Report

  • Special Report | Free Article
    Electronic Nicotine Delivery Systems: A Policy Statement from the American Association for Cancer Research and the American Society of Clinical Oncology
    Thomas H. Brandon, Maciej L. Goniewicz, Nasser H. Hanna, Dorothy K. Hatsukami, Roy S. Herbst, Jennifer A. Hobin, Jamie S. Ostroff, Peter G. Shields, Benjamin A. Toll, Courtney A. Tyne, Kasisomayajula Viswanath and Graham W. Warren
    Clin Cancer Res February 1 2015 21 (3) 514-525; DOI:10.1158/1078-0432.CCR-14-2544

Review

  • Review
    HER2 as a Therapeutic Target in Head and Neck Squamous Cell Carcinoma
    Netanya I. Pollock and Jennifer R. Grandis
    Clin Cancer Res February 1 2015 21 (3) 526-533; DOI:10.1158/1078-0432.CCR-14-1432

Cancer Therapy: Clinical

  • Cancer Therapy: Clinical
    Persistence of CTL Clones Targeting Melanocyte Differentiation Antigens Was Insufficient to Mediate Significant Melanoma Regression in Humans
    Smita S. Chandran, Biman C. Paria, Abhishek K. Srivastava, Luke D. Rothermel, Daniel J. Stephens, Mark E. Dudley, Robert Somerville, John R. Wunderlich, Richard M. Sherry, James C. Yang, Steven A. Rosenberg and Udai S. Kammula
    Clin Cancer Res February 1 2015 21 (3) 534-543; DOI:10.1158/1078-0432.CCR-14-2208

  • Cancer Therapy: Clinical
    Phase II Clinical and Exploratory Biomarker Study of Dacomitinib in Patients with Recurrent and/or Metastatic Squamous Cell Carcinoma of Head and Neck
    Han Sang Kim, Hyeong Ju Kwon, Inkyung Jung, Mi Ran Yun, Myung-Ju Ahn, Byung Woog Kang, Jong-Mu Sun, Sung Bae Kim, Dok-Hyun Yoon, Keon Uk Park, Se-Hoon Lee, Yoon Woo Koh, Se Hun Kim, Eun Chang Choi, Dong Hoe Koo, Jin Hee Sohn, Bomi Kim, Nak-Jung Kwon, Hwan Jung Yun, Min Goo Lee, Ji Hyun Lee, Tae-Min Kim, Hye Ryun Kim, Joo Hang Kim, Soonmyung Paik and Byoung Chul Cho
    Clin Cancer Res February 1 2015 21 (3) 544-552; DOI:10.1158/1078-0432.CCR-14-1756

  • Cancer Therapy: Clinical | AuthorChoice
    First-in-Human Dose Study of the Novel Transforming Growth Factor-β Receptor I Kinase Inhibitor LY2157299 Monohydrate in Patients with Advanced Cancer and Glioma
    Jordi Rodon, Michael A. Carducci, Juan M Sepulveda-Sánchez, Analia Azaro, Emiliano Calvo, Joan Seoane, Irene Braña, Elisabet Sicart, Ivelina Gueorguieva, Ann L. Cleverly, N. Sokalingum Pillay, Durisala Desaiah, Shawn T. Estrem, Luis Paz-Ares, Matthias Holdhoff, Jaishri Blakeley, Michael M. Lahn and Jose Baselga
    Clin Cancer Res February 1 2015 21 (3) 553-560; DOI:10.1158/1078-0432.CCR-14-1380

Personalized Medicine and Imaging

  • Personalized Medicine and Imaging | AuthorChoice
    The High-Dose Aldesleukin “Select” Trial: A Trial to Prospectively Validate Predictive Models of Response to Treatment in Patients with Metastatic Renal Cell Carcinoma
    David F. McDermott, Su-Chun Cheng, Sabina Signoretti, Kim A. Margolin, Joseph I. Clark, Jeffrey A. Sosman, Janice P. Dutcher, Theodore F. Logan, Brendan D. Curti, Marc S. Ernstoff, Leonard Appleman, Michael K.K. Wong, Nikhil I. Khushalani, Leslie Oleksowicz, Ulka N. Vaishampayan, James W. Mier, David J. Panka, Rupal S. Bhatt, Alexandra S. Bailey, Bradley C. Leibovich, Eugene D. Kwon, Fairooz F. Kabbinavar, Arie S. Belldegrun, Robert A. Figlin, Allan J. Pantuck, Meredith M. Regan and Michael B. Atkins
    Clin Cancer Res February 1 2015 21 (3) 561-568; DOI:10.1158/1078-0432.CCR-14-1520

  • Personalized Medicine and Imaging | AuthorChoice
    High HER2 Expression Correlates with Response to the Combination of Lapatinib and Trastuzumab
    Maurizio Scaltriti, Paolo Nuciforo, Ian Bradbury, Jeff Sperinde, Dominique Agbor-Tarh, Christine Campbell, Ahmed Chenna, John Winslow, Violeta Serra, Josep Lluis Parra, Ludmila Prudkin, José Jimenez, Claudia Aura, Nadia Harbeck, Lajos Pusztai, Catherine Ellis, Holger Eidtmann, Joaquin Arribas, Javier Cortes, Evandro de Azambuja, Martine Piccart and José Baselga
    Clin Cancer Res February 1 2015 21 (3) 569-576; DOI:10.1158/1078-0432.CCR-14-1824

  • Personalized Medicine and Imaging
    Optical Mammography Using Diffuse Optical Spectroscopy for Monitoring Tumor Response to Neoadjuvant Chemotherapy in Women with Locally Advanced Breast Cancer
    Boudewijn E. Schaafsma, Martijn van de Giessen, Ayoub Charehbili, Vincent T.H.B.M. Smit, Judith R. Kroep, Boudewijn P.F. Lelieveldt, Gerrit-Jan Liefers, Alan Chan, Clemens W.G.M. Löwik, Jouke Dijkstra, Cornelis J.H. van de Velde, Martin N.J.M. Wasser and Alexander L. Vahrmeijer
    Clin Cancer Res February 1 2015 21 (3) 577-584; DOI:10.1158/1078-0432.CCR-14-0736

  • Personalized Medicine and Imaging
    A Five-Gene Hedgehog Signature Developed as a Patient Preselection Tool for Hedgehog Inhibitor Therapy in Medulloblastoma
    Yaping Shou, Douglas M. Robinson, Dereck D. Amakye, Kristine L. Rose, Yoon-Jae Cho, Keith L. Ligon, Thad Sharp, Asifa S. Haider, Raj Bandaru, Yuichi Ando, Birgit Geoerger, François Doz, David M. Ashley, Darren R. Hargrave, Michela Casanova, Hussein A. Tawbi, Jordi Rodon, Anne L. Thomas, Alain C. Mita, Tobey J. MacDonald and Mark W. Kieran
    Clin Cancer Res February 1 2015 21 (3) 585-593; DOI:10.1158/1078-0432.CCR-13-1711

  • Personalized Medicine and Imaging
    Interobserver Agreement in Describing the Ultrasound Appearance of Adnexal Masses and in Calculating the Risk of Malignancy Using Logistic Regression Models
    Povilas Sladkevicius and Lil Valentin
    Clin Cancer Res February 1 2015 21 (3) 594-601; DOI:10.1158/1078-0432.CCR-14-0906

  • Personalized Medicine and Imaging
    Differential Platelet Levels Affect Response to Taxane-Based Therapy in Ovarian Cancer
    Justin Bottsford-Miller, Hyun-Jin Choi, Heather J. Dalton, Rebecca L. Stone, Min Soon Cho, Monika Haemmerle, Alpa M. Nick, Sunila Pradeep, Behrouz Zand, Rebecca A. Previs, Chad V. Pecot, Erin King Crane, Wei Hu, Susan K. Lutgendorf, Vahid Afshar-Kharghan and Anil K. Sood
    Clin Cancer Res February 1 2015 21 (3) 602-610; DOI:10.1158/1078-0432.CCR-14-0870

Cancer Therapy: Preclinical

  • Cancer Therapy: Preclinical | AuthorChoice
    Manipulating the Tumor Microenvironment Ex Vivo for Enhanced Expansion of Tumor-Infiltrating Lymphocytes for Adoptive Cell Therapy
    Jessica Ann Chacon, Amod A. Sarnaik, Jie Qing Chen, Caitlin Creasy, Charuta Kale, John Robinson, Jeffrey Weber, Patrick Hwu, Shari Pilon-Thomas and Laszlo Radvanyi
    Clin Cancer Res February 1 2015 21 (3) 611-621; DOI:10.1158/1078-0432.CCR-14-1934

Biology of Human Tumors

  • Biology of Human Tumors
    Serum CA19-9 Is Significantly Upregulated up to 2 Years before Diagnosis with Pancreatic Cancer: Implications for Early Disease Detection
    Darragh P. O'Brien, Neomal S. Sandanayake, Claire Jenkinson, Aleksandra Gentry-Maharaj, Sophia Apostolidou, Evangelia-Ourania Fourkala, Stephane Camuzeaux, Oleg Blyuss, Richard Gunu, Anne Dawnay, Alexey Zaikin, Ross C. Smith, Ian J. Jacobs, Usha Menon, Eithne Costello, Stephen P. Pereira and John F. Timms
    Clin Cancer Res February 1 2015 21 (3) 622-631; DOI:10.1158/1078-0432.CCR-14-0365

  • Biology of Human Tumors
    Integrative and Comparative Genomic Analysis of HPV-Positive and HPV-Negative Head and Neck Squamous Cell Carcinomas
    Tanguy Y. Seiwert, Zhixiang Zuo, Michaela K. Keck, Arun Khattri, Chandra S. Pedamallu, Thomas Stricker, Christopher Brown, Trevor J. Pugh, Petar Stojanov, Juok Cho, Michael S. Lawrence, Gad Getz, Johannes Brägelmann, Rebecca DeBoer, Ralph R. Weichselbaum, Alexander Langerman, Louis Portugal, Elizabeth Blair, Kerstin Stenson, Mark W. Lingen, Ezra E.W. Cohen, Everett E. Vokes, Kevin P. White and Peter S. Hammerman
    Clin Cancer Res February 1 2015 21 (3) 632-641; DOI:10.1158/1078-0432.CCR-13-3310

  • Biology of Human Tumors
    Podoplanin-Positive Cancer-Associated Fibroblasts in the Tumor Microenvironment Induce Primary Resistance to EGFR-TKIs in Lung Adenocarcinoma with EGFR Mutation
    Tatsuya Yoshida, Genichiro Ishii, Koichi Goto, Shinya Neri, Hiroko Hashimoto, Kiyotaka Yoh, Seiji Niho, Shigeki Umemura, Shingo Matsumoto, Hironobu Ohmatsu, Shinsuke Iida, Akio Niimi, Kanji Nagai, Yuichiro Ohe and Atsushi Ochiai
    Clin Cancer Res February 1 2015 21 (3) 642-651; DOI:10.1158/1078-0432.CCR-14-0846

  • Biology of Human Tumors
    Germline Mutation in BRCA1 or BRCA2 and Ten-Year Survival for Women Diagnosed with Epithelial Ovarian Cancer
    Francisco J. Candido-dos-Reis, Honglin Song, Ellen L. Goode, Julie M. Cunningham, Brooke L. Fridley, Melissa C. Larson, Kathryn Alsop, Ed Dicks, Patricia Harrington, Susan J. Ramus, Anna de Fazio, Gillian Mitchell, Sian Fereday, Kelly L. Bolton, Charlie Gourley, Caroline Michie, Beth Karlan, Jenny Lester, Christine Walsh, Ilana Cass, Håkan Olsson, Martin Gore, Javier J. Benitez, Maria J. Garcia, Irene Andrulis, Anna Marie Mulligan, Gord Glendon, Ignacio Blanco, Conxi Lazaro, Alice S. Whittemore, Valerie McGuire, Weiva Sieh, Marco Montagna, Elisa Alducci, Siegal Sadetzki, Angela Chetrit, Ava Kwong, Susanne K. Kjaer, Allan Jensen, Estrid Høgdall, Susan Neuhausen, Robert Nussbaum, Mary Daly, Mark H. Greene, Phuong L. Mai, Jennifer T. Loud, Kirsten Moysich, Amanda E. Toland, Diether Lambrechts, Steve Ellis, Debra Frost, James D. Brenton, Marc Tischkowitz, Douglas F. Easton, Antonis Antoniou, Georgia Chenevix-Trench, Simon A. Gayther, David Bowtell and Paul D.P. Pharoah; for EMBRACE; for kConFab Investigators; for The Australian Ovarian Cancer Study Group
    Clin Cancer Res February 1 2015 21 (3) 652-657; DOI:10.1158/1078-0432.CCR-14-2497

Letters to the Editor

  • Letters to the Editor
    DNA Repair Mutations and Outcomes in Ovarian Cancer—Letter
    Robert A. Soslow
    Clin Cancer Res February 1 2015 21 (3) 658-658; DOI:10.1158/1078-0432.CCR-14-2436

  • Letters to the Editor
    DNA Repair Mutations and Outcomes in Ovarian Cancer—Response
    Elizabeth M. Swisher, Barbara M. Norquist, Kathryn P. Pennington, Mara H. Rendi and Rochelle L. Garcia
    Clin Cancer Res February 1 2015 21 (3) 659-659; DOI:10.1158/1078-0432.CCR-14-2805

Corrections

  • Corrections
    Correction: First-in-Human Study of CH5132799, an Oral Class I PI3K Inhibitor, Studying Toxicity, Pharmacokinetics, and Pharmacodynamics, in Patients with Metastatic Cancer
    Clin Cancer Res February 1 2015 21 (3) 660-660; DOI:10.1158/1078-0432.CCR-14-3188

  • Corrections
    Correction: HDM2 Regulation by AURKA Promotes Cell Survival in Gastric Cancer
    Clin Cancer Res February 1 2015 21 (3) 661-661; DOI:10.1158/1078-0432.CCR-14-3207

  • Corrections
    Correction: Durable Therapeutic Efficacy Utilizing Combinatorial Blockade against IDO, CTLA-4, and PD-L1 in Mice with Brain Tumors
    Clin Cancer Res February 1 2015 21 (3) 662-662; DOI:10.1158/1078-0432.CCR-14-3211

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Clinical Cancer Research: 21 (3)
February 2015
Volume 21, Issue 3
  • Table of Contents
  • Table of Contents (PDF)
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Issue Highlights

  • Manipulating the Tumor Microenvironment Ex Vivo for Enhanced Expansion of Tumor-Infiltrating Lymphocytes for Adoptive Cell Therapy
  • High HER2 Expression Correlates with Response to the Combination of Lapatinib and Trastuzumab
  • Phase II Clinical and Exploratory Biomarker Study of Dacomitinib in Patients with Recurrent and/or Metastatic Squamous Cell Carcinoma of Head and Neck
  • A Five-Gene Hedgehog Signature Developed as a Patient Preselection Tool for Hedgehog Inhibitor Therapy in Medulloblastoma
  • Serum CA19-9 Is Significantly Upregulated up to 2 Years before Diagnosis with Pancreatic Cancer: Implications for Early Disease Detection

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Clinical Cancer Research
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