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Cancer Therapy: Clinical

Phase I Safety, Pharmacokinetic, and Pharmacodynamic Study of the Poly(ADP-ribose) Polymerase (PARP) Inhibitor Veliparib (ABT-888) in Combination with Irinotecan in Patients with Advanced Solid Tumors

Patricia M. LoRusso, Jing Li, Angelika Burger, Lance K. Heilbrun, Edward A. Sausville, Scott A. Boerner, Daryn Smith, Mary Jo Pilat, Jie Zhang, Sara M. Tolaney, James M. Cleary, Alice P. Chen, Lawrence Rubinstein, Julie L. Boerner, Adam Bowditch, Dongpo Cai, Tracy Bell, Andrew Wolanski, Allison M. Marrero, Yiping Zhang, Jiuping Ji, Katherine Ferry-Galow, Robert J. Kinders, Ralph E. Parchment and Geoffrey I. Shapiro
Patricia M. LoRusso
1Barbara Ann Karmanos Cancer Institute, Wayne State University, Detroit, Michigan.
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  • For correspondence: geoffrey_shapiro@dfci.harvard.edu
Jing Li
1Barbara Ann Karmanos Cancer Institute, Wayne State University, Detroit, Michigan.
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Angelika Burger
1Barbara Ann Karmanos Cancer Institute, Wayne State University, Detroit, Michigan.
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Lance K. Heilbrun
1Barbara Ann Karmanos Cancer Institute, Wayne State University, Detroit, Michigan.
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Edward A. Sausville
2University of Maryland Greenebaum Cancer Center, Baltimore, Maryland.
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Scott A. Boerner
1Barbara Ann Karmanos Cancer Institute, Wayne State University, Detroit, Michigan.
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Daryn Smith
1Barbara Ann Karmanos Cancer Institute, Wayne State University, Detroit, Michigan.
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Mary Jo Pilat
1Barbara Ann Karmanos Cancer Institute, Wayne State University, Detroit, Michigan.
3Wayne State University, Detroit, Michigan.
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Jie Zhang
1Barbara Ann Karmanos Cancer Institute, Wayne State University, Detroit, Michigan.
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Sara M. Tolaney
4Dana-Farber Cancer Institute, Brigham and Women's Hospital, and Harvard Medical School, Boston, Massachusetts.
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James M. Cleary
4Dana-Farber Cancer Institute, Brigham and Women's Hospital, and Harvard Medical School, Boston, Massachusetts.
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Alice P. Chen
5Division of Cancer Treatment and Diagnosis, National Cancer Institute, Bethesda, Maryland.
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Lawrence Rubinstein
5Division of Cancer Treatment and Diagnosis, National Cancer Institute, Bethesda, Maryland.
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Julie L. Boerner
1Barbara Ann Karmanos Cancer Institute, Wayne State University, Detroit, Michigan.
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Adam Bowditch
1Barbara Ann Karmanos Cancer Institute, Wayne State University, Detroit, Michigan.
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Dongpo Cai
4Dana-Farber Cancer Institute, Brigham and Women's Hospital, and Harvard Medical School, Boston, Massachusetts.
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Tracy Bell
4Dana-Farber Cancer Institute, Brigham and Women's Hospital, and Harvard Medical School, Boston, Massachusetts.
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Andrew Wolanski
4Dana-Farber Cancer Institute, Brigham and Women's Hospital, and Harvard Medical School, Boston, Massachusetts.
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Allison M. Marrero
6Clinical Pharmacodynamics Biomarker Program, Applied/Developmental Research Directorate, Leidos Biomedical Research, Inc., Frederick National Laboratory for Cancer Research, Frederick, Maryland.
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Yiping Zhang
6Clinical Pharmacodynamics Biomarker Program, Applied/Developmental Research Directorate, Leidos Biomedical Research, Inc., Frederick National Laboratory for Cancer Research, Frederick, Maryland.
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Jiuping Ji
6Clinical Pharmacodynamics Biomarker Program, Applied/Developmental Research Directorate, Leidos Biomedical Research, Inc., Frederick National Laboratory for Cancer Research, Frederick, Maryland.
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Katherine Ferry-Galow
6Clinical Pharmacodynamics Biomarker Program, Applied/Developmental Research Directorate, Leidos Biomedical Research, Inc., Frederick National Laboratory for Cancer Research, Frederick, Maryland.
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Robert J. Kinders
6Clinical Pharmacodynamics Biomarker Program, Applied/Developmental Research Directorate, Leidos Biomedical Research, Inc., Frederick National Laboratory for Cancer Research, Frederick, Maryland.
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Ralph E. Parchment
6Clinical Pharmacodynamics Biomarker Program, Applied/Developmental Research Directorate, Leidos Biomedical Research, Inc., Frederick National Laboratory for Cancer Research, Frederick, Maryland.
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Geoffrey I. Shapiro
4Dana-Farber Cancer Institute, Brigham and Women's Hospital, and Harvard Medical School, Boston, Massachusetts.
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DOI: 10.1158/1078-0432.CCR-15-0652 Published July 2016
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Cited By

Article Information

Volume 22, Issue 13, pp. 3227-3237

DOI 
https://doi.org/10.1158/1078-0432.CCR-15-0652
PubMed 
26842236

Published By 
American Association for Cancer Research
Print ISSN 
1078-0432
Online ISSN 
1557-3265
History 
  • Received March 17, 2015
  • Revision received January 20, 2016
  • Accepted January 26, 2016
  • Published first February 3, 2016.

Article Versions

  • Previous version (February 3, 2016 - 09:05).
  • Previous version (March 21, 2016 - 06:19).
  • Previous version (April 22, 2016 - 08:10).
  • You are viewing the most recent version of this article.
Copyright & Usage 
©2016 American Association for Cancer Research.

Author Information

  1. Patricia M. LoRusso1,*,
  2. Jing Li1,
  3. Angelika Burger1,
  4. Lance K. Heilbrun1,
  5. Edward A. Sausville2,
  6. Scott A. Boerner1,
  7. Daryn Smith1,
  8. Mary Jo Pilat1,3,
  9. Jie Zhang1,
  10. Sara M. Tolaney4,
  11. James M. Cleary4,
  12. Alice P. Chen5,
  13. Lawrence Rubinstein5,
  14. Julie L. Boerner1,
  15. Adam Bowditch1,
  16. Dongpo Cai4,
  17. Tracy Bell4,
  18. Andrew Wolanski4,
  19. Allison M. Marrero6,
  20. Yiping Zhang6,
  21. Jiuping Ji6,
  22. Katherine Ferry-Galow6,
  23. Robert J. Kinders6,
  24. Ralph E. Parchment6, and
  25. Geoffrey I. Shapiro4
  1. 1Barbara Ann Karmanos Cancer Institute, Wayne State University, Detroit, Michigan.
  2. 2University of Maryland Greenebaum Cancer Center, Baltimore, Maryland.
  3. 3Wayne State University, Detroit, Michigan.
  4. 4Dana-Farber Cancer Institute, Brigham and Women's Hospital, and Harvard Medical School, Boston, Massachusetts.
  5. 5Division of Cancer Treatment and Diagnosis, National Cancer Institute, Bethesda, Maryland.
  6. 6Clinical Pharmacodynamics Biomarker Program, Applied/Developmental Research Directorate, Leidos Biomedical Research, Inc., Frederick National Laboratory for Cancer Research, Frederick, Maryland.
  1. ↵*Corresponding Authors:
    Patricia M. LoRusso, Yale University, WWW217, 333 Cedar Street, New Haven, CT 06510. Phone: 203-785-5944; Fax: 203-785-4116; or Geoffrey I. Shapiro, Early Drug Development Center, Department of Medical Oncology, Dana-Farber Cancer Institute, 450 Brookline Avenue, Mayer 446, Boston, MA 02215. Phone: 617-632-4942; Fax: 617-632-1977; E-mail: geoffrey_shapiro{at}dfci.harvard.edu
  • Current address for P.M. LoRusso and S.A. Boerner: Yale Cancer Center, New Haven, Connecticut.

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Clinical Cancer Research: 22 (13)
July 2016
Volume 22, Issue 13
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Phase I Safety, Pharmacokinetic, and Pharmacodynamic Study of the Poly(ADP-ribose) Polymerase (PARP) Inhibitor Veliparib (ABT-888) in Combination with Irinotecan in Patients with Advanced Solid Tumors
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Phase I Safety, Pharmacokinetic, and Pharmacodynamic Study of the Poly(ADP-ribose) Polymerase (PARP) Inhibitor Veliparib (ABT-888) in Combination with Irinotecan in Patients with Advanced Solid Tumors
Patricia M. LoRusso, Jing Li, Angelika Burger, Lance K. Heilbrun, Edward A. Sausville, Scott A. Boerner, Daryn Smith, Mary Jo Pilat, Jie Zhang, Sara M. Tolaney, James M. Cleary, Alice P. Chen, Lawrence Rubinstein, Julie L. Boerner, Adam Bowditch, Dongpo Cai, Tracy Bell, Andrew Wolanski, Allison M. Marrero, Yiping Zhang, Jiuping Ji, Katherine Ferry-Galow, Robert J. Kinders, Ralph E. Parchment and Geoffrey I. Shapiro
Clin Cancer Res July 1 2016 (22) (13) 3227-3237; DOI: 10.1158/1078-0432.CCR-15-0652

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Phase I Safety, Pharmacokinetic, and Pharmacodynamic Study of the Poly(ADP-ribose) Polymerase (PARP) Inhibitor Veliparib (ABT-888) in Combination with Irinotecan in Patients with Advanced Solid Tumors
Patricia M. LoRusso, Jing Li, Angelika Burger, Lance K. Heilbrun, Edward A. Sausville, Scott A. Boerner, Daryn Smith, Mary Jo Pilat, Jie Zhang, Sara M. Tolaney, James M. Cleary, Alice P. Chen, Lawrence Rubinstein, Julie L. Boerner, Adam Bowditch, Dongpo Cai, Tracy Bell, Andrew Wolanski, Allison M. Marrero, Yiping Zhang, Jiuping Ji, Katherine Ferry-Galow, Robert J. Kinders, Ralph E. Parchment and Geoffrey I. Shapiro
Clin Cancer Res July 1 2016 (22) (13) 3227-3237; DOI: 10.1158/1078-0432.CCR-15-0652
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