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Clinical Cancer Research
Clinical Cancer Research
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Cancer Therapy: Preclinical

A Novel Carcinoembryonic Antigen T-Cell Bispecific Antibody (CEA TCB) for the Treatment of Solid Tumors

Marina Bacac, Tanja Fauti, Johannes Sam, Sara Colombetti, Tina Weinzierl, Djamila Ouaret, Walter Bodmer, Steffi Lehmann, Thomas Hofer, Ralf J. Hosse, Ekkehard Moessner, Oliver Ast, Peter Bruenker, Sandra Grau-Richards, Teilo Schaller, Annette Seidl, Christian Gerdes, Mario Perro, Valeria Nicolini, Nathalie Steinhoff, Sherri Dudal, Sebastian Neumann, Thomas von Hirschheydt, Christiane Jaeger, Jose Saro, Vaios Karanikas, Christian Klein and Pablo Umaña
Marina Bacac
1Oncology Discovery, Roche Innovation Center Zurich, Roche Pharmaceutical Research and Early Development, pRED, Zurich, Switzerland.
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  • For correspondence: marina.bacac@roche.com Pablo.umana@roche.com
Tanja Fauti
1Oncology Discovery, Roche Innovation Center Zurich, Roche Pharmaceutical Research and Early Development, pRED, Zurich, Switzerland.
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Johannes Sam
1Oncology Discovery, Roche Innovation Center Zurich, Roche Pharmaceutical Research and Early Development, pRED, Zurich, Switzerland.
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Sara Colombetti
1Oncology Discovery, Roche Innovation Center Zurich, Roche Pharmaceutical Research and Early Development, pRED, Zurich, Switzerland.
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Tina Weinzierl
1Oncology Discovery, Roche Innovation Center Zurich, Roche Pharmaceutical Research and Early Development, pRED, Zurich, Switzerland.
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Djamila Ouaret
2Cancer and Immunogenetics Laboratory, Weatherall Institute of Molecular Medicine, John Radcliffe Hospital, Oxford, United Kingdom.
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Walter Bodmer
2Cancer and Immunogenetics Laboratory, Weatherall Institute of Molecular Medicine, John Radcliffe Hospital, Oxford, United Kingdom.
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Steffi Lehmann
3Animal Imaging Center, Institute for Biomedical Engineering, ETH and University of Zurich, Zurich, Switzerland.
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Thomas Hofer
4Large Molecule Research, Roche Innovation Center Zurich, Roche Pharmaceutical Research and Early Development, pRED, Zurich, Switzerland.
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Ralf J. Hosse
4Large Molecule Research, Roche Innovation Center Zurich, Roche Pharmaceutical Research and Early Development, pRED, Zurich, Switzerland.
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Ekkehard Moessner
4Large Molecule Research, Roche Innovation Center Zurich, Roche Pharmaceutical Research and Early Development, pRED, Zurich, Switzerland.
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Oliver Ast
4Large Molecule Research, Roche Innovation Center Zurich, Roche Pharmaceutical Research and Early Development, pRED, Zurich, Switzerland.
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Peter Bruenker
4Large Molecule Research, Roche Innovation Center Zurich, Roche Pharmaceutical Research and Early Development, pRED, Zurich, Switzerland.
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Sandra Grau-Richards
4Large Molecule Research, Roche Innovation Center Zurich, Roche Pharmaceutical Research and Early Development, pRED, Zurich, Switzerland.
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Teilo Schaller
1Oncology Discovery, Roche Innovation Center Zurich, Roche Pharmaceutical Research and Early Development, pRED, Zurich, Switzerland.
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Annette Seidl
5Roche Diagnostics GmbH, Penzberg, Germany.
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Christian Gerdes
1Oncology Discovery, Roche Innovation Center Zurich, Roche Pharmaceutical Research and Early Development, pRED, Zurich, Switzerland.
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Mario Perro
1Oncology Discovery, Roche Innovation Center Zurich, Roche Pharmaceutical Research and Early Development, pRED, Zurich, Switzerland.
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Valeria Nicolini
1Oncology Discovery, Roche Innovation Center Zurich, Roche Pharmaceutical Research and Early Development, pRED, Zurich, Switzerland.
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Nathalie Steinhoff
1Oncology Discovery, Roche Innovation Center Zurich, Roche Pharmaceutical Research and Early Development, pRED, Zurich, Switzerland.
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Sherri Dudal
6Pharmaceutical Sciences, Roche Innovation Center Basel, Basel, Switzerland.
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Sebastian Neumann
7Global Technical Development Project Management, F. Hoffmann-La Roche AG, Basel, Switzerland.
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Thomas von Hirschheydt
8Large Molecule Research, Roche Innovation Center Penzberg, Germany.
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Christiane Jaeger
4Large Molecule Research, Roche Innovation Center Zurich, Roche Pharmaceutical Research and Early Development, pRED, Zurich, Switzerland.
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Jose Saro
9Translational Medicine, Roche Innovation Center Zurich, Zurich, Switzerland.
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Vaios Karanikas
9Translational Medicine, Roche Innovation Center Zurich, Zurich, Switzerland.
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Christian Klein
1Oncology Discovery, Roche Innovation Center Zurich, Roche Pharmaceutical Research and Early Development, pRED, Zurich, Switzerland.
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Pablo Umaña
1Oncology Discovery, Roche Innovation Center Zurich, Roche Pharmaceutical Research and Early Development, pRED, Zurich, Switzerland.
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  • For correspondence: marina.bacac@roche.com Pablo.umana@roche.com
DOI: 10.1158/1078-0432.CCR-15-1696 Published July 2016
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Cited By

Article Information

Volume 22, Issue 13, pp. 3286-3297

DOI 
https://doi.org/10.1158/1078-0432.CCR-15-1696
PubMed 
26861458

Published By 
American Association for Cancer Research
Print ISSN 
1078-0432
Online ISSN 
1557-3265
History 
  • Received July 25, 2015
  • Revision received January 12, 2016
  • Accepted January 15, 2016
  • Published first February 9, 2016.

Article Versions

  • Previous version (February 9, 2016 - 11:26).
  • Previous version (April 20, 2016 - 09:36).
  • You are viewing the most recent version of this article.
Copyright & Usage 
©2016 American Association for Cancer Research.

Author Information

  1. Marina Bacac1,*,
  2. Tanja Fauti1,
  3. Johannes Sam1,
  4. Sara Colombetti1,
  5. Tina Weinzierl1,
  6. Djamila Ouaret2,
  7. Walter Bodmer2,
  8. Steffi Lehmann3,
  9. Thomas Hofer4,
  10. Ralf J. Hosse4,
  11. Ekkehard Moessner4,
  12. Oliver Ast4,
  13. Peter Bruenker4,
  14. Sandra Grau-Richards4,
  15. Teilo Schaller1,
  16. Annette Seidl5,
  17. Christian Gerdes1,
  18. Mario Perro1,
  19. Valeria Nicolini1,
  20. Nathalie Steinhoff1,
  21. Sherri Dudal6,
  22. Sebastian Neumann7,
  23. Thomas von Hirschheydt8,
  24. Christiane Jaeger4,
  25. Jose Saro9,
  26. Vaios Karanikas9,
  27. Christian Klein1, and
  28. Pablo Umaña1,*
  1. 1Oncology Discovery, Roche Innovation Center Zurich, Roche Pharmaceutical Research and Early Development, pRED, Zurich, Switzerland.
  2. 2Cancer and Immunogenetics Laboratory, Weatherall Institute of Molecular Medicine, John Radcliffe Hospital, Oxford, United Kingdom.
  3. 3Animal Imaging Center, Institute for Biomedical Engineering, ETH and University of Zurich, Zurich, Switzerland.
  4. 4Large Molecule Research, Roche Innovation Center Zurich, Roche Pharmaceutical Research and Early Development, pRED, Zurich, Switzerland.
  5. 5Roche Diagnostics GmbH, Penzberg, Germany.
  6. 6Pharmaceutical Sciences, Roche Innovation Center Basel, Basel, Switzerland.
  7. 7Global Technical Development Project Management, F. Hoffmann-La Roche AG, Basel, Switzerland.
  8. 8Large Molecule Research, Roche Innovation Center Penzberg, Germany.
  9. 9Translational Medicine, Roche Innovation Center Zurich, Zurich, Switzerland.
  1. ↵*Corresponding Authors:
    Marina Bacac, Roche Pharma Research and Early Development, Roche Innovation Center Zurich, Wagistrasse 18, Schlieren, Zurich 8952, Switzerland. Phone: 414-4755-6141; Fax: +41 44 755 61 60; E-mail: marina.bacac{at}roche.com; and Pablo Umaña, Roche Pharma Research and Early Development, Roche Innovation Center Zurich, Wagistrasse 18, Schlieren, Zurich 8952, Switzerland. Phone: 414-4755-6141; Fax: +41 44 755 61 60; E-mail:Pablo.umana{at}roche.com
  1. C. Klein and P. Umaña contributed equally to this article.

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Clinical Cancer Research: 22 (13)
July 2016
Volume 22, Issue 13
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A Novel Carcinoembryonic Antigen T-Cell Bispecific Antibody (CEA TCB) for the Treatment of Solid Tumors
Marina Bacac, Tanja Fauti, Johannes Sam, Sara Colombetti, Tina Weinzierl, Djamila Ouaret, Walter Bodmer, Steffi Lehmann, Thomas Hofer, Ralf J. Hosse, Ekkehard Moessner, Oliver Ast, Peter Bruenker, Sandra Grau-Richards, Teilo Schaller, Annette Seidl, Christian Gerdes, Mario Perro, Valeria Nicolini, Nathalie Steinhoff, Sherri Dudal, Sebastian Neumann, Thomas von Hirschheydt, Christiane Jaeger, Jose Saro, Vaios Karanikas, Christian Klein and Pablo Umaña
Clin Cancer Res July 1 2016 (22) (13) 3286-3297; DOI: 10.1158/1078-0432.CCR-15-1696

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A Novel Carcinoembryonic Antigen T-Cell Bispecific Antibody (CEA TCB) for the Treatment of Solid Tumors
Marina Bacac, Tanja Fauti, Johannes Sam, Sara Colombetti, Tina Weinzierl, Djamila Ouaret, Walter Bodmer, Steffi Lehmann, Thomas Hofer, Ralf J. Hosse, Ekkehard Moessner, Oliver Ast, Peter Bruenker, Sandra Grau-Richards, Teilo Schaller, Annette Seidl, Christian Gerdes, Mario Perro, Valeria Nicolini, Nathalie Steinhoff, Sherri Dudal, Sebastian Neumann, Thomas von Hirschheydt, Christiane Jaeger, Jose Saro, Vaios Karanikas, Christian Klein and Pablo Umaña
Clin Cancer Res July 1 2016 (22) (13) 3286-3297; DOI: 10.1158/1078-0432.CCR-15-1696
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