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Cancer Therapy: Clinical

Toxicity Attribution in Phase I Trials: Evaluating the Effect of Dose on the Frequency of Related and Unrelated Toxicities

Anne Eaton, Alexia Iasonos, Mrinal M. Gounder, Erika G. Pamer, Alexander Drilon, Diana Vulih, Gary L. Smith, S. Percy Ivy, David R. Spriggs and David M. Hyman
Anne Eaton
1Department of Epidemiology and Biostatistics, Memorial Sloan Kettering Cancer Center, New York, New York.
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Alexia Iasonos
1Department of Epidemiology and Biostatistics, Memorial Sloan Kettering Cancer Center, New York, New York.
2Weill Cornell Medical College, New York, New York.
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Mrinal M. Gounder
2Weill Cornell Medical College, New York, New York.
3Developmental Therapeutics, Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, New York.
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Erika G. Pamer
3Developmental Therapeutics, Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, New York.
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Alexander Drilon
2Weill Cornell Medical College, New York, New York.
3Developmental Therapeutics, Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, New York.
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Diana Vulih
4Theradex Systems, Inc., Princeton, New Jersey.
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Gary L. Smith
5The National Cancer Institute, Bethesda, Maryland.
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S. Percy Ivy
5The National Cancer Institute, Bethesda, Maryland.
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David R. Spriggs
2Weill Cornell Medical College, New York, New York.
3Developmental Therapeutics, Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, New York.
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David M. Hyman
2Weill Cornell Medical College, New York, New York.
3Developmental Therapeutics, Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, New York.
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  • For correspondence: hymand@mskcc.org
DOI: 10.1158/1078-0432.CCR-15-0339 Published February 2016
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ARTICLE USAGE: August 2015 to January 2021

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Cited By

Article Information

Volume 22, Issue 3, pp. 553-559

DOI 
https://doi.org/10.1158/1078-0432.CCR-15-0339
PubMed 
26324741

Published By 
American Association for Cancer Research
Print ISSN 
1078-0432
Online ISSN 
1557-3265
History 
  • Received February 19, 2015
  • Revision received June 5, 2015
  • Accepted August 9, 2015
  • Published first August 31, 2015.

Article Versions

  • Previous version (August 31, 2015 - 11:49).
  • You are viewing the most recent version of this article.
Copyright & Usage 
©2015 American Association for Cancer Research.

Author Information

  1. Anne Eaton1,
  2. Alexia Iasonos1,2,
  3. Mrinal M. Gounder2,3,
  4. Erika G. Pamer3,
  5. Alexander Drilon2,3,
  6. Diana Vulih4,
  7. Gary L. Smith5,
  8. S. Percy Ivy5,
  9. David R. Spriggs2,3, and
  10. David M. Hyman2,3,*
  1. 1Department of Epidemiology and Biostatistics, Memorial Sloan Kettering Cancer Center, New York, New York.
  2. 2Weill Cornell Medical College, New York, New York.
  3. 3Developmental Therapeutics, Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, New York.
  4. 4Theradex Systems, Inc., Princeton, New Jersey.
  5. 5The National Cancer Institute, Bethesda, Maryland.
  1. ↵*Corresponding Author:
    David M. Hyman, Memorial Sloan Kettering Cancer Center, 1275 York Avenue, New York, NY 10065. Phone: 646-888-4544; Fax: 646-888-4586; E-mail: hymand{at}mskcc.org
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Clinical Cancer Research: 22 (3)
February 2016
Volume 22, Issue 3
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Toxicity Attribution in Phase I Trials: Evaluating the Effect of Dose on the Frequency of Related and Unrelated Toxicities
Anne Eaton, Alexia Iasonos, Mrinal M. Gounder, Erika G. Pamer, Alexander Drilon, Diana Vulih, Gary L. Smith, S. Percy Ivy, David R. Spriggs and David M. Hyman
Clin Cancer Res February 1 2016 (22) (3) 553-559; DOI: 10.1158/1078-0432.CCR-15-0339

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Toxicity Attribution in Phase I Trials: Evaluating the Effect of Dose on the Frequency of Related and Unrelated Toxicities
Anne Eaton, Alexia Iasonos, Mrinal M. Gounder, Erika G. Pamer, Alexander Drilon, Diana Vulih, Gary L. Smith, S. Percy Ivy, David R. Spriggs and David M. Hyman
Clin Cancer Res February 1 2016 (22) (3) 553-559; DOI: 10.1158/1078-0432.CCR-15-0339
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