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DNA Topoisomerase I Gene Copy Number and mRNA Expression Assessed as Predictive Biomarkers for Adjuvant Irinotecan in Stage II/III Colon Cancer

Sune Boris Nygård, Ben Vainer, Signe Lykke Nielsen, Fred Bosman, Sabine Tejpar, Arnaud Roth, Mauro Delorenzi, Nils Brünner and Eva Budinska
Sune Boris Nygård
1University of Copenhagen, Faculty of Health and Medical Sciences, Copenhagen, Denmark.
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Ben Vainer
2Department of Pathology, Rigshospitalet, Copenhagen University Hospital, Copenhagen, Denmark.
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Signe Lykke Nielsen
1University of Copenhagen, Faculty of Health and Medical Sciences, Copenhagen, Denmark.
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Fred Bosman
3University of Lausanne, University Institute of Pathology, Lausanne, Switzerland.
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Sabine Tejpar
4Digestive Oncology Unit, University Hospital Gasthuisberg, Leuven, Belgium.
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Arnaud Roth
5Oncosurgery Unit, University Hospital of Geneva, Geneva, Switzerland.
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Mauro Delorenzi
6SIB Swiss Institute of Bioinformatics, Bioinformatics Core Facility, Lausanne, Switzerland.
7University of Lausanne, Ludwig Center for Cancer Research, Lausanne, Switzerland.
8Oncology Department, University of Lausanne, Lausanne, Switzerland.
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Nils Brünner
1University of Copenhagen, Faculty of Health and Medical Sciences, Copenhagen, Denmark.
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  • For correspondence: nbr@sund.ku.dk
Eva Budinska
9Masaryk University, Institute of Biostatistics and Analyses, Brno, Czech Republic.
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DOI: 10.1158/1078-0432.CCR-15-0561 Published April 2016
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ARTICLE USAGE: November 2015 to January 2021

AbstractFull-text HTMLPDF
Total3013977831

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Article Information

Volume 22, Issue 7, pp. 1621-1631

DOI 
https://doi.org/10.1158/1078-0432.CCR-15-0561
PubMed 
26542057

Published By 
American Association for Cancer Research
Print ISSN 
1078-0432
Online ISSN 
1557-3265
History 
  • Received March 11, 2015
  • Revision received October 3, 2015
  • Accepted October 12, 2015
  • Published first November 5, 2015.

Article Versions

  • Previous version (November 5, 2015 - 06:38).
  • Previous version (January 28, 2016 - 08:02).
  • You are viewing the most recent version of this article.
Copyright & Usage 
©2015 American Association for Cancer Research.

Author Information

  1. Sune Boris Nygård1,
  2. Ben Vainer2,
  3. Signe Lykke Nielsen1,
  4. Fred Bosman3,
  5. Sabine Tejpar4,
  6. Arnaud Roth5,
  7. Mauro Delorenzi6,7,8,
  8. Nils Brünner1,*, and
  9. Eva Budinska9
  1. 1University of Copenhagen, Faculty of Health and Medical Sciences, Copenhagen, Denmark.
  2. 2Department of Pathology, Rigshospitalet, Copenhagen University Hospital, Copenhagen, Denmark.
  3. 3University of Lausanne, University Institute of Pathology, Lausanne, Switzerland.
  4. 4Digestive Oncology Unit, University Hospital Gasthuisberg, Leuven, Belgium.
  5. 5Oncosurgery Unit, University Hospital of Geneva, Geneva, Switzerland.
  6. 6SIB Swiss Institute of Bioinformatics, Bioinformatics Core Facility, Lausanne, Switzerland.
  7. 7University of Lausanne, Ludwig Center for Cancer Research, Lausanne, Switzerland.
  8. 8Oncology Department, University of Lausanne, Lausanne, Switzerland.
  9. 9Masaryk University, Institute of Biostatistics and Analyses, Brno, Czech Republic.
  1. ↵*Corresponding Author:
    Nils Brünner, University of Copenhagen, Molecular Disease Biology Section, Department of Veterinary Disease Biology, Faculty of Health and Medical Sciences, c/o Danish Cancer Society, Strandboulevarden 49, DK-2100 Copenhagen, Denmark. Phone: +45 3533-3130; Fax: 45-3533-2755, E-mail: nbr{at}sund.ku.dk
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Clinical Cancer Research: 22 (7)
April 2016
Volume 22, Issue 7
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DNA Topoisomerase I Gene Copy Number and mRNA Expression Assessed as Predictive Biomarkers for Adjuvant Irinotecan in Stage II/III Colon Cancer
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DNA Topoisomerase I Gene Copy Number and mRNA Expression Assessed as Predictive Biomarkers for Adjuvant Irinotecan in Stage II/III Colon Cancer
Sune Boris Nygård, Ben Vainer, Signe Lykke Nielsen, Fred Bosman, Sabine Tejpar, Arnaud Roth, Mauro Delorenzi, Nils Brünner and Eva Budinska
Clin Cancer Res April 1 2016 (22) (7) 1621-1631; DOI: 10.1158/1078-0432.CCR-15-0561

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DNA Topoisomerase I Gene Copy Number and mRNA Expression Assessed as Predictive Biomarkers for Adjuvant Irinotecan in Stage II/III Colon Cancer
Sune Boris Nygård, Ben Vainer, Signe Lykke Nielsen, Fred Bosman, Sabine Tejpar, Arnaud Roth, Mauro Delorenzi, Nils Brünner and Eva Budinska
Clin Cancer Res April 1 2016 (22) (7) 1621-1631; DOI: 10.1158/1078-0432.CCR-15-0561
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