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Cancer Therapy: Preclinical

Adrenergic Stimulation of DUSP1 Impairs Chemotherapy Response in Ovarian Cancer

Yu Kang, Archana S. Nagaraja, Guillermo N. Armaiz-Pena, Piotr L. Dorniak, Wei Hu, Rajesha Rupaimoole, Tao Liu, Kshipra M. Gharpure, Rebecca A. Previs, Jean M. Hansen, Cristian Rodriguez-Aguayo, Cristina Ivan, Prahlad Ram, Vasudha Sehgal, Gabriel Lopez-Berestein, Susan K. Lutgendorf, Steven W. Cole and Anil K. Sood
Yu Kang
1Shanghai Key Laboratory of Female Reproductive Endocrine-Related Diseases, Obstetrics and Gynecology Hospital of Fudan University, Shanghai, P.R. China.
2Department of Gynecologic Oncology and Reproductive Medicine, The University of Texas MD Anderson Cancer Center, Houston, Texas.
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Archana S. Nagaraja
2Department of Gynecologic Oncology and Reproductive Medicine, The University of Texas MD Anderson Cancer Center, Houston, Texas.
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Guillermo N. Armaiz-Pena
2Department of Gynecologic Oncology and Reproductive Medicine, The University of Texas MD Anderson Cancer Center, Houston, Texas.
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Piotr L. Dorniak
2Department of Gynecologic Oncology and Reproductive Medicine, The University of Texas MD Anderson Cancer Center, Houston, Texas.
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Wei Hu
2Department of Gynecologic Oncology and Reproductive Medicine, The University of Texas MD Anderson Cancer Center, Houston, Texas.
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Rajesha Rupaimoole
2Department of Gynecologic Oncology and Reproductive Medicine, The University of Texas MD Anderson Cancer Center, Houston, Texas.
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Tao Liu
2Department of Gynecologic Oncology and Reproductive Medicine, The University of Texas MD Anderson Cancer Center, Houston, Texas.
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Kshipra M. Gharpure
2Department of Gynecologic Oncology and Reproductive Medicine, The University of Texas MD Anderson Cancer Center, Houston, Texas.
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Rebecca A. Previs
2Department of Gynecologic Oncology and Reproductive Medicine, The University of Texas MD Anderson Cancer Center, Houston, Texas.
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Jean M. Hansen
2Department of Gynecologic Oncology and Reproductive Medicine, The University of Texas MD Anderson Cancer Center, Houston, Texas.
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Cristian Rodriguez-Aguayo
3Center for RNAi and Non-Coding RNA, The University of Texas MD Anderson Cancer Center, Houston, Texas.
4Department of Experimental Therapeutics, The University of Texas MD Anderson Cancer Center, Houston, Texas.
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Cristina Ivan
2Department of Gynecologic Oncology and Reproductive Medicine, The University of Texas MD Anderson Cancer Center, Houston, Texas.
3Center for RNAi and Non-Coding RNA, The University of Texas MD Anderson Cancer Center, Houston, Texas.
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Prahlad Ram
5Systems Biology, The University of Texas MD Anderson Cancer Center, Houston, Texas.
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Vasudha Sehgal
5Systems Biology, The University of Texas MD Anderson Cancer Center, Houston, Texas.
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Gabriel Lopez-Berestein
3Center for RNAi and Non-Coding RNA, The University of Texas MD Anderson Cancer Center, Houston, Texas.
4Department of Experimental Therapeutics, The University of Texas MD Anderson Cancer Center, Houston, Texas.
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Susan K. Lutgendorf
6Departments of Psychology, Obstetrics and Gynecology, and Urology and Holden Comprehensive Cancer Center, University of Iowa, Iowa City, Iowa.
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Steven W. Cole
7Department of Medicine and Jonsson Comprehensive Cancer Center, University of California, Los Angeles School of Medicine, UCLA Molecular Biology Institute, and Norman Cousins Center, Los Angeles, California.
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Anil K. Sood
2Department of Gynecologic Oncology and Reproductive Medicine, The University of Texas MD Anderson Cancer Center, Houston, Texas.
3Center for RNAi and Non-Coding RNA, The University of Texas MD Anderson Cancer Center, Houston, Texas.
8Cancer Biology, The University of Texas MD Anderson Cancer Center, Houston, Texas.
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  • For correspondence: asood@mdanderson.org
DOI: 10.1158/1078-0432.CCR-15-1275 Published April 2016
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ARTICLE USAGE: November 2015 to March 2021

AbstractFull-text HTMLPDF
Total295613671272

Cited By

Article Information

Volume 22, Issue 7, pp. 1713-1724

DOI 
https://doi.org/10.1158/1078-0432.CCR-15-1275
PubMed 
26581245

Published By 
American Association for Cancer Research
Print ISSN 
1078-0432
Online ISSN 
1557-3265
History 
  • Received May 31, 2015
  • Revision received October 6, 2015
  • Accepted October 13, 2015
  • Published first November 18, 2015.

Article Versions

  • Previous version (November 18, 2015 - 07:18).
  • Previous version (January 28, 2016 - 08:02).
  • You are viewing the most recent version of this article.
Copyright & Usage 
©2015 American Association for Cancer Research.

Author Information

  1. Yu Kang1,2,
  2. Archana S. Nagaraja2,
  3. Guillermo N. Armaiz-Pena2,
  4. Piotr L. Dorniak2,
  5. Wei Hu2,
  6. Rajesha Rupaimoole2,
  7. Tao Liu2,
  8. Kshipra M. Gharpure2,
  9. Rebecca A. Previs2,
  10. Jean M. Hansen2,
  11. Cristian Rodriguez-Aguayo3,4,
  12. Cristina Ivan2,3,
  13. Prahlad Ram5,
  14. Vasudha Sehgal5,
  15. Gabriel Lopez-Berestein3,4,
  16. Susan K. Lutgendorf6,
  17. Steven W. Cole7, and
  18. Anil K. Sood2,3,8,*
  1. 1Shanghai Key Laboratory of Female Reproductive Endocrine-Related Diseases, Obstetrics and Gynecology Hospital of Fudan University, Shanghai, P.R. China.
  2. 2Department of Gynecologic Oncology and Reproductive Medicine, The University of Texas MD Anderson Cancer Center, Houston, Texas.
  3. 3Center for RNAi and Non-Coding RNA, The University of Texas MD Anderson Cancer Center, Houston, Texas.
  4. 4Department of Experimental Therapeutics, The University of Texas MD Anderson Cancer Center, Houston, Texas.
  5. 5Systems Biology, The University of Texas MD Anderson Cancer Center, Houston, Texas.
  6. 6Departments of Psychology, Obstetrics and Gynecology, and Urology and Holden Comprehensive Cancer Center, University of Iowa, Iowa City, Iowa.
  7. 7Department of Medicine and Jonsson Comprehensive Cancer Center, University of California, Los Angeles School of Medicine, UCLA Molecular Biology Institute, and Norman Cousins Center, Los Angeles, California.
  8. 8Cancer Biology, The University of Texas MD Anderson Cancer Center, Houston, Texas.
  1. ↵*Corresponding Author:
    Anil K. Sood, The University of Texas MD Anderson Cancer Center, 1155 Herman Pressler, Unit 1362, Houston, TX 77030. Phone: 713-745-5266; Fax: 713-792-7586; E-mail: asood{at}mdanderson.org
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Clinical Cancer Research: 22 (7)
April 2016
Volume 22, Issue 7
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Adrenergic Stimulation of DUSP1 Impairs Chemotherapy Response in Ovarian Cancer
Yu Kang, Archana S. Nagaraja, Guillermo N. Armaiz-Pena, Piotr L. Dorniak, Wei Hu, Rajesha Rupaimoole, Tao Liu, Kshipra M. Gharpure, Rebecca A. Previs, Jean M. Hansen, Cristian Rodriguez-Aguayo, Cristina Ivan, Prahlad Ram, Vasudha Sehgal, Gabriel Lopez-Berestein, Susan K. Lutgendorf, Steven W. Cole and Anil K. Sood
Clin Cancer Res April 1 2016 (22) (7) 1713-1724; DOI: 10.1158/1078-0432.CCR-15-1275

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Adrenergic Stimulation of DUSP1 Impairs Chemotherapy Response in Ovarian Cancer
Yu Kang, Archana S. Nagaraja, Guillermo N. Armaiz-Pena, Piotr L. Dorniak, Wei Hu, Rajesha Rupaimoole, Tao Liu, Kshipra M. Gharpure, Rebecca A. Previs, Jean M. Hansen, Cristian Rodriguez-Aguayo, Cristina Ivan, Prahlad Ram, Vasudha Sehgal, Gabriel Lopez-Berestein, Susan K. Lutgendorf, Steven W. Cole and Anil K. Sood
Clin Cancer Res April 1 2016 (22) (7) 1713-1724; DOI: 10.1158/1078-0432.CCR-15-1275
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