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Clinical Cancer Research
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Table of Contents

Highlights

  • Highlights
    Highlights of This Issue
    Clin Cancer Res April 15 2016 22 (8) 1829-1829;

CCR Translations

  • CCR Translations
    Natural Killer Cell–Based Immunotherapy in Acute Myeloid Leukemia: Lessons for the Future
    Aura Muntasell and Miguel López-Botet
    Clin Cancer Res April 15 2016 22 (8) 1831-1833; DOI:10.1158/1078-0432.CCR-15-3168

  • CCR Translations
    Everything Old Is New Again: Using Nelfinavir to Radiosensitize Rectal Cancer
    Raymond E. Meyn, Sunil Krishnan and Heath D. Skinner
    Clin Cancer Res April 15 2016 22 (8) 1834-1836; DOI:10.1158/1078-0432.CCR-16-0024

Molecular Pathways

  • Molecular Pathways | AuthorChoice
    Molecular Pathways: Isocitrate Dehydrogenase Mutations in Cancer
    Owen Clark, Katharine Yen and Ingo K. Mellinghoff
    Clin Cancer Res April 15 2016 22 (8) 1837-1842; DOI:10.1158/1078-0432.CCR-13-1333

CCR Focus

  • CCR Focus
    Disruptive Immunology
    Susan E. Bates
    Clin Cancer Res April 15 2016 22 (8) 1844-1844; DOI:10.1158/1078-0432.CCR-15-1850

  • CCR Focus
    Emerging Opportunities and Challenges in Cancer Immunotherapy
    Theresa L. Whiteside, Sandra Demaria, Maria E. Rodriguez-Ruiz, Hassane M. Zarour and Ignacio Melero
    Clin Cancer Res April 15 2016 22 (8) 1845-1855; DOI:10.1158/1078-0432.CCR-16-0049

  • CCR Focus
    Reversing T-cell Dysfunction and Exhaustion in Cancer
    Hassane M. Zarour
    Clin Cancer Res April 15 2016 22 (8) 1856-1864; DOI:10.1158/1078-0432.CCR-15-1849

  • CCR Focus
    The Where, the When, and the How of Immune Monitoring for Cancer Immunotherapies in the Era of Checkpoint Inhibition
    Priti S. Hegde, Vaios Karanikas and Stefan Evers
    Clin Cancer Res April 15 2016 22 (8) 1865-1874; DOI:10.1158/1078-0432.CCR-15-1507

  • CCR Focus
    Making Better Chimeric Antigen Receptors for Adoptive T-cell Therapy
    Marcela V. Maus and Carl H. June
    Clin Cancer Res April 15 2016 22 (8) 1875-1884; DOI:10.1158/1078-0432.CCR-15-1433

  • CCR Focus
    Targeting the Heterogeneity of Cancer with Individualized Neoepitope Vaccines
    Özlem Türeci, Mathias Vormehr, Mustafa Diken, Sebastian Kreiter, Christoph Huber and Ugur Sahin
    Clin Cancer Res April 15 2016 22 (8) 1885-1896; DOI:10.1158/1078-0432.CCR-15-1509

  • CCR Focus
    Dendritic Cell–Based Immunotherapy: State of the Art and Beyond
    Kalijn F. Bol, Gerty Schreibelt, Winald R. Gerritsen, I. Jolanda M. de Vries and Carl G. Figdor
    Clin Cancer Res April 15 2016 22 (8) 1897-1906; DOI:10.1158/1078-0432.CCR-15-1399

Special Report

  • Special Report | Free Article
    Research Priorities, Measures, and Recommendations for Assessment of Tobacco Use in Clinical Cancer Research
    Stephanie R. Land, Benjamin A. Toll, Carol M. Moinpour, Sandra A. Mitchell, Jamie S. Ostroff, Dorothy K. Hatsukami, Sonia A. Duffy, Ellen R. Gritz, Nancy A. Rigotti, Thomas H. Brandon, Sheila A. Prindiville, Linda P. Sarna, Robert A. Schnoll, Roy S. Herbst, Paul M. Cinciripini, Scott J. Leischow, Carolyn M. Dresler, Michael C. Fiore and Graham W. Warren
    Clin Cancer Res April 15 2016 22 (8) 1907-1913; DOI:10.1158/1078-0432.CCR-16-0104

Cancer Therapy: Clinical

  • Cancer Therapy: Clinical
    Larger Size of Donor Alloreactive NK Cell Repertoire Correlates with Better Response to NK Cell Immunotherapy in Elderly Acute Myeloid Leukemia Patients
    Antonio Curti, Loredana Ruggeri, Sarah Parisi, Andrea Bontadini, Elisa Dan, Maria Rosa Motta, Simonetta Rizzi, Sara Trabanelli, Darina Ocadlikova, Mariangela Lecciso, Valeria Giudice, Fiorenza Fruet, Elena Urbani, Cristina Papayannidis, Giovanni Martinelli, Giuseppe Bandini, Francesca Bonifazi, Russell E. Lewis, Michele Cavo, Andrea Velardi and Roberto M. Lemoli
    Clin Cancer Res April 15 2016 22 (8) 1914-1921; DOI:10.1158/1078-0432.CCR-15-1604

  • Cancer Therapy: Clinical | AuthorChoice
    Clinical Trial of Oral Nelfinavir before and during Radiation Therapy for Advanced Rectal Cancer
    Esme J. Hill, Corran Roberts, Jamie M. Franklin, Monica Enescu, Nicholas West, Thomas P. MacGregor, Kwun-Ye Chu, Lucy Boyle, Claire Blesing, Lai-Mun Wang, Somnath Mukherjee, Ewan M. Anderson, Gina Brown, Susan Dutton, Sharon B. Love, Julia A. Schnabel, Phil Quirke, Ruth Muschel, William G. McKenna, Michael Partridge and Ricky A. Sharma
    Clin Cancer Res April 15 2016 22 (8) 1922-1931; DOI:10.1158/1078-0432.CCR-15-1489

  • Cancer Therapy: Clinical
    First-in-Human Phase I Study of GSK2126458, an Oral Pan-Class I Phosphatidylinositol-3-Kinase Inhibitor, in Patients with Advanced Solid Tumor Malignancies
    Pamela Munster, Rahul Aggarwal, David Hong, Jan H.M. Schellens, Ruud van der Noll, Jennifer Specht, Petronella O. Witteveen, Theresa L. Werner, E. Claire Dees, Emily Bergsland, Neeraj Agarwal, Joseph F. Kleha, Michael Durante, Laurel Adams, Deborah A. Smith, Thomas A. Lampkin, Shannon R. Morris and Razelle Kurzrock
    Clin Cancer Res April 15 2016 22 (8) 1932-1939; DOI:10.1158/1078-0432.CCR-15-1665

  • Cancer Therapy: Clinical | AuthorChoice
    KDR Amplification Is Associated with VEGF-Induced Activation of the mTOR and Invasion Pathways but does not Predict Clinical Benefit to the VEGFR TKI Vandetanib
    Monique B. Nilsson, Uma Giri, Jayanthi Gudikote, Ximing Tang, Wei Lu, Hai Tran, Youhong Fan, Andrew Koo, Lixia Diao, Pan Tong, Jing Wang, Roy Herbst, Bruce E. Johnson, Andy Ryan, Alan Webster, Philip Rowe, Ignacio I. Wistuba and John V. Heymach
    Clin Cancer Res April 15 2016 22 (8) 1940-1950; DOI:10.1158/1078-0432.CCR-15-1994

  • Cancer Therapy: Clinical
    Gemtuzumab Ozogamicin Reduces Relapse Risk in FLT3/ITD Acute Myeloid Leukemia: A Report from the Children's Oncology Group
    Katherine Tarlock, Todd A. Alonzo, Robert B. Gerbing, Susana C. Raimondi, Betsy A. Hirsch, Lillian Sung, Jessica A. Pollard, Richard Aplenc, Michael R. Loken, Alan S. Gamis and Soheil Meshinchi
    Clin Cancer Res April 15 2016 22 (8) 1951-1957; DOI:10.1158/1078-0432.CCR-15-1349

Personalized Medicine and Imaging

  • Personalized Medicine and Imaging
    The Stat3/5 Signaling Biosignature in Hematopoietic Stem/Progenitor Cells Predicts Response and Outcome in Myelodysplastic Syndrome Patients Treated with Azacitidine
    Paraskevi Miltiades, Eleftheria Lamprianidou, Theodoros P. Vassilakopoulos, Sotirios G. Papageorgiou, Athanasios G. Galanopoulos, Christos K. Kontos, Panagiotis G. Adamopoulos, Evangelia Nakou, Sofia Vakalopoulou, Vassilia Garypidou, Maria Papaioannou, Evdoxia Hatjiharissi, Helen A. Papadaki, Emmanuil Spanoudakis, Vassiliki Pappa, Andreas Scorilas, Constantinos Tsatalas and Ioannis Kotsianidis
    Clin Cancer Res April 15 2016 22 (8) 1958-1968; DOI:10.1158/1078-0432.CCR-15-1288

  • Personalized Medicine and Imaging
    The Immune Checkpoint Regulator PD-L1 Is Highly Expressed in Aggressive Primary Prostate Cancer
    Heidrun Gevensleben, Dimo Dietrich, Carsten Golletz, Susanne Steiner, Maria Jung, Thore Thiesler, Michael Majores, Johannes Stein, Barbara Uhl, Stefan Müller, Jörg Ellinger, Carsten Stephan, Klaus Jung, Peter Brossart and Glen Kristiansen
    Clin Cancer Res April 15 2016 22 (8) 1969-1977; DOI:10.1158/1078-0432.CCR-15-2042

Cancer Therapy: Preclinical

  • Cancer Therapy: Preclinical
    Selective Toxicity of Investigational Ixazomib for Human Leukemia Cells Expressing Mutant Cytoplasmic NPM1: Role of Reactive Oxygen Species
    Jacqueline S. Garcia, Min Huang, Bruno C. Medeiros and Beverly S. Mitchell
    Clin Cancer Res April 15 2016 22 (8) 1978-1988; DOI:10.1158/1078-0432.CCR-15-1440

  • Cancer Therapy: Preclinical | AuthorChoice
    AGS16F Is a Novel Antibody Drug Conjugate Directed against ENPP3 for the Treatment of Renal Cell Carcinoma
    Fernando Doñate, Arthur Raitano, Kendall Morrison, Zili An, Linnette Capo, Hector Aviña, Sher Karki, Karen Morrison, Peng Yang, Jimmy Ou, Ryuichi Moriya, Yuriy Shostak, Faisal Malik, Rossana Nadell, Wendy Liu, Daulet Satpayev, John Atkinson, Ingrid B.J. Joseph, Daniel S. Pereira, Pia M. Challita-Eid and David R. Stover
    Clin Cancer Res April 15 2016 22 (8) 1989-1999; DOI:10.1158/1078-0432.CCR-15-1542

  • Cancer Therapy: Preclinical | AuthorChoice
    Mechanistic Investigation of Bone Marrow Suppression Associated with Palbociclib and its Differentiation from Cytotoxic Chemotherapies
    Wenyue Hu, Tae Sung, Bart A. Jessen, Stephane Thibault, Martin B. Finkelstein, Nasir K. Khan and Aida I. Sacaan
    Clin Cancer Res April 15 2016 22 (8) 2000-2008; DOI:10.1158/1078-0432.CCR-15-1421

  • Cancer Therapy: Preclinical
    Taselisib (GDC-0032), a Potent β-Sparing Small Molecule Inhibitor of PI3K, Radiosensitizes Head and Neck Squamous Carcinomas Containing Activating PIK3CA Alterations
    Zachary S. Zumsteg, Natasha Morse, Gabriel Krigsfeld, Gaorav Gupta, Daniel S. Higginson, Nancy Y. Lee, Luc Morris, Ian Ganly, Stephan L. Shiao, Simon N. Powell, Christine H. Chung, Maurizio Scaltriti and José Baselga
    Clin Cancer Res April 15 2016 22 (8) 2009-2019; DOI:10.1158/1078-0432.CCR-15-2245

  • Cancer Therapy: Preclinical
    Romidepsin and Azacitidine Synergize in their Epigenetic Modulatory Effects to Induce Apoptosis in CTCL
    Sima Rozati, Phil F. Cheng, Daniel S. Widmer, Kazuyasu Fujii, Mitchell P. Levesque and Reinhard Dummer
    Clin Cancer Res April 15 2016 22 (8) 2020-2031; DOI:10.1158/1078-0432.CCR-15-1435

Biology of Human Tumors

  • Biology of Human Tumors
    An Immunogenetic Signature of Ongoing Antigen Interactions in Splenic Marginal Zone Lymphoma Expressing IGHV1-2*04 Receptors
    Vasilis Bikos, Maria Karypidou, Evangelia Stalika, Panagiotis Baliakas, Aliki Xochelli, Lesley-Ann Sutton, George Papadopoulos, Andreas Agathangelidis, Evdoxia Papadopoulou, Zadie Davis, Patricia Algara, George Kanellis, Alexandra Traverse-Glehen, Manuela Mollejo, Achilles Anagnostopoulos, Maurilio Ponzoni, David Gonzalez, Sarka Pospisilova, Estella Matutes, Miguel Angel Piris, Theodora Papadaki, Paolo Ghia, Richard Rosenquist, David Oscier, Nikos Darzentas, Dimitrios Tzovaras, Chrysoula Belessi, Anastasia Hadzidimitriou and Kostas Stamatopoulos
    Clin Cancer Res April 15 2016 22 (8) 2032-2040; DOI:10.1158/1078-0432.CCR-15-1170

  • Biology of Human Tumors
    ICAM-1–Related Noncoding RNA in Cancer Stem Cells Maintains ICAM-1 Expression in Hepatocellular Carcinoma
    Weixing Guo, Shupeng Liu, Yuqiang Cheng, Lei Lu, Jie Shi, Guixia Xu, Nan Li, Kai Cheng, Mengchao Wu, Shuqun Cheng and Shanrong Liu
    Clin Cancer Res April 15 2016 22 (8) 2041-2050; DOI:10.1158/1078-0432.CCR-14-3106

  • Biology of Human Tumors
    Identification of CD25 as STAT5-Dependent Growth Regulator of Leukemic Stem Cells in Ph+ CML
    Irina Sadovnik, Andrea Hoelbl-Kovacic, Harald Herrmann, Gregor Eisenwort, Sabine Cerny-Reiterer, Wolfgang Warsch, Gregor Hoermann, Georg Greiner, Katharina Blatt, Barbara Peter, Gabriele Stefanzl, Daniela Berger, Martin Bilban, Susanne Herndlhofer, Heinz Sill, Wolfgang R. Sperr, Berthold Streubel, Christine Mannhalter, Tessa L. Holyoake, Veronika Sexl and Peter Valent
    Clin Cancer Res April 15 2016 22 (8) 2051-2061; DOI:10.1158/1078-0432.CCR-15-0767

  • Biology of Human Tumors
    Defects in the Fanconi Anemia Pathway in Head and Neck Cancer Cells Stimulate Tumor Cell Invasion through DNA-PK and Rac1 Signaling
    Lindsey E. Romick-Rosendale, Elizabeth E. Hoskins, Lisa M. Privette Vinnedge, Grant D. Foglesong, Marion G. Brusadelli, S. Steven Potter, Kakajan Komurov, Samantha A. Brugmann, Paul F. Lambert, Randall J. Kimple, Elizabeth L. Virts, Helmut Hanenberg, Maura L. Gillison and Susanne I. Wells
    Clin Cancer Res April 15 2016 22 (8) 2062-2073; DOI:10.1158/1078-0432.CCR-15-2209

  • Biology of Human Tumors
    Genomic DNA Hypomethylation and Risk of Renal Cell Carcinoma: A Case–Control Study
    Julia Mendoza- Pérez, Jian Gu, Luis A. Herrera, Nizar M. Tannir, Surena F. Matin, Jose A. Karam, Maosheng Huang, David W. Chang, Christopher G. Wood and Xifeng Wu
    Clin Cancer Res April 15 2016 22 (8) 2074-2082; DOI:10.1158/1078-0432.CCR-15-0977

  • Biology of Human Tumors
    NOTCH1 and SOX10 are Essential for Proliferation and Radiation Resistance of Cancer Stem–Like Cells in Adenoid Cystic Carcinoma
    Alex Panaccione, Michael T. Chang, Beatrice E. Carbone, Yan Guo, Christopher A. Moskaluk, Renu K. Virk, Luis Chiriboga, Manju L. Prasad, Benjamin Judson, Saral Mehra, Wendell G. Yarbrough and Sergey V. Ivanov
    Clin Cancer Res April 15 2016 22 (8) 2083-2095; DOI:10.1158/1078-0432.CCR-15-2208

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Clinical Cancer Research: 22 (8)
April 2016
Volume 22, Issue 8
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Issue Highlights

  • NOTCH1 and SOX10 are Essential for Proliferation and Radiation Resistance of Cancer Stem–Like Cells in Adenoid Cystic Carcinoma
  • Larger Size of Donor Alloreactive NK Cell Repertoire Correlates with Better Response to NK Cell Immunotherapy in Elderly Acute Myeloid Leukemia Patients
  • The Stat3/5 Signaling Biosignature in Hematopoietic Stem/Progenitor Cells Predicts Response and Outcome in Myelodysplastic Syndrome Patients Treated with Azacitidine
  • Selective Toxicity of Investigational Ixazomib for Human Leukemia Cells Expressing Mutant Cytoplasmic NPM1: Role of Reactive Oxygen Species
  • An Immunogenetic Signature of Ongoing Antigen Interactions in Splenic Marginal Zone Lymphoma Expressing IGHV1-2*04 Receptors

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Clinical Cancer Research
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