Clinical Cancer Research: 22 (8)

Highlights

Highlights

Highlights of This Issue

Clin Cancer Res April 15 2016 22 (8) 1829-1829;

CCR Translations

CCR Translations

Natural Killer Cell–Based Immunotherapy in Acute Myeloid Leukemia: Lessons for the Future

Aura Muntasell and Miguel López-Botet

Clin Cancer Res April 15 2016 22 (8) 1831-1833; DOI:10.1158/1078-0432.CCR-15-3168
CCR Translations

Everything Old Is New Again: Using Nelfinavir to Radiosensitize Rectal Cancer

Raymond E. Meyn, Sunil Krishnan and Heath D. Skinner

Clin Cancer Res April 15 2016 22 (8) 1834-1836; DOI:10.1158/1078-0432.CCR-16-0024

Molecular Pathways

Molecular Pathways | AuthorChoice

Molecular Pathways: Isocitrate Dehydrogenase Mutations in Cancer

Owen Clark, Katharine Yen and Ingo K. Mellinghoff

Clin Cancer Res April 15 2016 22 (8) 1837-1842; DOI:10.1158/1078-0432.CCR-13-1333

CCR Focus

CCR Focus

Disruptive Immunology

Susan E. Bates

Clin Cancer Res April 15 2016 22 (8) 1844-1844; DOI:10.1158/1078-0432.CCR-15-1850
CCR Focus

Emerging Opportunities and Challenges in Cancer Immunotherapy

Theresa L. Whiteside, Sandra Demaria, Maria E. Rodriguez-Ruiz, Hassane M. Zarour and Ignacio Melero

Clin Cancer Res April 15 2016 22 (8) 1845-1855; DOI:10.1158/1078-0432.CCR-16-0049
CCR Focus

Reversing T-cell Dysfunction and Exhaustion in Cancer

Hassane M. Zarour

Clin Cancer Res April 15 2016 22 (8) 1856-1864; DOI:10.1158/1078-0432.CCR-15-1849
CCR Focus

The Where, the When, and the How of Immune Monitoring for Cancer Immunotherapies in the Era of Checkpoint Inhibition

Priti S. Hegde, Vaios Karanikas and Stefan Evers

Clin Cancer Res April 15 2016 22 (8) 1865-1874; DOI:10.1158/1078-0432.CCR-15-1507
CCR Focus

Making Better Chimeric Antigen Receptors for Adoptive T-cell Therapy

Marcela V. Maus and Carl H. June

Clin Cancer Res April 15 2016 22 (8) 1875-1884; DOI:10.1158/1078-0432.CCR-15-1433
CCR Focus

Targeting the Heterogeneity of Cancer with Individualized Neoepitope Vaccines

Özlem Türeci, Mathias Vormehr, Mustafa Diken, Sebastian Kreiter, Christoph Huber and Ugur Sahin

Clin Cancer Res April 15 2016 22 (8) 1885-1896; DOI:10.1158/1078-0432.CCR-15-1509
CCR Focus

Dendritic Cell–Based Immunotherapy: State of the Art and Beyond

Kalijn F. Bol, Gerty Schreibelt, Winald R. Gerritsen, I. Jolanda M. de Vries and Carl G. Figdor

Clin Cancer Res April 15 2016 22 (8) 1897-1906; DOI:10.1158/1078-0432.CCR-15-1399

Special Report

Special Report | Free Article

Research Priorities, Measures, and Recommendations for Assessment of Tobacco Use in Clinical Cancer Research

Stephanie R. Land, Benjamin A. Toll, Carol M. Moinpour, Sandra A. Mitchell, Jamie S. Ostroff, Dorothy K. Hatsukami, Sonia A. Duffy, Ellen R. Gritz, Nancy A. Rigotti, Thomas H. Brandon, Sheila A. Prindiville, Linda P. Sarna, Robert A. Schnoll, Roy S. Herbst, Paul M. Cinciripini, Scott J. Leischow, Carolyn M. Dresler, Michael C. Fiore and Graham W. Warren

Clin Cancer Res April 15 2016 22 (8) 1907-1913; DOI:10.1158/1078-0432.CCR-16-0104

Cancer Therapy: Clinical

Cancer Therapy: Clinical

Larger Size of Donor Alloreactive NK Cell Repertoire Correlates with Better Response to NK Cell Immunotherapy in Elderly Acute Myeloid Leukemia Patients

Antonio Curti, Loredana Ruggeri, Sarah Parisi, Andrea Bontadini, Elisa Dan, Maria Rosa Motta, Simonetta Rizzi, Sara Trabanelli, Darina Ocadlikova, Mariangela Lecciso, Valeria Giudice, Fiorenza Fruet, Elena Urbani, Cristina Papayannidis, Giovanni Martinelli, Giuseppe Bandini, Francesca Bonifazi, Russell E. Lewis, Michele Cavo, Andrea Velardi and Roberto M. Lemoli

Clin Cancer Res April 15 2016 22 (8) 1914-1921; DOI:10.1158/1078-0432.CCR-15-1604
Cancer Therapy: Clinical | AuthorChoice

Clinical Trial of Oral Nelfinavir before and during Radiation Therapy for Advanced Rectal Cancer

Esme J. Hill, Corran Roberts, Jamie M. Franklin, Monica Enescu, Nicholas West, Thomas P. MacGregor, Kwun-Ye Chu, Lucy Boyle, Claire Blesing, Lai-Mun Wang, Somnath Mukherjee, Ewan M. Anderson, Gina Brown, Susan Dutton, Sharon B. Love, Julia A. Schnabel, Phil Quirke, Ruth Muschel, William G. McKenna, Michael Partridge and Ricky A. Sharma

Clin Cancer Res April 15 2016 22 (8) 1922-1931; DOI:10.1158/1078-0432.CCR-15-1489
Cancer Therapy: Clinical

First-in-Human Phase I Study of GSK2126458, an Oral Pan-Class I Phosphatidylinositol-3-Kinase Inhibitor, in Patients with Advanced Solid Tumor Malignancies

Pamela Munster, Rahul Aggarwal, David Hong, Jan H.M. Schellens, Ruud van der Noll, Jennifer Specht, Petronella O. Witteveen, Theresa L. Werner, E. Claire Dees, Emily Bergsland, Neeraj Agarwal, Joseph F. Kleha, Michael Durante, Laurel Adams, Deborah A. Smith, Thomas A. Lampkin, Shannon R. Morris and Razelle Kurzrock

Clin Cancer Res April 15 2016 22 (8) 1932-1939; DOI:10.1158/1078-0432.CCR-15-1665
Cancer Therapy: Clinical | AuthorChoice

KDR Amplification Is Associated with VEGF-Induced Activation of the mTOR and Invasion Pathways but does not Predict Clinical Benefit to the VEGFR TKI Vandetanib

Monique B. Nilsson, Uma Giri, Jayanthi Gudikote, Ximing Tang, Wei Lu, Hai Tran, Youhong Fan, Andrew Koo, Lixia Diao, Pan Tong, Jing Wang, Roy Herbst, Bruce E. Johnson, Andy Ryan, Alan Webster, Philip Rowe, Ignacio I. Wistuba and John V. Heymach

Clin Cancer Res April 15 2016 22 (8) 1940-1950; DOI:10.1158/1078-0432.CCR-15-1994
Cancer Therapy: Clinical

Gemtuzumab Ozogamicin Reduces Relapse Risk in FLT3/ITD Acute Myeloid Leukemia: A Report from the Children's Oncology Group

Katherine Tarlock, Todd A. Alonzo, Robert B. Gerbing, Susana C. Raimondi, Betsy A. Hirsch, Lillian Sung, Jessica A. Pollard, Richard Aplenc, Michael R. Loken, Alan S. Gamis and Soheil Meshinchi

Clin Cancer Res April 15 2016 22 (8) 1951-1957; DOI:10.1158/1078-0432.CCR-15-1349

Personalized Medicine and Imaging

Personalized Medicine and Imaging

The Stat3/5 Signaling Biosignature in Hematopoietic Stem/Progenitor Cells Predicts Response and Outcome in Myelodysplastic Syndrome Patients Treated with Azacitidine

Paraskevi Miltiades, Eleftheria Lamprianidou, Theodoros P. Vassilakopoulos, Sotirios G. Papageorgiou, Athanasios G. Galanopoulos, Christos K. Kontos, Panagiotis G. Adamopoulos, Evangelia Nakou, Sofia Vakalopoulou, Vassilia Garypidou, Maria Papaioannou, Evdoxia Hatjiharissi, Helen A. Papadaki, Emmanuil Spanoudakis, Vassiliki Pappa, Andreas Scorilas, Constantinos Tsatalas and Ioannis Kotsianidis

Clin Cancer Res April 15 2016 22 (8) 1958-1968; DOI:10.1158/1078-0432.CCR-15-1288
Personalized Medicine and Imaging

The Immune Checkpoint Regulator PD-L1 Is Highly Expressed in Aggressive Primary Prostate Cancer

Heidrun Gevensleben, Dimo Dietrich, Carsten Golletz, Susanne Steiner, Maria Jung, Thore Thiesler, Michael Majores, Johannes Stein, Barbara Uhl, Stefan Müller, Jörg Ellinger, Carsten Stephan, Klaus Jung, Peter Brossart and Glen Kristiansen

Clin Cancer Res April 15 2016 22 (8) 1969-1977; DOI:10.1158/1078-0432.CCR-15-2042

Cancer Therapy: Preclinical

Cancer Therapy: Preclinical

Selective Toxicity of Investigational Ixazomib for Human Leukemia Cells Expressing Mutant Cytoplasmic NPM1: Role of Reactive Oxygen Species

Jacqueline S. Garcia, Min Huang, Bruno C. Medeiros and Beverly S. Mitchell

Clin Cancer Res April 15 2016 22 (8) 1978-1988; DOI:10.1158/1078-0432.CCR-15-1440
Cancer Therapy: Preclinical | AuthorChoice

AGS16F Is a Novel Antibody Drug Conjugate Directed against ENPP3 for the Treatment of Renal Cell Carcinoma

Fernando Doñate, Arthur Raitano, Kendall Morrison, Zili An, Linnette Capo, Hector Aviña, Sher Karki, Karen Morrison, Peng Yang, Jimmy Ou, Ryuichi Moriya, Yuriy Shostak, Faisal Malik, Rossana Nadell, Wendy Liu, Daulet Satpayev, John Atkinson, Ingrid B.J. Joseph, Daniel S. Pereira, Pia M. Challita-Eid and David R. Stover

Clin Cancer Res April 15 2016 22 (8) 1989-1999; DOI:10.1158/1078-0432.CCR-15-1542
Cancer Therapy: Preclinical | AuthorChoice

Mechanistic Investigation of Bone Marrow Suppression Associated with Palbociclib and its Differentiation from Cytotoxic Chemotherapies

Wenyue Hu, Tae Sung, Bart A. Jessen, Stephane Thibault, Martin B. Finkelstein, Nasir K. Khan and Aida I. Sacaan

Clin Cancer Res April 15 2016 22 (8) 2000-2008; DOI:10.1158/1078-0432.CCR-15-1421
Cancer Therapy: Preclinical

Taselisib (GDC-0032), a Potent β-Sparing Small Molecule Inhibitor of PI3K, Radiosensitizes Head and Neck Squamous Carcinomas Containing Activating PIK3CA Alterations

Zachary S. Zumsteg, Natasha Morse, Gabriel Krigsfeld, Gaorav Gupta, Daniel S. Higginson, Nancy Y. Lee, Luc Morris, Ian Ganly, Stephan L. Shiao, Simon N. Powell, Christine H. Chung, Maurizio Scaltriti and José Baselga

Clin Cancer Res April 15 2016 22 (8) 2009-2019; DOI:10.1158/1078-0432.CCR-15-2245
Cancer Therapy: Preclinical

Romidepsin and Azacitidine Synergize in their Epigenetic Modulatory Effects to Induce Apoptosis in CTCL

Sima Rozati, Phil F. Cheng, Daniel S. Widmer, Kazuyasu Fujii, Mitchell P. Levesque and Reinhard Dummer

Clin Cancer Res April 15 2016 22 (8) 2020-2031; DOI:10.1158/1078-0432.CCR-15-1435

Biology of Human Tumors

Biology of Human Tumors

An Immunogenetic Signature of Ongoing Antigen Interactions in Splenic Marginal Zone Lymphoma Expressing IGHV1-2*04 Receptors

Vasilis Bikos, Maria Karypidou, Evangelia Stalika, Panagiotis Baliakas, Aliki Xochelli, Lesley-Ann Sutton, George Papadopoulos, Andreas Agathangelidis, Evdoxia Papadopoulou, Zadie Davis, Patricia Algara, George Kanellis, Alexandra Traverse-Glehen, Manuela Mollejo, Achilles Anagnostopoulos, Maurilio Ponzoni, David Gonzalez, Sarka Pospisilova, Estella Matutes, Miguel Angel Piris, Theodora Papadaki, Paolo Ghia, Richard Rosenquist, David Oscier, Nikos Darzentas, Dimitrios Tzovaras, Chrysoula Belessi, Anastasia Hadzidimitriou and Kostas Stamatopoulos

Clin Cancer Res April 15 2016 22 (8) 2032-2040; DOI:10.1158/1078-0432.CCR-15-1170
Biology of Human Tumors

ICAM-1–Related Noncoding RNA in Cancer Stem Cells Maintains ICAM-1 Expression in Hepatocellular Carcinoma

Weixing Guo, Shupeng Liu, Yuqiang Cheng, Lei Lu, Jie Shi, Guixia Xu, Nan Li, Kai Cheng, Mengchao Wu, Shuqun Cheng and Shanrong Liu

Clin Cancer Res April 15 2016 22 (8) 2041-2050; DOI:10.1158/1078-0432.CCR-14-3106
Biology of Human Tumors

Identification of CD25 as STAT5-Dependent Growth Regulator of Leukemic Stem Cells in Ph⁺ CML

Irina Sadovnik, Andrea Hoelbl-Kovacic, Harald Herrmann, Gregor Eisenwort, Sabine Cerny-Reiterer, Wolfgang Warsch, Gregor Hoermann, Georg Greiner, Katharina Blatt, Barbara Peter, Gabriele Stefanzl, Daniela Berger, Martin Bilban, Susanne Herndlhofer, Heinz Sill, Wolfgang R. Sperr, Berthold Streubel, Christine Mannhalter, Tessa L. Holyoake, Veronika Sexl and Peter Valent

Clin Cancer Res April 15 2016 22 (8) 2051-2061; DOI:10.1158/1078-0432.CCR-15-0767
Biology of Human Tumors

Defects in the Fanconi Anemia Pathway in Head and Neck Cancer Cells Stimulate Tumor Cell Invasion through DNA-PK and Rac1 Signaling

Lindsey E. Romick-Rosendale, Elizabeth E. Hoskins, Lisa M. Privette Vinnedge, Grant D. Foglesong, Marion G. Brusadelli, S. Steven Potter, Kakajan Komurov, Samantha A. Brugmann, Paul F. Lambert, Randall J. Kimple, Elizabeth L. Virts, Helmut Hanenberg, Maura L. Gillison and Susanne I. Wells

Clin Cancer Res April 15 2016 22 (8) 2062-2073; DOI:10.1158/1078-0432.CCR-15-2209
Biology of Human Tumors

Genomic DNA Hypomethylation and Risk of Renal Cell Carcinoma: A Case–Control Study

Julia Mendoza- Pérez, Jian Gu, Luis A. Herrera, Nizar M. Tannir, Surena F. Matin, Jose A. Karam, Maosheng Huang, David W. Chang, Christopher G. Wood and Xifeng Wu

Clin Cancer Res April 15 2016 22 (8) 2074-2082; DOI:10.1158/1078-0432.CCR-15-0977
Biology of Human Tumors

NOTCH1 and SOX10 are Essential for Proliferation and Radiation Resistance of Cancer Stem–Like Cells in Adenoid Cystic Carcinoma

Alex Panaccione, Michael T. Chang, Beatrice E. Carbone, Yan Guo, Christopher A. Moskaluk, Renu K. Virk, Luis Chiriboga, Manju L. Prasad, Benjamin Judson, Saral Mehra, Wendell G. Yarbrough and Sergey V. Ivanov

Clin Cancer Res April 15 2016 22 (8) 2083-2095; DOI:10.1158/1078-0432.CCR-15-2208

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CCR Translations

Molecular Pathways

CCR Focus

Special Report

Cancer Therapy: Clinical

Personalized Medicine and Imaging

Cancer Therapy: Preclinical

Biology of Human Tumors

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