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Table of Contents

Highlights

  • Highlights
    Highlights of This Issue
    Clin Cancer Res May 1 2016 22 (9) 2097-2097;

CCR Translations

  • CCR Translations
    Pharmacology in the Era of Targeted Therapies: The Case of PI3K Inhibitors
    Eneda Toska and José Baselga
    Clin Cancer Res May 1 2016 22 (9) 2099-2101; DOI:10.1158/1078-0432.CCR-16-0038

  • CCR Translations | Free Article
    Predictive Biomarkers for PD-1 Axis Therapies: The Hidden Treasure or a Call for Research
    Kurt A. Schalper, Edward Kaftan and Roy S. Herbst
    Clin Cancer Res May 1 2016 22 (9) 2102-2104; DOI:10.1158/1078-0432.CCR-16-0169

CCR New Strategies

  • CCR New Strategies
    New Strategies in Breast Cancer: Immunotherapy
    Lajos Pusztai, Thomas Karn, Anton Safonov, Maysa M. Abu-Khalaf and Giampaolo Bianchini
    Clin Cancer Res May 1 2016 22 (9) 2105-2110; DOI:10.1158/1078-0432.CCR-15-1315

CCR Perspectives in Regulatory Science and Policy

  • CCR Perspectives in Regulatory Science and Policy
    The Majority of Expedited Investigational New Drug Safety Reports Are Uninformative
    Jonathan P. Jarow, Sandra Casak, Meredith Chuk, Lori A. Ehrlich and Sean Khozin
    Clin Cancer Res May 1 2016 22 (9) 2111-2113; DOI:10.1158/1078-0432.CCR-15-2082

Statistics in Clinical Cancer Research

  • Statistics in Clinical Cancer Research
    Quantifying Treatment Benefit in Molecular Subgroups to Assess a Predictive Biomarker
    Alexia Iasonos, Paul B. Chapman and Jaya M. Satagopan
    Clin Cancer Res May 1 2016 22 (9) 2114-2120; DOI:10.1158/1078-0432.CCR-15-2517

    CME

Molecular Pathways

  • Molecular Pathways
    Molecular Pathways: Immunosuppressive Roles of IRE1α-XBP1 Signaling in Dendritic Cells of the Tumor Microenvironment
    Juan R. Cubillos-Ruiz, Sarah E. Bettigole and Laurie H. Glimcher
    Clin Cancer Res May 1 2016 22 (9) 2121-2126; DOI:10.1158/1078-0432.CCR-15-1570

Perspectives

  • Perspectives | AuthorChoice
    Are Doses and Schedules of Small-Molecule Targeted Anticancer Drugs Recommended by Phase I Studies Realistic?
    Desamparados Roda, Begoña Jimenez and Udai Banerji
    Clin Cancer Res May 1 2016 22 (9) 2127-2132; DOI:10.1158/1078-0432.CCR-15-1855

  • Perspectives | AuthorChoice
    Defining the Value of a Comparative Approach to Cancer Drug Development
    Amy K. LeBlanc, Christina N. Mazcko and Chand Khanna
    Clin Cancer Res May 1 2016 22 (9) 2133-2138; DOI:10.1158/1078-0432.CCR-15-2347

Cancer Therapy: Clinical

  • Cancer Therapy: Clinical | AuthorChoice
    A Phase Ib/II Study of Afatinib in Combination with Nimotuzumab in Non–Small Cell Lung Cancer Patients with Acquired Resistance to Gefitinib or Erlotinib
    Ji Yun Lee, Jong-Mu Sun, Sung Hee Lim, Hae Su Kim, Kwai Han Yoo, Ki Sun Jung, Haa-Na Song, Bo Mi Ku, Jiae Koh, Yeon-Hee Bae, Se-Hoon Lee, Jin Seok Ahn, Keunchil Park and Myung-Ju Ahn
    Clin Cancer Res May 1 2016 22 (9) 2139-2145; DOI:10.1158/1078-0432.CCR-15-1653

  • Cancer Therapy: Clinical | AuthorChoice
    A Phase I Study of the Anti-Activin Receptor-Like Kinase 1 (ALK-1) Monoclonal Antibody PF-03446962 in Patients with Advanced Solid Tumors
    Laura W. Goff, Roger B. Cohen, Jordan D. Berlin, Filippo G. de Braud, Andrej Lyshchik, Cristina Noberasco, Francesco Bertolini, Marina Carpentieri, Corrado Gallo Stampino, Antonello Abbattista, Erjan Wang and Hossein Borghaei
    Clin Cancer Res May 1 2016 22 (9) 2146-2154; DOI:10.1158/1078-0432.CCR-15-1622

  • Cancer Therapy: Clinical | AuthorChoice
    Effective Clinical Responses in Metastatic Melanoma Patients after Vaccination with Primary Myeloid Dendritic Cells
    Gerty Schreibelt, Kalijn F. Bol, Harm Westdorp, Florian Wimmers, Erik H.J.G. Aarntzen, Tjitske Duiveman-de Boer, Mandy W.M.M. van de Rakt, Nicole M. Scharenborg, Annemiek J. de Boer, Jeanette M. Pots, Michel A.M. Olde Nordkamp, Tom G.M. van Oorschot, Jurjen Tel, Gregor Winkels, Katja Petry, Willeke A.M. Blokx, Michelle M. van Rossum, Marieke E.B. Welzen, Roel D.M. Mus, Sandra A.J. Croockewit, Rutger H.T. Koornstra, Joannes F.M. Jacobs, Sander Kelderman, Christian U. Blank, Winald R. Gerritsen, Cornelis J.A. Punt, Carl G. Figdor and I. Jolanda M. de Vries
    Clin Cancer Res May 1 2016 22 (9) 2155-2166; DOI:10.1158/1078-0432.CCR-15-2205

Personalized Medicine and Imaging

  • Personalized Medicine and Imaging
    Comparing Patient-Derived Xenograft and Computational Response Prediction for Targeted Therapy in Patients of Early-Stage Large Cell Lung Cancer
    Jian Li, Changkun Ye and Ulrich R. Mansmann
    Clin Cancer Res May 1 2016 22 (9) 2167-2176; DOI:10.1158/1078-0432.CCR-15-2401

  • Personalized Medicine and Imaging
    Heterogeneity of Programmed Cell Death Ligand 1 Expression in Multifocal Lung Cancer
    Aaron S. Mansfield, Stephen J. Murphy, Tobias Peikert, Eunhee S. Yi, George Vasmatzis, Dennis A. Wigle and Marie Christine Aubry
    Clin Cancer Res May 1 2016 22 (9) 2177-2182; DOI:10.1158/1078-0432.CCR-15-2246

  • Personalized Medicine and Imaging | AuthorChoice
    Genetic Effect of Chemotherapy Exposure in Children of Testicular Cancer Survivors
    Gregory V. Kryukov, Craig M. Bielski, Kaitlin Samocha, Menachem Fromer, Sara Seepo, Carleen Gentry, Benjamin Neale, Levi A. Garraway, Christopher J. Sweeney, Mary-Ellen Taplin and Eliezer M. Van Allen
    Clin Cancer Res May 1 2016 22 (9) 2183-2189; DOI:10.1158/1078-0432.CCR-15-2317

  • Personalized Medicine and Imaging
    Late Pseudoprogression in Glioblastoma: Diagnostic Value of Dynamic O-(2-[18F]fluoroethyl)-L-Tyrosine PET
    Sied Kebir, Rolf Fimmers, Norbert Galldiks, Niklas Schäfer, Frederic Mack, Christina Schaub, Moritz Stuplich, Michael Niessen, Theophilos Tzaridis, Matthias Simon, Gabriele Stoffels, Karl-Josef Langen, Björn Scheffler, Martin Glas and Ulrich Herrlinger
    Clin Cancer Res May 1 2016 22 (9) 2190-2196; DOI:10.1158/1078-0432.CCR-15-1334

  • Personalized Medicine and Imaging
    Enumeration and Molecular Characterization of Tumor Cells in Lung Cancer Patients Using a Novel In Vivo Device for Capturing Circulating Tumor Cells
    Tobias M. Gorges, Nicole Penkalla, Thomas Schalk, Simon A. Joosse, Sabine Riethdorf, Johannes Tucholski, Klaus Lücke, Harriet Wikman, Stephen Jackson, Nora Brychta, Oliver von Ahsen, Christian Schumann, Thomas Krahn and Klaus Pantel
    Clin Cancer Res May 1 2016 22 (9) 2197-2206; DOI:10.1158/1078-0432.CCR-15-1416

Cancer Therapy: Preclinical

  • Cancer Therapy: Preclinical
    The Antitumor Efficacy of IL2/IL21-Cultured Polyfunctional Neu-Specific T Cells Is TNFα/IL17 Dependent
    Vy Phan-Lai, Yushe Dang, Ekram Gad, Jennifer Childs and Mary L. Disis
    Clin Cancer Res May 1 2016 22 (9) 2207-2216; DOI:10.1158/1078-0432.CCR-15-2273

  • Cancer Therapy: Preclinical
    The Oncolytic Adenovirus VCN-01 as Therapeutic Approach Against Pediatric Osteosarcoma
    Naiara Martínez-Vélez, Enric Xipell, Beatriz Vera, Arlet Acanda de la Rocha, Marta Zalacain, Lucía Marrodán, Marisol Gonzalez-Huarriz, Gemma Toledo, Manel Cascallo, Ramón Alemany, Ana Patiño and Marta M. Alonso
    Clin Cancer Res May 1 2016 22 (9) 2217-2225; DOI:10.1158/1078-0432.CCR-15-1899

  • Cancer Therapy: Preclinical
    Toward Personalized Lymphoma Immunotherapy: Identification of Common Driver Mutations Recognized by Patient CD8+ T Cells
    Julie S. Nielsen, Colin G. Sedgwick, Aniqa Shahid, Zusheng Zong, Zabrina L. Brumme, Stephen Yu, Lewis Liu, David R. Kroeger, Steven P. Treon, Joseph M. Connors, Randy D. Gascoyne, Brian R. Berry, Marco A. Marra, Ryan D. Morin, Nicol Macpherson and Brad H. Nelson
    Clin Cancer Res May 1 2016 22 (9) 2226-2236; DOI:10.1158/1078-0432.CCR-15-2023

  • Cancer Therapy: Preclinical
    Identification of an Immunogenic Subset of Metastatic Uveal Melanoma
    Luke D. Rothermel, Arvind C. Sabesan, Daniel J. Stephens, Smita S. Chandran, Biman C. Paria, Abhishek K. Srivastava, Robert Somerville, John R. Wunderlich, Chyi-Chia R. Lee, Liqiang Xi, Trinh H. Pham, Mark Raffeld, Parthav Jailwala, Manjula Kasoji and Udai S. Kammula
    Clin Cancer Res May 1 2016 22 (9) 2237-2249; DOI:10.1158/1078-0432.CCR-15-2294

  • Cancer Therapy: Preclinical
    Strategically Timing Inhibition of Phosphatidylinositol 3-Kinase to Maximize Therapeutic Index in Estrogen Receptor Alpha–Positive, PIK3CA-Mutant Breast Cancer
    Wei Yang, Sarah R. Hosford, Lloye M. Dillon, Kevin Shee, Stephanie C. Liu, Jennifer R. Bean, Laurent Salphati, Jodie Pang, Xiaolin Zhang, Michelle A. Nannini, Eugene Demidenko, Darcy Bates, Lionel D. Lewis, Jonathan D. Marotti, Alan R. Eastman and Todd W. Miller
    Clin Cancer Res May 1 2016 22 (9) 2250-2260; DOI:10.1158/1078-0432.CCR-15-2276

Biology of Human Tumors

  • Biology of Human Tumors
    Pan-Cancer Immunogenomic Perspective on the Tumor Microenvironment Based on PD-L1 and CD8 T-Cell Infiltration
    Chan-Young Ock, Bhumsuk Keam, Sehui Kim, Ju-Seog Lee, Miso Kim, Tae Min Kim, Yoon Kyung Jeon, Dong-Wan Kim, Doo Hyun Chung and Dae Seog Heo
    Clin Cancer Res May 1 2016 22 (9) 2261-2270; DOI:10.1158/1078-0432.CCR-15-2834

  • Biology of Human Tumors
    Expression and Function of Phosphodiesterase Type 5 in Human Breast Cancer Cell Lines and Tissues: Implications for Targeted Therapy
    Stefania Catalano, Antonella Campana, Cinzia Giordano, Balázs Győrffy, Roberta Tarallo, Antonio Rinaldi, Giuseppina Bruno, Aurora Ferraro, Francesco Romeo, Marilena Lanzino, Fabio Naro, Daniela Bonofiglio, Sebastiano Andò and Ines Barone
    Clin Cancer Res May 1 2016 22 (9) 2271-2282; DOI:10.1158/1078-0432.CCR-15-1900

  • Biology of Human Tumors
    Systemic Correlates of White Adipose Tissue Inflammation in Early-Stage Breast Cancer
    Neil M. Iyengar, Xi Kathy Zhou, Ayca Gucalp, Patrick G. Morris, Louise R. Howe, Dilip D. Giri, Monica Morrow, Hanhan Wang, Michael Pollak, Lee W. Jones, Clifford A. Hudis and Andrew J. Dannenberg
    Clin Cancer Res May 1 2016 22 (9) 2283-2289; DOI:10.1158/1078-0432.CCR-15-2239

  • Biology of Human Tumors | AuthorChoice
    Genetic Landscapes of Relapsed and Refractory Diffuse Large B-Cell Lymphomas
    Ryan D. Morin, Sarit Assouline, Miguel Alcaide, Arezoo Mohajeri, Rebecca L. Johnston, Lauren Chong, Jasleen Grewal, Stephen Yu, Daniel Fornika, Kevin Bushell, Torsten Holm Nielsen, Tina Petrogiannis-Haliotis, Michael Crump, Axel Tosikyan, Bruno M. Grande, David MacDonald, Caroline Rousseau, Maryam Bayat, Pierre Sesques, Remi Froment, Marco Albuquerque, Yury Monczak, Kathleen Klein Oros, Celia Greenwood, Yasser Riazalhosseini, Madeleine Arseneault, Errol Camlioglu, André Constantin, Qiang Pan-Hammarstrom, Roujun Peng, Koren K. Mann and Nathalie A. Johnson
    Clin Cancer Res May 1 2016 22 (9) 2290-2300; DOI:10.1158/1078-0432.CCR-15-2123

  • Biology of Human Tumors
    Recurrent Mutations of Chromatin-Remodeling Genes and Kinase Receptors in Pheochromocytomas and Paragangliomas
    Rodrigo A. Toledo, Yuejuan Qin, Zi-Ming Cheng, Qing Gao, Shintaro Iwata, Gustavo M. Silva, Manju L. Prasad, I. Tolgay Ocal, Sarika Rao, Neil Aronin, Marta Barontini, Jan Bruder, Robert L. Reddick, Yidong Chen, Ricardo C.T. Aguiar and Patricia L.M. Dahia
    Clin Cancer Res May 1 2016 22 (9) 2301-2310; DOI:10.1158/1078-0432.CCR-15-1841

Letter to the Editor

  • Letter to the Editor
    Significance of FcγRIIIa-V158F Polymorphism—Letter
    Janardan P. Pandey
    Clin Cancer Res May 1 2016 22 (9) 2311-2311; DOI:10.1158/1078-0432.CCR-16-0428

Corrections

  • Corrections
    Correction: Cabozantinib Suppresses Tumor Growth and Metastasis in Hepatocellular Carcinoma by a Dual Blockade of VEGFR2 and MET
    Clin Cancer Res May 1 2016 22 (9) 2312-2312; DOI:10.1158/1078-0432.CCR-16-0034

  • Corrections
    Correction: Preclinical Efficacy of the MDM2 Inhibitor RG7112 in MDM2-Amplified and TP53 Wild-type Glioblastomas
    Clin Cancer Res May 1 2016 22 (9) 2313-2313; DOI:10.1158/1078-0432.CCR-16-0703

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Clinical Cancer Research: 22 (9)
May 2016
Volume 22, Issue 9
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Issue Highlights

  • Genetic Landscapes of Relapsed and Refractory Diffuse Large B-Cell Lymphomas
  • Comparing Patient-Derived Xenograft and Computational Response Prediction for Targeted Therapy in Patients of Early-Stage Large Cell Lung Cancer
  • Heterogeneity of Programmed Cell Death Ligand 1 Expression in Multifocal Lung Cancer
  • Pan-Cancer Immunogenomic Perspective on the Tumor Microenvironment Based on PD-L1 and CD8 T-Cell Infiltration
  • Expression and Function of Phosphodiesterase Type 5 in Human Breast Cancer Cell Lines and Tissues: Implications for Targeted Therapy

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Clinical Cancer Research
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