Clinical Cancer Research: 23 (11)

CCR Pediatric Oncology Series: Articles from the AACR Childhood Cancer Predisposition Workshop

CCR Pediatric Oncology Series | Free Article

Pediatric Cancer Predisposition and Surveillance: An Overview, and a Tribute to Alfred G. Knudson Jr

Garrett M. Brodeur, Kim E. Nichols, Sharon E. Plon, Joshua D. Schiffman and David Malkin

Clin Cancer Res June 1 2017 23 (11) e1-e5; DOI:10.1158/1078-0432.CCR-17-0702
CCR Pediatric Oncology Series | Free Article

Pediatric Cancer Predisposition Imaging: Focus on Whole-Body MRI

Mary-Louise C. Greer, Stephan D. Voss and Lisa J. States

Clin Cancer Res June 1 2017 23 (11) e6-e13; DOI:10.1158/1078-0432.CCR-17-0515
CCR Pediatric Oncology Series | Free Article

Recommendations for Surveillance for Children with Leukemia-Predisposing Conditions

Christopher C. Porter, Todd E. Druley, Ayelet Erez, Roland P. Kuiper, Kenan Onel, Joshua D. Schiffman, Kami Wolfe Schneider, Sarah R. Scollon, Hamish S. Scott, Louise C. Strong, Michael F. Walsh and Kim E. Nichols

Clin Cancer Res June 1 2017 23 (11) e14-e22; DOI:10.1158/1078-0432.CCR-17-0428
CCR Pediatric Oncology Series | Free Article

Recommendations for Childhood Cancer Screening and Surveillance in DNA Repair Disorders

Michael F. Walsh, Vivian Y. Chang, Wendy K. Kohlmann, Hamish S. Scott, Christopher Cunniff, Franck Bourdeaut, Jan J. Molenaar, Christopher C. Porter, John T. Sandlund, Sharon E. Plon, Lisa L. Wang and Sharon A. Savage

Clin Cancer Res June 1 2017 23 (11) e23-e31; DOI:10.1158/1078-0432.CCR-17-0465
CCR Pediatric Oncology Series | Free Article

Clinical Management and Tumor Surveillance Recommendations of Inherited Mismatch Repair Deficiency in Childhood

Uri Tabori, Jordan R. Hansford, Maria Isabel Achatz, Christian P. Kratz, Sharon E. Plon, Thierry Frebourg and Laurence Brugières

Clin Cancer Res June 1 2017 23 (11) e32-e37; DOI:10.1158/1078-0432.CCR-17-0574
CCR Pediatric Oncology Series | Free Article

Cancer Screening Recommendations for Individuals with Li-Fraumeni Syndrome

Christian P. Kratz, Maria Isabel Achatz, Laurence Brugières, Thierry Frebourg, Judy E. Garber, Mary-Louise C. Greer, Jordan R. Hansford, Katherine A. Janeway, Wendy K. Kohlmann, Rose McGee, Charles G. Mullighan, Kenan Onel, Kristian W. Pajtler, Stefan M. Pfister, Sharon A. Savage, Joshua D. Schiffman, Katherine A. Schneider, Louise C. Strong, D. Gareth R. Evans, Jonathan D. Wasserman, Anita Villani and David Malkin

Clin Cancer Res June 1 2017 23 (11) e38-e45; DOI:10.1158/1078-0432.CCR-17-0408

Highlights of This Issue

Highlights

Highlights of This Issue

Clin Cancer Res June 1 2017 23 (11) 2607-2607; DOI:10.1158/1078-0432.CCR-HOTI-11

CCR Focus

CCR Focus

Base Pairs to Populations

Susan E. Bates

Clin Cancer Res June 1 2017 23 (11) 2610-2610; DOI:10.1158/1078-0432.CCR-16-2631
CCR Focus

Unmet Needs in Clinical Research in Breast Cancer: Where Do We Need to Go?

Ann H. Partridge and Lisa A. Carey

Clin Cancer Res June 1 2017 23 (11) 2611-2616; DOI:10.1158/1078-0432.CCR-16-2633
CCR Focus

Mutational Signatures in Breast Cancer: The Problem at the DNA Level

Serena Nik-Zainal and Sandro Morganella

Clin Cancer Res June 1 2017 23 (11) 2617-2629; DOI:10.1158/1078-0432.CCR-16-2810
CCR Focus

Translational Genomics: Practical Applications of the Genomic Revolution in Breast Cancer

Lucy R. Yates and Christine Desmedt

Clin Cancer Res June 1 2017 23 (11) 2630-2639; DOI:10.1158/1078-0432.CCR-16-2548
CCR Focus

Immunotherapy for Breast Cancer: What Are We Missing?

Robert H. Vonderheide, Susan M. Domchek and Amy S. Clark

Clin Cancer Res June 1 2017 23 (11) 2640-2646; DOI:10.1158/1078-0432.CCR-16-2569
CCR Focus

Emerging Data and Current Challenges for Young, Old, Obese, or Male Patients with Breast Cancer

Rachel A. Freedman and Ann H. Partridge

Clin Cancer Res June 1 2017 23 (11) 2647-2654; DOI:10.1158/1078-0432.CCR-16-2552
CCR Focus

Breast Cancer Disparities at Home and Abroad: A Review of the Challenges and Opportunities for System-Level Change

Katherine E. Reeder-Hayes and Benjamin O. Anderson

Clin Cancer Res June 1 2017 23 (11) 2655-2664; DOI:10.1158/1078-0432.CCR-16-2630

Clinical Trial Brief Report

Clinical Trial Brief Report

Adverse Metaphase Cytogenetics Can Be Overcome by Adding Bortezomib and Thalidomide to Fractionated Melphalan Transplants

Yogesh S. Jethava, Alan Mitchell, Joshua Epstein, Maurizio Zangari, Shmuel Yaccoby, Erming Tian, Sarah Waheed, Rashid Khan, Xenofon Papanikolaou, Monica Grazziutti, Michele Cottler-Fox, Nathan Petty, Douglas Steward, Susan Panozzo, Clyde Bailey, Antje Hoering, John Crowley, Jeffrey Sawyer, Gareth Morgan, Bart Barlogie and Frits van Rhee

Clin Cancer Res June 1 2017 23 (11) 2665-2672; DOI:10.1158/1078-0432.CCR-15-2620

Cancer Therapy: Clinical

Cancer Therapy: Clinical

Phase I Study of Epigenetic Priming with Azacitidine Prior to Standard Neoadjuvant Chemotherapy for Patients with Resectable Gastric and Esophageal Adenocarcinoma: Evidence of Tumor Hypomethylation as an Indicator of Major Histopathologic Response

Bryan J. Schneider, Manish A. Shah, Kelsey Klute, Allyson Ocean, Elizabeta Popa, Nasser Altorki, Michael Lieberman, Andrew Schreiner, Rhonda Yantiss, Paul J. Christos, Romae Palmer, Daoqi You, Agnes Viale, Pouneh Kermani and Joseph M. Scandura

Clin Cancer Res June 1 2017 23 (11) 2673-2680; DOI:10.1158/1078-0432.CCR-16-1896
Cancer Therapy: Clinical

Circulating Tumor Cells Expressing Markers of Tumor-Initiating Cells Predict Poor Survival and Cancer Recurrence in Patients with Pancreatic Ductal Adenocarcinoma

Katherine E. Poruk, Amanda L. Blackford, Matthew J. Weiss, John L. Cameron, Jin He, Michael Goggins, Zeshaan A. Rasheed, Christopher L. Wolfgang and Laura D. Wood

Clin Cancer Res June 1 2017 23 (11) 2681-2690; DOI:10.1158/1078-0432.CCR-16-1467
Cancer Therapy: Clinical | Free Article

Combination Epigenetic Therapy in Advanced Breast Cancer with 5-Azacitidine and Entinostat: A Phase II National Cancer Institute/Stand Up to Cancer Study

Roisin M. Connolly, Huili Li, Rachel C. Jankowitz, Zhe Zhang, Michelle A. Rudek, Stacie C. Jeter, Shannon A. Slater, Penny Powers, Antonio C. Wolff, John H. Fetting, Adam Brufsky, Richard Piekarz, Nita Ahuja, Peter W. Laird, Hui Shen, Daniel J. Weisenberger, Leslie Cope, James G. Herman, George Somlo, Agustin A. Garcia, Peter A. Jones, Stephen B. Baylin, Nancy E. Davidson, Cynthia A. Zahnow and Vered Stearns

Clin Cancer Res June 1 2017 23 (11) 2691-2701; DOI:10.1158/1078-0432.CCR-16-1729
Cancer Therapy: Clinical | AuthorChoice

The Prognostic Role of Androgen Receptor in Patients with Early-Stage Breast Cancer: A Meta-analysis of Clinical and Gene Expression Data

Ivana Bozovic-Spasojevic, Dimitrios Zardavas, Sylvain Brohée, Lieveke Ameye, Debora Fumagalli, Felipe Ades, Evandro de Azambuja, Yacine Bareche, Martine Piccart, Marianne Paesmans and Christos Sotiriou

Clin Cancer Res June 1 2017 23 (11) 2702-2712; DOI:10.1158/1078-0432.CCR-16-0979

Personalized Medicine and Imaging

Personalized Medicine and Imaging | AuthorChoice

Integrative Analysis Identifies a Novel AXL–PI3 Kinase–PD-L1 Signaling Axis Associated with Radiation Resistance in Head and Neck Cancer

Heath D. Skinner, Uma Giri, Liang P. Yang, Manish Kumar, Ying Liu, Michael D. Story, Curtis R. Pickering, Lauren A. Byers, Michelle D. Williams, Jing Wang, Li Shen, Suk Y. Yoo, You Hong Fan, David P. Molkentine, Beth M. Beadle, Raymond E. Meyn, Jeffrey N. Myers and John V. Heymach

Clin Cancer Res June 1 2017 23 (11) 2713-2722; DOI:10.1158/1078-0432.CCR-16-2586
Personalized Medicine and Imaging

E6 and E7 Antibody Levels Are Potential Biomarkers of Recurrence in Patients with Advanced-Stage Human Papillomavirus–Positive Oropharyngeal Squamous Cell Carcinoma

Matthew E. Spector, Assuntina G. Sacco, Emily Bellile, Jeremy M.G. Taylor, Tamara Jones, Kan Sun, William C. Brown, Andrew C. Birkeland, Carol R. Bradford, Gregory T. Wolf, Mark E. Prince, Jeffrey S. Moyer, Kelly Malloy, Paul Swiecicki, Avraham Eisbruch, Jonathan B. McHugh, Douglas B. Chepeha, Laura Rozek and Francis P. Worden

Clin Cancer Res June 1 2017 23 (11) 2723-2729; DOI:10.1158/1078-0432.CCR-16-1617
Personalized Medicine and Imaging | AuthorChoice

Tumor-Specific Uptake of Fluorescent Bevacizumab–IRDye800CW Microdosing in Patients with Primary Breast Cancer: A Phase I Feasibility Study

Laetitia E. Lamberts, Maximillian Koch, Johannes S. de Jong, Arthur L.L. Adams, Jürgen Glatz, Mariëtte E.G. Kranendonk, Anton G.T. Terwisscha van Scheltinga, Liesbeth Jansen, Jakob de Vries, Marjolijn N. Lub-de Hooge, Carolien P. Schröder, Annelies Jorritsma-Smit, Matthijs D. Linssen, Esther de Boer, Bert van der Vegt, Wouter B. Nagengast, Sjoerd G. Elias, Sabrina Oliveira, Arjen J. Witkamp, Willem P.Th.M. Mali, Elsken Van der Wall, Paul J. van Diest, Elisabeth G.E. de Vries, Vasilis Ntziachristos and Gooitzen M. van Dam

Clin Cancer Res June 1 2017 23 (11) 2730-2741; DOI:10.1158/1078-0432.CCR-16-0437
Personalized Medicine and Imaging

BRAF and NRAS Locus-Specific Variants Have Different Outcomes on Survival to Colorectal Cancer

Matthew G. Summers, Christopher G. Smith, Timothy S. Maughan, Richard Kaplan, Valentina Escott-Price and Jeremy P. Cheadle

Clin Cancer Res June 1 2017 23 (11) 2742-2749; DOI:10.1158/1078-0432.CCR-16-1541
Personalized Medicine and Imaging

A Glycomics-Based Test Predicts the Development of Hepatocellular Carcinoma in Cirrhosis

Xavier Verhelst, Dieter Vanderschaeghe, Laurent Castéra, Tom Raes, Anja Geerts, Claire Francoz, Roos Colman, François Durand, Nico Callewaert and Hans Van Vlierberghe

Clin Cancer Res June 1 2017 23 (11) 2750-2758; DOI:10.1158/1078-0432.CCR-16-1500
Personalized Medicine and Imaging

Bone Marrow Cell Trafficking Analyzed by ⁸⁹Zr-oxine Positron Emission Tomography in a Murine Transplantation Model

Kingsley O. Asiedu, Sho Koyasu, Lawrence P. Szajek, Peter L. Choyke and Noriko Sato

Clin Cancer Res June 1 2017 23 (11) 2759-2768; DOI:10.1158/1078-0432.CCR-16-1561

Cancer Therapy: Preclinical

Cancer Therapy: Preclinical

ADNP Is a Therapeutically Inducible Repressor of WNT Signaling in Colorectal Cancer

Cristina Blaj, Agnes Bringmann, Eva Marina Schmidt, Manuela Urbischek, Sebastian Lamprecht, Thomas Fröhlich, Georg J. Arnold, Stefan Krebs, Helmut Blum, Heiko Hermeking, Andreas Jung, Thomas Kirchner and David Horst

Clin Cancer Res June 1 2017 23 (11) 2769-2780; DOI:10.1158/1078-0432.CCR-16-1604
Cancer Therapy: Preclinical

AMPK–ULK1-Mediated Autophagy Confers Resistance to BET Inhibitor JQ1 in Acute Myeloid Leukemia Stem Cells

Ji Eun Jang, Ju-In Eom, Hoi-Kyung Jeung, June-Won Cheong, Jung Yeon Lee, Jin Seok Kim and Yoo Hong Min

Clin Cancer Res June 1 2017 23 (11) 2781-2794; DOI:10.1158/1078-0432.CCR-16-1903
Cancer Therapy: Preclinical

Combined Inhibition of Both p110α and p110β Isoforms of Phosphatidylinositol 3-Kinase Is Required for Sustained Therapeutic Effect in PTEN-Deficient, ER⁺ Breast Cancer

Sarah R. Hosford, Lloye M. Dillon, Stephanie J. Bouley, Rachele Rosati, Wei Yang, Vivian S. Chen, Eugene Demidenko, Rocco P. Morra Jr and Todd W. Miller

Clin Cancer Res June 1 2017 23 (11) 2795-2805; DOI:10.1158/1078-0432.CCR-15-2764
Cancer Therapy: Preclinical

Therapeutic Activity of Anti-AXL Antibody against Triple-Negative Breast Cancer Patient-Derived Xenografts and Metastasis

Wilhem Leconet, Myriam Chentouf, Stanislas du Manoir, Clément Chevalier, Audrey Sirvent, Imade Aït-Arsa, Muriel Busson, Marta Jarlier, Nina Radosevic-Robin, Charles Theillet, Dany Chalbos, Jean-Max Pasquet, André Pèlegrin, Christel Larbouret and Bruno Robert

Clin Cancer Res June 1 2017 23 (11) 2806-2816; DOI:10.1158/1078-0432.CCR-16-1316
Cancer Therapy: Preclinical | AuthorChoice

Heterodimeric IL15 Treatment Enhances Tumor Infiltration, Persistence, and Effector Functions of Adoptively Transferred Tumor-specific T Cells in the Absence of Lymphodepletion

Sinnie Sin Man Ng, Bethany A. Nagy, Shawn M. Jensen, Xintao Hu, Candido Alicea, Bernard A. Fox, Barbara K. Felber, Cristina Bergamaschi and George N. Pavlakis

Clin Cancer Res June 1 2017 23 (11) 2817-2830; DOI:10.1158/1078-0432.CCR-16-1808
Cancer Therapy: Preclinical

The Bruton Tyrosine Kinase (BTK) Inhibitor Acalabrutinib Demonstrates Potent On-Target Effects and Efficacy in Two Mouse Models of Chronic Lymphocytic Leukemia

Sarah E.M. Herman, Arnau Montraveta, Carsten U. Niemann, Helena Mora-Jensen, Michael Gulrajani, Fanny Krantz, Rose Mantel, Lisa L. Smith, Fabienne McClanahan, Bonnie K. Harrington, Dolors Colomer, Todd Covey, John C. Byrd, Raquel Izumi, Allard Kaptein, Roger Ulrich, Amy J. Johnson, Brian J. Lannutti, Adrian Wiestner and Jennifer A. Woyach

Clin Cancer Res June 1 2017 23 (11) 2831-2841; DOI:10.1158/1078-0432.CCR-16-0463
Cancer Therapy: Preclinical

Gas6/AXL Signaling Regulates Self-Renewal of Chronic Myelogenous Leukemia Stem Cells by Stabilizing β-Catenin

Yanli Jin, Danian Nie, Juan Li, Xin Du, Yuhong Lu, Yangqiu Li, Chang Liu, Jingfeng Zhou and Jingxuan Pan

Clin Cancer Res June 1 2017 23 (11) 2842-2855; DOI:10.1158/1078-0432.CCR-16-1298
Cancer Therapy: Preclinical

Dual ALK and CDK4/6 Inhibition Demonstrates Synergy against Neuroblastoma

Andrew C. Wood, Kateryna Krytska, Hannah T. Ryles, Nicole R. Infarinato, Renata Sano, Theodore D. Hansel, Lori S. Hart, Frederick J. King, Timothy R. Smith, Edward Ainscow, Kathryn B. Grandinetti, Tove Tuntland, Sunkyu Kim, Giordano Caponigro, You Qun He, Shiva Krupa, Nanxin Li, Jennifer L. Harris and Yaël P. Mossé

Clin Cancer Res June 1 2017 23 (11) 2856-2868; DOI:10.1158/1078-0432.CCR-16-1114
Cancer Therapy: Preclinical

Disruption of Autophagic Degradation with ROC-325 Antagonizes Renal Cell Carcinoma Pathogenesis

Jennifer S. Carew, Claudia M. Espitia, William Zhao, Yingchun Han, Valeria Visconte, James Phillips and Steffan T. Nawrocki

Clin Cancer Res June 1 2017 23 (11) 2869-2879; DOI:10.1158/1078-0432.CCR-16-1742
Cancer Therapy: Preclinical | AuthorChoice

Drug-Repositioning Screens Identify Triamterene as a Selective Drug for the Treatment of DNA Mismatch Repair Deficient Cells

Delphine Guillotin, Philip Austin, Rumena Begum, Marta O. Freitas, Ashirwad Merve, Tim Brend, Susan Short, Silvia Marino and Sarah A. Martin

Clin Cancer Res June 1 2017 23 (11) 2880-2890; DOI:10.1158/1078-0432.CCR-16-1216

Biology of Human Tumors

Biology of Human Tumors

Combining Anti-Mir-155 with Chemotherapy for the Treatment of Lung Cancers

Katrien Van Roosbroeck, Francesca Fanini, Tetsuro Setoyama, Cristina Ivan, Cristian Rodriguez-Aguayo, Enrique Fuentes-Mattei, Lianchun Xiao, Ivan Vannini, Roxana S. Redis, Lucilla D'Abundo, Xinna Zhang, Milena S. Nicoloso, Simona Rossi, Vianey Gonzalez-Villasana, Rajesha Rupaimoole, Manuela Ferracin, Fortunato Morabito, Antonino Neri, Peter P. Ruvolo, Vivian R. Ruvolo, Chad V. Pecot, Dino Amadori, Lynne Abruzzo, Steliana Calin, Xuemei Wang, M. James You, Alessandra Ferrajoli, Robert Orlowski, William Plunkett, Tara M. Lichtenberg, Ramana V. Davuluri, Ioana Berindan-Neagoe, Massimo Negrini, Ignacio I. Wistuba, Hagop M. Kantarjian, Anil K. Sood, Gabriel Lopez-Berestein, Michael J. Keating, Muller Fabbri and George A. Calin

Clin Cancer Res June 1 2017 23 (11) 2891-2904; DOI:10.1158/1078-0432.CCR-16-1025
Biology of Human Tumors | AuthorChoice

microRNA-221 Enhances MYCN via Targeting Nemo-like Kinase and Functions as an Oncogene Related to Poor Prognosis in Neuroblastoma

Xiao-yan He, Zheng-lan Tan, Qin Mou, Fang-jie Liu, Shan Liu, Chao-wen Yu, Jin Zhu, Lin-ya Lv, Jun Zhang, Shan Wang, Li-ming Bao, Bin Peng, Hui Zhao and Lin Zou

Clin Cancer Res June 1 2017 23 (11) 2905-2918; DOI:10.1158/1078-0432.CCR-16-1591

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Table of Contents

CCR Pediatric Oncology Series: Articles from the AACR Childhood Cancer Predisposition Workshop

Highlights of This Issue

CCR Focus

Clinical Trial Brief Report

Cancer Therapy: Clinical

Personalized Medicine and Imaging

Cancer Therapy: Preclinical

Biology of Human Tumors

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