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Mutational Signatures in Breast Cancer: The Problem at the DNA Level

Serena Nik-Zainal and Sandro Morganella
Serena Nik-Zainal
1Wellcome Trust Sanger Institute, Hinxton Genome Campus, Cambridge, United Kingdom.
2East Anglian Medical Genetics Service, Cambridge University Hospitals NHS Foundation Trust, Cambridge, United Kingdom.
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  • For correspondence: snz@sanger.ac.uk
Sandro Morganella
1Wellcome Trust Sanger Institute, Hinxton Genome Campus, Cambridge, United Kingdom.
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DOI: 10.1158/1078-0432.CCR-16-2810 Published June 2017
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Article Information

Volume 23, Issue 11, pp. 2617-2629

DOI 
https://doi.org/10.1158/1078-0432.CCR-16-2810
PubMed 
28572256

Published By 
American Association for Cancer Research
Print ISSN 
1078-0432
Online ISSN 
1557-3265
History 
  • Received January 18, 2017
  • Revision received February 27, 2017
  • Accepted April 7, 2017
  • Published first May 31, 2017.

Copyright & Usage 
©2017 American Association for Cancer Research.

Author Information

  1. Serena Nik-Zainal1,2,* and
  2. Sandro Morganella1
  1. 1Wellcome Trust Sanger Institute, Hinxton Genome Campus, Cambridge, United Kingdom.
  2. 2East Anglian Medical Genetics Service, Cambridge University Hospitals NHS Foundation Trust, Cambridge, United Kingdom.
  1. ↵*Corresponding Author:
    Serena Nik-Zainal, Wellcome Trust Sanger Institute, Wellcome Genome Campus, Hinxton, Cambridge CB10 1SA, United Kingdom. Phone: 0044-1223-834244; E-mail: snz{at}sanger.ac.uk
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Clinical Cancer Research: 23 (11)
June 2017
Volume 23, Issue 11
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Mutational Signatures in Breast Cancer: The Problem at the DNA Level
Serena Nik-Zainal and Sandro Morganella
Clin Cancer Res June 1 2017 (23) (11) 2617-2629; DOI: 10.1158/1078-0432.CCR-16-2810

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Mutational Signatures in Breast Cancer: The Problem at the DNA Level
Serena Nik-Zainal and Sandro Morganella
Clin Cancer Res June 1 2017 (23) (11) 2617-2629; DOI: 10.1158/1078-0432.CCR-16-2810
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  • Article
    • Abstract
    • Introduction: Breast Cancer Genomics—Access All Areas
    • Mutational Signatures: Making Sense of the Mayhem
    • Base Substitution Mutational Signatures in Breast Cancer
    • Advancing the Frameworks of Mutational Signatures
    • Localized Mutational Signatures
    • Dynamic Cellular Processes and Mutational Signatures
    • In the Midst of Chaos, Lies Opportunity
    • Critical Dissection of the Mutational Signatures Concept
    • Future Directions
    • Disclosure of Potential Conflicts of Interest
    • Grant Support
    • Acknowledgments
    • Footnotes
    • References
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Clinical Cancer Research
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