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Cancer Therapy: Clinical

A Phase I–II Study of the Oral PARP Inhibitor Rucaparib in Patients with Germline BRCA1/2-Mutated Ovarian Carcinoma or Other Solid Tumors

Rebecca Kristeleit, Geoffrey I. Shapiro, Howard A. Burris, Amit M. Oza, Patricia LoRusso, Manish R. Patel, Susan M. Domchek, Judith Balmaña, Yvette Drew, Lee-may Chen, Tamar Safra, Ana Montes, Heidi Giordano, Lara Maloney, Sandra Goble, Jeff Isaacson, Jim Xiao, Jen Borrow, Lindsey Rolfe and Ronnie Shapira-Frommer
Rebecca Kristeleit
1Research Department of Oncology, UCL Cancer Institute, London, United Kingdom.
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  • For correspondence: r.kristeleit@ucl.ac.uk
Geoffrey I. Shapiro
2Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, Massachusetts.
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Howard A. Burris
3Department of Medical Oncology, Sarah Cannon Research Institute, Tennessee Oncology, PLLC, Nashville, Tennessee.
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Amit M. Oza
4Department of Obstetrics and Gynecology, Princess Margaret Cancer Centre, University Health Network, Toronto, Ontario, Canada.
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Patricia LoRusso
5Department of Medical Oncology, Yale University, New Haven, Connecticut.
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Manish R. Patel
6Department of Medical Oncology, Sarah Cannon Research Institute/Florida Cancer Specialists, Sarasota, Florida.
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Susan M. Domchek
7Department of Medical Oncology, Basser Center for BRCA, University of Pennsylvania, Philadelphia, Pennsylvania.
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Judith Balmaña
8Department of Medical Oncology, Vall d'Hebron University Hospital and Vall d'Hebron Institute of Oncology, Barcelona, Spain.
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Yvette Drew
9Department of Medical Oncology, Northern Centre for Cancer Care, Newcastle upon Tyne, United Kingdom.
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Lee-may Chen
10Department of Obstetrics, Gynecology, and Reproductive Sciences, Helen Diller Family Comprehensive Cancer Center, University of California, San Francisco, San Francisco, California.
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Tamar Safra
11Department of Oncology, Tel Aviv Sourasky Medical Center, Tel Aviv, Israel.
12Sackler School of Medicine, Tel Aviv University, Tel Aviv, Israel.
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Ana Montes
13Department of Medical Oncology, Guy's Hospital, London, United Kingdom.
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Heidi Giordano
14Clinical Science, Clovis Oncology, Inc., Boulder, Colorado.
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Lara Maloney
14Clinical Science, Clovis Oncology, Inc., Boulder, Colorado.
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Sandra Goble
15Biostatistics, Clovis Oncology, Inc., Boulder, Colorado.
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Jeff Isaacson
16Statistics and Data Management, Clovis Oncology, Inc., Boulder, Colorado.
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Jim Xiao
17Clinical Pharmacology and Nonclinical DMPK, Clovis Oncology, Inc., Boulder, Colorado.
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Jen Borrow
18Clinical Development, Clovis Oncology, Inc., Boulder, Colorado.
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Lindsey Rolfe
19Clinical and Preclinical Development, Clovis Oncology, Inc., Boulder, Colorado.
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Ronnie Shapira-Frommer
20Department of Oncology, Sheba Medical Center, Ramat Gan, Israel.
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DOI: 10.1158/1078-0432.CCR-16-2796 Published August 2017
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Article Information

Volume 23, Issue 15, pp. 4095-4106

DOI 
https://doi.org/10.1158/1078-0432.CCR-16-2796
PubMed 
28264872

Published By 
American Association for Cancer Research
Print ISSN 
1078-0432
Online ISSN 
1557-3265
History 
  • Received November 9, 2016
  • Revision received December 5, 2016
  • Accepted February 28, 2017
  • Published first March 6, 2017.

Article Versions

  • Previous version (March 6, 2017 - 10:03).
  • Previous version (May 17, 2017 - 07:40).
  • You are viewing the most recent version of this article.
Copyright & Usage 
©2017 American Association for Cancer Research.

Author Information

  1. Rebecca Kristeleit1,*,
  2. Geoffrey I. Shapiro2,
  3. Howard A. Burris3,
  4. Amit M. Oza4,
  5. Patricia LoRusso5,
  6. Manish R. Patel6,
  7. Susan M. Domchek7,
  8. Judith Balmaña8,
  9. Yvette Drew9,
  10. Lee-may Chen10,
  11. Tamar Safra11,12,
  12. Ana Montes13,
  13. Heidi Giordano14,
  14. Lara Maloney14,
  15. Sandra Goble15,
  16. Jeff Isaacson16,
  17. Jim Xiao17,
  18. Jen Borrow18,
  19. Lindsey Rolfe19, and
  20. Ronnie Shapira-Frommer20
  1. 1Research Department of Oncology, UCL Cancer Institute, London, United Kingdom.
  2. 2Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, Massachusetts.
  3. 3Department of Medical Oncology, Sarah Cannon Research Institute, Tennessee Oncology, PLLC, Nashville, Tennessee.
  4. 4Department of Obstetrics and Gynecology, Princess Margaret Cancer Centre, University Health Network, Toronto, Ontario, Canada.
  5. 5Department of Medical Oncology, Yale University, New Haven, Connecticut.
  6. 6Department of Medical Oncology, Sarah Cannon Research Institute/Florida Cancer Specialists, Sarasota, Florida.
  7. 7Department of Medical Oncology, Basser Center for BRCA, University of Pennsylvania, Philadelphia, Pennsylvania.
  8. 8Department of Medical Oncology, Vall d'Hebron University Hospital and Vall d'Hebron Institute of Oncology, Barcelona, Spain.
  9. 9Department of Medical Oncology, Northern Centre for Cancer Care, Newcastle upon Tyne, United Kingdom.
  10. 10Department of Obstetrics, Gynecology, and Reproductive Sciences, Helen Diller Family Comprehensive Cancer Center, University of California, San Francisco, San Francisco, California.
  11. 11Department of Oncology, Tel Aviv Sourasky Medical Center, Tel Aviv, Israel.
  12. 12Sackler School of Medicine, Tel Aviv University, Tel Aviv, Israel.
  13. 13Department of Medical Oncology, Guy's Hospital, London, United Kingdom.
  14. 14Clinical Science, Clovis Oncology, Inc., Boulder, Colorado.
  15. 15Biostatistics, Clovis Oncology, Inc., Boulder, Colorado.
  16. 16Statistics and Data Management, Clovis Oncology, Inc., Boulder, Colorado.
  17. 17Clinical Pharmacology and Nonclinical DMPK, Clovis Oncology, Inc., Boulder, Colorado.
  18. 18Clinical Development, Clovis Oncology, Inc., Boulder, Colorado.
  19. 19Clinical and Preclinical Development, Clovis Oncology, Inc., Boulder, Colorado.
  20. 20Department of Oncology, Sheba Medical Center, Ramat Gan, Israel.
  1. ↵*Corresponding Author:
    Rebecca Kristeleit, UCL Cancer Institute, 72 Huntley Street, London WC1E 6BT, United Kingdom. Phone: 4420-7679-0744; Fax: 4420-3447-9055; E-mail: r.kristeleit{at}ucl.ac.uk
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Clinical Cancer Research: 23 (15)
August 2017
Volume 23, Issue 15
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A Phase I–II Study of the Oral PARP Inhibitor Rucaparib in Patients with Germline BRCA1/2-Mutated Ovarian Carcinoma or Other Solid Tumors
Rebecca Kristeleit, Geoffrey I. Shapiro, Howard A. Burris, Amit M. Oza, Patricia LoRusso, Manish R. Patel, Susan M. Domchek, Judith Balmaña, Yvette Drew, Lee-may Chen, Tamar Safra, Ana Montes, Heidi Giordano, Lara Maloney, Sandra Goble, Jeff Isaacson, Jim Xiao, Jen Borrow, Lindsey Rolfe and Ronnie Shapira-Frommer
Clin Cancer Res August 1 2017 (23) (15) 4095-4106; DOI: 10.1158/1078-0432.CCR-16-2796

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A Phase I–II Study of the Oral PARP Inhibitor Rucaparib in Patients with Germline BRCA1/2-Mutated Ovarian Carcinoma or Other Solid Tumors
Rebecca Kristeleit, Geoffrey I. Shapiro, Howard A. Burris, Amit M. Oza, Patricia LoRusso, Manish R. Patel, Susan M. Domchek, Judith Balmaña, Yvette Drew, Lee-may Chen, Tamar Safra, Ana Montes, Heidi Giordano, Lara Maloney, Sandra Goble, Jeff Isaacson, Jim Xiao, Jen Borrow, Lindsey Rolfe and Ronnie Shapira-Frommer
Clin Cancer Res August 1 2017 (23) (15) 4095-4106; DOI: 10.1158/1078-0432.CCR-16-2796
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