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Personalized Medicine and Imaging

Analytic, Preanalytic, and Clinical Validation of p53 IHC for Detection of TP53 Missense Mutation in Prostate Cancer

Liana B. Guedes, Fawaz Almutairi, Michael C. Haffner, Gaurav Rajoria, Zach Liu, Szczepan Klimek, Roberto Zoino, Kasra Yousefi, Rajni Sharma, Angelo M. De Marzo, George J. Netto, William B. Isaacs, Ashley E. Ross, Edward M. Schaeffer and Tamara L. Lotan
Liana B. Guedes
1Department of Pathology, Johns Hopkins University School of Medicine, Baltimore, Maryland.
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Fawaz Almutairi
1Department of Pathology, Johns Hopkins University School of Medicine, Baltimore, Maryland.
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Michael C. Haffner
1Department of Pathology, Johns Hopkins University School of Medicine, Baltimore, Maryland.
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Gaurav Rajoria
2Pathline Emerge Pathology Services, Ramsey, New Jersey.
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Zach Liu
2Pathline Emerge Pathology Services, Ramsey, New Jersey.
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Szczepan Klimek
2Pathline Emerge Pathology Services, Ramsey, New Jersey.
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Roberto Zoino
2Pathline Emerge Pathology Services, Ramsey, New Jersey.
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Kasra Yousefi
3GenomeDx Biosciences, Vancouver, British Columbia.
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Rajni Sharma
1Department of Pathology, Johns Hopkins University School of Medicine, Baltimore, Maryland.
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Angelo M. De Marzo
1Department of Pathology, Johns Hopkins University School of Medicine, Baltimore, Maryland.
4Department of Urology, Johns Hopkins University School of Medicine, Baltimore, Maryland.
5Department of Oncology, Johns Hopkins University School of Medicine, Baltimore, Maryland.
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George J. Netto
1Department of Pathology, Johns Hopkins University School of Medicine, Baltimore, Maryland.
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William B. Isaacs
4Department of Urology, Johns Hopkins University School of Medicine, Baltimore, Maryland.
5Department of Oncology, Johns Hopkins University School of Medicine, Baltimore, Maryland.
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Ashley E. Ross
4Department of Urology, Johns Hopkins University School of Medicine, Baltimore, Maryland.
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Edward M. Schaeffer
4Department of Urology, Johns Hopkins University School of Medicine, Baltimore, Maryland.
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Tamara L. Lotan
1Department of Pathology, Johns Hopkins University School of Medicine, Baltimore, Maryland.
5Department of Oncology, Johns Hopkins University School of Medicine, Baltimore, Maryland.
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  • For correspondence: tlotan1@jhmi.edu
DOI: 10.1158/1078-0432.CCR-17-0257 Published August 2017
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Article Information

Volume 23, Issue 16, pp. 4693-4703

DOI 
https://doi.org/10.1158/1078-0432.CCR-17-0257
PubMed 
28446506

Published By 
American Association for Cancer Research
Print ISSN 
1078-0432
Online ISSN 
1557-3265
History 
  • Received January 31, 2017
  • Revision received March 14, 2017
  • Accepted April 21, 2017
  • Published first April 26, 2017.

Article Versions

  • Previous version (April 26, 2017 - 09:51).
  • Previous version (June 27, 2017 - 06:46).
  • You are viewing the most recent version of this article.
Copyright & Usage 
©2017 American Association for Cancer Research.

Author Information

  1. Liana B. Guedes1,
  2. Fawaz Almutairi1,
  3. Michael C. Haffner1,
  4. Gaurav Rajoria2,
  5. Zach Liu2,
  6. Szczepan Klimek2,
  7. Roberto Zoino2,
  8. Kasra Yousefi3,
  9. Rajni Sharma1,
  10. Angelo M. De Marzo1,4,5,
  11. George J. Netto1,
  12. William B. Isaacs4,5,
  13. Ashley E. Ross4,
  14. Edward M. Schaeffer4, and
  15. Tamara L. Lotan1,5,*
  1. 1Department of Pathology, Johns Hopkins University School of Medicine, Baltimore, Maryland.
  2. 2Pathline Emerge Pathology Services, Ramsey, New Jersey.
  3. 3GenomeDx Biosciences, Vancouver, British Columbia.
  4. 4Department of Urology, Johns Hopkins University School of Medicine, Baltimore, Maryland.
  5. 5Department of Oncology, Johns Hopkins University School of Medicine, Baltimore, Maryland.
  1. ↵*Corresponding Author:
    Tamara L. Lotan, Johns Hopkins University School of Medicine, CRB II Rm 343, 1550 Orleans Street, Baltimore, MD 21231. Phone: 410-614-9196; Fax: 410-614-0671; E-mail: tlotan1{at}jhmi.edu
  • Current address for G.J. Netto: Department of Pathology, University of Alabama Medicine, Birmingham, Alabama.

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Clinical Cancer Research: 23 (16)
August 2017
Volume 23, Issue 16
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Analytic, Preanalytic, and Clinical Validation of p53 IHC for Detection of TP53 Missense Mutation in Prostate Cancer
Liana B. Guedes, Fawaz Almutairi, Michael C. Haffner, Gaurav Rajoria, Zach Liu, Szczepan Klimek, Roberto Zoino, Kasra Yousefi, Rajni Sharma, Angelo M. De Marzo, George J. Netto, William B. Isaacs, Ashley E. Ross, Edward M. Schaeffer and Tamara L. Lotan
Clin Cancer Res August 15 2017 (23) (16) 4693-4703; DOI: 10.1158/1078-0432.CCR-17-0257

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Analytic, Preanalytic, and Clinical Validation of p53 IHC for Detection of TP53 Missense Mutation in Prostate Cancer
Liana B. Guedes, Fawaz Almutairi, Michael C. Haffner, Gaurav Rajoria, Zach Liu, Szczepan Klimek, Roberto Zoino, Kasra Yousefi, Rajni Sharma, Angelo M. De Marzo, George J. Netto, William B. Isaacs, Ashley E. Ross, Edward M. Schaeffer and Tamara L. Lotan
Clin Cancer Res August 15 2017 (23) (16) 4693-4703; DOI: 10.1158/1078-0432.CCR-17-0257
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