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Oxidative Phosphorylation as an Emerging Target in Cancer Therapy

Thomas M. Ashton, W. Gillies McKenna, Leoni A. Kunz-Schughart and Geoff S. Higgins
Thomas M. Ashton
1CRUK/MRC Oxford Institute for Radiation Oncology, Gray Laboratories, Oxford, United Kingdom.
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W. Gillies McKenna
1CRUK/MRC Oxford Institute for Radiation Oncology, Gray Laboratories, Oxford, United Kingdom.
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Leoni A. Kunz-Schughart
1CRUK/MRC Oxford Institute for Radiation Oncology, Gray Laboratories, Oxford, United Kingdom.
2OncoRay, National Center for Radiation Research in Oncology, Faculty of Medicine and University Hospital Carl Gustav Carus, TU Dresden, and Helmholtz-Zentrum Dresden-Rossendorf, Germany.
3National Center for Tumor Diseases (NCT), partner site Dresden, Germany.
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  • For correspondence: geoffrey.higgins@oncology.ox.ac.uk leoni.kunz-schughart@oncoray.de
Geoff S. Higgins
1CRUK/MRC Oxford Institute for Radiation Oncology, Gray Laboratories, Oxford, United Kingdom.
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  • For correspondence: geoffrey.higgins@oncology.ox.ac.uk leoni.kunz-schughart@oncoray.de
DOI: 10.1158/1078-0432.CCR-17-3070 Published June 2018
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Article Information

Volume 24, Issue 11, pp. 2482-2490

DOI 
https://doi.org/10.1158/1078-0432.CCR-17-3070
PubMed 
29420223

Published By 
American Association for Cancer Research
Print ISSN 
1078-0432
Online ISSN 
1557-3265
History 
  • Received October 17, 2017
  • Revision received January 7, 2018
  • Accepted January 30, 2018
  • Published first February 2, 2018.

Article Versions

  • Previous version (February 2, 2018 - 07:03).
  • Previous version (April 26, 2018 - 09:37).
  • You are viewing the most recent version of this article.
Copyright & Usage 
©2018 American Association for Cancer Research.

Author Information

  1. Thomas M. Ashton1,
  2. W. Gillies McKenna1,
  3. Leoni A. Kunz-Schughart1,2,3,*, and
  4. Geoff S. Higgins1,*
  1. 1CRUK/MRC Oxford Institute for Radiation Oncology, Gray Laboratories, Oxford, United Kingdom.
  2. 2OncoRay, National Center for Radiation Research in Oncology, Faculty of Medicine and University Hospital Carl Gustav Carus, TU Dresden, and Helmholtz-Zentrum Dresden-Rossendorf, Germany.
  3. 3National Center for Tumor Diseases (NCT), partner site Dresden, Germany.
  1. ↵*Corresponding Authors:
    Geoff S. Higgins, CRUK/MRC Oxford Institute for Radiation Oncology, Old Road Campus Research Building, Roosevelt Drive, Oxford OX3 7DQ, UK. Phone: 44-186-561-7355; Fax: 44-018-6561-7318; E-mail: geoffrey.higgins{at}oncology.ox.ac.uk; and Leoni A. Kunz-Schughart, OncoRay, National Center for Radiation Research in Oncology, Faculty of Medicine and University Hospital Carl Gustav Carus, TU Dresden, and Helmholtz-Zentrum Dresden-Rossendorf, Institute of Radiooncology, Dresden, Germany. Phone: 49-351-458-7405; E-mail: leoni.kunz-schughart{at}oncoray.de
  1. Note: L.A. Kunz-Schughart and G.S. Higgins contributed equally to this article.

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Clinical Cancer Research: 24 (11)
June 2018
Volume 24, Issue 11
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Oxidative Phosphorylation as an Emerging Target in Cancer Therapy
Thomas M. Ashton, W. Gillies McKenna, Leoni A. Kunz-Schughart and Geoff S. Higgins
Clin Cancer Res June 1 2018 (24) (11) 2482-2490; DOI: 10.1158/1078-0432.CCR-17-3070

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Oxidative Phosphorylation as an Emerging Target in Cancer Therapy
Thomas M. Ashton, W. Gillies McKenna, Leoni A. Kunz-Schughart and Geoff S. Higgins
Clin Cancer Res June 1 2018 (24) (11) 2482-2490; DOI: 10.1158/1078-0432.CCR-17-3070
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    • Abstract
    • Introduction
    • OXPHOS as an Anticancer Target
    • OCR Inhibition to Alleviate Tumor Hypoxia
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