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Cancer Therapy: Preclinical

Capecitabine Efficacy Is Correlated with TYMP and RB1 Expression in PDX Established from Triple-Negative Breast Cancers

Elisabetta Marangoni, Cécile Laurent, Florence Coussy, Rania El-Botty, Sophie Château-Joubert, Jean-Luc Servely, Ludmilla de Plater, Franck Assayag, Ahmed Dahmani, Elodie Montaudon, Fariba Nemati, Justine Fleury, Sophie Vacher, David Gentien, Audrey Rapinat, Pierre Foidart, Nor Eddine Sounni, Agnès Noel, Anne Vincent-Salomon, Marick Lae, Didier Decaudin, Sergio Roman-Roman, Ivan Bièche, Martine Piccart and Fabien Reyal
Elisabetta Marangoni
1Translational Research Department, Institut Curie, PSL Research University, Paris, France.
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  • For correspondence: elisabetta.marangoni@curie.fr
Cécile Laurent
1Translational Research Department, Institut Curie, PSL Research University, Paris, France.
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Florence Coussy
1Translational Research Department, Institut Curie, PSL Research University, Paris, France.
2Medical Oncology Department, Institut Curie, PSL Research University, Paris, France.
3Genetics Department, Institut Curie, PSL Research University, Paris, France.
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Rania El-Botty
1Translational Research Department, Institut Curie, PSL Research University, Paris, France.
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Sophie Château-Joubert
4BioPôle Alfort, Ecole Nationale Vétérinaire d'Alfort, Maisons Alfort, France.
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Jean-Luc Servely
4BioPôle Alfort, Ecole Nationale Vétérinaire d'Alfort, Maisons Alfort, France.
5INRA, PHASE Department, Paris, France.
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Ludmilla de Plater
1Translational Research Department, Institut Curie, PSL Research University, Paris, France.
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  • ORCID record for Ludmilla de Plater
Franck Assayag
1Translational Research Department, Institut Curie, PSL Research University, Paris, France.
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Ahmed Dahmani
1Translational Research Department, Institut Curie, PSL Research University, Paris, France.
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Elodie Montaudon
1Translational Research Department, Institut Curie, PSL Research University, Paris, France.
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Fariba Nemati
1Translational Research Department, Institut Curie, PSL Research University, Paris, France.
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Justine Fleury
1Translational Research Department, Institut Curie, PSL Research University, Paris, France.
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Sophie Vacher
3Genetics Department, Institut Curie, PSL Research University, Paris, France.
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David Gentien
1Translational Research Department, Institut Curie, PSL Research University, Paris, France.
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  • ORCID record for David Gentien
Audrey Rapinat
1Translational Research Department, Institut Curie, PSL Research University, Paris, France.
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Pierre Foidart
6Laboratory of Tumor and Developmental Biology, Groupe Interdisciplinaire de Génoprotéomique Appliqué-Cancer (GIGA-Cancer), University of Liège, Liège, Belgium.
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Nor Eddine Sounni
6Laboratory of Tumor and Developmental Biology, Groupe Interdisciplinaire de Génoprotéomique Appliqué-Cancer (GIGA-Cancer), University of Liège, Liège, Belgium.
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Agnès Noel
6Laboratory of Tumor and Developmental Biology, Groupe Interdisciplinaire de Génoprotéomique Appliqué-Cancer (GIGA-Cancer), University of Liège, Liège, Belgium.
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Anne Vincent-Salomon
7Department of Pathology, Institut Curie, PSL Research University, Paris, France.
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Marick Lae
7Department of Pathology, Institut Curie, PSL Research University, Paris, France.
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Didier Decaudin
1Translational Research Department, Institut Curie, PSL Research University, Paris, France.
2Medical Oncology Department, Institut Curie, PSL Research University, Paris, France.
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Sergio Roman-Roman
1Translational Research Department, Institut Curie, PSL Research University, Paris, France.
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Ivan Bièche
3Genetics Department, Institut Curie, PSL Research University, Paris, France.
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Martine Piccart
8Department of Medical Oncology, Institut Jules Bordet, Université Libre de Bruxelles, Brussels, Belgium.
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Fabien Reyal
1Translational Research Department, Institut Curie, PSL Research University, Paris, France.
9Surgery Department, Institut Curie, PSL Research University, Paris, France.
10Translational Research Department, INSERM, U932, Immunity and Cancer, Institut Curie, PSL Research University, 26, rue d'Ulm, Paris, France.
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DOI: 10.1158/1078-0432.CCR-17-3490 Published June 2018
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Article Information

Volume 24, Issue 11, pp. 2605-2615

DOI 
https://doi.org/10.1158/1078-0432.CCR-17-3490
PubMed 
29463559

Published By 
American Association for Cancer Research
Print ISSN 
1078-0432
Online ISSN 
1557-3265
History 
  • Received November 21, 2017
  • Revision received January 25, 2018
  • Accepted February 14, 2018
  • Published first February 20, 2018.

Article Versions

  • Previous version (February 20, 2018 - 06:46).
  • Previous version (April 24, 2018 - 09:11).
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Copyright & Usage 
©2018 American Association for Cancer Research.

Author Information

  1. Elisabetta Marangoni1,*,
  2. Cécile Laurent1,
  3. Florence Coussy1,2,3,
  4. Rania El-Botty1,
  5. Sophie Château-Joubert4,
  6. Jean-Luc Servely4,5,
  7. Ludmilla de Plater1,
  8. Franck Assayag1,
  9. Ahmed Dahmani1,
  10. Elodie Montaudon1,
  11. Fariba Nemati1,
  12. Justine Fleury1,
  13. Sophie Vacher3,
  14. David Gentien1,
  15. Audrey Rapinat1,
  16. Pierre Foidart6,
  17. Nor Eddine Sounni6,
  18. Agnès Noel6,
  19. Anne Vincent-Salomon7,
  20. Marick Lae7,
  21. Didier Decaudin1,2,
  22. Sergio Roman-Roman1,
  23. Ivan Bièche3,
  24. Martine Piccart8, and
  25. Fabien Reyal1,9,10
  1. 1Translational Research Department, Institut Curie, PSL Research University, Paris, France.
  2. 2Medical Oncology Department, Institut Curie, PSL Research University, Paris, France.
  3. 3Genetics Department, Institut Curie, PSL Research University, Paris, France.
  4. 4BioPôle Alfort, Ecole Nationale Vétérinaire d'Alfort, Maisons Alfort, France.
  5. 5INRA, PHASE Department, Paris, France.
  6. 6Laboratory of Tumor and Developmental Biology, Groupe Interdisciplinaire de Génoprotéomique Appliqué-Cancer (GIGA-Cancer), University of Liège, Liège, Belgium.
  7. 7Department of Pathology, Institut Curie, PSL Research University, Paris, France.
  8. 8Department of Medical Oncology, Institut Jules Bordet, Université Libre de Bruxelles, Brussels, Belgium.
  9. 9Surgery Department, Institut Curie, PSL Research University, Paris, France.
  10. 10Translational Research Department, INSERM, U932, Immunity and Cancer, Institut Curie, PSL Research University, 26, rue d'Ulm, Paris, France.
  1. ↵*Corresponding Author:
    Elisabetta Marangoni, Translational Research Department, Institut Curie, 26 rue d'Ulm, Paris 75005, France. Phone: 33-1-56-24-62-42; Fax: 33-1-56-24-63; E-mail: elisabetta.marangoni{at}curie.fr
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Clinical Cancer Research: 24 (11)
June 2018
Volume 24, Issue 11
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Capecitabine Efficacy Is Correlated with TYMP and RB1 Expression in PDX Established from Triple-Negative Breast Cancers
Elisabetta Marangoni, Cécile Laurent, Florence Coussy, Rania El-Botty, Sophie Château-Joubert, Jean-Luc Servely, Ludmilla de Plater, Franck Assayag, Ahmed Dahmani, Elodie Montaudon, Fariba Nemati, Justine Fleury, Sophie Vacher, David Gentien, Audrey Rapinat, Pierre Foidart, Nor Eddine Sounni, Agnès Noel, Anne Vincent-Salomon, Marick Lae, Didier Decaudin, Sergio Roman-Roman, Ivan Bièche, Martine Piccart and Fabien Reyal
Clin Cancer Res June 1 2018 (24) (11) 2605-2615; DOI: 10.1158/1078-0432.CCR-17-3490

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Capecitabine Efficacy Is Correlated with TYMP and RB1 Expression in PDX Established from Triple-Negative Breast Cancers
Elisabetta Marangoni, Cécile Laurent, Florence Coussy, Rania El-Botty, Sophie Château-Joubert, Jean-Luc Servely, Ludmilla de Plater, Franck Assayag, Ahmed Dahmani, Elodie Montaudon, Fariba Nemati, Justine Fleury, Sophie Vacher, David Gentien, Audrey Rapinat, Pierre Foidart, Nor Eddine Sounni, Agnès Noel, Anne Vincent-Salomon, Marick Lae, Didier Decaudin, Sergio Roman-Roman, Ivan Bièche, Martine Piccart and Fabien Reyal
Clin Cancer Res June 1 2018 (24) (11) 2605-2615; DOI: 10.1158/1078-0432.CCR-17-3490
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