Table of Contents

Translational Cancer Mechanisms and Therapy

• Translational Cancer Mechanisms and Therapy | AuthorChoice

  Integrin β3 Inhibition Enhances the Antitumor Activity of ALK Inhibitor in ALK-Rearranged NSCLC

  Ka-Won Noh, Insuk Sohn, Ji-Young Song, Hyun-Tae Shin, Yu-Jin Kim, Kyungsoo Jung, Minjung Sung, Mingi Kim, Sungbin An, Joungho Han, Se-Hoon Lee, Mi-Sook Lee and Yoon-La Choi

  Clin Cancer Res September 1 2018 24 (17) 4162-4174; DOI:10.1158/1078-0432.CCR-17-3492

  
  
• Translational Cancer Mechanisms and Therapy | AuthorChoice

  T-Cell Exhaustion Signatures Vary with Tumor Type and Are Severe in Glioblastoma

  Karolina Woroniecka, Pakawat Chongsathidkiet, Kristen Rhodin, Hanna Kemeny, Cosette Dechant, S. Harrison Farber, Aladine A. Elsamadicy, Xiuyu Cui, Shohei Koyama, Christina Jackson, Landon J. Hansen, Tanner M. Johanns, Luis Sanchez-Perez, Vidyalakshmi Chandramohan, Yen-Rei Andrea Yu, Darell D. Bigner, Amber Giles, Patrick Healy, Glenn Dranoff, Kent J. Weinhold, Gavin P. Dunn and Peter E. Fecci

  Clin Cancer Res September 1 2018 24 (17) 4175-4186; DOI:10.1158/1078-0432.CCR-17-1846

  
  
• Translational Cancer Mechanisms and Therapy

  Immunophenotyping of Newly Diagnosed and Recurrent Glioblastoma Defines Distinct Immune Exhaustion Profiles in Peripheral and Tumor-infiltrating Lymphocytes

  Malte Mohme, Simon Schliffke, Cecile L. Maire, Alessandra Rünger, Laura Glau, Klaus C. Mende, Jakob Matschke, Christina Gehbauer, Nuray Akyüz, Svenja Zapf, Mareike Holz, Miriam Schaper, Tobias Martens, Nils O. Schmidt, Sven Peine, Manfred Westphal, Mascha Binder, Eva Tolosa and Katrin Lamszus

  Clin Cancer Res September 1 2018 24 (17) 4187-4200; DOI:10.1158/1078-0432.CCR-17-2617

  
  
• Translational Cancer Mechanisms and Therapy

  MAPK Reliance via Acquired CDK4/6 Inhibitor Resistance in Cancer

  Renée de Leeuw, Christopher McNair, Matthew J. Schiewer, Neermala Poudel Neupane, Lucas J. Brand, Michael A. Augello, Zhen Li, Larry C. Cheng, Akihiro Yoshida, Sean M. Courtney, E. Starr Hazard, Gary Hardiman, Maha H. Hussain, J. Alan Diehl, Justin M. Drake, Wm. Kevin Kelly and Karen E. Knudsen

  Clin Cancer Res September 1 2018 24 (17) 4201-4214; DOI:10.1158/1078-0432.CCR-18-0410

  
  
• Translational Cancer Mechanisms and Therapy

  Ad5_NULL-A20: A Tropism-Modified, αvβ6 Integrin-Selective Oncolytic Adenovirus for Epithelial Ovarian Cancer Therapies

  Hanni Uusi-Kerttula, James A. Davies, Jill M. Thompson, Phonphimon Wongthida, Laura Evgin, Kevin G. Shim, Angela Bradshaw, Alexander T. Baker, Pierre J. Rizkallah, Rachel Jones, Louise Hanna, Emma Hudson, Richard G. Vile, John D. Chester and Alan L. Parker

  Clin Cancer Res September 1 2018 24 (17) 4215-4224; DOI:10.1158/1078-0432.CCR-18-1089

  
  
• Translational Cancer Mechanisms and Therapy

  Dual Suppressive Effect of miR-34a on the FOXM1/eEF2-Kinase Axis Regulates Triple-Negative Breast Cancer Growth and Invasion

  Recep Bayraktar, Cristina Ivan, Emine Bayraktar, Pinar Kanlikilicer, Nashwa N. Kabil, Nermin Kahraman, Hamada A. Mokhlis, Didem Karakas, Cristian Rodriguez-Aguayo, Ahmet Arslan, Jianting Sheng, Stephen Wong, Gabriel Lopez-Berestein, George A. Calin and Bulent Ozpolat

  Clin Cancer Res September 1 2018 24 (17) 4225-4241; DOI:10.1158/1078-0432.CCR-17-1959

  
  
• Translational Cancer Mechanisms and Therapy

  Mitigating SOX2-potentiated Immune Escape of Head and Neck Squamous Cell Carcinoma with a STING-inducing Nanosatellite Vaccine

  Yee Sun Tan, Kanokwan Sansanaphongpricha, Yuying Xie, Christopher R. Donnelly, Xiaobo Luo, Blake R. Heath, Xinyi Zhao, Emily Bellile, Hongxiang Hu, Hongwei Chen, Peter J. Polverini, Qianming Chen, Simon Young, Thomas E. Carey, Jacques E. Nör, Robert L. Ferris, Gregory T. Wolf, Duxin Sun and Yu L. Lei

  Clin Cancer Res September 1 2018 24 (17) 4242-4255; DOI:10.1158/1078-0432.CCR-17-2807

  
  
• Translational Cancer Mechanisms and Therapy | AuthorChoice

  Target-Based Screening against eIF4A1 Reveals the Marine Natural Product Elatol as a Novel Inhibitor of Translation Initiation with In Vivo Antitumor Activity

  Tara L. Peters, Joseph Tillotson, Alison M. Yeomans, Sarah Wilmore, Elizabeth Lemm, Carlos Jiménez-Romero, Luis A. Amador, Lingxiao Li, Amit D. Amin, Praechompoo Pongtornpipat, Christopher J. Zerio, Andrew J. Ambrose, Gillian Paine-Murrieta, Patricia Greninger, Francisco Vega, Cyril H. Benes, Graham Packham, Abimael D. Rodríguez, Eli Chapman and Jonathan H. Schatz

  Clin Cancer Res September 1 2018 24 (17) 4256-4270; DOI:10.1158/1078-0432.CCR-17-3645

  
  
• Translational Cancer Mechanisms and Therapy

  Copper Chelation as Targeted Therapy in a Mouse Model of Oncogenic BRAF-Driven Papillary Thyroid Cancer

  MengMeng Xu, Michael Casio, Danielle E. Range, Julie A. Sosa and Christopher M. Counter

  Clin Cancer Res September 1 2018 24 (17) 4271-4281; DOI:10.1158/1078-0432.CCR-17-3705

  
  
• Translational Cancer Mechanisms and Therapy

  The IGF2/IR/IGF1R Pathway in Tumor Cells and Myofibroblasts Mediates Resistance to EGFR Inhibition in Cholangiocarcinoma

  Javier Vaquero, Cindy Lobe, Sylvana Tahraoui, Audrey Clapéron, Martine Mergey, Fatiha Merabtene, Dominique Wendum, Cédric Coulouarn, Chantal Housset, Christèle Desbois-Mouthon, Françoise Praz and Laura Fouassier

  Clin Cancer Res September 1 2018 24 (17) 4282-4296; DOI:10.1158/1078-0432.CCR-17-3725

  
  
• Translational Cancer Mechanisms and Therapy | AuthorChoice

  Preclinical Antitumor Activity of a Novel Anti–c-KIT Antibody–Drug Conjugate against Mutant and Wild-type c-KIT–Positive Solid Tumors

  Tinya Abrams, Anu Connor, Christie Fanton, Steven B. Cohen, Thomas Huber, Kathy Miller, E. Erica Hong, Xiaohong Niu, Janine Kline, Marjorie Ison-Dugenny, Sarah Harris, Dana Walker, Klaus Krauser, Francesco Galimi, Zhen Wang, Majid Ghoddusi, Keith Mansfield, Si Tuen Lee-Hoeflich, Jocelyn Holash, Nancy Pryer, William Kluwe, Seth A. Ettenberg, William R. Sellers, Emma Lees, Paul Kwon, Judith A. Abraham and Siew C. Schleyer

  Clin Cancer Res September 1 2018 24 (17) 4297-4308; DOI:10.1158/1078-0432.CCR-17-3795

  
  
• Translational Cancer Mechanisms and Therapy

  High-Fat Diet-Induced Inflammation Accelerates Prostate Cancer Growth via IL6 Signaling

  Takuji Hayashi, Kazutoshi Fujita, Satoshi Nojima, Yujiro Hayashi, Kosuke Nakano, Yu Ishizuya, Cong Wang, Yoshiyuki Yamamoto, Toshiro Kinouchi, Kyosuke Matsuzaki, Kentaro Jingushi, Taigo Kato, Atsunari Kawashima, Akira Nagahara, Takeshi Ujike, Motohide Uemura, Maria Del Carmen Rodriguez Pena, Jennifer B. Gordetsky, Eiichi Morii, Kazutake Tsujikawa, George J. Netto and Norio Nonomura

  Clin Cancer Res September 1 2018 24 (17) 4309-4318; DOI:10.1158/1078-0432.CCR-18-0106

  
  
• Translational Cancer Mechanisms and Therapy

  Targeting Galectin-1 Impairs Castration-Resistant Prostate Cancer Progression and Invasion

  Tsung-Chieh Shih, Ruiwu Liu, Chun-Te Wu, Xiaocen Li, Wenwu Xiao, Xiaojun Deng, Sophie Kiss, Ting Wang, Xiao-Jia Chen, Randy Carney, Hsing-Jien Kung, Yong Duan, Paramita M. Ghosh and Kit S. Lam

  Clin Cancer Res September 1 2018 24 (17) 4319-4331; DOI:10.1158/1078-0432.CCR-18-0157

  
  
• Translational Cancer Mechanisms and Therapy

  A PDX/Organoid Biobank of Advanced Prostate Cancers Captures Genomic and Phenotypic Heterogeneity for Disease Modeling and Therapeutic Screening

  Michael L. Beshiri, Caitlin M. Tice, Crystal Tran, Holly M. Nguyen, Adam G. Sowalsky, Supreet Agarwal, Keith H. Jansson, Qi Yang, Kerry M. McGowen, JuanJuan Yin, Aian Neil Alilin, Fatima H. Karzai, William L. Dahut, Eva Corey and Kathleen Kelly

  Clin Cancer Res September 1 2018 24 (17) 4332-4345; DOI:10.1158/1078-0432.CCR-18-0409