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Table of Contents

Highlights

  • Highlights
    Highlights of This Issue
    Clin Cancer Res September 1 2018 24 (17) 4057-4057;

CCR Translations

  • CCR Translations
    Immunotherapy for Glioblastoma: Playing Chess, Not Checkers
    Christopher M. Jackson and Michael Lim
    Clin Cancer Res September 1 2018 24 (17) 4059-4061; DOI:10.1158/1078-0432.CCR-18-0491

  • CCR Translations
    PARP Inhibitors in Ovarian Cancer: A Trailblazing and Transformative Journey
    Panagiotis A. Konstantinopoulos and Ursula A. Matulonis
    Clin Cancer Res September 1 2018 24 (17) 4062-4065; DOI:10.1158/1078-0432.CCR-18-1314

CCR Drug Updates

  • CCR Drug Updates
    FDA Approval Summary: Niraparib for the Maintenance Treatment of Patients with Recurrent Ovarian Cancer in Response to Platinum-Based Chemotherapy
    Gwynn Ison, Lynn J. Howie, Laleh Amiri-Kordestani, Lijun Zhang, Shenghui Tang, Rajeshwari Sridhara, Vadryn Pierre, Rosane Charlab, Anuradha Ramamoorthy, Pengfei Song, Fang Li, Jingyu Yu, Wimolnut Manheng, Todd R. Palmby, Soma Ghosh, Hisani N. Horne, Eunice Y. Lee, Reena Philip, Kaushalkumar Dave, Xiao Hong Chen, Sharon L. Kelly, Kumar G. Janoria, Anamitro Banerjee, Okponanabofa Eradiri, Jeannette Dinin, Kirsten B. Goldberg, William F. Pierce, Amna Ibrahim, Paul G. Kluetz, Gideon M. Blumenthal, Julia A. Beaver and Richard Pazdur
    Clin Cancer Res September 1 2018 24 (17) 4066-4071; DOI:10.1158/1078-0432.CCR-18-0042

Clinical Trials: Targeted Therapy

  • Clinical Trials: Targeted Therapy
    Phase I Study of CC-486 Alone and in Combination with Carboplatin or nab-Paclitaxel in Patients with Relapsed or Refractory Solid Tumors
    Daniel D. Von Hoff, Drew W. Rasco, Elisabeth I. Heath, Pamela N. Munster, Jan H.M. Schellens, Nicolas Isambert, Christophe Le Tourneau, Bert O'Neil, Ron H.J. Mathijssen, Jose A. Lopez-Martin, W. Jeff Edenfield, Miguel Martin, Patricia M. LoRusso, Gordon L. Bray, Jorge DiMartino, Aaron Nguyen, Kejian Liu, Eric Laille and Johanna C. Bendell
    Clin Cancer Res September 1 2018 24 (17) 4072-4080; DOI:10.1158/1078-0432.CCR-17-3716

  • Clinical Trials: Targeted Therapy
    Radium-223 Dichloride in Combination with Vascular Endothelial Growth Factor–Targeting Therapy in Advanced Renal Cell Carcinoma with Bone Metastases
    Rana R. McKay, Dominick Bossé, Kathryn P. Gray, M. Dror Michaelson, Katherine Krajewski, Heather A. Jacene, Meghara Walsh, Joaquim Bellmunt, Mark Pomerantz, Lauren C. Harshman and Toni K. Choueiri
    Clin Cancer Res September 1 2018 24 (17) 4081-4088; DOI:10.1158/1078-0432.CCR-17-3577

  • Clinical Trials: Targeted Therapy
    Vitamin D Supplementation and Survival of Patients with Non–small Cell Lung Cancer: A Randomized, Double-Blind, Placebo-Controlled Trial
    Tadashi Akiba, Toshiaki Morikawa, Makoto Odaka, Takeo Nakada, Noriki Kamiya, Makoto Yamashita, Mitsuo Yabe, Takuya Inagaki, Hisatoshi Asano, Shohei Mori, Yo Tsukamoto and Mitsuyoshi Urashima
    Clin Cancer Res September 1 2018 24 (17) 4089-4097; DOI:10.1158/1078-0432.CCR-18-0483

Clinical Trials: Immunotherapy

  • Clinical Trials: Immunotherapy
    Infusion of Alloanergized Donor Lymphocytes after CD34-selected Haploidentical Myeloablative Hematopoietic Stem Cell Transplantation
    Jeff K. Davies, Lisa L. Brennan, John R. Wingard, Christopher R. Cogle, Neena Kapoor, Ami J. Shah, Bimalangshu R. Dey, Thomas R. Spitzer, Marcos de Lima, Laurence J. Cooper, Peter F. Thall, Richard E. Champlin, Lee M. Nadler and Eva C. Guinan
    Clin Cancer Res September 1 2018 24 (17) 4098-4109; DOI:10.1158/1078-0432.CCR-18-0449

Precision Medicine and Imaging

  • Precision Medicine and Imaging
    Magnetic Resonance Imaging of Tumor-Associated Macrophages: Clinical Translation
    Maryam Aghighi, Ashok J. Theruvath, Anuj Pareek, Laura L. Pisani, Raphael Alford, Anne M. Muehe, Tarsheen K. Sethi, Samantha J. Holdsworth, Florette K. Hazard, Dita Gratzinger, Sandra Luna-Fineman, Ranjana Advani, Sheri L. Spunt and Heike E. Daldrup-Link
    Clin Cancer Res September 1 2018 24 (17) 4110-4118; DOI:10.1158/1078-0432.CCR-18-0673

  • Precision Medicine and Imaging
    Role of Elevated PHIP Copy Number as a Prognostic and Progression Marker for Cutaneous Melanoma
    Vladimir Bezrookove, Mehdi Nosrati, James R. Miller III, David De Semir, Altaf A. Dar, Elham Vosoughi, Edith Vaquero, Antje Sucker, Alexander J. Lazar, Jeffrey E. Gershenwald, Michael A. Davies, Dirk Schadendorf and Mohammed Kashani-Sabet
    Clin Cancer Res September 1 2018 24 (17) 4119-4125; DOI:10.1158/1078-0432.CCR-18-0791

  • Precision Medicine and Imaging
    The Epigenomic Landscape of Pituitary Adenomas Reveals Specific Alterations and Differentiates Among Acromegaly, Cushing's Disease and Endocrine-Inactive Subtypes
    Matthew P. Salomon, Xiaowen Wang, Diego M. Marzese, Sandy C. Hsu, Nellie Nelson, Xin Zhang, Chikako Matsuba, Yuki Takasumi, Carmen Ballesteros-Merino, Bernard A. Fox, Garni Barkhoudarian, Daniel F. Kelly and Dave S.B. Hoon
    Clin Cancer Res September 1 2018 24 (17) 4126-4136; DOI:10.1158/1078-0432.CCR-17-2206

  • Precision Medicine and Imaging
    Genomic Heterogeneity and the Small Renal Mass
    Daiki Ueno, Zuoquan Xie, Marta Boeke, Jamil Syed, Kevin A. Nguyen, Patrick McGillivray, Adebowale Adeniran, Peter Humphrey, Garrett M. Dancik, Yuval Kluger, Zongzhi Liu, Harriet Kluger and Brian Shuch
    Clin Cancer Res September 1 2018 24 (17) 4137-4144; DOI:10.1158/1078-0432.CCR-18-0214

  • Precision Medicine and Imaging
    STAG2 Is a Biomarker for Prediction of Recurrence and Progression in Papillary Non–Muscle-Invasive Bladder Cancer
    Alana Lelo, Frederik Prip, Brent T. Harris, David Solomon, Deborah L. Berry, Krysta Chaldekas, Anagha Kumar, Jeffry Simko, Jørgen Bjerggaard Jensen, Pritish Bhattacharyya, Ciaran Mannion, Jung-Sik Kim, George Philips, Lars Dyrskjøt and Todd Waldman
    Clin Cancer Res September 1 2018 24 (17) 4145-4153; DOI:10.1158/1078-0432.CCR-17-3244

  • Precision Medicine and Imaging
    Comprehensive Molecular Profiling of Intrahepatic and Extrahepatic Cholangiocarcinomas: Potential Targets for Intervention
    Maeve A. Lowery, Ryan Ptashkin, Emmet Jordan, Michael F. Berger, Ahmet Zehir, Marinela Capanu, Nancy E. Kemeny, Eileen M. O'Reilly, Imane El-Dika, William R. Jarnagin, James J. Harding, Michael I. D'Angelica, Andrea Cercek, Jaclyn F. Hechtman, David B. Solit, Nikolaus Schultz, David M. Hyman, David S. Klimstra, Leonard B. Saltz and Ghassan K. Abou-Alfa
    Clin Cancer Res September 1 2018 24 (17) 4154-4161; DOI:10.1158/1078-0432.CCR-18-0078

Translational Cancer Mechanisms and Therapy

  • Translational Cancer Mechanisms and Therapy | AuthorChoice
    Integrin β3 Inhibition Enhances the Antitumor Activity of ALK Inhibitor in ALK-Rearranged NSCLC
    Ka-Won Noh, Insuk Sohn, Ji-Young Song, Hyun-Tae Shin, Yu-Jin Kim, Kyungsoo Jung, Minjung Sung, Mingi Kim, Sungbin An, Joungho Han, Se-Hoon Lee, Mi-Sook Lee and Yoon-La Choi
    Clin Cancer Res September 1 2018 24 (17) 4162-4174; DOI:10.1158/1078-0432.CCR-17-3492

  • Translational Cancer Mechanisms and Therapy | AuthorChoice
    T-Cell Exhaustion Signatures Vary with Tumor Type and Are Severe in Glioblastoma
    Karolina Woroniecka, Pakawat Chongsathidkiet, Kristen Rhodin, Hanna Kemeny, Cosette Dechant, S. Harrison Farber, Aladine A. Elsamadicy, Xiuyu Cui, Shohei Koyama, Christina Jackson, Landon J. Hansen, Tanner M. Johanns, Luis Sanchez-Perez, Vidyalakshmi Chandramohan, Yen-Rei Andrea Yu, Darell D. Bigner, Amber Giles, Patrick Healy, Glenn Dranoff, Kent J. Weinhold, Gavin P. Dunn and Peter E. Fecci
    Clin Cancer Res September 1 2018 24 (17) 4175-4186; DOI:10.1158/1078-0432.CCR-17-1846

  • Translational Cancer Mechanisms and Therapy
    Immunophenotyping of Newly Diagnosed and Recurrent Glioblastoma Defines Distinct Immune Exhaustion Profiles in Peripheral and Tumor-infiltrating Lymphocytes
    Malte Mohme, Simon Schliffke, Cecile L. Maire, Alessandra Rünger, Laura Glau, Klaus C. Mende, Jakob Matschke, Christina Gehbauer, Nuray Akyüz, Svenja Zapf, Mareike Holz, Miriam Schaper, Tobias Martens, Nils O. Schmidt, Sven Peine, Manfred Westphal, Mascha Binder, Eva Tolosa and Katrin Lamszus
    Clin Cancer Res September 1 2018 24 (17) 4187-4200; DOI:10.1158/1078-0432.CCR-17-2617

  • Translational Cancer Mechanisms and Therapy
    MAPK Reliance via Acquired CDK4/6 Inhibitor Resistance in Cancer
    Renée de Leeuw, Christopher McNair, Matthew J. Schiewer, Neermala Poudel Neupane, Lucas J. Brand, Michael A. Augello, Zhen Li, Larry C. Cheng, Akihiro Yoshida, Sean M. Courtney, E. Starr Hazard, Gary Hardiman, Maha H. Hussain, J. Alan Diehl, Justin M. Drake, Wm. Kevin Kelly and Karen E. Knudsen
    Clin Cancer Res September 1 2018 24 (17) 4201-4214; DOI:10.1158/1078-0432.CCR-18-0410

  • Translational Cancer Mechanisms and Therapy
    Ad5NULL-A20: A Tropism-Modified, αvβ6 Integrin-Selective Oncolytic Adenovirus for Epithelial Ovarian Cancer Therapies
    Hanni Uusi-Kerttula, James A. Davies, Jill M. Thompson, Phonphimon Wongthida, Laura Evgin, Kevin G. Shim, Angela Bradshaw, Alexander T. Baker, Pierre J. Rizkallah, Rachel Jones, Louise Hanna, Emma Hudson, Richard G. Vile, John D. Chester and Alan L. Parker
    Clin Cancer Res September 1 2018 24 (17) 4215-4224; DOI:10.1158/1078-0432.CCR-18-1089

  • Translational Cancer Mechanisms and Therapy
    Dual Suppressive Effect of miR-34a on the FOXM1/eEF2-Kinase Axis Regulates Triple-Negative Breast Cancer Growth and Invasion
    Recep Bayraktar, Cristina Ivan, Emine Bayraktar, Pinar Kanlikilicer, Nashwa N. Kabil, Nermin Kahraman, Hamada A. Mokhlis, Didem Karakas, Cristian Rodriguez-Aguayo, Ahmet Arslan, Jianting Sheng, Stephen Wong, Gabriel Lopez-Berestein, George A. Calin and Bulent Ozpolat
    Clin Cancer Res September 1 2018 24 (17) 4225-4241; DOI:10.1158/1078-0432.CCR-17-1959

  • Translational Cancer Mechanisms and Therapy
    Mitigating SOX2-potentiated Immune Escape of Head and Neck Squamous Cell Carcinoma with a STING-inducing Nanosatellite Vaccine
    Yee Sun Tan, Kanokwan Sansanaphongpricha, Yuying Xie, Christopher R. Donnelly, Xiaobo Luo, Blake R. Heath, Xinyi Zhao, Emily Bellile, Hongxiang Hu, Hongwei Chen, Peter J. Polverini, Qianming Chen, Simon Young, Thomas E. Carey, Jacques E. Nör, Robert L. Ferris, Gregory T. Wolf, Duxin Sun and Yu L. Lei
    Clin Cancer Res September 1 2018 24 (17) 4242-4255; DOI:10.1158/1078-0432.CCR-17-2807

  • Translational Cancer Mechanisms and Therapy | AuthorChoice
    Target-Based Screening against eIF4A1 Reveals the Marine Natural Product Elatol as a Novel Inhibitor of Translation Initiation with In Vivo Antitumor Activity
    Tara L. Peters, Joseph Tillotson, Alison M. Yeomans, Sarah Wilmore, Elizabeth Lemm, Carlos Jiménez-Romero, Luis A. Amador, Lingxiao Li, Amit D. Amin, Praechompoo Pongtornpipat, Christopher J. Zerio, Andrew J. Ambrose, Gillian Paine-Murrieta, Patricia Greninger, Francisco Vega, Cyril H. Benes, Graham Packham, Abimael D. Rodríguez, Eli Chapman and Jonathan H. Schatz
    Clin Cancer Res September 1 2018 24 (17) 4256-4270; DOI:10.1158/1078-0432.CCR-17-3645

  • Translational Cancer Mechanisms and Therapy
    Copper Chelation as Targeted Therapy in a Mouse Model of Oncogenic BRAF-Driven Papillary Thyroid Cancer
    MengMeng Xu, Michael Casio, Danielle E. Range, Julie A. Sosa and Christopher M. Counter
    Clin Cancer Res September 1 2018 24 (17) 4271-4281; DOI:10.1158/1078-0432.CCR-17-3705

  • Translational Cancer Mechanisms and Therapy
    The IGF2/IR/IGF1R Pathway in Tumor Cells and Myofibroblasts Mediates Resistance to EGFR Inhibition in Cholangiocarcinoma
    Javier Vaquero, Cindy Lobe, Sylvana Tahraoui, Audrey Clapéron, Martine Mergey, Fatiha Merabtene, Dominique Wendum, Cédric Coulouarn, Chantal Housset, Christèle Desbois-Mouthon, Françoise Praz and Laura Fouassier
    Clin Cancer Res September 1 2018 24 (17) 4282-4296; DOI:10.1158/1078-0432.CCR-17-3725

  • Translational Cancer Mechanisms and Therapy | AuthorChoice
    Preclinical Antitumor Activity of a Novel Anti–c-KIT Antibody–Drug Conjugate against Mutant and Wild-type c-KIT–Positive Solid Tumors
    Tinya Abrams, Anu Connor, Christie Fanton, Steven B. Cohen, Thomas Huber, Kathy Miller, E. Erica Hong, Xiaohong Niu, Janine Kline, Marjorie Ison-Dugenny, Sarah Harris, Dana Walker, Klaus Krauser, Francesco Galimi, Zhen Wang, Majid Ghoddusi, Keith Mansfield, Si Tuen Lee-Hoeflich, Jocelyn Holash, Nancy Pryer, William Kluwe, Seth A. Ettenberg, William R. Sellers, Emma Lees, Paul Kwon, Judith A. Abraham and Siew C. Schleyer
    Clin Cancer Res September 1 2018 24 (17) 4297-4308; DOI:10.1158/1078-0432.CCR-17-3795

  • Translational Cancer Mechanisms and Therapy
    High-Fat Diet-Induced Inflammation Accelerates Prostate Cancer Growth via IL6 Signaling
    Takuji Hayashi, Kazutoshi Fujita, Satoshi Nojima, Yujiro Hayashi, Kosuke Nakano, Yu Ishizuya, Cong Wang, Yoshiyuki Yamamoto, Toshiro Kinouchi, Kyosuke Matsuzaki, Kentaro Jingushi, Taigo Kato, Atsunari Kawashima, Akira Nagahara, Takeshi Ujike, Motohide Uemura, Maria Del Carmen Rodriguez Pena, Jennifer B. Gordetsky, Eiichi Morii, Kazutake Tsujikawa, George J. Netto and Norio Nonomura
    Clin Cancer Res September 1 2018 24 (17) 4309-4318; DOI:10.1158/1078-0432.CCR-18-0106

  • Translational Cancer Mechanisms and Therapy
    Targeting Galectin-1 Impairs Castration-Resistant Prostate Cancer Progression and Invasion
    Tsung-Chieh Shih, Ruiwu Liu, Chun-Te Wu, Xiaocen Li, Wenwu Xiao, Xiaojun Deng, Sophie Kiss, Ting Wang, Xiao-Jia Chen, Randy Carney, Hsing-Jien Kung, Yong Duan, Paramita M. Ghosh and Kit S. Lam
    Clin Cancer Res September 1 2018 24 (17) 4319-4331; DOI:10.1158/1078-0432.CCR-18-0157

  • Translational Cancer Mechanisms and Therapy
    A PDX/Organoid Biobank of Advanced Prostate Cancers Captures Genomic and Phenotypic Heterogeneity for Disease Modeling and Therapeutic Screening
    Michael L. Beshiri, Caitlin M. Tice, Crystal Tran, Holly M. Nguyen, Adam G. Sowalsky, Supreet Agarwal, Keith H. Jansson, Qi Yang, Kerry M. McGowen, JuanJuan Yin, Aian Neil Alilin, Fatima H. Karzai, William L. Dahut, Eva Corey and Kathleen Kelly
    Clin Cancer Res September 1 2018 24 (17) 4332-4345; DOI:10.1158/1078-0432.CCR-18-0409

Editor's Notes

  • Editor's Notes | Free Article
    Editor's Note: Capsaicin Is a Novel Blocker of Constitutive and Interleukin-6–Inducible STAT3 Activation
    Clin Cancer Res September 1 2018 24 (17) 4346-4346; DOI:10.1158/1078-0432.CCR-18-2524

  • Editor's Notes | Free Article
    Editor's Note: Guggulsterone Inhibits Osteoclastogenesis Induced by Receptor Activator of Nuclear Factor-κB Ligand and by Tumor Cells by Suppressing Nuclear Factor-κB Activation
    Clin Cancer Res September 1 2018 24 (17) 4347-4347; DOI:10.1158/1078-0432.CCR-18-2525

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Clinical Cancer Research: 24 (17)
September 2018
Volume 24, Issue 17
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Issue Highlights

  • Magnetic Resonance Imaging of Tumor-Associated Macrophages: Clinical Translation
  • Role of Elevated PHIP Copy Number as a Prognostic and Progression Marker for Cutaneous Melanoma
  • The Epigenomic Landscape of Pituitary Adenomas Reveals Specific Alterations and Differentiates Among Acromegaly, Cushing's Disease and Endocrine-Inactive Subtypes
  • Ad5NULL-A20: A Tropism-Modified, αvβ6 Integrin-Selective Oncolytic Adenovirus for Epithelial Ovarian Cancer Therapies

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  • Immune Checkpoint Blockade Requires Macrophage CXCL9/CXCL10
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Clinical Cancer Research
eISSN: 1557-3265
ISSN: 1078-0432

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