Clinical Cancer Research: 24 (20)

Highlights

Highlights

Highlights of This Issue

Clin Cancer Res October 15 2018 24 (20) 4913-4913;

CCR Translations

CCR Translations

Bigger Is Not Always Better: Tumor Size and Prognosis in Advanced Melanoma

Allison Betof Warner and Michael A. Postow

Clin Cancer Res October 15 2018 24 (20) 4915-4917; DOI:10.1158/1078-0432.CCR-18-1311
CCR Translations

Advantages and Adversities of the Weighted Toxicity Score

Ulka Vaishampayan

Clin Cancer Res October 15 2018 24 (20) 4918-4920; DOI:10.1158/1078-0432.CCR-18-1562

Statistics in CCR

Statistics in CCR

Time-to-Event Bayesian Optimal Interval Design to Accelerate Phase I Trials

Ying Yuan, Ruitao Lin, Daniel Li, Lei Nie and Katherine E. Warren

Clin Cancer Res October 15 2018 24 (20) 4921-4930; DOI:10.1158/1078-0432.CCR-18-0246

Review

Review

Targeting the IDH2 Pathway in Acute Myeloid Leukemia

Maria L. Amaya and Daniel A. Pollyea

Clin Cancer Res October 15 2018 24 (20) 4931-4936; DOI:10.1158/1078-0432.CCR-18-0536

Clinical Trial Brief Report

Clinical Trial Brief Report

Therapeutic Immune Modulation against Solid Cancers with Intratumoral Poly-ICLC: A Pilot Trial

Chrisann Kyi, Vladimir Roudko, Rachel Sabado, Yvonne Saenger, William Loging, John Mandeli, Tin Htwe Thin, Deborah Lehrer, Michael Donovan, Marshall Posner, Krzysztof Misiukiewicz, Benjamin Greenbaum, Andres Salazar, Philip Friedlander and Nina Bhardwaj

Clin Cancer Res October 15 2018 24 (20) 4937-4948; DOI:10.1158/1078-0432.CCR-17-1866

Clinical Trials: Targeted Therapy

Clinical Trials: Targeted Therapy

Final Report of a Phase I Trial of Olaparib with Cetuximab and Radiation for Heavy Smoker Patients with Locally Advanced Head and Neck Cancer

Sana D. Karam, Krishna Reddy, Patrick J. Blatchford, Tim Waxweiler, Alicia M. DeLouize, Ayman Oweida, Hilary Somerset, Carrie Marshall, Christian Young, Kurtis D. Davies, Madeleine Kane, Aik Choo Tan, Xiao Jing Wang, Antonio Jimeno, Dara L. Aisner, Daniel W. Bowles and David Raben

Clin Cancer Res October 15 2018 24 (20) 4949-4959; DOI:10.1158/1078-0432.CCR-18-0467

Precision Medicine and Imaging

Precision Medicine and Imaging | AuthorChoice

Baseline Tumor Size Is an Independent Prognostic Factor for Overall Survival in Patients with Melanoma Treated with Pembrolizumab

Richard W. Joseph, Jeroen Elassaiss-Schaap, Richard Kefford, Wen-Jen Hwu, Jedd D. Wolchok, Anthony M. Joshua, Antoni Ribas, F. Stephen Hodi, Omid Hamid, Caroline Robert, Adil Daud, Roxana Dronca, Peter Hersey, Jeffrey S. Weber, Amita Patnaik, Dinesh P. de Alwis, Andrea Perrone, Jin Zhang, S. Peter Kang, Scot Ebbinghaus, Keaven M. Anderson and Tara C. Gangadhar

Clin Cancer Res October 15 2018 24 (20) 4960-4967; DOI:10.1158/1078-0432.CCR-17-2386
Precision Medicine and Imaging

A Method to Summarize Toxicity in Cancer Randomized Clinical Trials

Mariana Carbini, Mayte Suárez-Fariñas and Robert G. Maki

Clin Cancer Res October 15 2018 24 (20) 4968-4975; DOI:10.1158/1078-0432.CCR-17-3314
Precision Medicine and Imaging

CD8⁺ T-Cell Density Imaging with ⁶⁴Cu-Labeled Cys-Diabody Informs Immunotherapy Protocols

Jai Woong Seo, Richard Tavaré, Lisa M. Mahakian, Matthew T. Silvestrini, Sarah Tam, Elizabeth S. Ingham, Felix B. Salazar, Alexander D. Borowsky, Anna M. Wu and Katherine W. Ferrara

Clin Cancer Res October 15 2018 24 (20) 4976-4987; DOI:10.1158/1078-0432.CCR-18-0261
Precision Medicine and Imaging

Molecular Imaging of Radiolabeled Bispecific T-Cell Engager ⁸⁹Zr-AMG211 Targeting CEA-Positive Tumors

Stijn J.H. Waaijer, Frank J. Warnders, Sabine Stienen, Matthias Friedrich, Alexander Sternjak, H. Kam Cheung, Anton G.T. Terwisscha van Scheltinga, Carolien P. Schröder, Elisabeth G.E. de Vries and Marjolijn N. Lub-de Hooge

Clin Cancer Res October 15 2018 24 (20) 4988-4996; DOI:10.1158/1078-0432.CCR-18-0786
Precision Medicine and Imaging

Dynamics of Genome Alterations in Crohn's Disease–Associated Colorectal Carcinogenesis

Daniela Hirsch, Darawalee Wangsa, Yuelin J. Zhu, Yue Hu, Daniel C. Edelman, Paul S. Meltzer, Kerstin Heselmeyer-Haddad, Claudia Ott, Peter Kienle, Christian Galata, Karoline Horisberger, Thomas Ried and Timo Gaiser

Clin Cancer Res October 15 2018 24 (20) 4997-5011; DOI:10.1158/1078-0432.CCR-18-0630
Precision Medicine and Imaging

Disparities in Neurotoxicity Risk and Outcomes among Pediatric Acute Lymphoblastic Leukemia Patients

Olga A. Taylor, Austin L. Brown, Julienne Brackett, ZoAnn E. Dreyer, Ida Ki Moore, Pauline Mitby, Mary C. Hooke, Marilyn J. Hockenberry, Philip J. Lupo and Michael E. Scheurer

Clin Cancer Res October 15 2018 24 (20) 5012-5017; DOI:10.1158/1078-0432.CCR-18-0939
Precision Medicine and Imaging

Molecular Profiling of Patients with Pancreatic Cancer: Initial Results from the Know Your Tumor Initiative

Michael J. Pishvaian, Robert J. Bender, David Halverson, Lola Rahib, Andrew E. Hendifar, Sameh Mikhail, Vincent Chung, Vincent J. Picozzi, Davendra Sohal, Edik M. Blais, Kimberly Mason, Emily E. Lyons, Lynn M. Matrisian, Jonathan R. Brody, Subha Madhavan and Emanuel F. Petricoin III

Clin Cancer Res October 15 2018 24 (20) 5018-5027; DOI:10.1158/1078-0432.CCR-18-0531
Precision Medicine and Imaging

Skeletal Muscle Loss Is an Imaging Biomarker of Outcome after Definitive Chemoradiotherapy for Locally Advanced Cervical Cancer

Jie Lee, Chih-Long Chang, Jhen-Bin Lin, Meng-Hao Wu, Fang-Ju Sun, Ya-Ting Jan, Shih-Ming Hsu and Yu-Jen Chen

Clin Cancer Res October 15 2018 24 (20) 5028-5036; DOI:10.1158/1078-0432.CCR-18-0788
Precision Medicine and Imaging

Consensus on Molecular Subtypes of High-Grade Serous Ovarian Carcinoma

Gregory M. Chen, Lavanya Kannan, Ludwig Geistlinger, Victor Kofia, Zhaleh Safikhani, Deena M.A. Gendoo, Giovanni Parmigiani, Michael Birrer, Benjamin Haibe-Kains and Levi Waldron

Clin Cancer Res October 15 2018 24 (20) 5037-5047; DOI:10.1158/1078-0432.CCR-18-0784
Precision Medicine and Imaging

The Light Chain IgLV3-21 Defines a New Poor Prognostic Subgroup in Chronic Lymphocytic Leukemia: Results of a Multicenter Study

Basile Stamatopoulos, Thomas Smith, Emerence Crompot, Karlien Pieters, Ruth Clifford, Marek Mraz, Pauline Robbe, Adam Burns, Adele Timbs, David Bruce, Peter Hillmen, Nathalie Meuleman, Philippe Mineur, Radu Firescu, Marie Maerevoet, Virginie De Wilde, André Efira, Jan Philippé, Bruno Verhasselt, Fritz Offner, David Sims, Andreas Heger, Hélène Dreau and Anna Schuh

Clin Cancer Res October 15 2018 24 (20) 5048-5057; DOI:10.1158/1078-0432.CCR-18-0133

Translational Cancer Mechanisms and Therapy

Translational Cancer Mechanisms and Therapy

Elective Nodal Irradiation Attenuates the Combinatorial Efficacy of Stereotactic Radiation Therapy and Immunotherapy

Ariel E. Marciscano, Ali Ghasemzadeh, Thomas R. Nirschl, Debebe Theodros, Christina M. Kochel, Brian J. Francica, Yuki Muroyama, Robert A. Anders, Andrew B. Sharabi, Esteban Velarde, Wendy Mao, Kunal R. Chaudhary, Matthew G. Chaimowitz, John Wong, Mark J. Selby, Kent B. Thudium, Alan J. Korman, David Ulmert, Daniel L.J. Thorek, Theodore L. DeWeese and Charles G. Drake

Clin Cancer Res October 15 2018 24 (20) 5058-5071; DOI:10.1158/1078-0432.CCR-17-3427
Translational Cancer Mechanisms and Therapy

Paclitaxel Sensitivity of Ovarian Cancer Can be Enhanced by Knocking Down Pairs of Kinases that Regulate MAP4 Phosphorylation and Microtubule Stability

Hailing Yang, Weiqun Mao, Cristian Rodriguez-Aguayo, Lingegowda S. Mangala, Geoffrey Bartholomeusz, Lakesla R. Iles, Nicholas B. Jennings, Ahmed Ashour Ahmed, Anil K. Sood, Gabriel Lopez-Berestein, Zhen Lu and Robert C. Bast Jr.

Clin Cancer Res October 15 2018 24 (20) 5072-5084; DOI:10.1158/1078-0432.CCR-18-0504
Translational Cancer Mechanisms and Therapy

Mast Cell Activation and KSHV Infection in Kaposi Sarcoma

Leona W. Ayers, Arturo Barbachano-Guerrero, Shane C. McAllister, Julie A. Ritchie, Elizabeth Asiago-Reddy, Linda C. Bartlett, Ethel Cesarman, Dongliang Wang, Rosemary Rochford, Jeffrey N. Martin and Christine A. King

Clin Cancer Res October 15 2018 24 (20) 5085-5097; DOI:10.1158/1078-0432.CCR-18-0873
Translational Cancer Mechanisms and Therapy | AuthorChoice

Anti-Folate Receptor Alpha–Directed Antibody Therapies Restrict the Growth of Triple-negative Breast Cancer

Anthony Cheung, James Opzoomer, Kristina M. Ilieva, Patrycja Gazinska, Ricarda M. Hoffmann, Hasan Mirza, Rebecca Marlow, Erika Francesch-Domenech, Matthew Fittall, Diana Dominguez Rodriguez, Angela Clifford, Luned Badder, Nirmesh Patel, Silvia Mele, Giulia Pellizzari, Heather J. Bax, Silvia Crescioli, Gyula Petranyi, Daniel Larcombe-Young, Debra H. Josephs, Silvana Canevari, Mariangela Figini, Sarah Pinder, Frank O. Nestle, Cheryl Gillett, James F. Spicer, Anita Grigoriadis, Andrew N.J. Tutt and Sophia N. Karagiannis

Clin Cancer Res October 15 2018 24 (20) 5098-5111; DOI:10.1158/1078-0432.CCR-18-0652
Translational Cancer Mechanisms and Therapy | AuthorChoice

High-Throughput Functional Evaluation of Variants of Unknown Significance in ERBB2

Masaaki Nagano, Shinji Kohsaka, Toshihide Ueno, Shinya Kojima, Kanju Saka, Hirotaro Iwase, Masahito Kawazu and Hiroyuki Mano

Clin Cancer Res October 15 2018 24 (20) 5112-5122; DOI:10.1158/1078-0432.CCR-18-0991
Translational Cancer Mechanisms and Therapy | AuthorChoice

Characterization of Alternative Splicing Events in HPV-Negative Head and Neck Squamous Cell Carcinoma Identifies an Oncogenic DOCK5 Variant

Chao Liu, Theresa Guo, Guorong Xu, Akihiro Sakai, Shuling Ren, Takahito Fukusumi, Mizuo Ando, Sayed Sadat, Yuki Saito, Zubair Khan, Kathleen M. Fisch and Joseph Califano

Clin Cancer Res October 15 2018 24 (20) 5123-5132; DOI:10.1158/1078-0432.CCR-18-0752
Translational Cancer Mechanisms and Therapy | AuthorChoice

Mutational Analysis Identifies Therapeutic Biomarkers in Inflammatory Bowel Disease–Associated Colorectal Cancers

Shahida Din, Kim Wong, Mike F. Mueller, Anca Oniscu, James Hewinson, Catherine J. Black, Martin L. Miller, Alejandro Jiménez-Sánchez, Roy Rabbie, Mamunar Rashid, Jack Satsangi, David J. Adams and Mark J. Arends

Clin Cancer Res October 15 2018 24 (20) 5133-5142; DOI:10.1158/1078-0432.CCR-17-3713
Translational Cancer Mechanisms and Therapy

Talazoparib Is a Potent Radiosensitizer in Small Cell Lung Cancer Cell Lines and Xenografts

James H. Laird, Benjamin H. Lok, Jennifer Ma, Andrew Bell, Elisa de Stanchina, John T. Poirier and Charles M. Rudin

Clin Cancer Res October 15 2018 24 (20) 5143-5152; DOI:10.1158/1078-0432.CCR-18-0401
Translational Cancer Mechanisms and Therapy

The Combination of the PARP Inhibitor Olaparib and the WEE1 Inhibitor AZD1775 as a New Therapeutic Option for Small Cell Lung Cancer

Alice Lallo, Kristopher K. Frese, Christopher J. Morrow, Robert Sloane, Sakshi Gulati, Maximillian W. Schenk, Francesca Trapani, Nicole Simms, Melanie Galvin, Stewart Brown, Cassandra L. Hodgkinson, Lynsey Priest, Adina Hughes, Zhongwu Lai, Elaine Cadogan, Garima Khandelwal, Kathryn L. Simpson, Crispin Miller, Fiona Blackhall, Mark J. O'Connor and Caroline Dive

Clin Cancer Res October 15 2018 24 (20) 5153-5164; DOI:10.1158/1078-0432.CCR-17-2805
Translational Cancer Mechanisms and Therapy

Loss of E-cadherin Enhances IGF1–IGF1R Pathway Activation and Sensitizes Breast Cancers to Anti-IGF1R/InsR Inhibitors

Alison M. Nagle, Kevin M. Levine, Nilgun Tasdemir, Julie A. Scott, Kara Burlbaugh, Justin Kehm, Tiffany A. Katz, David N. Boone, Britta M. Jacobsen, Jennifer M. Atkinson, Steffi Oesterreich and Adrian V. Lee

Clin Cancer Res October 15 2018 24 (20) 5165-5177; DOI:10.1158/1078-0432.CCR-18-0279
Translational Cancer Mechanisms and Therapy

A Novel, Fully Human Anti–fucosyl-GM1 Antibody Demonstrates Potent In Vitro and In Vivo Antitumor Activity in Preclinical Models of Small Cell Lung Cancer

Paul Ponath, Daniel Menezes, Chin Pan, Bing Chen, Miho Oyasu, Debbie Strachan, Heidi LeBlanc, Huadong Sun, Xi-Tao Wang, Vangipuram S. Rangan, Shrikant Deshpande, Sandra Cristea, Kwon-Sik Park, Julien Sage and Pina M. Cardarelli

Clin Cancer Res October 15 2018 24 (20) 5178-5189; DOI:10.1158/1078-0432.CCR-18-0018

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Highlights

CCR Translations

Statistics in CCR

Review

Clinical Trial Brief Report

Clinical Trials: Targeted Therapy

Precision Medicine and Imaging

Translational Cancer Mechanisms and Therapy

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