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Clinical Cancer Research

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Table of Contents

Highlights

  • Highlights
    Highlights of This Issue
    Clin Cancer Res October 15 2018 24 (20) 4913-4913;

CCR Translations

  • CCR Translations
    Bigger Is Not Always Better: Tumor Size and Prognosis in Advanced Melanoma
    Allison Betof Warner and Michael A. Postow
    Clin Cancer Res October 15 2018 24 (20) 4915-4917; DOI:10.1158/1078-0432.CCR-18-1311

  • CCR Translations
    Advantages and Adversities of the Weighted Toxicity Score
    Ulka Vaishampayan
    Clin Cancer Res October 15 2018 24 (20) 4918-4920; DOI:10.1158/1078-0432.CCR-18-1562

Statistics in CCR

  • Statistics in CCR
    Time-to-Event Bayesian Optimal Interval Design to Accelerate Phase I Trials
    Ying Yuan, Ruitao Lin, Daniel Li, Lei Nie and Katherine E. Warren
    Clin Cancer Res October 15 2018 24 (20) 4921-4930; DOI:10.1158/1078-0432.CCR-18-0246

Review

  • Review
    Targeting the IDH2 Pathway in Acute Myeloid Leukemia
    Maria L. Amaya and Daniel A. Pollyea
    Clin Cancer Res October 15 2018 24 (20) 4931-4936; DOI:10.1158/1078-0432.CCR-18-0536

Clinical Trial Brief Report

  • Clinical Trial Brief Report
    Therapeutic Immune Modulation against Solid Cancers with Intratumoral Poly-ICLC: A Pilot Trial
    Chrisann Kyi, Vladimir Roudko, Rachel Sabado, Yvonne Saenger, William Loging, John Mandeli, Tin Htwe Thin, Deborah Lehrer, Michael Donovan, Marshall Posner, Krzysztof Misiukiewicz, Benjamin Greenbaum, Andres Salazar, Philip Friedlander and Nina Bhardwaj
    Clin Cancer Res October 15 2018 24 (20) 4937-4948; DOI:10.1158/1078-0432.CCR-17-1866

Clinical Trials: Targeted Therapy

  • Clinical Trials: Targeted Therapy
    Final Report of a Phase I Trial of Olaparib with Cetuximab and Radiation for Heavy Smoker Patients with Locally Advanced Head and Neck Cancer
    Sana D. Karam, Krishna Reddy, Patrick J. Blatchford, Tim Waxweiler, Alicia M. DeLouize, Ayman Oweida, Hilary Somerset, Carrie Marshall, Christian Young, Kurtis D. Davies, Madeleine Kane, Aik Choo Tan, Xiao Jing Wang, Antonio Jimeno, Dara L. Aisner, Daniel W. Bowles and David Raben
    Clin Cancer Res October 15 2018 24 (20) 4949-4959; DOI:10.1158/1078-0432.CCR-18-0467

Precision Medicine and Imaging

  • Precision Medicine and Imaging | AuthorChoice
    Baseline Tumor Size Is an Independent Prognostic Factor for Overall Survival in Patients with Melanoma Treated with Pembrolizumab
    Richard W. Joseph, Jeroen Elassaiss-Schaap, Richard Kefford, Wen-Jen Hwu, Jedd D. Wolchok, Anthony M. Joshua, Antoni Ribas, F. Stephen Hodi, Omid Hamid, Caroline Robert, Adil Daud, Roxana Dronca, Peter Hersey, Jeffrey S. Weber, Amita Patnaik, Dinesh P. de Alwis, Andrea Perrone, Jin Zhang, S. Peter Kang, Scot Ebbinghaus, Keaven M. Anderson and Tara C. Gangadhar
    Clin Cancer Res October 15 2018 24 (20) 4960-4967; DOI:10.1158/1078-0432.CCR-17-2386

  • Precision Medicine and Imaging
    A Method to Summarize Toxicity in Cancer Randomized Clinical Trials
    Mariana Carbini, Mayte Suárez-Fariñas and Robert G. Maki
    Clin Cancer Res October 15 2018 24 (20) 4968-4975; DOI:10.1158/1078-0432.CCR-17-3314

  • Precision Medicine and Imaging
    CD8+ T-Cell Density Imaging with 64Cu-Labeled Cys-Diabody Informs Immunotherapy Protocols
    Jai Woong Seo, Richard Tavaré, Lisa M. Mahakian, Matthew T. Silvestrini, Sarah Tam, Elizabeth S. Ingham, Felix B. Salazar, Alexander D. Borowsky, Anna M. Wu and Katherine W. Ferrara
    Clin Cancer Res October 15 2018 24 (20) 4976-4987; DOI:10.1158/1078-0432.CCR-18-0261

  • Precision Medicine and Imaging
    Molecular Imaging of Radiolabeled Bispecific T-Cell Engager 89Zr-AMG211 Targeting CEA-Positive Tumors
    Stijn J.H. Waaijer, Frank J. Warnders, Sabine Stienen, Matthias Friedrich, Alexander Sternjak, H. Kam Cheung, Anton G.T. Terwisscha van Scheltinga, Carolien P. Schröder, Elisabeth G.E. de Vries and Marjolijn N. Lub-de Hooge
    Clin Cancer Res October 15 2018 24 (20) 4988-4996; DOI:10.1158/1078-0432.CCR-18-0786

  • Precision Medicine and Imaging
    Dynamics of Genome Alterations in Crohn's Disease–Associated Colorectal Carcinogenesis
    Daniela Hirsch, Darawalee Wangsa, Yuelin J. Zhu, Yue Hu, Daniel C. Edelman, Paul S. Meltzer, Kerstin Heselmeyer-Haddad, Claudia Ott, Peter Kienle, Christian Galata, Karoline Horisberger, Thomas Ried and Timo Gaiser
    Clin Cancer Res October 15 2018 24 (20) 4997-5011; DOI:10.1158/1078-0432.CCR-18-0630

  • Precision Medicine and Imaging
    Disparities in Neurotoxicity Risk and Outcomes among Pediatric Acute Lymphoblastic Leukemia Patients
    Olga A. Taylor, Austin L. Brown, Julienne Brackett, ZoAnn E. Dreyer, Ida Ki Moore, Pauline Mitby, Mary C. Hooke, Marilyn J. Hockenberry, Philip J. Lupo and Michael E. Scheurer
    Clin Cancer Res October 15 2018 24 (20) 5012-5017; DOI:10.1158/1078-0432.CCR-18-0939

  • Precision Medicine and Imaging
    Molecular Profiling of Patients with Pancreatic Cancer: Initial Results from the Know Your Tumor Initiative
    Michael J. Pishvaian, Robert J. Bender, David Halverson, Lola Rahib, Andrew E. Hendifar, Sameh Mikhail, Vincent Chung, Vincent J. Picozzi, Davendra Sohal, Edik M. Blais, Kimberly Mason, Emily E. Lyons, Lynn M. Matrisian, Jonathan R. Brody, Subha Madhavan and Emanuel F. Petricoin III
    Clin Cancer Res October 15 2018 24 (20) 5018-5027; DOI:10.1158/1078-0432.CCR-18-0531

  • Precision Medicine and Imaging
    Skeletal Muscle Loss Is an Imaging Biomarker of Outcome after Definitive Chemoradiotherapy for Locally Advanced Cervical Cancer
    Jie Lee, Chih-Long Chang, Jhen-Bin Lin, Meng-Hao Wu, Fang-Ju Sun, Ya-Ting Jan, Shih-Ming Hsu and Yu-Jen Chen
    Clin Cancer Res October 15 2018 24 (20) 5028-5036; DOI:10.1158/1078-0432.CCR-18-0788

  • Precision Medicine and Imaging
    Consensus on Molecular Subtypes of High-Grade Serous Ovarian Carcinoma
    Gregory M. Chen, Lavanya Kannan, Ludwig Geistlinger, Victor Kofia, Zhaleh Safikhani, Deena M.A. Gendoo, Giovanni Parmigiani, Michael Birrer, Benjamin Haibe-Kains and Levi Waldron
    Clin Cancer Res October 15 2018 24 (20) 5037-5047; DOI:10.1158/1078-0432.CCR-18-0784

  • Precision Medicine and Imaging
    The Light Chain IgLV3-21 Defines a New Poor Prognostic Subgroup in Chronic Lymphocytic Leukemia: Results of a Multicenter Study
    Basile Stamatopoulos, Thomas Smith, Emerence Crompot, Karlien Pieters, Ruth Clifford, Marek Mraz, Pauline Robbe, Adam Burns, Adele Timbs, David Bruce, Peter Hillmen, Nathalie Meuleman, Philippe Mineur, Radu Firescu, Marie Maerevoet, Virginie De Wilde, André Efira, Jan Philippé, Bruno Verhasselt, Fritz Offner, David Sims, Andreas Heger, Hélène Dreau and Anna Schuh
    Clin Cancer Res October 15 2018 24 (20) 5048-5057; DOI:10.1158/1078-0432.CCR-18-0133

Translational Cancer Mechanisms and Therapy

  • Translational Cancer Mechanisms and Therapy
    Elective Nodal Irradiation Attenuates the Combinatorial Efficacy of Stereotactic Radiation Therapy and Immunotherapy
    Ariel E. Marciscano, Ali Ghasemzadeh, Thomas R. Nirschl, Debebe Theodros, Christina M. Kochel, Brian J. Francica, Yuki Muroyama, Robert A. Anders, Andrew B. Sharabi, Esteban Velarde, Wendy Mao, Kunal R. Chaudhary, Matthew G. Chaimowitz, John Wong, Mark J. Selby, Kent B. Thudium, Alan J. Korman, David Ulmert, Daniel L.J. Thorek, Theodore L. DeWeese and Charles G. Drake
    Clin Cancer Res October 15 2018 24 (20) 5058-5071; DOI:10.1158/1078-0432.CCR-17-3427

  • Translational Cancer Mechanisms and Therapy
    Paclitaxel Sensitivity of Ovarian Cancer Can be Enhanced by Knocking Down Pairs of Kinases that Regulate MAP4 Phosphorylation and Microtubule Stability
    Hailing Yang, Weiqun Mao, Cristian Rodriguez-Aguayo, Lingegowda S. Mangala, Geoffrey Bartholomeusz, Lakesla R. Iles, Nicholas B. Jennings, Ahmed Ashour Ahmed, Anil K. Sood, Gabriel Lopez-Berestein, Zhen Lu and Robert C. Bast Jr.
    Clin Cancer Res October 15 2018 24 (20) 5072-5084; DOI:10.1158/1078-0432.CCR-18-0504

  • Translational Cancer Mechanisms and Therapy
    Mast Cell Activation and KSHV Infection in Kaposi Sarcoma
    Leona W. Ayers, Arturo Barbachano-Guerrero, Shane C. McAllister, Julie A. Ritchie, Elizabeth Asiago-Reddy, Linda C. Bartlett, Ethel Cesarman, Dongliang Wang, Rosemary Rochford, Jeffrey N. Martin and Christine A. King
    Clin Cancer Res October 15 2018 24 (20) 5085-5097; DOI:10.1158/1078-0432.CCR-18-0873

  • Translational Cancer Mechanisms and Therapy | AuthorChoice
    Anti-Folate Receptor Alpha–Directed Antibody Therapies Restrict the Growth of Triple-negative Breast Cancer
    Anthony Cheung, James Opzoomer, Kristina M. Ilieva, Patrycja Gazinska, Ricarda M. Hoffmann, Hasan Mirza, Rebecca Marlow, Erika Francesch-Domenech, Matthew Fittall, Diana Dominguez Rodriguez, Angela Clifford, Luned Badder, Nirmesh Patel, Silvia Mele, Giulia Pellizzari, Heather J. Bax, Silvia Crescioli, Gyula Petranyi, Daniel Larcombe-Young, Debra H. Josephs, Silvana Canevari, Mariangela Figini, Sarah Pinder, Frank O. Nestle, Cheryl Gillett, James F. Spicer, Anita Grigoriadis, Andrew N.J. Tutt and Sophia N. Karagiannis
    Clin Cancer Res October 15 2018 24 (20) 5098-5111; DOI:10.1158/1078-0432.CCR-18-0652

  • Translational Cancer Mechanisms and Therapy | AuthorChoice
    High-Throughput Functional Evaluation of Variants of Unknown Significance in ERBB2
    Masaaki Nagano, Shinji Kohsaka, Toshihide Ueno, Shinya Kojima, Kanju Saka, Hirotaro Iwase, Masahito Kawazu and Hiroyuki Mano
    Clin Cancer Res October 15 2018 24 (20) 5112-5122; DOI:10.1158/1078-0432.CCR-18-0991

  • Translational Cancer Mechanisms and Therapy | AuthorChoice
    Characterization of Alternative Splicing Events in HPV-Negative Head and Neck Squamous Cell Carcinoma Identifies an Oncogenic DOCK5 Variant
    Chao Liu, Theresa Guo, Guorong Xu, Akihiro Sakai, Shuling Ren, Takahito Fukusumi, Mizuo Ando, Sayed Sadat, Yuki Saito, Zubair Khan, Kathleen M. Fisch and Joseph Califano
    Clin Cancer Res October 15 2018 24 (20) 5123-5132; DOI:10.1158/1078-0432.CCR-18-0752

  • Translational Cancer Mechanisms and Therapy | AuthorChoice
    Mutational Analysis Identifies Therapeutic Biomarkers in Inflammatory Bowel Disease–Associated Colorectal Cancers
    Shahida Din, Kim Wong, Mike F. Mueller, Anca Oniscu, James Hewinson, Catherine J. Black, Martin L. Miller, Alejandro Jiménez-Sánchez, Roy Rabbie, Mamunar Rashid, Jack Satsangi, David J. Adams and Mark J. Arends
    Clin Cancer Res October 15 2018 24 (20) 5133-5142; DOI:10.1158/1078-0432.CCR-17-3713

  • Translational Cancer Mechanisms and Therapy
    Talazoparib Is a Potent Radiosensitizer in Small Cell Lung Cancer Cell Lines and Xenografts
    James H. Laird, Benjamin H. Lok, Jennifer Ma, Andrew Bell, Elisa de Stanchina, John T. Poirier and Charles M. Rudin
    Clin Cancer Res October 15 2018 24 (20) 5143-5152; DOI:10.1158/1078-0432.CCR-18-0401

  • Translational Cancer Mechanisms and Therapy
    The Combination of the PARP Inhibitor Olaparib and the WEE1 Inhibitor AZD1775 as a New Therapeutic Option for Small Cell Lung Cancer
    Alice Lallo, Kristopher K. Frese, Christopher J. Morrow, Robert Sloane, Sakshi Gulati, Maximillian W. Schenk, Francesca Trapani, Nicole Simms, Melanie Galvin, Stewart Brown, Cassandra L. Hodgkinson, Lynsey Priest, Adina Hughes, Zhongwu Lai, Elaine Cadogan, Garima Khandelwal, Kathryn L. Simpson, Crispin Miller, Fiona Blackhall, Mark J. O'Connor and Caroline Dive
    Clin Cancer Res October 15 2018 24 (20) 5153-5164; DOI:10.1158/1078-0432.CCR-17-2805

  • Translational Cancer Mechanisms and Therapy
    Loss of E-cadherin Enhances IGF1–IGF1R Pathway Activation and Sensitizes Breast Cancers to Anti-IGF1R/InsR Inhibitors
    Alison M. Nagle, Kevin M. Levine, Nilgun Tasdemir, Julie A. Scott, Kara Burlbaugh, Justin Kehm, Tiffany A. Katz, David N. Boone, Britta M. Jacobsen, Jennifer M. Atkinson, Steffi Oesterreich and Adrian V. Lee
    Clin Cancer Res October 15 2018 24 (20) 5165-5177; DOI:10.1158/1078-0432.CCR-18-0279

  • Translational Cancer Mechanisms and Therapy
    A Novel, Fully Human Anti–fucosyl-GM1 Antibody Demonstrates Potent In Vitro and In Vivo Antitumor Activity in Preclinical Models of Small Cell Lung Cancer
    Paul Ponath, Daniel Menezes, Chin Pan, Bing Chen, Miho Oyasu, Debbie Strachan, Heidi LeBlanc, Huadong Sun, Xi-Tao Wang, Vangipuram S. Rangan, Shrikant Deshpande, Sandra Cristea, Kwon-Sik Park, Julien Sage and Pina M. Cardarelli
    Clin Cancer Res October 15 2018 24 (20) 5178-5189; DOI:10.1158/1078-0432.CCR-18-0018

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Clinical Cancer Research: 24 (20)
October 2018
Volume 24, Issue 20
  • Table of Contents
  • Table of Contents (PDF)
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Issue Highlights

  • Mast Cell Activation and KSHV Infection in Kaposi Sarcoma
  • Dynamics of Genome Alterations in Crohn's Disease–Associated Colorectal Carcinogenesis
  • High-Throughput Functional Evaluation of Variants of Unknown Significance in ERBB2
  • Anti-Folate Receptor Alpha–Directed Antibody Therapies Restrict the Growth of Triple-negative Breast Cancer

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Clinical Cancer Research
eISSN: 1557-3265
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