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Clinical Cancer Research
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Cancer Therapy: Preclinical

Epigenetic Reprogramming Strategies to Reverse Global Loss of 5-Hydroxymethylcytosine, a Prognostic Factor for Poor Survival in High-grade Serous Ovarian Cancer

Douglass W. Tucker, Christopher R. Getchell, Eric T. McCarthy, Anders W. Ohman, Naoko Sasamoto, Shuyun Xu, Joo Yeon Ko, Mamta Gupta, Amy Shafrir, Jamie E. Medina, Jonathan J. Lee, Lauren A. MacDonald, Ammara Malik, Kathleen T Hasselblatt, Wenjing Li, Hong Zhang, Samuel J. Kaplan, George F. Murphy, Michelle S. Hirsch, Joyce F. Liu, Ursula A. Matulonis, Kathryn L. Terry, Christine G. Lian and Daniela M. Dinulescu
Douglass W. Tucker
1Department of Pathology, Division of Women's and Perinatal Pathology, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts.
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Christopher R. Getchell
1Department of Pathology, Division of Women's and Perinatal Pathology, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts.
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Eric T. McCarthy
1Department of Pathology, Division of Women's and Perinatal Pathology, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts.
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Anders W. Ohman
1Department of Pathology, Division of Women's and Perinatal Pathology, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts.
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Naoko Sasamoto
2Epidemiology Center, Department of Obstetrics, Gynecology, and Reproductive Biology, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts.
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Shuyun Xu
3Department of Pathology, Division of Dermatopathology, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts.
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Joo Yeon Ko
4Department of Dermatology, Hanyang University College of Medicine, Seoul, Korea.
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Mamta Gupta
2Epidemiology Center, Department of Obstetrics, Gynecology, and Reproductive Biology, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts.
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Amy Shafrir
2Epidemiology Center, Department of Obstetrics, Gynecology, and Reproductive Biology, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts.
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Jamie E. Medina
1Department of Pathology, Division of Women's and Perinatal Pathology, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts.
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Jonathan J. Lee
3Department of Pathology, Division of Dermatopathology, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts.
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Lauren A. MacDonald
5Department of Medical Oncology, Dana-Farber Cancer Institute (DFCI), Boston, Massachusetts.
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Ammara Malik
5Department of Medical Oncology, Dana-Farber Cancer Institute (DFCI), Boston, Massachusetts.
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Kathleen T Hasselblatt
6Gynecologic Oncology Laboratory, Department of Obstetrics, Gynecology, and Reproductive Biology, Brigham and Women's Hospital, Boston, Massachusetts.
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Wenjing Li
7Department of Medicine, Division of Endocrinology, Brigham and Women's Hospital, Harvard Medical School Boston, Massachusetts.
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Hong Zhang
1Department of Pathology, Division of Women's and Perinatal Pathology, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts.
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Samuel J. Kaplan
1Department of Pathology, Division of Women's and Perinatal Pathology, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts.
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George F. Murphy
3Department of Pathology, Division of Dermatopathology, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts.
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Michelle S. Hirsch
1Department of Pathology, Division of Women's and Perinatal Pathology, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts.
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Joyce F. Liu
5Department of Medical Oncology, Dana-Farber Cancer Institute (DFCI), Boston, Massachusetts.
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Ursula A. Matulonis
5Department of Medical Oncology, Dana-Farber Cancer Institute (DFCI), Boston, Massachusetts.
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Kathryn L. Terry
2Epidemiology Center, Department of Obstetrics, Gynecology, and Reproductive Biology, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts.
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  • For correspondence: ddinulescu@bwh.harvard.edu cglian@bwh.harvard.edu kterry@bwh.harvard.edu
Christine G. Lian
3Department of Pathology, Division of Dermatopathology, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts.
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  • For correspondence: ddinulescu@bwh.harvard.edu cglian@bwh.harvard.edu kterry@bwh.harvard.edu
Daniela M. Dinulescu
1Department of Pathology, Division of Women's and Perinatal Pathology, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts.
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  • For correspondence: ddinulescu@bwh.harvard.edu cglian@bwh.harvard.edu kterry@bwh.harvard.edu
DOI: 10.1158/1078-0432.CCR-17-1958 Published March 2018
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Article Information

Volume 24, Issue 6, pp. 1389-1401

DOI 
https://doi.org/10.1158/1078-0432.CCR-17-1958
PubMed 
29263182

Published By 
American Association for Cancer Research
Print ISSN 
1078-0432
Online ISSN 
1557-3265
History 
  • Received July 10, 2017
  • Revision received October 11, 2017
  • Accepted December 14, 2017
  • Published first December 20, 2017.

Article Versions

  • Previous version (December 20, 2017 - 06:53).
  • Previous version (February 13, 2018 - 07:53).
  • You are viewing the most recent version of this article.
Copyright & Usage 
©2017 American Association for Cancer Research.

Author Information

  1. Douglass W. Tucker1,
  2. Christopher R. Getchell1,
  3. Eric T. McCarthy1,
  4. Anders W. Ohman1,
  5. Naoko Sasamoto2,
  6. Shuyun Xu3,
  7. Joo Yeon Ko4,
  8. Mamta Gupta2,
  9. Amy Shafrir2,
  10. Jamie E. Medina1,
  11. Jonathan J. Lee3,
  12. Lauren A. MacDonald5,
  13. Ammara Malik5,
  14. Kathleen T Hasselblatt6,
  15. Wenjing Li7,
  16. Hong Zhang1,
  17. Samuel J. Kaplan1,
  18. George F. Murphy3,
  19. Michelle S. Hirsch1,
  20. Joyce F. Liu5,
  21. Ursula A. Matulonis5,
  22. Kathryn L. Terry2,*,
  23. Christine G. Lian3,*, and
  24. Daniela M. Dinulescu1,*
  1. 1Department of Pathology, Division of Women's and Perinatal Pathology, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts.
  2. 2Epidemiology Center, Department of Obstetrics, Gynecology, and Reproductive Biology, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts.
  3. 3Department of Pathology, Division of Dermatopathology, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts.
  4. 4Department of Dermatology, Hanyang University College of Medicine, Seoul, Korea.
  5. 5Department of Medical Oncology, Dana-Farber Cancer Institute (DFCI), Boston, Massachusetts.
  6. 6Gynecologic Oncology Laboratory, Department of Obstetrics, Gynecology, and Reproductive Biology, Brigham and Women's Hospital, Boston, Massachusetts.
  7. 7Department of Medicine, Division of Endocrinology, Brigham and Women's Hospital, Harvard Medical School Boston, Massachusetts.
  1. ↵*Corresponding Authors:
    Daniela M. Dinulescu, Brigham and Women's Hospital, Harvard Medical School, 221 Longwood Ave. EBRC 401A, Boston, MA 02115. Phone: 617-732-5318; Fax: 617-264-5149; E-mail: ddinulescu{at}bwh.harvard.edu; Christine G. Lian, cglian{at}bwh.harvard.edu; and Kathryn L. Terry, kterry{at}bwh.harvard.edu
  1. C.R. Getchell and E.T. McCarthy contributed equally to this article.

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Clinical Cancer Research: 24 (6)
March 2018
Volume 24, Issue 6
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Epigenetic Reprogramming Strategies to Reverse Global Loss of 5-Hydroxymethylcytosine, a Prognostic Factor for Poor Survival in High-grade Serous Ovarian Cancer
Douglass W. Tucker, Christopher R. Getchell, Eric T. McCarthy, Anders W. Ohman, Naoko Sasamoto, Shuyun Xu, Joo Yeon Ko, Mamta Gupta, Amy Shafrir, Jamie E. Medina, Jonathan J. Lee, Lauren A. MacDonald, Ammara Malik, Kathleen T Hasselblatt, Wenjing Li, Hong Zhang, Samuel J. Kaplan, George F. Murphy, Michelle S. Hirsch, Joyce F. Liu, Ursula A. Matulonis, Kathryn L. Terry, Christine G. Lian and Daniela M. Dinulescu
Clin Cancer Res March 15 2018 (24) (6) 1389-1401; DOI: 10.1158/1078-0432.CCR-17-1958

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Epigenetic Reprogramming Strategies to Reverse Global Loss of 5-Hydroxymethylcytosine, a Prognostic Factor for Poor Survival in High-grade Serous Ovarian Cancer
Douglass W. Tucker, Christopher R. Getchell, Eric T. McCarthy, Anders W. Ohman, Naoko Sasamoto, Shuyun Xu, Joo Yeon Ko, Mamta Gupta, Amy Shafrir, Jamie E. Medina, Jonathan J. Lee, Lauren A. MacDonald, Ammara Malik, Kathleen T Hasselblatt, Wenjing Li, Hong Zhang, Samuel J. Kaplan, George F. Murphy, Michelle S. Hirsch, Joyce F. Liu, Ursula A. Matulonis, Kathryn L. Terry, Christine G. Lian and Daniela M. Dinulescu
Clin Cancer Res March 15 2018 (24) (6) 1389-1401; DOI: 10.1158/1078-0432.CCR-17-1958
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