Skip to main content
  • AACR Publications
    • Blood Cancer Discovery
    • Cancer Discovery
    • Cancer Epidemiology, Biomarkers & Prevention
    • Cancer Immunology Research
    • Cancer Prevention Research
    • Cancer Research
    • Clinical Cancer Research
    • Molecular Cancer Research
    • Molecular Cancer Therapeutics

AACR logo

  • Register
  • Log in
  • My Cart
Advertisement

Main menu

  • Home
  • About
    • The Journal
    • AACR Journals
    • Subscriptions
    • Permissions and Reprints
  • Articles
    • OnlineFirst
    • Current Issue
    • Past Issues
    • CCR Focus Archive
    • Meeting Abstracts
    • Collections
      • COVID-19 & Cancer Resource Center
      • Breast Cancer
      • Clinical Trials
      • Immunotherapy: Facts and Hopes
      • Editors' Picks
      • "Best of" Collection
  • For Authors
    • Information for Authors
    • Author Services
    • Best of: Author Profiles
    • Submit
  • Alerts
    • Table of Contents
    • Editors' Picks
    • OnlineFirst
    • Citation
    • Author/Keyword
    • RSS Feeds
    • My Alert Summary & Preferences
  • News
    • Cancer Discovery News
  • COVID-19
  • Webinars
  • Search More

    Advanced Search

  • AACR Publications
    • Blood Cancer Discovery
    • Cancer Discovery
    • Cancer Epidemiology, Biomarkers & Prevention
    • Cancer Immunology Research
    • Cancer Prevention Research
    • Cancer Research
    • Clinical Cancer Research
    • Molecular Cancer Research
    • Molecular Cancer Therapeutics

User menu

  • Register
  • Log in
  • My Cart

Search

  • Advanced search
Clinical Cancer Research
Clinical Cancer Research
  • Home
  • About
    • The Journal
    • AACR Journals
    • Subscriptions
    • Permissions and Reprints
  • Articles
    • OnlineFirst
    • Current Issue
    • Past Issues
    • CCR Focus Archive
    • Meeting Abstracts
    • Collections
      • COVID-19 & Cancer Resource Center
      • Breast Cancer
      • Clinical Trials
      • Immunotherapy: Facts and Hopes
      • Editors' Picks
      • "Best of" Collection
  • For Authors
    • Information for Authors
    • Author Services
    • Best of: Author Profiles
    • Submit
  • Alerts
    • Table of Contents
    • Editors' Picks
    • OnlineFirst
    • Citation
    • Author/Keyword
    • RSS Feeds
    • My Alert Summary & Preferences
  • News
    • Cancer Discovery News
  • COVID-19
  • Webinars
  • Search More

    Advanced Search

Cancer Therapy: Preclinical

Administration of Hypoxia-Activated Prodrug Evofosfamide after Conventional Adjuvant Therapy Enhances Therapeutic Outcome and Targets Cancer-Initiating Cells in Preclinical Models of Colorectal Cancer

Jennifer Haynes, Trevor D. McKee, Andrew Haller, Yadong Wang, Cherry Leung, Deena M.A. Gendoo, Evelyne Lima-Fernandes, Antonija Kreso, Robin Wolman, Eva Szentgyorgyi, Douglass C. Vines, Benjamin Haibe-Kains, Bradly G. Wouters, Ur Metser, David A. Jaffray, Myles Smith and Catherine A. O'Brien
Jennifer Haynes
1Princess Margaret Cancer Centre, University Health Network, Toronto, Ontario, Canada.
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Trevor D. McKee
1Princess Margaret Cancer Centre, University Health Network, Toronto, Ontario, Canada.
2STTARR Innovation Centre, University Health Network, Toronto, Ontario, Canada.
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Andrew Haller
1Princess Margaret Cancer Centre, University Health Network, Toronto, Ontario, Canada.
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Yadong Wang
1Princess Margaret Cancer Centre, University Health Network, Toronto, Ontario, Canada.
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Cherry Leung
1Princess Margaret Cancer Centre, University Health Network, Toronto, Ontario, Canada.
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Deena M.A. Gendoo
1Princess Margaret Cancer Centre, University Health Network, Toronto, Ontario, Canada.
3Department of Medical Biophysics, University of Toronto, Toronto, Ontario, Canada.
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Evelyne Lima-Fernandes
4Structural Genomics Consortium, Toronto, Ontario, Canada.
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Antonija Kreso
1Princess Margaret Cancer Centre, University Health Network, Toronto, Ontario, Canada.
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Robin Wolman
1Princess Margaret Cancer Centre, University Health Network, Toronto, Ontario, Canada.
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Eva Szentgyorgyi
5Department of Pathology, University Health Network, Toronto, Ontario, Canada.
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Douglass C. Vines
1Princess Margaret Cancer Centre, University Health Network, Toronto, Ontario, Canada.
2STTARR Innovation Centre, University Health Network, Toronto, Ontario, Canada.
6Department of Radiation Oncology, University of Toronto, Toronto, Ontario, Canada.
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Benjamin Haibe-Kains
1Princess Margaret Cancer Centre, University Health Network, Toronto, Ontario, Canada.
3Department of Medical Biophysics, University of Toronto, Toronto, Ontario, Canada.
7Department of Computer Science, University of Toronto, Toronto, Ontario, Canada.
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Bradly G. Wouters
1Princess Margaret Cancer Centre, University Health Network, Toronto, Ontario, Canada.
3Department of Medical Biophysics, University of Toronto, Toronto, Ontario, Canada.
6Department of Radiation Oncology, University of Toronto, Toronto, Ontario, Canada.
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Ur Metser
1Princess Margaret Cancer Centre, University Health Network, Toronto, Ontario, Canada.
8Department of Medical Imaging, University of Toronto, Toronto, Ontario, Canada.
9Techna Institute for the Advancement of Technology for Health, University Health Network, Toronto, Ontario, Canada.
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
David A. Jaffray
1Princess Margaret Cancer Centre, University Health Network, Toronto, Ontario, Canada.
2STTARR Innovation Centre, University Health Network, Toronto, Ontario, Canada.
3Department of Medical Biophysics, University of Toronto, Toronto, Ontario, Canada.
6Department of Radiation Oncology, University of Toronto, Toronto, Ontario, Canada.
9Techna Institute for the Advancement of Technology for Health, University Health Network, Toronto, Ontario, Canada.
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Myles Smith
10Department of Surgery, The Royal Marsden Hospital and Institute of Cancer Research, London, United Kingdom.
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Catherine A. O'Brien
1Princess Margaret Cancer Centre, University Health Network, Toronto, Ontario, Canada.
11Department of Laboratory Medicine and Pathobiology, University of Toronto, Toronto, Ontario, Canada.
12Department of Physiology, University of Toronto, Toronto, Ontario, Canada.
13Department of Surgery, University Health Network, Toronto, Ontario, Canada.
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
  • For correspondence: Catherine.OBrien@uhnresearch.ca
DOI: 10.1158/1078-0432.CCR-17-1715 Published May 2018
  • Article
  • Figures & Data
  • Info & Metrics
  • PDF
Loading

Online Impact

Statistics from Altmetric.com

ARTICLE USAGE

ARTICLE USAGE: February 2018 to April 2021

AbstractFull-text HTMLPDF
Total525617631450

Cited By

Article Information

Volume 24, Issue 9, pp. 2116-2127

DOI 
https://doi.org/10.1158/1078-0432.CCR-17-1715
PubMed 
29476017

Published By 
American Association for Cancer Research
Print ISSN 
1078-0432
Online ISSN 
1557-3265
History 
  • Received June 16, 2017
  • Revision received December 21, 2017
  • Accepted February 19, 2018
  • Published first February 23, 2018.

Article Versions

  • Previous version (February 23, 2018 - 06:54).
  • Previous version (March 27, 2018 - 08:40).
  • Previous version (April 5, 2018 - 11:04).
  • You are viewing the most recent version of this article.
Copyright & Usage 
©2018 American Association for Cancer Research.

Author Information

  1. Jennifer Haynes1,
  2. Trevor D. McKee1,2,
  3. Andrew Haller1,
  4. Yadong Wang1,
  5. Cherry Leung1,
  6. Deena M.A. Gendoo1,3,
  7. Evelyne Lima-Fernandes4,
  8. Antonija Kreso1,
  9. Robin Wolman1,
  10. Eva Szentgyorgyi5,
  11. Douglass C. Vines1,2,6,
  12. Benjamin Haibe-Kains1,3,7,
  13. Bradly G. Wouters1,3,6,
  14. Ur Metser1,8,9,
  15. David A. Jaffray1,2,3,6,9,
  16. Myles Smith10, and
  17. Catherine A. O'Brien1,11,12,13,*
  1. 1Princess Margaret Cancer Centre, University Health Network, Toronto, Ontario, Canada.
  2. 2STTARR Innovation Centre, University Health Network, Toronto, Ontario, Canada.
  3. 3Department of Medical Biophysics, University of Toronto, Toronto, Ontario, Canada.
  4. 4Structural Genomics Consortium, Toronto, Ontario, Canada.
  5. 5Department of Pathology, University Health Network, Toronto, Ontario, Canada.
  6. 6Department of Radiation Oncology, University of Toronto, Toronto, Ontario, Canada.
  7. 7Department of Computer Science, University of Toronto, Toronto, Ontario, Canada.
  8. 8Department of Medical Imaging, University of Toronto, Toronto, Ontario, Canada.
  9. 9Techna Institute for the Advancement of Technology for Health, University Health Network, Toronto, Ontario, Canada.
  10. 10Department of Surgery, The Royal Marsden Hospital and Institute of Cancer Research, London, United Kingdom.
  11. 11Department of Laboratory Medicine and Pathobiology, University of Toronto, Toronto, Ontario, Canada.
  12. 12Department of Physiology, University of Toronto, Toronto, Ontario, Canada.
  13. 13Department of Surgery, University Health Network, Toronto, Ontario, Canada.
  1. ↵*Corresponding Author:
    Catherine A. O'Brien, Princess Margaret Cancer Research Tower, 101 College St, Room 13-704, Toronto, ON M5G 1L7, Canada. Phone: 416-581-7537; Fax: 416-340-3808; E-mail: Catherine.OBrien{at}uhnresearch.ca
View Full Text
PreviousNext
Back to top
Clinical Cancer Research: 24 (9)
May 2018
Volume 24, Issue 9
  • Table of Contents
  • Table of Contents (PDF)
  • About the Cover
  • Editorial Board (PDF)

Sign up for alerts

View this article with LENS

Open full page PDF
Article Alerts
Sign In to Email Alerts with your Email Address
Email Article

Thank you for sharing this Clinical Cancer Research article.

NOTE: We request your email address only to inform the recipient that it was you who recommended this article, and that it is not junk mail. We do not retain these email addresses.

Enter multiple addresses on separate lines or separate them with commas.
Administration of Hypoxia-Activated Prodrug Evofosfamide after Conventional Adjuvant Therapy Enhances Therapeutic Outcome and Targets Cancer-Initiating Cells in Preclinical Models of Colorectal Cancer
(Your Name) has forwarded a page to you from Clinical Cancer Research
(Your Name) thought you would be interested in this article in Clinical Cancer Research.
CAPTCHA
This question is for testing whether or not you are a human visitor and to prevent automated spam submissions.
Citation Tools
Administration of Hypoxia-Activated Prodrug Evofosfamide after Conventional Adjuvant Therapy Enhances Therapeutic Outcome and Targets Cancer-Initiating Cells in Preclinical Models of Colorectal Cancer
Jennifer Haynes, Trevor D. McKee, Andrew Haller, Yadong Wang, Cherry Leung, Deena M.A. Gendoo, Evelyne Lima-Fernandes, Antonija Kreso, Robin Wolman, Eva Szentgyorgyi, Douglass C. Vines, Benjamin Haibe-Kains, Bradly G. Wouters, Ur Metser, David A. Jaffray, Myles Smith and Catherine A. O'Brien
Clin Cancer Res May 1 2018 (24) (9) 2116-2127; DOI: 10.1158/1078-0432.CCR-17-1715

Citation Manager Formats

  • BibTeX
  • Bookends
  • EasyBib
  • EndNote (tagged)
  • EndNote 8 (xml)
  • Medlars
  • Mendeley
  • Papers
  • RefWorks Tagged
  • Ref Manager
  • RIS
  • Zotero
Share
Administration of Hypoxia-Activated Prodrug Evofosfamide after Conventional Adjuvant Therapy Enhances Therapeutic Outcome and Targets Cancer-Initiating Cells in Preclinical Models of Colorectal Cancer
Jennifer Haynes, Trevor D. McKee, Andrew Haller, Yadong Wang, Cherry Leung, Deena M.A. Gendoo, Evelyne Lima-Fernandes, Antonija Kreso, Robin Wolman, Eva Szentgyorgyi, Douglass C. Vines, Benjamin Haibe-Kains, Bradly G. Wouters, Ur Metser, David A. Jaffray, Myles Smith and Catherine A. O'Brien
Clin Cancer Res May 1 2018 (24) (9) 2116-2127; DOI: 10.1158/1078-0432.CCR-17-1715
del.icio.us logo Digg logo Reddit logo Twitter logo CiteULike logo Facebook logo Google logo Mendeley logo
  • Tweet Widget
  • Facebook Like
  • Google Plus One

Jump to section

  • Article
    • Abstract
    • Introduction
    • Materials and Methods
    • Results
    • Discussion
    • Disclosure of Potential Conflicts of Interest
    • Authors' Contributions
    • Acknowledgments
    • Footnotes
    • References
  • Figures & Data
  • Info & Metrics
  • PDF
Advertisement

Related Articles

Cited By...

More in this TOC Section

  • Radiotherapy with IDO1/PD-1 Blockade Treats Advanced GBM
  • Enhanced Delivery of SN38-TOA NPs in NBs
  • Toxicity and Efficacy of a GADD34-encoding Oncolytic HSV
Show more Cancer Therapy: Preclinical
  • Home
  • Alerts
  • Feedback
  • Privacy Policy
Facebook  Twitter  LinkedIn  YouTube  RSS

Articles

  • Online First
  • Current Issue
  • Past Issues
  • CCR Focus Archive
  • Meeting Abstracts

Info for

  • Authors
  • Subscribers
  • Advertisers
  • Librarians

About Clinical Cancer Research

  • About the Journal
  • Editorial Board
  • Permissions
  • Submit a Manuscript
AACR logo

Copyright © 2021 by the American Association for Cancer Research.

Clinical Cancer Research
eISSN: 1557-3265
ISSN: 1078-0432

Advertisement