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Clinical Cancer Research
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Table of Contents

Highlights

  • Highlights
    Highlights of This Issue
    Clin Cancer Res December 1 2019 25 (23) 6885-6885;

CCR Translations

  • CCR Translations
    Ushering in Liquid Biopsy for the Microsatellite Status: Advantages and Caveats
    Linghua Wang and Jaffer A. Ajani
    Clin Cancer Res December 1 2019 25 (23) 6887-6889; DOI:10.1158/1078-0432.CCR-19-2585

  • CCR Translations
    Today's Special on the Anticancer Menu: Immunomodulation by Antifolates
    Aitziber Buque, Lorenzo Galluzzi and Noelia Casares
    Clin Cancer Res December 1 2019 25 (23) 6890-6892; DOI:10.1158/1078-0432.CCR-19-2775

  • CCR Translations
    ctDNA in Gastric and Gastroesophageal Cancer: Prognostic, Predictive, or Preliminary?
    Alexander M. Frankell and Elizabeth C. Smyth
    Clin Cancer Res December 1 2019 25 (23) 6893-6895; DOI:10.1158/1078-0432.CCR-19-2774

  • CCR Translations
    Class(y) Dissection of BRAF Heterogeneity: Beyond Non-V600
    Elisa Fontana and Nicola Valeri
    Clin Cancer Res December 1 2019 25 (23) 6896-6898; DOI:10.1158/1078-0432.CCR-19-2732

Reviews

  • Reviews
    Mechanisms of Innate and Acquired Resistance to Anti-EGFR Therapy: A Review of Current Knowledge with a Focus on Rechallenge Therapies
    Christine M. Parseghian, Stefania Napolitano, Jonathan M. Loree and Scott Kopetz
    Clin Cancer Res December 1 2019 25 (23) 6899-6908; DOI:10.1158/1078-0432.CCR-19-0823

  • Reviews
    Use of Circulating Tumor DNA for Cancer Immunotherapy
    Alexandra Snyder, Michael P. Morrissey and Matthew D. Hellmann
    Clin Cancer Res December 1 2019 25 (23) 6909-6915; DOI:10.1158/1078-0432.CCR-18-2688

Perspectives

  • Perspectives
    The Role of Lineage Plasticity in Prostate Cancer Therapy Resistance
    Himisha Beltran, Andrew Hruszkewycz, Howard I. Scher, Jeffrey Hildesheim, Jennifer Isaacs, Evan Y. Yu, Kathleen Kelly, Daniel Lin, Adam Dicker, Julia Arnold, Toby Hecht, Max Wicha, Rosalie Sears, David Rowley, Richard White, James L. Gulley, John Lee, Maria Diaz Meco, Eric J. Small, Michael Shen, Karen Knudsen, David W. Goodrich, Tamara Lotan, Amina Zoubeidi, Charles L. Sawyers, Charles M. Rudin, Massimo Loda, Timothy Thompson, Mark A. Rubin, Abdul Tawab-Amiri, William Dahut and Peter S. Nelson
    Clin Cancer Res December 1 2019 25 (23) 6916-6924; DOI:10.1158/1078-0432.CCR-19-1423

  • Perspectives
    Transforming the Early Drug Development Paradigm at the National Cancer Institute: The Formation of NCI's Experimental Therapeutics Clinical Trials Network (ETCTN)
    Holly A. Massett, Grace Mishkin, Jeffrey A. Moscow, Amy Gravell, Michael Steketee, Martha Kruhm, Sae H. Han, Barbara Barry, Michael Montello, James Zwiebel, Jeffrey S. Abrams, James H. Doroshow and S. Percy Ivy
    Clin Cancer Res December 1 2019 25 (23) 6925-6931; DOI:10.1158/1078-0432.CCR-19-1754

Clinical Trial Brief Report

  • Clinical Trial Brief Report
    Phase I Study of a CD45-Targeted Antibody–Radionuclide Conjugate for High-Risk Lymphoma
    Ryan D. Cassaday, Oliver W. Press, John M. Pagel, Joseph G. Rajendran, Ted A. Gooley, Darrell R. Fisher, Leona A. Holmberg, Robert S. Miyaoka, Brenda M. Sandmaier, Damian J. Green and Ajay K. Gopal
    Clin Cancer Res December 1 2019 25 (23) 6932-6938; DOI:10.1158/1078-0432.CCR-19-1567

Clinical Trials: Targeted Therapy

  • Clinical Trials: Targeted Therapy
    Phase I Trial of Well-Differentiated Neuroendocrine Tumors (NETs) with Radiolabeled Somatostatin Antagonist 177Lu-Satoreotide Tetraxetan
    Diane Reidy-Lagunes, Neeta Pandit-Taskar, Joseph A. O'Donoghue, Simone Krebs, Kevin D. Staton, Serge K. Lyashchenko, Jason S. Lewis, Nitya Raj, Mithat Gönen, Christian Lohrmann, Lisa Bodei and Wolfgang A. Weber
    Clin Cancer Res December 1 2019 25 (23) 6939-6947; DOI:10.1158/1078-0432.CCR-19-1026

  • Clinical Trials: Targeted Therapy
    Macrophage Exclusion after Radiation Therapy (MERT): A First in Human Phase I/II Trial using a CXCR4 Inhibitor in Glioblastoma
    Reena P. Thomas, Seema Nagpal, Michael Iv, Scott G. Soltys, Sophie Bertrand, Judith S. Pelpola, Robyn Ball, Jaden Yang, Vandana Sundaram, Jonathan Lavezo, Donald Born, Hannes Vogel, J. Martin Brown and Lawrence D. Recht
    Clin Cancer Res December 1 2019 25 (23) 6948-6957; DOI:10.1158/1078-0432.CCR-19-1421

  • Clinical Trials: Targeted Therapy | AuthorChoice
    Efficacy and Safety of Rovalpituzumab Tesirine in Third-Line and Beyond Patients with DLL3-Expressing, Relapsed/Refractory Small-Cell Lung Cancer: Results From the Phase II TRINITY Study
    Daniel Morgensztern, Benjamin Besse, Laurent Greillier, Rafael Santana-Davila, Neal Ready, Christine L. Hann, Bonnie S. Glisson, Anna F. Farago, Afshin Dowlati, Charles M. Rudin, Sylvestre Le Moulec, Satwant Lally, Sreeni Yalamanchili, Jürgen Wolf, Ramaswamy Govindan and David P. Carbone
    Clin Cancer Res December 1 2019 25 (23) 6958-6966; DOI:10.1158/1078-0432.CCR-19-1133

  • Clinical Trials: Targeted Therapy
    Combination of Metformin and Gefitinib as First-Line Therapy for Nondiabetic Advanced NSCLC Patients with EGFR Mutations: A Randomized, Double-Blind Phase II Trial
    Li Li, Liyan Jiang, Yubo Wang, Yizhuo Zhao, Xiao-Ju Zhang, Guoming Wu, Xiangdong Zhou, Jianguo Sun, Jun Bai, Biyong Ren, Kun Tian, Zhi Xu, Hua-liang Xiao, Qi Zhou, Rui Han, Hengyi Chen, Haidong Wang, Zhenzhou Yang, Chan Gao, Shangli Cai and Yong He
    Clin Cancer Res December 1 2019 25 (23) 6967-6975; DOI:10.1158/1078-0432.CCR-19-0437

  • Clinical Trials: Targeted Therapy
    Phase II Study of the ALK5 Inhibitor Galunisertib in Very Low-, Low-, and Intermediate-Risk Myelodysplastic Syndromes
    Valeria Santini, David Valcárcel, Uwe Platzbecker, Rami S. Komrokji, Ann L. Cleverly, Michael M. Lahn, Jan Janssen, Yumin Zhao, Alan Chiang, Aristoteles Giagounidis, Susan C. Guba, Ivelina Gueorguieva, Allicia C. Girvan, Mariana da Silva Ferreira, Tushar D. Bhagat, Kith Pradhan, Ulrich Steidl, Ashwin Sridharan, Britta Will and Amit Verma
    Clin Cancer Res December 1 2019 25 (23) 6976-6985; DOI:10.1158/1078-0432.CCR-19-1338

  • Clinical Trials: Targeted Therapy
    A Phase I Study of ADCT-402 (Loncastuximab Tesirine), a Novel Pyrrolobenzodiazepine-Based Antibody–Drug Conjugate, in Relapsed/Refractory B-Cell Non-Hodgkin Lymphoma
    Brad S. Kahl, Mehdi Hamadani, John Radford, Carmelo Carlo-Stella, Paolo Caimi, Erin Reid, Jay M. Feingold, Kirit M. Ardeshna, Melhem Solh, Leonard T. Heffner, David Ungar, Shui He, Joseph Boni, Karin Havenith and Owen A. O'Connor
    Clin Cancer Res December 1 2019 25 (23) 6986-6994; DOI:10.1158/1078-0432.CCR-19-0711

Clinical Trials: Immunotherapy

  • Clinical Trials: Immunotherapy
    Clinical Efficacy and Tumor Microenvironment Influence in a Dose-Escalation Study of Anti-CD19 Chimeric Antigen Receptor T Cells in Refractory B-Cell Non-Hodgkin's Lymphoma
    Zi-Xun Yan, Li Li, Wen Wang, Bin-Shen OuYang, Shu Cheng, Li Wang, Wen Wu, Peng-Peng Xu, Muharrem Muftuoglu, Ming Hao, Su Yang, Mu-Chen Zhang, Zhong Zheng, James Li and Wei-Li Zhao
    Clin Cancer Res December 1 2019 25 (23) 6995-7003; DOI:10.1158/1078-0432.CCR-19-0101

  • Clinical Trials: Immunotherapy
    A Phase I Study of the Combination of Rituximab and Ipilimumab in Patients with Relapsed/Refractory B-Cell Lymphoma
    Joseph M. Tuscano, Emanual Maverakis, Susan Groshen, Denice Tsao-Wei, Guillaume Luxardi, Alexander A. Merleev, Anne Beaven, John F. DiPersio, Leslie Popplewell, Robert Chen, Mark Kirschbaum, Mark A. Schroeder and Edward M. Newman
    Clin Cancer Res December 1 2019 25 (23) 7004-7013; DOI:10.1158/1078-0432.CCR-19-0438

  • Clinical Trials: Immunotherapy
    Retooling a Blood-Based Biomarker: Phase I Assessment of the High-Affinity CA19-9 Antibody HuMab-5B1 for Immuno-PET Imaging of Pancreatic Cancer
    Christian Lohrmann, Eileen M. O'Reilly, Joseph A. O'Donoghue, Neeta Pandit-Taskar, Jorge A. Carrasquillo, Serge K. Lyashchenko, Shutian Ruan, Rebecca Teng, Wolfgang Scholz, Paul W. Maffuid, Jason S. Lewis and Wolfgang A. Weber
    Clin Cancer Res December 1 2019 25 (23) 7014-7023; DOI:10.1158/1078-0432.CCR-18-3667

Precision Medicine and Imaging

  • Precision Medicine and Imaging | AuthorChoice
    Noninvasive Detection of Microsatellite Instability and High Tumor Mutation Burden in Cancer Patients Treated with PD-1 Blockade
    Andrew Georgiadis, Jennifer N. Durham, Laurel A. Keefer, Bjarne R. Bartlett, Magdalena Zielonka, Derek Murphy, James R. White, Steve Lu, Ellen L. Verner, Finey Ruan, David Riley, Robert A. Anders, Erika Gedvilaite, Sam Angiuoli, Siân Jones, Victor E. Velculescu, Dung T. Le, Luis A. Diaz Jr and Mark Sausen
    Clin Cancer Res December 1 2019 25 (23) 7024-7034; DOI:10.1158/1078-0432.CCR-19-1372

  • Precision Medicine and Imaging | AuthorChoice
    Validation of Microsatellite Instability Detection Using a Comprehensive Plasma-Based Genotyping Panel
    Jason Willis, Martina I. Lefterova, Alexander Artyomenko, Pashtoon Murtaza Kasi, Yoshiaki Nakamura, Kabir Mody, Daniel V.T. Catenacci, Marwan Fakih, Catalin Barbacioru, Jing Zhao, Marcin Sikora, Stephen R. Fairclough, Hyuk Lee, Kyoung-Mee Kim, Seung Tae Kim, Jinchul Kim, Danielle Gavino, Manuel Benavides, Nir Peled, Timmy Nguyen, Mike Cusnir, Ramez N. Eskander, Georges Azzi, Takayuki Yoshino, Kimberly C. Banks, Victoria M. Raymond, Richard B. Lanman, Darya I. Chudova, AmirAli Talasaz, Scott Kopetz, Jeeyun Lee and Justin I. Odegaard
    Clin Cancer Res December 1 2019 25 (23) 7035-7045; DOI:10.1158/1078-0432.CCR-19-1324

  • Precision Medicine and Imaging
    Chimeric Antigen Receptor T Cells Targeting CD79b Show Efficacy in Lymphoma with or without Cotargeting CD19
    Maria Ormhøj, Irene Scarfò, Maria L. Cabral, Stefanie R. Bailey, Selena J. Lorrey, Amanda A. Bouffard, Ana P. Castano, Rebecca C. Larson, Lauren S. Riley, Andrea Schmidts, Bryan D. Choi, Rikke S. Andersen, Oriane Cédile, Charlotte G. Nyvold, Jacob H. Christensen, Morten F. Gjerstorff, Henrik J. Ditzel, David M. Weinstock, Torben Barington, Matthew J. Frigault and Marcela V. Maus
    Clin Cancer Res December 1 2019 25 (23) 7046-7057; DOI:10.1158/1078-0432.CCR-19-1337

  • Precision Medicine and Imaging
    Perioperative Dynamic Changes in Circulating Tumor DNA in Patients with Lung Cancer (DYNAMIC)
    Kezhong Chen, Heng Zhao, Yanbin Shi, Fan Yang, Lien Tu Wang, Guannan Kang, Yuntao Nie and Jun Wang
    Clin Cancer Res December 1 2019 25 (23) 7058-7067; DOI:10.1158/1078-0432.CCR-19-1213

  • Precision Medicine and Imaging
    Individual Assignment of Adult Diffuse Gliomas into the EM/PM Molecular Subtypes Using a TaqMan Low-Density Array
    Jiuyi Li, Yang Xue, Anna Wenger, Yingyu Sun, Zheng Wang, Chuanbao Zhang, Yunqiu Zhang, Boglarka Fekete, Bertil Rydenhag, Asgeir Store Jakola, Tao Jiang, Helena Carén and Xiaolong Fan
    Clin Cancer Res December 1 2019 25 (23) 7068-7077; DOI:10.1158/1078-0432.CCR-19-0299

  • Precision Medicine and Imaging
    Nomogram to Predict the Benefit of Intensive Treatment for Locoregionally Advanced Head and Neck Cancer
    Loren K. Mell, Hanjie Shen, Phuc Felix Nguyen-Tân, David I. Rosenthal, Kaveh Zakeri, Lucas K. Vitzthum, Steven J. Frank, Peter B. Schiff, Andy M. Trotti III, James A. Bonner, Christopher U. Jones, Sue S. Yom, Wade L. Thorstad, Stuart J. Wong, George Shenouda, John A. Ridge, Qiang E. Zhang and Quynh-Thu Le
    Clin Cancer Res December 1 2019 25 (23) 7078-7088; DOI:10.1158/1078-0432.CCR-19-1832

Translational Cancer Mechanisms and Therapy

  • Translational Cancer Mechanisms and Therapy
    Response to Anti-EGFR Therapy in Patients with BRAF non-V600–Mutant Metastatic Colorectal Cancer
    Rona Yaeger, Daisuke Kotani, Sebastián Mondaca, Aparna R. Parikh, Hideaki Bando, Emily E. Van Seventer, Hiroya Taniguchi, HuiYong Zhao, Claire N. Thant, Elisa de Stanchina, Neal Rosen, Ryan B. Corcoran, Takayuki Yoshino, Zhan Yao and Hiromichi Ebi
    Clin Cancer Res December 1 2019 25 (23) 7089-7097; DOI:10.1158/1078-0432.CCR-19-2004

  • Translational Cancer Mechanisms and Therapy | AuthorChoice
    Circulating Tumor DNA Sequencing Analysis of Gastroesophageal Adenocarcinoma
    Steven B. Maron, Leah M. Chase, Samantha Lomnicki, Sara Kochanny, Kelly L. Moore, Smita S. Joshi, Stacie Landron, Julie Johnson, Lesli A. Kiedrowski, Rebecca J. Nagy, Richard B. Lanman, Seung Tae Kim, Jeeyun Lee and Daniel V.T. Catenacci
    Clin Cancer Res December 1 2019 25 (23) 7098-7112; DOI:10.1158/1078-0432.CCR-19-1704

  • Translational Cancer Mechanisms and Therapy
    Comprehensive Next-Generation Sequencing Unambiguously Distinguishes Separate Primary Lung Carcinomas From Intrapulmonary Metastases: Comparison with Standard Histopathologic Approach
    Jason C. Chang, Deepu Alex, Matthew Bott, Kay See Tan, Venkatraman Seshan, Andrew Golden, Jennifer L. Sauter, Darren J. Buonocore, Chad M. Vanderbilt, Sounak Gupta, Patrice Desmeules, Francis M. Bodd, Gregory J. Riely, Valerie W. Rusch, David R. Jones, Maria E. Arcila, William D. Travis, Marc Ladanyi and Natasha Rekhtman
    Clin Cancer Res December 1 2019 25 (23) 7113-7125; DOI:10.1158/1078-0432.CCR-19-1700

  • Translational Cancer Mechanisms and Therapy
    NKT Cells Coexpressing a GD2-Specific Chimeric Antigen Receptor and IL15 Show Enhanced In Vivo Persistence and Antitumor Activity against Neuroblastoma
    Xin Xu, Wei Huang, Andras Heczey, Daofeng Liu, Linjie Guo, Michael Wood, Jingling Jin, Amy N. Courtney, Bin Liu, Erica J. Di Pierro, John Hicks, Gabriel A. Barragan, Ho Ngai, Yuhui Chen, Barbara Savoldo, Gianpietro Dotti and Leonid S. Metelitsa
    Clin Cancer Res December 1 2019 25 (23) 7126-7138; DOI:10.1158/1078-0432.CCR-19-0421

  • Translational Cancer Mechanisms and Therapy
    BET Inhibition as a Rational Therapeutic Strategy for Invasive Lobular Breast Cancer
    Louise Walsh, Kathryn E. Haley, Bruce Moran, Brian Mooney, Finbarr Tarrant, Stephen F. Madden, Alessandra Di Grande, Yue Fan, Sudipto Das, Oscar M. Rueda, Catríona M. Dowling, Damir Varešlija, Suet-Feung Chin, Sabine Linn, Leonie S. Young, Karin Jirström, John P. Crown, Rene Bernards, Carlos Caldas, William M. Gallagher, Darran P. O'Connor and Tríona Ní Chonghaile
    Clin Cancer Res December 1 2019 25 (23) 7139-7150; DOI:10.1158/1078-0432.CCR-19-0713

  • Translational Cancer Mechanisms and Therapy
    A Novel HER3-Targeting Antibody–Drug Conjugate, U3-1402, Exhibits Potent Therapeutic Efficacy through the Delivery of Cytotoxic Payload by Efficient Internalization
    Yuuri Hashimoto, Kumiko Koyama, Yasuki Kamai, Kenji Hirotani, Yusuke Ogitani, Akiko Zembutsu, Manabu Abe, Yuki Kaneda, Naoyuki Maeda, Yoshinobu Shiose, Takuma Iguchi, Tomomichi Ishizaka, Tsuyoshi Karibe, Ichiro Hayakawa, Koji Morita, Takashi Nakada, Taisei Nomura, Kenichi Wakita, Takashi Kagari, Yuki Abe, Masato Murakami, Suguru Ueno and Toshinori Agatsuma
    Clin Cancer Res December 1 2019 25 (23) 7151-7161; DOI:10.1158/1078-0432.CCR-19-1745

  • Translational Cancer Mechanisms and Therapy | AuthorChoice
    Bioactivation of Napabucasin Triggers Reactive Oxygen Species–Mediated Cancer Cell Death
    Fieke E.M. Froeling, Manojit Mosur Swamynathan, Astrid Deschênes, Iok In Christine Chio, Erin Brosnan, Melissa A. Yao, Priya Alagesan, Matthew Lucito, Juying Li, An-Yun Chang, Lloyd C. Trotman, Pascal Belleau, Youngkyu Park, Harry A. Rogoff, James D. Watson and David A. Tuveson
    Clin Cancer Res December 1 2019 25 (23) 7162-7174; DOI:10.1158/1078-0432.CCR-19-0302

  • Translational Cancer Mechanisms and Therapy
    The Folate Pathway Inhibitor Pemetrexed Pleiotropically Enhances Effects of Cancer Immunotherapy
    David A. Schaer, Sandaruwan Geeganage, Nelusha Amaladas, Zhao Hai Lu, Erik R. Rasmussen, Andreas Sonyi, Darin Chin, Andrew Capen, Yanxia Li, Catalina M. Meyer, Bonita D. Jones, Xiaodong Huang, Shuang Luo, Carmine Carpenito, Kenneth D. Roth, Alexander Nikolayev, Bo Tan, Manisha Brahmachary, Krishna Chodavarapu, Frank C. Dorsey, Jason R. Manro, Thompson N. Doman, Gregory P. Donoho, David Surguladze, Gerald E. Hall, Michael Kalos and Ruslan D. Novosiadly
    Clin Cancer Res December 1 2019 25 (23) 7175-7188; DOI:10.1158/1078-0432.CCR-19-0433

  • Translational Cancer Mechanisms and Therapy
    Therapeutic Targeting of TGFβ Ligands in Glioblastoma Using Novel Antisense Oligonucleotides Reduces the Growth of Experimental Gliomas
    Alexandros Papachristodoulou, Manuela Silginer, Michael Weller, Hannah Schneider, Kathy Hasenbach, Michel Janicot and Patrick Roth
    Clin Cancer Res December 1 2019 25 (23) 7189-7201; DOI:10.1158/1078-0432.CCR-17-3024

  • Translational Cancer Mechanisms and Therapy
    Adaptive Resistance to Dual BRAF/MEK Inhibition in BRAF-Driven Tumors through Autocrine FGFR Pathway Activation
    Victoria E. Wang, Jenny Y. Xue, Dennie T. Frederick, Yi Cao, Eva Lin, Catherine Wilson, Anatoly Urisman, David P. Carbone, Keith T. Flaherty, Rene Bernards, Piro Lito, Jeff Settleman and Frank McCormick
    Clin Cancer Res December 1 2019 25 (23) 7202-7217; DOI:10.1158/1078-0432.CCR-18-2779

  • Translational Cancer Mechanisms and Therapy
    NKG2D Controls Natural Reactivity of Vγ9Vδ2 T Lymphocytes against Mesenchymal Glioblastoma Cells
    Cynthia Chauvin, Noémie Joalland, Jeanne Perroteau, Ulrich Jarry, Laura Lafrance, Catherine Willem, Christelle Retière, Lisa Oliver, Catherine Gratas, Laetitia Gautreau-Rolland, Xavier Saulquin, François M. Vallette, Henri Vié, Emmanuel Scotet and Claire Pecqueur
    Clin Cancer Res December 1 2019 25 (23) 7218-7228; DOI:10.1158/1078-0432.CCR-19-0375

  • Translational Cancer Mechanisms and Therapy
    Metastatic Breast Carcinoma–Associated Fibroblasts Have Enhanced Protumorigenic Properties Related to Increased IGF2 Expression
    Yirui Gui, Adriana Aguilar-Mahecha, Urszula Krzemien, Abdel Hosein, Marguerite Buchanan, Josiane Lafleur, Michael Pollak, Cristiano Ferrario and Mark Basik
    Clin Cancer Res December 1 2019 25 (23) 7229-7242; DOI:10.1158/1078-0432.CCR-19-1268

  • Translational Cancer Mechanisms and Therapy
    Cisplatin Facilitates Radiation-Induced Abscopal Effects in Conjunction with PD-1 Checkpoint Blockade Through CXCR3/CXCL10-Mediated T-cell Recruitment
    Ren Luo, Elke Firat, Simone Gaedicke, Elena Guffart, Tsubasa Watanabe and Gabriele Niedermann
    Clin Cancer Res December 1 2019 25 (23) 7243-7255; DOI:10.1158/1078-0432.CCR-19-1344

  • Translational Cancer Mechanisms and Therapy
    Molecular Characterization of Locally Relapsed Head and Neck Cancer after Concomitant Chemoradiotherapy
    Reinout H. de Roest, Steven W. Mes, Jos B. Poell, Arjen Brink, Mark A. van de Wiel, Elisabeth Bloemena, Elena Thai, Tito Poli, C. René Leemans and Ruud H. Brakenhoff
    Clin Cancer Res December 1 2019 25 (23) 7256-7265; DOI:10.1158/1078-0432.CCR-19-0628

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Clinical Cancer Research: 25 (23)
December 2019
Volume 25, Issue 23
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Issue Highlights

  • Phase I Trial of Well-Differentiated Neuroendocrine Tumors (NETs) with Radiolabeled Somatostatin Antagonist 177Lu-Satoreotide Tetraxetan
  • Chimeric Antigen Receptor T Cells Targeting CD79b Show Efficacy in Lymphoma with or without Cotargeting CD19
  • Comprehensive Next-Generation Sequencing Unambiguously Distinguishes Separate Primary Lung Carcinomas From Intrapulmonary Metastases: Comparison with Standard Histopathologic Approach
  • NKT Cells Coexpressing a GD2-Specific Chimeric Antigen Receptor and IL15 Show Enhanced In Vivo Persistence and Antitumor Activity against Neuroblastoma

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Clinical Cancer Research
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