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Translational Cancer Mechanisms and Therapy

Adaptive Resistance to Dual BRAF/MEK Inhibition in BRAF-Driven Tumors through Autocrine FGFR Pathway Activation

Victoria E. Wang, Jenny Y. Xue, Dennie T. Frederick, Yi Cao, Eva Lin, Catherine Wilson, Anatoly Urisman, David P. Carbone, Keith T. Flaherty, Rene Bernards, Piro Lito, Jeff Settleman and Frank McCormick
Victoria E. Wang
1Department of Medicine, University of California, San Francisco, San Francisco, California.
2Helen Diller Comprehensive Cancer Center, University of California, San Francisco, San Francisco, California.
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Jenny Y. Xue
3Human Oncology and Pathogenesis Program, Memorial Sloan Kettering Cancer Center, New York, New York.
4Weill Cornell/Rockefeller/Sloan Kettering Tri-Institutional MD-PhD Program, New York, New York.
5Weill Cornell Medical College, Cornell University, New York, New York.
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  • ORCID record for Jenny Y. Xue
Dennie T. Frederick
6Massachusetts General Hospital Cancer Center, Boston, Massachusetts.
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Yi Cao
7Discovery Oncology, Genentech, South San Francisco, California.
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Eva Lin
7Discovery Oncology, Genentech, South San Francisco, California.
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Catherine Wilson
7Discovery Oncology, Genentech, South San Francisco, California.
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Anatoly Urisman
2Helen Diller Comprehensive Cancer Center, University of California, San Francisco, San Francisco, California.
9The Ohio State University Comprehensive Cancer Center, Columbus, Ohio.
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David P. Carbone
10Department of Molecular Carcinogenesis, Netherlands Cancer Institute, Amsterdam, the Netherlands.
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Keith T. Flaherty
6Massachusetts General Hospital Cancer Center, Boston, Massachusetts.
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Rene Bernards
10Department of Molecular Carcinogenesis, Netherlands Cancer Institute, Amsterdam, the Netherlands.
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Piro Lito
3Human Oncology and Pathogenesis Program, Memorial Sloan Kettering Cancer Center, New York, New York.
4Weill Cornell/Rockefeller/Sloan Kettering Tri-Institutional MD-PhD Program, New York, New York.
5Weill Cornell Medical College, Cornell University, New York, New York.
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Jeff Settleman
7Discovery Oncology, Genentech, South San Francisco, California.
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  • For correspondence: Frank.mccormick@ucsf.edu jeffrey.settleman@pfizer.com
Frank McCormick
2Helen Diller Comprehensive Cancer Center, University of California, San Francisco, San Francisco, California.
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  • For correspondence: Frank.mccormick@ucsf.edu jeffrey.settleman@pfizer.com
DOI: 10.1158/1078-0432.CCR-18-2779 Published December 2019
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Article Information

Volume 25, Issue 23, pp. 7202-7217

DOI 
https://doi.org/10.1158/1078-0432.CCR-18-2779
PubMed 
31515463

Published By 
American Association for Cancer Research
Print ISSN 
1078-0432
Online ISSN 
1557-3265
History 
  • Received August 27, 2018
  • Revision received March 18, 2019
  • Accepted September 6, 2019
  • Published first September 12, 2019.

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  • Previous version (September 12, 2019 - 06:24).
  • Previous version (October 22, 2019 - 07:14).
  • You are viewing the most recent version of this article.
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©2019 American Association for Cancer Research.

Author Information

  1. Victoria E. Wang1,2,
  2. Jenny Y. Xue3,4,5,
  3. Dennie T. Frederick6,
  4. Yi Cao7,
  5. Eva Lin7,
  6. Catherine Wilson7,
  7. Anatoly Urisman2,8,
  8. David P. Carbone9,
  9. Keith T. Flaherty6,
  10. Rene Bernards10,
  11. Piro Lito3,4,5,
  12. Jeff Settleman7,*, and
  13. Frank McCormick2,*
  1. 1Department of Medicine, University of California, San Francisco, San Francisco, California.
  2. 2Helen Diller Comprehensive Cancer Center, University of California, San Francisco, San Francisco, California.
  3. 3Human Oncology and Pathogenesis Program, Memorial Sloan Kettering Cancer Center, New York, New York.
  4. 4Weill Cornell/Rockefeller/Sloan Kettering Tri-Institutional MD-PhD Program, New York, New York.
  5. 5Weill Cornell Medical College, Cornell University, New York, New York.
  6. 6Massachusetts General Hospital Cancer Center, Boston, Massachusetts.
  7. 7Discovery Oncology, Genentech, South San Francisco, California.
  8. 8Department of Pathology, University of California, San Francisco, San Francisco, California.
  9. 9The Ohio State University Comprehensive Cancer Center, Columbus, Ohio.
  10. 10Department of Molecular Carcinogenesis, Netherlands Cancer Institute, Amsterdam, the Netherlands.
  1. ↵*Corresponding Authors:
    Frank McCormick, UCSF Helen Diller Comprehensive Cancer Center, 1450 Third Street, San Francisco, CA 94158. Phone: 415-502-1710; Fax: 415-502-1712; E-mail: Frank.mccormick{at}ucsf.edu; and Jeff Settleman, Pfizer, Inc., Science Center Drive, San Diego, CA 92121. E-mail: jeffrey.settleman{at}pfizer.com
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Clinical Cancer Research: 25 (23)
December 2019
Volume 25, Issue 23
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Adaptive Resistance to Dual BRAF/MEK Inhibition in BRAF-Driven Tumors through Autocrine FGFR Pathway Activation
Victoria E. Wang, Jenny Y. Xue, Dennie T. Frederick, Yi Cao, Eva Lin, Catherine Wilson, Anatoly Urisman, David P. Carbone, Keith T. Flaherty, Rene Bernards, Piro Lito, Jeff Settleman and Frank McCormick
Clin Cancer Res December 1 2019 (25) (23) 7202-7217; DOI: 10.1158/1078-0432.CCR-18-2779

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Adaptive Resistance to Dual BRAF/MEK Inhibition in BRAF-Driven Tumors through Autocrine FGFR Pathway Activation
Victoria E. Wang, Jenny Y. Xue, Dennie T. Frederick, Yi Cao, Eva Lin, Catherine Wilson, Anatoly Urisman, David P. Carbone, Keith T. Flaherty, Rene Bernards, Piro Lito, Jeff Settleman and Frank McCormick
Clin Cancer Res December 1 2019 (25) (23) 7202-7217; DOI: 10.1158/1078-0432.CCR-18-2779
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