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Table of Contents

Highlights

  • Highlights
    Highlights of This Issue
    Clin Cancer Res December 15 2019 25 (24) 7267-7267;

CCR Translations

  • CCR Translations
    A New Pathway Emerges to Interpret Lung Cancer Genomic Alterations
    Collin M. Blakely
    Clin Cancer Res December 15 2019 25 (24) 7269-7271; DOI:10.1158/1078-0432.CCR-19-2861

  • CCR Translations
    Mogamulizumab Forecast: Clearer Patients, with a Slight Chance of Immune Mayhem
    Cecilia Larocca, Thomas S. Kupper and Nicole R. LeBoeuf
    Clin Cancer Res December 15 2019 25 (24) 7272-7274; DOI:10.1158/1078-0432.CCR-19-2742

CCR Drug Updates

  • CCR Drug Updates
    FDA Approval Summary: Mogamulizumab-kpkc for Mycosis Fungoides and Sézary Syndrome
    Yvette L. Kasamon, Haiyan Chen, R. Angelo de Claro, Lei Nie, Jingjing Ye, Gideon M. Blumenthal, Ann T. Farrell and Richard Pazdur
    Clin Cancer Res December 15 2019 25 (24) 7275-7280; DOI:10.1158/1078-0432.CCR-19-2030

Perspectives

  • Perspectives
    Lessons Learned from Deescalation Trials in Favorable Risk HPV-Associated Squamous Cell Head and Neck Cancer–A Perspective on Future Trial Designs
    Steffen Ventz, Lorenzo Trippa and Jonathan D. Schoenfeld
    Clin Cancer Res December 15 2019 25 (24) 7281-7286; DOI:10.1158/1078-0432.CCR-19-0945

Clinical Trials: Targeted Therapy

  • Clinical Trials: Targeted Therapy
    Phase I Study of Rapid Alternation of Sunitinib and Regorafenib for the Treatment of Tyrosine Kinase Inhibitor Refractory Gastrointestinal Stromal Tumors
    César Serrano, Alessandro Leal, Yanan Kuang, Jeffrey A. Morgan, Constance M. Barysauskas, Jillian Phallen, Olivia Triplett, Adrián Mariño-Enríquez, Andrew J. Wagner, George D. Demetri, Victor E. Velculescu, Cloud P. Paweletz, Jonathan A. Fletcher and Suzanne George
    Clin Cancer Res December 15 2019 25 (24) 7287-7293; DOI:10.1158/1078-0432.CCR-19-2150

  • Clinical Trials: Targeted Therapy
    A Phase I and Pharmacokinetic Study of Oral Dabrafenib in Children and Adolescent Patients with Recurrent or Refractory BRAF V600 Mutation–Positive Solid Tumors
    Mark W. Kieran, Birgit Geoerger, Ira J. Dunkel, Alberto Broniscer, Darren Hargrave, Pooja Hingorani, Isabelle Aerts, Anne-Isabelle Bertozzi, Kenneth J. Cohen, Trent R. Hummel, Violet Shen, Eric Bouffet, Christine A. Pratilas, Andrew D.J. Pearson, Lillian Tseng, Noelia Nebot, Steven Green, Mark W. Russo and James A. Whitlock
    Clin Cancer Res December 15 2019 25 (24) 7294-7302; DOI:10.1158/1078-0432.CCR-17-3572

  • Clinical Trials: Targeted Therapy
    Efficacy and Safety of Dabrafenib in Pediatric Patients with BRAF V600 Mutation–Positive Relapsed or Refractory Low-Grade Glioma: Results from a Phase I/IIa Study
    Darren R. Hargrave, Eric Bouffet, Uri Tabori, Alberto Broniscer, Kenneth J. Cohen, Jordan R. Hansford, Birgit Geoerger, Pooja Hingorani, Ira J. Dunkel, Mark W. Russo, Lillian Tseng, Kohinoor Dasgupta, Eduard Gasal, James A. Whitlock and Mark W. Kieran
    Clin Cancer Res December 15 2019 25 (24) 7303-7311; DOI:10.1158/1078-0432.CCR-19-2177

  • Clinical Trials: Targeted Therapy | AuthorChoice
    Crizotinib in MET-Deregulated or ROS1-Rearranged Pretreated Non–Small Cell Lung Cancer (METROS): A Phase II, Prospective, Multicenter, Two-Arms Trial
    Lorenza Landi, Rita Chiari, Marcello Tiseo, Federica D'Incà, Claudio Dazzi, Antonio Chella, Angelo Delmonte, Laura Bonanno, Diana Giannarelli, Diego Luigi Cortinovis, Filippo de Marinis, Gloria Borra, Alessandro Morabito, Cesare Gridelli, Domenico Galetta, Fausto Barbieri, Francesco Grossi, Enrica Capelletto, Gabriele Minuti, Francesca Mazzoni, Claudio Verusio, Emilio Bria, Greta Alì, Rossella Bruno, Agnese Proietti, Gabriella Fontanini, Lucio Crinò and Federico Cappuzzo
    Clin Cancer Res December 15 2019 25 (24) 7312-7319; DOI:10.1158/1078-0432.CCR-19-0994

  • Clinical Trials: Targeted Therapy
    Sorafenib Population Pharmacokinetics and Skin Toxicities in Children and Adolescents with Refractory/Relapsed Leukemia or Solid Tumor Malignancies
    Hiroto Inaba, John C. Panetta, Stanley B. Pounds, Lei Wang, Lie Li, Fariba Navid, Sara M. Federico, Eric D. Eisenmann, Aksana Vasilyeva, Yong-Dong Wang, Sheila Shurtleff, Ching-Hon Pui, Tanja A. Gruber, Raul C. Ribeiro, Jeffrey E. Rubnitz and Sharyn D. Baker
    Clin Cancer Res December 15 2019 25 (24) 7320-7330; DOI:10.1158/1078-0432.CCR-19-0470

  • Clinical Trials: Targeted Therapy
    Phase I Study of the Novel Enhancer of Zeste Homolog 2 (EZH2) Inhibitor GSK2816126 in Patients with Advanced Hematologic and Solid Tumors
    Timothy A. Yap, Jane N. Winter, Lisa Giulino-Roth, Jemma Longley, Juanita Lopez, Jean-Marie Michot, John P. Leonard, Vincent Ribrag, Michael T. McCabe, Caretha L. Creasy, Melissa Stern, Teodora Pene Dumitrescu, Xiaowei Wang, Steve Frey, Jennifer Carver, Thierry Horner, Choon Oh, Ahmed Khaled, Arindam Dhar and Peter W.M. Johnson
    Clin Cancer Res December 15 2019 25 (24) 7331-7339; DOI:10.1158/1078-0432.CCR-18-4121

Clinical Trials: Immunotherapy

  • Clinical Trials: Immunotherapy
    T-Cell Receptor Stimulation Enhances the Expansion and Function of CD19 Chimeric Antigen Receptor–Expressing T Cells
    Natalia Lapteva, Margaret Gilbert, Iulia Diaconu, Lisa A. Rollins, Mina Al-Sabbagh, Swati Naik, Robert A. Krance, Tamara Tripic, Manasa Hiregange, Darshana Raghavan, Olga Dakhova, Rayne H. Rouce, Hao Liu, Bilal Omer, Barbara Savoldo, Gianpietro Dotti, Conrad Russel Cruz, Keli Sharpe, Melissa Gates, Aaron Orozco, April Durett, Elizabeth Pacheco, Adrian P. Gee, Carlos A. Ramos, Helen E. Heslop, Malcolm K. Brenner and Cliona M. Rooney
    Clin Cancer Res December 15 2019 25 (24) 7340-7350; DOI:10.1158/1078-0432.CCR-18-3199

  • Clinical Trials: Immunotherapy | AuthorChoice
    Guadecitabine Plus Ipilimumab in Unresectable Melanoma: The NIBIT-M4 Clinical Trial
    Anna Maria Di Giacomo, Alessia Covre, Francesca Finotello, Dietmar Rieder, Riccardo Danielli, Luca Sigalotti, Diana Giannarelli, Florent Petitprez, Laetitia Lacroix, Monica Valente, Ornella Cutaia, Carolina Fazio, Giovanni Amato, Andrea Lazzeri, Santa Monterisi, Clelia Miracco, Sandra Coral, Andrea Anichini, Christoph Bock, Amelie Nemc, Aram Oganesian, James Lowder, Mohammad Azab, Wolf H. Fridman, Catherine Sautès-Fridman, Zlatko Trajanoski and Michele Maio
    Clin Cancer Res December 15 2019 25 (24) 7351-7362; DOI:10.1158/1078-0432.CCR-19-1335

  • Clinical Trials: Immunotherapy
    A Single-Arm, Multicenter, Phase II Study of Camrelizumab in Relapsed or Refractory Classical Hodgkin Lymphoma
    Yuqin Song, Jianqiu Wu, Xinchuan Chen, Tongyu Lin, Junning Cao, Yanyan Liu, Yaozhong Zhao, Jie Jin, Haiwen Huang, Jianda Hu, Jun Luo, Liling Zhang, Hongwei Xue, Qingyuan Zhang, Weiwei Wang, Chunxia Chen, Jifeng Feng and Jun Zhu
    Clin Cancer Res December 15 2019 25 (24) 7363-7369; DOI:10.1158/1078-0432.CCR-19-1680

Precision Medicine and Imaging

  • Precision Medicine and Imaging
    Analysis of Biomarkers and Association With Clinical Outcomes in Patients With Differentiated Thyroid Cancer: Subanalysis of the Sorafenib Phase III DECISION Trial
    Marcia S. Brose, Martin Schlumbeger, Michael Jeffers, Christian Kappeler, Gerold Meinhardt and Carol E.A. Peña
    Clin Cancer Res December 15 2019 25 (24) 7370-7380; DOI:10.1158/1078-0432.CCR-18-3439

  • Precision Medicine and Imaging
    Impact of FDG PET Imaging for Expanding Patient Eligibility and Measuring Treatment Response in a Genome-Driven Basket Trial of the Pan-HER Kinase Inhibitor, Neratinib
    Gary A. Ulaner, Cristina Saura, Sarina A. Piha-Paul, Ingrid Mayer, David Quinn, Komal Jhaveri, Ben Stone, Seta Shahin, Grace Mann, Melanie Dujka, Richard Bryce, Funda Meric-Bernstam, David B. Solit and David M. Hyman
    Clin Cancer Res December 15 2019 25 (24) 7381-7387; DOI:10.1158/1078-0432.CCR-19-1658

  • Precision Medicine and Imaging
    Long-Term Survival Analysis of Adjuvant Chemotherapy with or without Trastuzumab in Patients with T1, Node-Negative HER2-Positive Breast Cancer
    Xuexin He, Jiali Ji, Mei Tian, Francisco J. Esteva, Gabriel N. Hortobagyi and Sai-Ching Jim Yeung
    Clin Cancer Res December 15 2019 25 (24) 7388-7395; DOI:10.1158/1078-0432.CCR-19-0463

  • Precision Medicine and Imaging
    Discovery, Validation, and Application of Novel Methylated DNA Markers for Detection of Esophageal Cancer in Plasma
    Yi Qin, Chung W. Wu, William R. Taylor, Tarek Sawas, Kelli N. Burger, Douglas W. Mahoney, Zhifu Sun, Tracy C. Yab, Graham P. Lidgard, Hatim T. Allawi, Navtej S. Buttar, Thomas C. Smyrk, Prasad G. Iyer, David A. Katzka, David A. Ahlquist and John B. Kisiel
    Clin Cancer Res December 15 2019 25 (24) 7396-7404; DOI:10.1158/1078-0432.CCR-19-0740

  • Precision Medicine and Imaging
    Antibody Responses to Cancer Antigens Identify Patients with a Poor Prognosis among HPV-Positive and HPV-Negative Head and Neck Squamous Cell Carcinoma Patients
    Simon Laban, Dominik S. Gangkofner, Dana Holzinger, Lea Schroeder, Stefan B. Eichmüller, Inka Zörnig, Dirk Jäger, Gunnar Wichmann, Andreas Dietz, Martina A. Broglie, Christel C. Herold-Mende, Gerhard Dyckhoff, Paolo Boscolo-Rizzo, Jasmin Ezić, Ralf Marienfeld, Peter Möller, Johann M. Kraus, Gunnar Völkel, Hans A. Kestler, Cornelia Brunner, Patrick J. Schuler, Marlene C. Wigand, Marie-Nicole Theodoraki, Johannes Doescher, Thomas K. Hoffmann, Michael Pawlita, Tim Waterboer and Julia Butt
    Clin Cancer Res December 15 2019 25 (24) 7405-7412; DOI:10.1158/1078-0432.CCR-19-1490

  • Precision Medicine and Imaging
    Combination of TMB and CNA Stratifies Prognostic and Predictive Responses to Immunotherapy Across Metastatic Cancer
    Li Liu, Xue Bai, Jian Wang, Xin-Ran Tang, De-Hua Wu, Sha-Sha Du, Xiu-Ju Du, Yao-Wei Zhang, Hong-Bo Zhu, Yuan Fang, Ze-Qin Guo, Qin Zeng, Xue-Jun Guo, Zhu Liu and Zhong-Yi Dong
    Clin Cancer Res December 15 2019 25 (24) 7413-7423; DOI:10.1158/1078-0432.CCR-19-0558

  • Precision Medicine and Imaging | AuthorChoice
    Transcriptomic Analysis Reveals Prognostic Molecular Signatures of Stage I Melanoma
    Rohit Thakur, Jonathan P. Laye, Martin Lauss, Joey Mark S. Diaz, Sally Jane O'Shea, Joanna Poźniak, Anastasia Filia, Mark Harland, Joanne Gascoyne, Juliette A. Randerson-Moor, May Chan, Tracey Mell, Göran Jönsson, D. Timothy Bishop, Julia Newton-Bishop, Jennifer H. Barrett and Jérémie Nsengimana
    Clin Cancer Res December 15 2019 25 (24) 7424-7435; DOI:10.1158/1078-0432.CCR-18-3659

  • Precision Medicine and Imaging
    Longitudinal Photoacoustic Imaging of the Pharmacodynamic Effect of Vascular Targeted Therapy on Tumors
    S. Peter Johnson, Olumide Ogunlade, Mark F. Lythgoe, Paul Beard and R. Barbara Pedley
    Clin Cancer Res December 15 2019 25 (24) 7436-7447; DOI:10.1158/1078-0432.CCR-19-0360

  • Precision Medicine and Imaging
    Prostate-Specific Membrane Antigen Ligand Positron Emission Tomography in Men with Nonmetastatic Castration-Resistant Prostate Cancer
    Wolfgang P. Fendler, Manuel Weber, Amir Iravani, Michael S. Hofman, Jérémie Calais, Johannes Czernin, Harun Ilhan, Fred Saad, Eric J. Small, Matthew R. Smith, Paola M. Perez, Thomas A. Hope, Isabel Rauscher, Anil Londhe, Angela Lopez-Gitlitz, Shinta Cheng, Tobias Maurer, Ken Herrmann, Matthias Eiber and Boris Hadaschik
    Clin Cancer Res December 15 2019 25 (24) 7448-7454; DOI:10.1158/1078-0432.CCR-19-1050

  • Precision Medicine and Imaging | AuthorChoice
    Predicting the 1p/19q Codeletion Status of Presumed Low-Grade Glioma with an Externally Validated Machine Learning Algorithm
    Sebastian R. van der Voort, Fatih Incekara, Maarten M.J. Wijnenga, Georgios Kapas, Mayke Gardeniers, Joost W. Schouten, Martijn P.A. Starmans, Rishie Nandoe Tewarie, Geert J. Lycklama, Pim J. French, Hendrikus J. Dubbink, Martin J. van den Bent, Arnaud J.P.E. Vincent, Wiro J. Niessen, Stefan Klein and Marion Smits
    Clin Cancer Res December 15 2019 25 (24) 7455-7462; DOI:10.1158/1078-0432.CCR-19-1127

  • Precision Medicine and Imaging
    ImmunoPET, [64Cu]Cu-DOTA-Anti-CD33 PET-CT, Imaging of an AML Xenograft Model
    Sargur Madabushi Srideshikan, Jamison Brooks, Darren Zuro, Bijender Kumar, James Sanchez, Liliana Echavarria Parra, Marvin Orellana, Paresh Vishwasrao, Indu Nair, Junie Chea, Kofi Poku, Nicole Bowles, Aaron Miller, Todd Ebner, Justin Molnar, Joseph Rosenthal, Daniel A. Vallera, Jeffrey Y.C. Wong, Anthony S. Stein, David Colcher, John E. Shively, Paul J. Yazaki and Susanta K. Hui
    Clin Cancer Res December 15 2019 25 (24) 7463-7474; DOI:10.1158/1078-0432.CCR-19-1106

Translational Cancer Mechanisms and Therapy

  • Translational Cancer Mechanisms and Therapy
    Analysis of Tumor Genomic Pathway Alterations Using Broad-Panel Next-Generation Sequencing in Surgically Resected Lung Adenocarcinoma
    Jian Zhou, Francisco Sanchez-Vega, Raul Caso, Kay See Tan, Whitney S. Brandt, Gregory D. Jones, Shi Yan, Prasad S. Adusumilli, Matthew Bott, James Huang, James M. Isbell, Smita Sihag, Daniela Molena, Valerie W. Rusch, Walid K. Chatila, Natasha Rekhtman, Fan Yang, Marc Ladanyi, David B. Solit, Michael F. Berger, Nikolaus Schultz and David R. Jones
    Clin Cancer Res December 15 2019 25 (24) 7475-7484; DOI:10.1158/1078-0432.CCR-19-1651

  • Translational Cancer Mechanisms and Therapy | AuthorChoice
    Early Enrichment of ESR1 Mutations and the Impact on Gene Expression in Presurgical Primary Breast Cancer Treated with Aromatase Inhibitors
    Mariana Ferreira Leal, Ben P. Haynes, Eugene Schuster, Belinda Yeo, Maria Afentakis, Lila Zabaglo, Vera Martins, Richard Buus, Andrew Dodson, Maggie C.U. Cheang, Ian E. Smith, Lesley-Ann Martin and Mitch Dowsett
    Clin Cancer Res December 15 2019 25 (24) 7485-7496; DOI:10.1158/1078-0432.CCR-19-1129

  • Translational Cancer Mechanisms and Therapy
    Plasma 25-Hydroxyvitamin D Levels and Survival in Patients with Advanced or Metastatic Colorectal Cancer: Findings from CALGB/SWOG 80405 (Alliance)
    Chen Yuan, Kaori Sato, Bruce W. Hollis, Sui Zhang, Donna Niedzwiecki, Fang-Shu Ou, I-Wen Chang, Bert H. O'Neil, Federico Innocenti, Heinz-Josef Lenz, Charles D. Blanke, Richard M. Goldberg, Alan P. Venook, Robert J. Mayer, Charles S. Fuchs, Jeffrey A. Meyerhardt and Kimmie Ng
    Clin Cancer Res December 15 2019 25 (24) 7497-7505; DOI:10.1158/1078-0432.CCR-19-0877

  • Translational Cancer Mechanisms and Therapy
    Multispecific Targeting with Synthetic Ankyrin Repeat Motif Chimeric Antigen Receptors
    Ashwini Balakrishnan, Anusha Rajan, Alexander I. Salter, Paula L. Kosasih, Qian Wu, Jenna Voutsinas, Michael C. Jensen, Andreas Plückthun and Stanley R. Riddell
    Clin Cancer Res December 15 2019 25 (24) 7506-7516; DOI:10.1158/1078-0432.CCR-19-1479

  • Translational Cancer Mechanisms and Therapy | AuthorChoice
    Germline BRCA-Associated Endometrial Carcinoma Is a Distinct Clinicopathologic Entity
    Marthe M. de Jonge, Lauren L. Ritterhouse, Cornelis D. de Kroon, Maaike P.G. Vreeswijk, Jeremy P. Segal, Rutika Puranik; for the HEBON Group, Harry Hollema, Matti A. Rookus, Christi J. van Asperen, Flora E. van Leeuwen, Vincent T.H.B.M. Smit, Brooke E. Howitt and Tjalling Bosse
    Clin Cancer Res December 15 2019 25 (24) 7517-7526; DOI:10.1158/1078-0432.CCR-19-0848

  • Translational Cancer Mechanisms and Therapy | AuthorChoice
    Purinostat Mesylate Is a Uniquely Potent and Selective Inhibitor of HDACs for the Treatment of BCR-ABL–Induced B-Cell Acute Lymphoblastic Leukemia
    Linyu Yang, Qiang Qiu, Minghai Tang, Fang Wang, Yuyao Yi, Dongni Yi, Zhuang Yang, Zejiang Zhu, Shoujun Zheng, Jianhong Yang, Heying Pei, Li Zheng, Yong Chen, Liping Gou, Liya Luo, Xing Deng, Haoyu Ye, Yiguo Hu, Ting Niu and Lijuan Chen
    Clin Cancer Res December 15 2019 25 (24) 7527-7539; DOI:10.1158/1078-0432.CCR-19-0516

  • Translational Cancer Mechanisms and Therapy | AuthorChoice
    Decreased NOTCH1 Activation Correlates with Response to Ibrutinib in Chronic Lymphocytic Leukemia
    Beatrice Del Papa, Stefano Baldoni, Erica Dorillo, Filomena De Falco, Chiara Rompietti, Debora Cecchini, Maria Grazia Cantelmi, Daniele Sorcini, Manuel Nogarotto, Francesco Maria Adamo, Federica Mezzasoma, Estevão Carlos Silva Barcelos, Elisa Albi, Roberta Iacucci Ostini, Ambra Di Tommaso, Andrea Marra, Guido Montanaro, Maria Paola Martelli, Franca Falzetti, Mauro Di Ianni, Emanuela Rosati and Paolo Sportoletti
    Clin Cancer Res December 15 2019 25 (24) 7540-7553; DOI:10.1158/1078-0432.CCR-19-1009

  • Translational Cancer Mechanisms and Therapy
    Interleukin-15 Enhances Anti-GD2 Antibody-Mediated Cytotoxicity in an Orthotopic PDX Model of Neuroblastoma
    Rosa Nguyen, Ardiana Moustaki, Jacqueline L. Norrie, Shantel Brown, Walter J. Akers, Abbas Shirinifard and Michael A. Dyer
    Clin Cancer Res December 15 2019 25 (24) 7554-7564; DOI:10.1158/1078-0432.CCR-19-1045

  • Translational Cancer Mechanisms and Therapy
    Combination of PPARγ Agonist Pioglitazone and Trabectedin Induce Adipocyte Differentiation to Overcome Trabectedin Resistance in Myxoid Liposarcomas
    Roberta Frapolli, Ezia Bello, Marianna Ponzo, Ilaria Craparotta, Laura Mannarino, Sara Ballabio, Sergio Marchini, Laura Carrassa, Paolo Ubezio, Luca Porcu, Silvia Brich, Roberta Sanfilippo, Paolo Giovanni Casali, Alessandro Gronchi, Silvana Pilotti and Maurizio D'Incalci
    Clin Cancer Res December 15 2019 25 (24) 7565-7575; DOI:10.1158/1078-0432.CCR-19-0976

  • Translational Cancer Mechanisms and Therapy
    Triple Therapy with MerTK and PD1 Inhibition Plus Radiotherapy Promotes Abscopal Antitumor Immune Responses
    Mauricio S. Caetano, Ahmed I. Younes, Hampartsoum B. Barsoumian, Michael Quigley, Hari Menon, Chan Gao, Thomas Spires, Timothy P. Reilly, Alexandra P. Cadena, Taylor R. Cushman, Jonathan E. Schoenhals, Ailin Li, Quynh-Nhu Nguyen, Maria Angelica Cortez and James W. Welsh
    Clin Cancer Res December 15 2019 25 (24) 7576-7584; DOI:10.1158/1078-0432.CCR-19-0795

  • Translational Cancer Mechanisms and Therapy
    Correlation of Tumor Burden in Sentinel Lymph Nodes with Tumor Burden in Nonsentinel Lymph Nodes and Survival in Cutaneous Melanoma
    Kenjiro Namikawa, Phyu P. Aung, Denái R. Milton, Michael T. Tetzlaff, Carlos A. Torres-Cabala, Jonathan L. Curry, Priyadharsini Nagarajan, Doina Ivan, Merrick Ross, Jeffrey E. Gershenwald and Victor G. Prieto
    Clin Cancer Res December 15 2019 25 (24) 7585-7593; DOI:10.1158/1078-0432.CCR-19-1194

  • Translational Cancer Mechanisms and Therapy
    Mechanisms and Antitumor Activity of a Binary EGFR/DNA–Targeting Strategy Overcomes Resistance of Glioblastoma Stem Cells to Temozolomide
    Zeinab Sharifi, Bassam Abdulkarim, Brian Meehan, Janusz Rak, Paul Daniel, Julie Schmitt, Nidia Lauzon, Kolja Eppert, Heather M. Duncan, Kevin Petrecca, Marie-Christine Guiot, Bertrand Jean-Claude and Siham Sabri
    Clin Cancer Res December 15 2019 25 (24) 7594-7608; DOI:10.1158/1078-0432.CCR-19-0955

Letter to the Editor

  • Letter to the Editor
    Exercise Window Trial in Newly Diagnosed Breast Cancer–Letter
    Andrew H. Sims, Melanie Leggate and Anna Campbell
    Clin Cancer Res December 15 2019 25 (24) 7609-7610; DOI:10.1158/1078-0432.CCR-19-2571

Correction

  • Correction | Free Article
    Correction: Novel Oncolytic Adenovirus Selectively Targets Tumor-Associated Polo-Like Kinase 1 and Tumor Cell Viability
    Jianfeng Zhou, Qinglei Gao, Gang Chen, Xiaoyuan Huang, Yunping Lu, Kanyan Li, Daxing Xie, Liang Zhuang, Jingniu Deng and Ding Ma
    Clin Cancer Res December 15 2019 25 (24) 7611-7611; DOI:10.1158/1078-0432.CCR-19-3370

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Clinical Cancer Research: 25 (24)
December 2019
Volume 25, Issue 24
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  • Table of Contents (PDF)
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Issue Highlights

  • Phase I Study of Rapid Alternation of Sunitinib and Regorafenib for the Treatment of Tyrosine Kinase Inhibitor Refractory Gastrointestinal Stromal Tumors
  • Efficacy and Safety of Dabrafenib in Pediatric Patients with BRAF V600 Mutation–Positive Relapsed or Refractory Low-Grade Glioma: Results from a Phase I/IIa Study
  • Guadecitabine Plus Ipilimumab in Unresectable Melanoma: The NIBIT-M4 Clinical Trial
  • Impact of FDG PET Imaging for Expanding Patient Eligibility and Measuring Treatment Response in a Genome-Driven Basket Trial of the Pan-HER Kinase Inhibitor, Neratinib

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Clinical Cancer Research
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