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Clinical Trials: Targeted Therapy

Efficacy and Safety of Dabrafenib in Pediatric Patients with BRAF V600 Mutation–Positive Relapsed or Refractory Low-Grade Glioma: Results from a Phase I/IIa Study

Darren R. Hargrave, Eric Bouffet, Uri Tabori, Alberto Broniscer, Kenneth J. Cohen, Jordan R. Hansford, Birgit Geoerger, Pooja Hingorani, Ira J. Dunkel, Mark W. Russo, Lillian Tseng, Kohinoor Dasgupta, Eduard Gasal, James A. Whitlock and Mark W. Kieran
Darren R. Hargrave
1Pediatric Oncology Unit, UCL Great Ormond Street Institute of Child Health, London, United Kingdom.
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  • For correspondence: darren.hargrave@nhs.net
Eric Bouffet
2Department of Pediatrics, Hospital for Sick Children, University of Toronto, Toronto, Ontario, Canada.
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Uri Tabori
3Arthur and Sonia Labatt Brain Tumor Research Center, Division of Hematology/Oncology, Hospital for Sick Children, University of Toronto, Toronto, Ontario, Canada.
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Alberto Broniscer
4Department of Oncology, St. Jude Children's Research Hospital, Memphis, Tennessee.
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Kenneth J. Cohen
5The Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins, Division of Pediatric Oncology, Baltimore, Maryland.
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Jordan R. Hansford
6Department of Pediatrics, The Royal Children's Hospital, Murdoch Children's Research Institute, University of Melbourne, Melbourne, Victoria, Australia.
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Birgit Geoerger
7Department of Childhood and Adolescent Oncology, Gustave Roussy Cancer Center, Université Paris-Saclay, Villejuif, France.
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Pooja Hingorani
8Phoenix Children's Hospital, Center for Cancer and Blood Disorders, Phoenix, Arizona.
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Ira J. Dunkel
9Department of Pediatrics, Memorial Sloan Kettering Cancer Center, New York, New York.
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Mark W. Russo
10Novartis Pharmaceuticals Corporation, East Hanover, New Jersey.
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Lillian Tseng
10Novartis Pharmaceuticals Corporation, East Hanover, New Jersey.
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Kohinoor Dasgupta
11Novartis Healthcare Pvt. Ltd., Hyderabad, India.
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Eduard Gasal
10Novartis Pharmaceuticals Corporation, East Hanover, New Jersey.
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James A. Whitlock
2Department of Pediatrics, Hospital for Sick Children, University of Toronto, Toronto, Ontario, Canada.
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Mark W. Kieran
12Harvard Medical School, Boston Children's Hospital, Dana-Farber Cancer Institute, Boston, Massachusetts.
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DOI: 10.1158/1078-0432.CCR-19-2177 Published December 2019
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Cited By

Article Information

Volume 25, Issue 24, pp. 7303-7311

DOI 
https://doi.org/10.1158/1078-0432.CCR-19-2177
PubMed 
31811016

Published By 
American Association for Cancer Research
Print ISSN 
1078-0432
Online ISSN 
1557-3265
History 
  • Received July 2, 2019
  • Revision received September 19, 2019
  • Accepted October 17, 2019
  • Published first December 6, 2019.

Article Versions

  • Previous version (December 6, 2019 - 00:05).
  • You are viewing the most recent version of this article.
Copyright & Usage 
©2019 American Association for Cancer Research.

Author Information

  1. Darren R. Hargrave1,*,
  2. Eric Bouffet2,
  3. Uri Tabori3,
  4. Alberto Broniscer4,
  5. Kenneth J. Cohen5,
  6. Jordan R. Hansford6,
  7. Birgit Geoerger7,
  8. Pooja Hingorani8,
  9. Ira J. Dunkel9,
  10. Mark W. Russo10,
  11. Lillian Tseng10,
  12. Kohinoor Dasgupta11,
  13. Eduard Gasal10,
  14. James A. Whitlock2, and
  15. Mark W. Kieran12
  1. 1Pediatric Oncology Unit, UCL Great Ormond Street Institute of Child Health, London, United Kingdom.
  2. 2Department of Pediatrics, Hospital for Sick Children, University of Toronto, Toronto, Ontario, Canada.
  3. 3Arthur and Sonia Labatt Brain Tumor Research Center, Division of Hematology/Oncology, Hospital for Sick Children, University of Toronto, Toronto, Ontario, Canada.
  4. 4Department of Oncology, St. Jude Children's Research Hospital, Memphis, Tennessee.
  5. 5The Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins, Division of Pediatric Oncology, Baltimore, Maryland.
  6. 6Department of Pediatrics, The Royal Children's Hospital, Murdoch Children's Research Institute, University of Melbourne, Melbourne, Victoria, Australia.
  7. 7Department of Childhood and Adolescent Oncology, Gustave Roussy Cancer Center, Université Paris-Saclay, Villejuif, France.
  8. 8Phoenix Children's Hospital, Center for Cancer and Blood Disorders, Phoenix, Arizona.
  9. 9Department of Pediatrics, Memorial Sloan Kettering Cancer Center, New York, New York.
  10. 10Novartis Pharmaceuticals Corporation, East Hanover, New Jersey.
  11. 11Novartis Healthcare Pvt. Ltd., Hyderabad, India.
  12. 12Harvard Medical School, Boston Children's Hospital, Dana-Farber Cancer Institute, Boston, Massachusetts.
  1. ↵*Corresponding Author:
    Darren R. Hargrave, UCL Great Ormond Street Institute of Child Health, Great Ormond Street, London, WC1N 3JH, United Kingdom. Phone: 4420-7813-8525; Fax: 4420-7813-8588; E-mail: darren.hargrave{at}nhs.net
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Clinical Cancer Research: 25 (24)
December 2019
Volume 25, Issue 24
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Efficacy and Safety of Dabrafenib in Pediatric Patients with BRAF V600 Mutation–Positive Relapsed or Refractory Low-Grade Glioma: Results from a Phase I/IIa Study
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Efficacy and Safety of Dabrafenib in Pediatric Patients with BRAF V600 Mutation–Positive Relapsed or Refractory Low-Grade Glioma: Results from a Phase I/IIa Study
Darren R. Hargrave, Eric Bouffet, Uri Tabori, Alberto Broniscer, Kenneth J. Cohen, Jordan R. Hansford, Birgit Geoerger, Pooja Hingorani, Ira J. Dunkel, Mark W. Russo, Lillian Tseng, Kohinoor Dasgupta, Eduard Gasal, James A. Whitlock and Mark W. Kieran
Clin Cancer Res December 15 2019 (25) (24) 7303-7311; DOI: 10.1158/1078-0432.CCR-19-2177

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Efficacy and Safety of Dabrafenib in Pediatric Patients with BRAF V600 Mutation–Positive Relapsed or Refractory Low-Grade Glioma: Results from a Phase I/IIa Study
Darren R. Hargrave, Eric Bouffet, Uri Tabori, Alberto Broniscer, Kenneth J. Cohen, Jordan R. Hansford, Birgit Geoerger, Pooja Hingorani, Ira J. Dunkel, Mark W. Russo, Lillian Tseng, Kohinoor Dasgupta, Eduard Gasal, James A. Whitlock and Mark W. Kieran
Clin Cancer Res December 15 2019 (25) (24) 7303-7311; DOI: 10.1158/1078-0432.CCR-19-2177
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