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Clinical Cancer Research
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Table of Contents

Highlights

  • Highlights
    Highlights of This Issue
    Clin Cancer Res March 1 2019 25 (5) 1439-1439;

CCR Translations

  • CCR Translations
    Predicting Outcome in Head and Neck Cancer: miRNAs with Potentially Big Effects
    David A. Clump, Curtis R. Pickering and Heath D. Skinner
    Clin Cancer Res March 1 2019 25 (5) 1441-1442; DOI:10.1158/1078-0432.CCR-18-3078

  • CCR Translations
    Predicting Treatment Response Based on RNA Expression in Large Datasets
    Aaron S. Mansfield and Jin Jen
    Clin Cancer Res March 1 2019 25 (5) 1443-1445; DOI:10.1158/1078-0432.CCR-18-2823

  • CCR Translations
    Virus, Vessel, Victory: A Novel Approach to Tumor Killing
    Yonina Bykov and Dmitriy Zamarin
    Clin Cancer Res March 1 2019 25 (5) 1446-1448; DOI:10.1158/1078-0432.CCR-18-3441

  • CCR Translations
    Tumor-Infiltrating Lymphocytes—Location for Prognostic Evaluation
    Michael Peled, Amir Onn and Roy S. Herbst
    Clin Cancer Res March 1 2019 25 (5) 1449-1451; DOI:10.1158/1078-0432.CCR-18-3803

  • CCR Translations
    Biomarkers for Immunotherapy Toxicity: Are Cytokines the Answer?
    Douglas B. Johnson and Justin M. Balko
    Clin Cancer Res March 1 2019 25 (5) 1452-1454; DOI:10.1158/1078-0432.CCR-18-3858

CCR Perspectives in Regulatory Science and Policy

  • CCR Perspectives in Regulatory Science and Policy
    Clinical Development of Novel Drug–Radiotherapy Combinations
    Saif S. Ahmad, Marka R. Crittenden, Phuoc T. Tran, Paul G. Kluetz, Gideon M. Blumenthal, Helen Bulbeck, Richard D. Baird, Kaye J. Williams, Tim Illidge, Stephen M. Hahn, Theodore S. Lawrence, Patricia A. Spears, Amanda J. Walker and Ricky A. Sharma
    Clin Cancer Res March 1 2019 25 (5) 1455-1461; DOI:10.1158/1078-0432.CCR-18-2466

Review

  • Review | AuthorChoice
    Reimagining IDO Pathway Inhibition in Cancer Immunotherapy via Downstream Focus on the Tryptophan–Kynurenine–Aryl Hydrocarbon Axis
    Brian W. Labadie, Riyue Bao and Jason J. Luke
    Clin Cancer Res March 1 2019 25 (5) 1462-1471; DOI:10.1158/1078-0432.CCR-18-2882

Clinical Trials: Targeted Therapy

  • Clinical Trials: Targeted Therapy
    Phase IB Dose Escalation and Expansion Study of AKT Inhibitor Afuresertib with Carboplatin and Paclitaxel in Recurrent Platinum-resistant Ovarian Cancer
    Sarah P. Blagden, Anne L. Hamilton, Linda Mileshkin, Shirley Wong, Agnieszka Michael, Marcia Hall, Jeffrey C. Goh, Alla S. Lisyanskaya, Michelle DeSilvio, Eleni Frangou, Euan A. Stronach, Prashanth Gopalakrishna, Tarek M. Meniawy and Hani Gabra
    Clin Cancer Res March 1 2019 25 (5) 1472-1478; DOI:10.1158/1078-0432.CCR-18-2277

  • Clinical Trials: Targeted Therapy | AuthorChoice
    Impact of Concomitant Administration of Gastric Acid–Suppressive Agents and Pazopanib on Outcomes in Soft-Tissue Sarcoma Patients Treated within the EORTC 62043/62072 Trials
    Olivier Mir, Nathan Touati, Michela Lia, Saskia Litière, Axel Le Cesne, Stefan Sleijfer, Jean-Yves Blay, Michael Leahy, Robin Young, Ron H.J. Mathijssen, Nielka P. Van Erp, Hans Gelderblom, Winette T. Van der Graaf and Alessandro Gronchi
    Clin Cancer Res March 1 2019 25 (5) 1479-1485; DOI:10.1158/1078-0432.CCR-18-2748

Clinical Trials: Immunotherapy

  • Clinical Trials: Immunotherapy
    A Phase II Study of Tumor-infiltrating Lymphocyte Therapy for Human Papillomavirus–associated Epithelial Cancers
    Sanja Stevanović, Sarah R. Helman, John R. Wunderlich, Michelle M. Langhan, Stacey L. Doran, Mei Li M. Kwong, Robert P.T. Somerville, Christopher A. Klebanoff, Udai S. Kammula, Richard M. Sherry, James C. Yang, Steven A. Rosenberg and Christian S. Hinrichs
    Clin Cancer Res March 1 2019 25 (5) 1486-1493; DOI:10.1158/1078-0432.CCR-18-2722

  • Clinical Trials: Immunotherapy | AuthorChoice
    Autologous Dendritic Cell-Cytokine Induced Killer Cell Immunotherapy Combined with S-1 Plus Cisplatin in Patients with Advanced Gastric Cancer: A Prospective Study
    Guoliang Qiao, Xiaoli Wang, Lei Zhou, Xinna Zhou, Yuguang Song, Shuo Wang, Lei Zhao, Michael A. Morse, Amy Hobeika, Jin Song, Xin Yi, Xuefeng Xia, Jun Ren and Herbert Kim Lyerly
    Clin Cancer Res March 1 2019 25 (5) 1494-1504; DOI:10.1158/1078-0432.CCR-18-2360

Precision Medicine and Imaging

  • Precision Medicine and Imaging
    A Five-MicroRNA Signature Predicts Survival and Disease Control of Patients with Head and Neck Cancer Negative for HPV Infection
    Julia Hess, Kristian Unger, Cornelius Maihoefer, Lars Schüttrumpf, Ludmila Wintergerst, Theresa Heider, Peter Weber, Sebastian Marschner, Herbert Braselmann, Daniel Samaga, Sebastian Kuger, Ulrike Pflugradt, Philipp Baumeister, Axel Walch, Christine Woischke, Thomas Kirchner, Martin Werner, Kristin Werner, Michael Baumann, Volker Budach, Stephanie E. Combs, Jürgen Debus, Anca-Ligia Grosu, Mechthild Krause, Annett Linge, Claus Rödel, Martin Stuschke, Daniel Zips, Horst Zitzelsberger, Ute Ganswindt, Michael Henke and Claus Belka
    Clin Cancer Res March 1 2019 25 (5) 1505-1516; DOI:10.1158/1078-0432.CCR-18-0776

  • Precision Medicine and Imaging
    Rare, Pathogenic Germline Variants in Fanconi Anemia Genes Increase Risk for Squamous Lung Cancer
    Myvizhi Esai Selvan, Robert J. Klein and Zeynep H. Gümüş
    Clin Cancer Res March 1 2019 25 (5) 1517-1525; DOI:10.1158/1078-0432.CCR-18-2660

  • Precision Medicine and Imaging
    Spatial Architecture and Arrangement of Tumor-Infiltrating Lymphocytes for Predicting Likelihood of Recurrence in Early-Stage Non–Small Cell Lung Cancer
    Germán Corredor, Xiangxue Wang, Yu Zhou, Cheng Lu, Pingfu Fu, Konstantinos Syrigos, David L. Rimm, Michael Yang, Eduardo Romero, Kurt A. Schalper, Vamsidhar Velcheti and Anant Madabhushi
    Clin Cancer Res March 1 2019 25 (5) 1526-1534; DOI:10.1158/1078-0432.CCR-18-2013

  • Precision Medicine and Imaging
    NK Cell Infiltrates and HLA Class I Expression in Primary HER2+ Breast Cancer Predict and Uncouple Pathological Response and Disease-free Survival
    Aura Muntasell, Federico Rojo, Sonia Servitja, Carlota Rubio-Perez, Mariona Cabo, David Tamborero, Marcel Costa-García, María Martínez-Garcia, Sílvia Menéndez, Ivonne Vazquez, Ana Lluch, Abel Gonzalez-Perez, Ana Rovira, Miguel López-Botet and Joan Albanell
    Clin Cancer Res March 1 2019 25 (5) 1535-1545; DOI:10.1158/1078-0432.CCR-18-2365

  • Precision Medicine and Imaging | AuthorChoice
    Development and Validation of a Novel Signature to Predict Overall Survival in “Driver Gene–negative” Lung Adenocarcinoma (LUAD): Results of a Multicenter Study
    Yongmei Cui, Wenfeng Fang, Chaofeng Li, Kejing Tang, Jian Zhang, Yiyan Lei, Weiling He, Sui Peng, Ming Kuang, Hui Zhang, Lili Chen, Di Xu, Cuilan Tang, Wenhui Zhang, Yuxin Zhu, Wenting Jiang, Neng Jiang, Yu Sun, Yangshan Chen, Han Wang, Yingrong Lai, Shuhua Li, Qiong He, Jianwen Zhou, Yang Zhang, Millicent Lin, Honglei Chen, Chenzhi Zhou, Chunlin Wang, Jianhong Wang, Xuenong Zou, Liantang Wang and Zunfu Ke
    Clin Cancer Res March 1 2019 25 (5) 1546-1556; DOI:10.1158/1078-0432.CCR-18-2545

Translational Cancer Mechanisms and Therapy

  • Translational Cancer Mechanisms and Therapy
    Circulating Cytokines Predict Immune-Related Toxicity in Melanoma Patients Receiving Anti-PD-1–Based Immunotherapy
    Su Y. Lim, Jenny H. Lee, Tuba N. Gide, Alexander M. Menzies, Alexander Guminski, Matteo S. Carlino, Edmond J. Breen, Jean Y.H. Yang, Shila Ghazanfar, Richard F. Kefford, Richard A. Scolyer, Georgina V. Long and Helen Rizos
    Clin Cancer Res March 1 2019 25 (5) 1557-1563; DOI:10.1158/1078-0432.CCR-18-2795

  • Translational Cancer Mechanisms and Therapy
    Molecular Profiling of Cohorts of Tumor Samples to Guide Clinical Development of Pembrolizumab as Monotherapy
    Mark Ayers, Michael Nebozhyn, Razvan Cristescu, Terrill K. McClanahan, Rodolfo Perini, Eric Rubin, Jonathan D. Cheng, David R. Kaufman and Andrey Loboda
    Clin Cancer Res March 1 2019 25 (5) 1564-1573; DOI:10.1158/1078-0432.CCR-18-1316

  • Translational Cancer Mechanisms and Therapy
    AKT/mTORC2 Inhibition Activates FOXO1 Function in CLL Cells Reducing B-Cell Receptor-Mediated Survival
    Emilio Cosimo, Anuradha Tarafdar, Michael W. Moles, Ailsa K. Holroyd, Natasha Malik, Mark A. Catherwood, Jodie Hay, Karen M. Dunn, Alan M. Macdonald, Sylvie M. Guichard, Declan O'Rourke, Michael T. Leach, Owen J. Sansom, Sabina C. Cosulich, Alison M. McCaig and Alison M. Michie
    Clin Cancer Res March 1 2019 25 (5) 1574-1587; DOI:10.1158/1078-0432.CCR-18-2036

  • Translational Cancer Mechanisms and Therapy
    Ablation of Cancer Stem Cells by Therapeutic Inhibition of the MDM2–p53 Interaction in Mucoepidermoid Carcinoma
    April Andrews, Kristy Warner, Christie Rodriguez-Ramirez, Alexander T. Pearson, Felipe Nör, Zhaocheng Zhang, Samuel Kerk, Aditi Kulkarni, Joseph I. Helman, J. Chad Brenner, Max S. Wicha, Shaomeng Wang and Jacques E. Nör
    Clin Cancer Res March 1 2019 25 (5) 1588-1600; DOI:10.1158/1078-0432.CCR-17-2730

  • Translational Cancer Mechanisms and Therapy
    Eradication of Central Nervous System Leukemia of T-Cell Origin with a Brain-Permeable LSD1 Inhibitor
    Shiori Saito, Jiro Kikuchi, Daisuke Koyama, Shin Sato, Hiroo Koyama, Naoki Osada, Yoshiaki Kuroda, Koshi Akahane, Takeshi Inukai, Takashi Umehara and Yusuke Furukawa
    Clin Cancer Res March 1 2019 25 (5) 1601-1611; DOI:10.1158/1078-0432.CCR-18-0919

  • Translational Cancer Mechanisms and Therapy
    Tumor Microenvironment Remodeling by Intratumoral Oncolytic Vaccinia Virus Enhances the Efficacy of Immune-Checkpoint Blockade
    Hong Jae Chon, Won Suk Lee, Hannah Yang, So Jung Kong, Na Keum Lee, Eun Sang Moon, Jiwon Choi, Eun Chun Han, Joo Hoon Kim, Joong Bae Ahn, Joo Hang Kim and Chan Kim
    Clin Cancer Res March 1 2019 25 (5) 1612-1623; DOI:10.1158/1078-0432.CCR-18-1932

  • Translational Cancer Mechanisms and Therapy
    Combining Vascular Normalization with an Oncolytic Virus Enhances Immunotherapy in a Preclinical Model of Advanced-Stage Ovarian Cancer
    Kathy Matuszewska, Lisa A. Santry, Jacob P. van Vloten, Amanda W.K. AuYeung, Pierre P. Major, Jack Lawler, Sarah K. Wootton, Byram W. Bridle and Jim Petrik
    Clin Cancer Res March 1 2019 25 (5) 1624-1638; DOI:10.1158/1078-0432.CCR-18-0220

  • Translational Cancer Mechanisms and Therapy
    NRF2 through RPS6 Activation Is Related to Anti-HER2 Drug Resistance in HER2-Amplified Gastric Cancer
    Valentina Gambardella, Francisco Gimeno-Valiente, Noelia Tarazona, Carolina Martinez Ciarpaglini, Desamparados Roda, Tania Fleitas, Pablo Tolosa, Juan Miguel Cejalvo, Marisol Huerta, Susana Roselló, Josefa Castillo and Andrés Cervantes
    Clin Cancer Res March 1 2019 25 (5) 1639-1649; DOI:10.1158/1078-0432.CCR-18-2421

  • Translational Cancer Mechanisms and Therapy
    The COX2 Effector Microsomal PGE2 Synthase 1 is a Regulator of Immunosuppression in Cutaneous Melanoma
    Sun-Hee Kim, Jason Roszik, Sung-Nam Cho, Dai Ogata, Denái R. Milton, Weiyi Peng, David G. Menter, Suhendan Ekmekcioglu and Elizabeth A. Grimm
    Clin Cancer Res March 1 2019 25 (5) 1650-1663; DOI:10.1158/1078-0432.CCR-18-1163

  • Translational Cancer Mechanisms and Therapy
    The Ewing Family of Tumors Relies on BCL-2 and BCL-XL to Escape PARP Inhibitor Toxicity
    Daniel A.R. Heisey, Timothy L. Lochmann, Konstantinos V. Floros, Colin M. Coon, Krista M. Powell, Sheeba Jacob, Marissa L. Calbert, Maninderjit S. Ghotra, Giovanna T. Stein, Yuki Kato Maves, Steven C. Smith, Cyril H. Benes, Joel D. Leverson, Andrew J. Souers, Sosipatros A. Boikos and Anthony C. Faber
    Clin Cancer Res March 1 2019 25 (5) 1664-1675; DOI:10.1158/1078-0432.CCR-18-0277

  • Translational Cancer Mechanisms and Therapy | AuthorChoice
    Anagrelide for Gastrointestinal Stromal Tumor
    Olli-Pekka Pulkka, Yemarshet K. Gebreyohannes, Agnieszka Wozniak, John-Patrick Mpindi, Olli Tynninen, Katherine Icay, Alejandra Cervera, Salla Keskitalo, Astrid Murumägi, Evgeny Kulesskiy, Maria Laaksonen, Krister Wennerberg, Markku Varjosalo, Pirjo Laakkonen, Rainer Lehtonen, Sampsa Hautaniemi, Olli Kallioniemi, Patrick Schöffski, Harri Sihto and Heikki Joensuu
    Clin Cancer Res March 1 2019 25 (5) 1676-1687; DOI:10.1158/1078-0432.CCR-18-0815

Letters to the Editor

  • Letters to the Editor
    DICER1 and Associated Conditions: Identification of At-risk Individuals and Recommended Surveillance Strategies—Letter
    Leeyan S. Gilmour, Penny J. Hunt, Karen E. Mackenzie and Martin de Bock
    Clin Cancer Res March 1 2019 25 (5) 1688-1688; DOI:10.1158/1078-0432.CCR-18-2897

  • Letters to the Editor
    DICER1 and Associated Conditions: Identification of At-risk Individuals and Recommended Surveillance Strategies—Response
    Andrew J. Bauer, Douglas R. Stewart, Junne Kamihara, Anne K. Harris, Joyce Turner, Rachana Shah, Kami Wolfe Schneider, Katherine Schneider, Ann Garrity Carr, Laura A. Harney, A. Lindsay Frazier, Daniel Orbach, Dominik T. Schneider, David Malkin, Louis P. Dehner, Yoav H. Messinger, D. Ashley Hill and Kris Ann P. Schultz
    Clin Cancer Res March 1 2019 25 (5) 1689-1690; DOI:10.1158/1078-0432.CCR-18-3495

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Clinical Cancer Research: 25 (5)
March 2019
Volume 25, Issue 5
  • Table of Contents
  • Table of Contents (PDF)
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  • Editorial Board (PDF)

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Issue Highlights

  • NK Cell Infiltrates and HLA Class I Expression in Primary HER2+ Breast Cancer Predict and Uncouple Pathological Response and Disease-free Survival
  • Phase IB Dose Escalation and Expansion Study of AKT Inhibitor Afuresertib with Carboplatin and Paclitaxel in Recurrent Platinum-resistant Ovarian Cancer
  • Eradication of Central Nervous System Leukemia of T-Cell Origin with a Brain-Permeable LSD1 Inhibitor
  • Tumor Microenvironment Remodeling by Intratumoral Oncolytic Vaccinia Virus Enhances the Efficacy of Immune-Checkpoint Blockade

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  • Characterization of Glioblastoma Patient-Derived Xenografts
  • FLASH-RT Spares Lung Progenitor Cells
  • AR Gene Rearrangements in Prostate Cancer
  • PDAC and GATA6 Expression
  • Guadecitabine and Carboplatin in Ovarian Cancer
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Clinical Cancer Research
eISSN: 1557-3265
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