Clinical Cancer Research: 25 (5)

Highlights

Highlights

Highlights of This Issue

Clin Cancer Res March 1 2019 25 (5) 1439-1439;

CCR Translations

CCR Translations

Predicting Outcome in Head and Neck Cancer: miRNAs with Potentially Big Effects

David A. Clump, Curtis R. Pickering and Heath D. Skinner

Clin Cancer Res March 1 2019 25 (5) 1441-1442; DOI:10.1158/1078-0432.CCR-18-3078
CCR Translations

Predicting Treatment Response Based on RNA Expression in Large Datasets

Aaron S. Mansfield and Jin Jen

Clin Cancer Res March 1 2019 25 (5) 1443-1445; DOI:10.1158/1078-0432.CCR-18-2823
CCR Translations

Virus, Vessel, Victory: A Novel Approach to Tumor Killing

Yonina Bykov and Dmitriy Zamarin

Clin Cancer Res March 1 2019 25 (5) 1446-1448; DOI:10.1158/1078-0432.CCR-18-3441
CCR Translations

Tumor-Infiltrating Lymphocytes—Location for Prognostic Evaluation

Michael Peled, Amir Onn and Roy S. Herbst

Clin Cancer Res March 1 2019 25 (5) 1449-1451; DOI:10.1158/1078-0432.CCR-18-3803
CCR Translations

Biomarkers for Immunotherapy Toxicity: Are Cytokines the Answer?

Douglas B. Johnson and Justin M. Balko

Clin Cancer Res March 1 2019 25 (5) 1452-1454; DOI:10.1158/1078-0432.CCR-18-3858

CCR Perspectives in Regulatory Science and Policy

CCR Perspectives in Regulatory Science and Policy

Clinical Development of Novel Drug–Radiotherapy Combinations

Saif S. Ahmad, Marka R. Crittenden, Phuoc T. Tran, Paul G. Kluetz, Gideon M. Blumenthal, Helen Bulbeck, Richard D. Baird, Kaye J. Williams, Tim Illidge, Stephen M. Hahn, Theodore S. Lawrence, Patricia A. Spears, Amanda J. Walker and Ricky A. Sharma

Clin Cancer Res March 1 2019 25 (5) 1455-1461; DOI:10.1158/1078-0432.CCR-18-2466

Review

Review | AuthorChoice

Reimagining IDO Pathway Inhibition in Cancer Immunotherapy via Downstream Focus on the Tryptophan–Kynurenine–Aryl Hydrocarbon Axis

Brian W. Labadie, Riyue Bao and Jason J. Luke

Clin Cancer Res March 1 2019 25 (5) 1462-1471; DOI:10.1158/1078-0432.CCR-18-2882

Clinical Trials: Targeted Therapy

Clinical Trials: Targeted Therapy

Phase IB Dose Escalation and Expansion Study of AKT Inhibitor Afuresertib with Carboplatin and Paclitaxel in Recurrent Platinum-resistant Ovarian Cancer

Sarah P. Blagden, Anne L. Hamilton, Linda Mileshkin, Shirley Wong, Agnieszka Michael, Marcia Hall, Jeffrey C. Goh, Alla S. Lisyanskaya, Michelle DeSilvio, Eleni Frangou, Euan A. Stronach, Prashanth Gopalakrishna, Tarek M. Meniawy and Hani Gabra

Clin Cancer Res March 1 2019 25 (5) 1472-1478; DOI:10.1158/1078-0432.CCR-18-2277
Clinical Trials: Targeted Therapy | AuthorChoice

Impact of Concomitant Administration of Gastric Acid–Suppressive Agents and Pazopanib on Outcomes in Soft-Tissue Sarcoma Patients Treated within the EORTC 62043/62072 Trials

Olivier Mir, Nathan Touati, Michela Lia, Saskia Litière, Axel Le Cesne, Stefan Sleijfer, Jean-Yves Blay, Michael Leahy, Robin Young, Ron H.J. Mathijssen, Nielka P. Van Erp, Hans Gelderblom, Winette T. Van der Graaf and Alessandro Gronchi

Clin Cancer Res March 1 2019 25 (5) 1479-1485; DOI:10.1158/1078-0432.CCR-18-2748

Clinical Trials: Immunotherapy

Clinical Trials: Immunotherapy

A Phase II Study of Tumor-infiltrating Lymphocyte Therapy for Human Papillomavirus–associated Epithelial Cancers

Sanja Stevanović, Sarah R. Helman, John R. Wunderlich, Michelle M. Langhan, Stacey L. Doran, Mei Li M. Kwong, Robert P.T. Somerville, Christopher A. Klebanoff, Udai S. Kammula, Richard M. Sherry, James C. Yang, Steven A. Rosenberg and Christian S. Hinrichs

Clin Cancer Res March 1 2019 25 (5) 1486-1493; DOI:10.1158/1078-0432.CCR-18-2722
Clinical Trials: Immunotherapy | AuthorChoice

Autologous Dendritic Cell-Cytokine Induced Killer Cell Immunotherapy Combined with S-1 Plus Cisplatin in Patients with Advanced Gastric Cancer: A Prospective Study

Guoliang Qiao, Xiaoli Wang, Lei Zhou, Xinna Zhou, Yuguang Song, Shuo Wang, Lei Zhao, Michael A. Morse, Amy Hobeika, Jin Song, Xin Yi, Xuefeng Xia, Jun Ren and Herbert Kim Lyerly

Clin Cancer Res March 1 2019 25 (5) 1494-1504; DOI:10.1158/1078-0432.CCR-18-2360

Precision Medicine and Imaging

Precision Medicine and Imaging

A Five-MicroRNA Signature Predicts Survival and Disease Control of Patients with Head and Neck Cancer Negative for HPV Infection

Julia Hess, Kristian Unger, Cornelius Maihoefer, Lars Schüttrumpf, Ludmila Wintergerst, Theresa Heider, Peter Weber, Sebastian Marschner, Herbert Braselmann, Daniel Samaga, Sebastian Kuger, Ulrike Pflugradt, Philipp Baumeister, Axel Walch, Christine Woischke, Thomas Kirchner, Martin Werner, Kristin Werner, Michael Baumann, Volker Budach, Stephanie E. Combs, Jürgen Debus, Anca-Ligia Grosu, Mechthild Krause, Annett Linge, Claus Rödel, Martin Stuschke, Daniel Zips, Horst Zitzelsberger, Ute Ganswindt, Michael Henke and Claus Belka

Clin Cancer Res March 1 2019 25 (5) 1505-1516; DOI:10.1158/1078-0432.CCR-18-0776
Precision Medicine and Imaging

Rare, Pathogenic Germline Variants in Fanconi Anemia Genes Increase Risk for Squamous Lung Cancer

Myvizhi Esai Selvan, Robert J. Klein and Zeynep H. Gümüş

Clin Cancer Res March 1 2019 25 (5) 1517-1525; DOI:10.1158/1078-0432.CCR-18-2660
Precision Medicine and Imaging

Spatial Architecture and Arrangement of Tumor-Infiltrating Lymphocytes for Predicting Likelihood of Recurrence in Early-Stage Non–Small Cell Lung Cancer

Germán Corredor, Xiangxue Wang, Yu Zhou, Cheng Lu, Pingfu Fu, Konstantinos Syrigos, David L. Rimm, Michael Yang, Eduardo Romero, Kurt A. Schalper, Vamsidhar Velcheti and Anant Madabhushi

Clin Cancer Res March 1 2019 25 (5) 1526-1534; DOI:10.1158/1078-0432.CCR-18-2013
Precision Medicine and Imaging

NK Cell Infiltrates and HLA Class I Expression in Primary HER2⁺ Breast Cancer Predict and Uncouple Pathological Response and Disease-free Survival

Aura Muntasell, Federico Rojo, Sonia Servitja, Carlota Rubio-Perez, Mariona Cabo, David Tamborero, Marcel Costa-García, María Martínez-Garcia, Sílvia Menéndez, Ivonne Vazquez, Ana Lluch, Abel Gonzalez-Perez, Ana Rovira, Miguel López-Botet and Joan Albanell

Clin Cancer Res March 1 2019 25 (5) 1535-1545; DOI:10.1158/1078-0432.CCR-18-2365
Precision Medicine and Imaging | AuthorChoice

Development and Validation of a Novel Signature to Predict Overall Survival in “Driver Gene–negative” Lung Adenocarcinoma (LUAD): Results of a Multicenter Study

Yongmei Cui, Wenfeng Fang, Chaofeng Li, Kejing Tang, Jian Zhang, Yiyan Lei, Weiling He, Sui Peng, Ming Kuang, Hui Zhang, Lili Chen, Di Xu, Cuilan Tang, Wenhui Zhang, Yuxin Zhu, Wenting Jiang, Neng Jiang, Yu Sun, Yangshan Chen, Han Wang, Yingrong Lai, Shuhua Li, Qiong He, Jianwen Zhou, Yang Zhang, Millicent Lin, Honglei Chen, Chenzhi Zhou, Chunlin Wang, Jianhong Wang, Xuenong Zou, Liantang Wang and Zunfu Ke

Clin Cancer Res March 1 2019 25 (5) 1546-1556; DOI:10.1158/1078-0432.CCR-18-2545

Translational Cancer Mechanisms and Therapy

Translational Cancer Mechanisms and Therapy

Circulating Cytokines Predict Immune-Related Toxicity in Melanoma Patients Receiving Anti-PD-1–Based Immunotherapy

Su Y. Lim, Jenny H. Lee, Tuba N. Gide, Alexander M. Menzies, Alexander Guminski, Matteo S. Carlino, Edmond J. Breen, Jean Y.H. Yang, Shila Ghazanfar, Richard F. Kefford, Richard A. Scolyer, Georgina V. Long and Helen Rizos

Clin Cancer Res March 1 2019 25 (5) 1557-1563; DOI:10.1158/1078-0432.CCR-18-2795
Translational Cancer Mechanisms and Therapy

Molecular Profiling of Cohorts of Tumor Samples to Guide Clinical Development of Pembrolizumab as Monotherapy

Mark Ayers, Michael Nebozhyn, Razvan Cristescu, Terrill K. McClanahan, Rodolfo Perini, Eric Rubin, Jonathan D. Cheng, David R. Kaufman and Andrey Loboda

Clin Cancer Res March 1 2019 25 (5) 1564-1573; DOI:10.1158/1078-0432.CCR-18-1316
Translational Cancer Mechanisms and Therapy

AKT/mTORC2 Inhibition Activates FOXO1 Function in CLL Cells Reducing B-Cell Receptor-Mediated Survival

Emilio Cosimo, Anuradha Tarafdar, Michael W. Moles, Ailsa K. Holroyd, Natasha Malik, Mark A. Catherwood, Jodie Hay, Karen M. Dunn, Alan M. Macdonald, Sylvie M. Guichard, Declan O'Rourke, Michael T. Leach, Owen J. Sansom, Sabina C. Cosulich, Alison M. McCaig and Alison M. Michie

Clin Cancer Res March 1 2019 25 (5) 1574-1587; DOI:10.1158/1078-0432.CCR-18-2036
Translational Cancer Mechanisms and Therapy

Ablation of Cancer Stem Cells by Therapeutic Inhibition of the MDM2–p53 Interaction in Mucoepidermoid Carcinoma

April Andrews, Kristy Warner, Christie Rodriguez-Ramirez, Alexander T. Pearson, Felipe Nör, Zhaocheng Zhang, Samuel Kerk, Aditi Kulkarni, Joseph I. Helman, J. Chad Brenner, Max S. Wicha, Shaomeng Wang and Jacques E. Nör

Clin Cancer Res March 1 2019 25 (5) 1588-1600; DOI:10.1158/1078-0432.CCR-17-2730
Translational Cancer Mechanisms and Therapy

Eradication of Central Nervous System Leukemia of T-Cell Origin with a Brain-Permeable LSD1 Inhibitor

Shiori Saito, Jiro Kikuchi, Daisuke Koyama, Shin Sato, Hiroo Koyama, Naoki Osada, Yoshiaki Kuroda, Koshi Akahane, Takeshi Inukai, Takashi Umehara and Yusuke Furukawa

Clin Cancer Res March 1 2019 25 (5) 1601-1611; DOI:10.1158/1078-0432.CCR-18-0919
Translational Cancer Mechanisms and Therapy

Tumor Microenvironment Remodeling by Intratumoral Oncolytic Vaccinia Virus Enhances the Efficacy of Immune-Checkpoint Blockade

Hong Jae Chon, Won Suk Lee, Hannah Yang, So Jung Kong, Na Keum Lee, Eun Sang Moon, Jiwon Choi, Eun Chun Han, Joo Hoon Kim, Joong Bae Ahn, Joo Hang Kim and Chan Kim

Clin Cancer Res March 1 2019 25 (5) 1612-1623; DOI:10.1158/1078-0432.CCR-18-1932
Translational Cancer Mechanisms and Therapy

Combining Vascular Normalization with an Oncolytic Virus Enhances Immunotherapy in a Preclinical Model of Advanced-Stage Ovarian Cancer

Kathy Matuszewska, Lisa A. Santry, Jacob P. van Vloten, Amanda W.K. AuYeung, Pierre P. Major, Jack Lawler, Sarah K. Wootton, Byram W. Bridle and Jim Petrik

Clin Cancer Res March 1 2019 25 (5) 1624-1638; DOI:10.1158/1078-0432.CCR-18-0220
Translational Cancer Mechanisms and Therapy

NRF2 through RPS6 Activation Is Related to Anti-HER2 Drug Resistance in HER2-Amplified Gastric Cancer

Valentina Gambardella, Francisco Gimeno-Valiente, Noelia Tarazona, Carolina Martinez Ciarpaglini, Desamparados Roda, Tania Fleitas, Pablo Tolosa, Juan Miguel Cejalvo, Marisol Huerta, Susana Roselló, Josefa Castillo and Andrés Cervantes

Clin Cancer Res March 1 2019 25 (5) 1639-1649; DOI:10.1158/1078-0432.CCR-18-2421
Translational Cancer Mechanisms and Therapy

The COX2 Effector Microsomal PGE2 Synthase 1 is a Regulator of Immunosuppression in Cutaneous Melanoma

Sun-Hee Kim, Jason Roszik, Sung-Nam Cho, Dai Ogata, Denái R. Milton, Weiyi Peng, David G. Menter, Suhendan Ekmekcioglu and Elizabeth A. Grimm

Clin Cancer Res March 1 2019 25 (5) 1650-1663; DOI:10.1158/1078-0432.CCR-18-1163
Translational Cancer Mechanisms and Therapy

The Ewing Family of Tumors Relies on BCL-2 and BCL-X_L to Escape PARP Inhibitor Toxicity

Daniel A.R. Heisey, Timothy L. Lochmann, Konstantinos V. Floros, Colin M. Coon, Krista M. Powell, Sheeba Jacob, Marissa L. Calbert, Maninderjit S. Ghotra, Giovanna T. Stein, Yuki Kato Maves, Steven C. Smith, Cyril H. Benes, Joel D. Leverson, Andrew J. Souers, Sosipatros A. Boikos and Anthony C. Faber

Clin Cancer Res March 1 2019 25 (5) 1664-1675; DOI:10.1158/1078-0432.CCR-18-0277
Translational Cancer Mechanisms and Therapy | AuthorChoice

Anagrelide for Gastrointestinal Stromal Tumor

Olli-Pekka Pulkka, Yemarshet K. Gebreyohannes, Agnieszka Wozniak, John-Patrick Mpindi, Olli Tynninen, Katherine Icay, Alejandra Cervera, Salla Keskitalo, Astrid Murumägi, Evgeny Kulesskiy, Maria Laaksonen, Krister Wennerberg, Markku Varjosalo, Pirjo Laakkonen, Rainer Lehtonen, Sampsa Hautaniemi, Olli Kallioniemi, Patrick Schöffski, Harri Sihto and Heikki Joensuu

Clin Cancer Res March 1 2019 25 (5) 1676-1687; DOI:10.1158/1078-0432.CCR-18-0815

Letters to the Editor

Letters to the Editor

DICER1 and Associated Conditions: Identification of At-risk Individuals and Recommended Surveillance Strategies—Letter

Leeyan S. Gilmour, Penny J. Hunt, Karen E. Mackenzie and Martin de Bock

Clin Cancer Res March 1 2019 25 (5) 1688-1688; DOI:10.1158/1078-0432.CCR-18-2897
Letters to the Editor

DICER1 and Associated Conditions: Identification of At-risk Individuals and Recommended Surveillance Strategies—Response

Andrew J. Bauer, Douglas R. Stewart, Junne Kamihara, Anne K. Harris, Joyce Turner, Rachana Shah, Kami Wolfe Schneider, Katherine Schneider, Ann Garrity Carr, Laura A. Harney, A. Lindsay Frazier, Daniel Orbach, Dominik T. Schneider, David Malkin, Louis P. Dehner, Yoav H. Messinger, D. Ashley Hill and Kris Ann P. Schultz

Clin Cancer Res March 1 2019 25 (5) 1689-1690; DOI:10.1158/1078-0432.CCR-18-3495

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Table of Contents

Highlights

CCR Translations

CCR Perspectives in Regulatory Science and Policy

Review

Clinical Trials: Targeted Therapy

Clinical Trials: Immunotherapy

Precision Medicine and Imaging

Translational Cancer Mechanisms and Therapy

Letters to the Editor

Issue Highlights

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