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CCR Translations

The Long and Winding Road for Breast Cancer Biomarkers to Reach Clinical Utility

Natasha B. Hunter, Mark R. Kilgore and Nancy E. Davidson
Natasha B. Hunter
1Division of Medical Oncology, Department of Medicine, University of Washington, Seattle, Washington.
3Fred Hutchinson Cancer Research Center, Seattle, Washington.
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  • ORCID record for Natasha B. Hunter
Mark R. Kilgore
2Department of Laboratory Medicine and Pathology, University of Washington, Seattle, Washington.
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Nancy E. Davidson
1Division of Medical Oncology, Department of Medicine, University of Washington, Seattle, Washington.
3Fred Hutchinson Cancer Research Center, Seattle, Washington.
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  • For correspondence: ndavidson@fredhutch.org
DOI: 10.1158/1078-0432.CCR-20-2451 Published November 2020
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Abstract

Tumor data from the ABCSG 5 trial of chemotherapy versus endocrine therapy for premenopausal ER+ breast cancer supports molecular subtyping by Ki-67 IHC as a prognostic marker. But while this tissue was handled uniformly, Ki-67 testing overall is unstandardized, complicating clinical utility. Increasing potential biomarkers herald more challenges in biomarker validation.

See related article by Bago-Horvath et al., p. 5682

Footnotes

  • Clin Cancer Res 2020;26:5543–5

  • Received July 10, 2020.
  • Revision received July 20, 2020.
  • Accepted August 25, 2020.
  • Published first August 28, 2020.
  • ©2020 American Association for Cancer Research.
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Clinical Cancer Research: 26 (21)
November 2020
Volume 26, Issue 21
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The Long and Winding Road for Breast Cancer Biomarkers to Reach Clinical Utility
Natasha B. Hunter, Mark R. Kilgore and Nancy E. Davidson
Clin Cancer Res November 1 2020 (26) (21) 5543-5545; DOI: 10.1158/1078-0432.CCR-20-2451

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The Long and Winding Road for Breast Cancer Biomarkers to Reach Clinical Utility
Natasha B. Hunter, Mark R. Kilgore and Nancy E. Davidson
Clin Cancer Res November 1 2020 (26) (21) 5543-5545; DOI: 10.1158/1078-0432.CCR-20-2451
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Clinical Cancer Research
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