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Integrating Immunotherapy and Targeted Therapy in Cancer Treatment: Mechanistic Insights and Clinical Implications

Johann S. Bergholz, Qiwei Wang, Sheheryar Kabraji and Jean J. Zhao
Johann S. Bergholz
1Department of Cancer Biology, Dana-Farber Cancer Institute, Boston, Massachusetts.
2Department of Biological Chemistry and Molecular Pharmacology, Harvard Medical School, Boston, Massachusetts.
3Broad Institute of Harvard and MIT, Cambridge, Massachusetts.
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  • For correspondence: jean_zhao@dfci.harvard.edu johann_bergholz@dfci.harvard.edu
Qiwei Wang
1Department of Cancer Biology, Dana-Farber Cancer Institute, Boston, Massachusetts.
2Department of Biological Chemistry and Molecular Pharmacology, Harvard Medical School, Boston, Massachusetts.
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Sheheryar Kabraji
1Department of Cancer Biology, Dana-Farber Cancer Institute, Boston, Massachusetts.
4Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, Massachusetts.
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Jean J. Zhao
1Department of Cancer Biology, Dana-Farber Cancer Institute, Boston, Massachusetts.
2Department of Biological Chemistry and Molecular Pharmacology, Harvard Medical School, Boston, Massachusetts.
3Broad Institute of Harvard and MIT, Cambridge, Massachusetts.
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  • For correspondence: jean_zhao@dfci.harvard.edu johann_bergholz@dfci.harvard.edu
DOI: 10.1158/1078-0432.CCR-19-2300 Published November 2020
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Article Information

Volume 26, Issue 21, pp. 5557-5566

DOI 
https://doi.org/10.1158/1078-0432.CCR-19-2300
PubMed 
32576627

Published By 
American Association for Cancer Research
Print ISSN 
1078-0432
Online ISSN 
1557-3265
History 
  • Received January 15, 2020
  • Revision received May 8, 2020
  • Accepted June 19, 2020
  • Published first June 23, 2020.

Article Versions

  • Previous version (June 23, 2020 - 06:24).
  • Previous version (September 17, 2020 - 05:56).
  • You are viewing the most recent version of this article.
Copyright & Usage 
©2020 American Association for Cancer Research.

Author Information

  1. Johann S. Bergholz1,2,3,*,#,
  2. Qiwei Wang1,2,#,
  3. Sheheryar Kabraji1,4, and
  4. Jean J. Zhao1,2,3,*
  1. 1Department of Cancer Biology, Dana-Farber Cancer Institute, Boston, Massachusetts.
  2. 2Department of Biological Chemistry and Molecular Pharmacology, Harvard Medical School, Boston, Massachusetts.
  3. 3Broad Institute of Harvard and MIT, Cambridge, Massachusetts.
  4. 4Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, Massachusetts.
  1. ↵*Corresponding Authors:
    Jean J. Zhao, Dana-Farber Cancer Institute, 450 Brookline Avenue, Boston, MA 02215. Phone: 617-632-2932; Fax: 617-632-4770; E-mail: jean_zhao{at}dfci.harvard.edu; and Johann S. Bergholz, johann_bergholz{at}dfci.harvard.edu
  1. ↵#J.S. Bergholz and Q. Wang contributed equally to this article.

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Clinical Cancer Research: 26 (21)
November 2020
Volume 26, Issue 21
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Integrating Immunotherapy and Targeted Therapy in Cancer Treatment: Mechanistic Insights and Clinical Implications
Johann S. Bergholz, Qiwei Wang, Sheheryar Kabraji and Jean J. Zhao
Clin Cancer Res November 1 2020 (26) (21) 5557-5566; DOI: 10.1158/1078-0432.CCR-19-2300

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Integrating Immunotherapy and Targeted Therapy in Cancer Treatment: Mechanistic Insights and Clinical Implications
Johann S. Bergholz, Qiwei Wang, Sheheryar Kabraji and Jean J. Zhao
Clin Cancer Res November 1 2020 (26) (21) 5557-5566; DOI: 10.1158/1078-0432.CCR-19-2300
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  • Article
    • Abstract
    • Introduction
    • Immune Evasion by Cancer Cells
    • Oncogenic Signaling Pathways Shape the Tumor Immune Microenvironment
    • Integrating Small-molecule Targeted Therapy and Immunotherapy to Improve Therapeutic Outcomes
    • Future Prospects
    • Disclosure of Potential Conflicts of Interest
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