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Clinical Cancer Research
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Clinical Trials: Targeted Therapy

Safety and Efficacy of Vorinostat Plus Sirolimus or Everolimus in Patients with Relapsed Refractory Hodgkin Lymphoma

Filip Janku, Haeseong Park, S. Greg Call, Kiran Madwani, Yasuhiro Oki, Vivek Subbiah, David S. Hong, Aung Naing, Vivianne M. Velez-Bravo, Tamara G. Barnes, Fredrick B. Hagemeister, Gerald S. Falchook, Daniel D. Karp, Jennifer J. Wheler, Sarina A. Piha-Paul, Ignacio Garrido-Laguna, Elizabeth J. Shpall, Luis E. Fayad, Sattva S. Neelapu, Funda Meric-Bernstam, Razelle Kurzrock and Michelle A. Fanale
Filip Janku
1Department of Investigational Cancer Therapeutics (Phase I Clinical Trials Program), Division of Cancer Medicine, The University of Texas MD Anderson Cancer Center, Houston, Texas.
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  • ORCID record for Filip Janku
  • For correspondence: fjanku@mdanderson.org
Haeseong Park
1Department of Investigational Cancer Therapeutics (Phase I Clinical Trials Program), Division of Cancer Medicine, The University of Texas MD Anderson Cancer Center, Houston, Texas.
2Department of Internal Medicine (Division of Oncology), Washington University School of Medicine, St. Louis, Missouri.
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S. Greg Call
1Department of Investigational Cancer Therapeutics (Phase I Clinical Trials Program), Division of Cancer Medicine, The University of Texas MD Anderson Cancer Center, Houston, Texas.
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Kiran Madwani
1Department of Investigational Cancer Therapeutics (Phase I Clinical Trials Program), Division of Cancer Medicine, The University of Texas MD Anderson Cancer Center, Houston, Texas.
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Yasuhiro Oki
3Department of Lymphoma and Myeloma, The University of Texas MD Anderson Cancer Center, Houston, Texas.
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Vivek Subbiah
1Department of Investigational Cancer Therapeutics (Phase I Clinical Trials Program), Division of Cancer Medicine, The University of Texas MD Anderson Cancer Center, Houston, Texas.
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  • ORCID record for Vivek Subbiah
David S. Hong
1Department of Investigational Cancer Therapeutics (Phase I Clinical Trials Program), Division of Cancer Medicine, The University of Texas MD Anderson Cancer Center, Houston, Texas.
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Aung Naing
1Department of Investigational Cancer Therapeutics (Phase I Clinical Trials Program), Division of Cancer Medicine, The University of Texas MD Anderson Cancer Center, Houston, Texas.
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Vivianne M. Velez-Bravo
1Department of Investigational Cancer Therapeutics (Phase I Clinical Trials Program), Division of Cancer Medicine, The University of Texas MD Anderson Cancer Center, Houston, Texas.
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Tamara G. Barnes
1Department of Investigational Cancer Therapeutics (Phase I Clinical Trials Program), Division of Cancer Medicine, The University of Texas MD Anderson Cancer Center, Houston, Texas.
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Fredrick B. Hagemeister
3Department of Lymphoma and Myeloma, The University of Texas MD Anderson Cancer Center, Houston, Texas.
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Gerald S. Falchook
1Department of Investigational Cancer Therapeutics (Phase I Clinical Trials Program), Division of Cancer Medicine, The University of Texas MD Anderson Cancer Center, Houston, Texas.
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Daniel D. Karp
1Department of Investigational Cancer Therapeutics (Phase I Clinical Trials Program), Division of Cancer Medicine, The University of Texas MD Anderson Cancer Center, Houston, Texas.
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Jennifer J. Wheler
1Department of Investigational Cancer Therapeutics (Phase I Clinical Trials Program), Division of Cancer Medicine, The University of Texas MD Anderson Cancer Center, Houston, Texas.
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Sarina A. Piha-Paul
1Department of Investigational Cancer Therapeutics (Phase I Clinical Trials Program), Division of Cancer Medicine, The University of Texas MD Anderson Cancer Center, Houston, Texas.
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Ignacio Garrido-Laguna
1Department of Investigational Cancer Therapeutics (Phase I Clinical Trials Program), Division of Cancer Medicine, The University of Texas MD Anderson Cancer Center, Houston, Texas.
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Elizabeth J. Shpall
4Department of Stem Cell Transplantation, The University of Texas MD Anderson Cancer Center, Houston, Texas.
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Luis E. Fayad
3Department of Lymphoma and Myeloma, The University of Texas MD Anderson Cancer Center, Houston, Texas.
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Sattva S. Neelapu
3Department of Lymphoma and Myeloma, The University of Texas MD Anderson Cancer Center, Houston, Texas.
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Funda Meric-Bernstam
1Department of Investigational Cancer Therapeutics (Phase I Clinical Trials Program), Division of Cancer Medicine, The University of Texas MD Anderson Cancer Center, Houston, Texas.
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Razelle Kurzrock
1Department of Investigational Cancer Therapeutics (Phase I Clinical Trials Program), Division of Cancer Medicine, The University of Texas MD Anderson Cancer Center, Houston, Texas.
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Michelle A. Fanale
3Department of Lymphoma and Myeloma, The University of Texas MD Anderson Cancer Center, Houston, Texas.
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DOI: 10.1158/1078-0432.CCR-20-1215 Published November 2020
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Article Information

Volume 26, Issue 21, pp. 5579-5587

DOI 
https://doi.org/10.1158/1078-0432.CCR-20-1215
PubMed 
33055173

Published By 
American Association for Cancer Research
Print ISSN 
1078-0432
Online ISSN 
1557-3265
History 
  • Received March 31, 2020
  • Revision received July 25, 2020
  • Accepted August 24, 2020
  • Published first October 14, 2020.

Article Versions

  • Previous version (October 14, 2020 - 00:05).
  • You are viewing the most recent version of this article.
Copyright & Usage 
©2020 American Association for Cancer Research.

Author Information

  1. Filip Janku1,*,
  2. Haeseong Park1,2,
  3. S. Greg Call1,
  4. Kiran Madwani1,
  5. Yasuhiro Oki3,
  6. Vivek Subbiah1,
  7. David S. Hong1,
  8. Aung Naing1,
  9. Vivianne M. Velez-Bravo1,
  10. Tamara G. Barnes1,
  11. Fredrick B. Hagemeister3,
  12. Gerald S. Falchook1,
  13. Daniel D. Karp1,
  14. Jennifer J. Wheler1,
  15. Sarina A. Piha-Paul1,
  16. Ignacio Garrido-Laguna1,
  17. Elizabeth J. Shpall4,
  18. Luis E. Fayad3,
  19. Sattva S. Neelapu3,
  20. Funda Meric-Bernstam1,
  21. Razelle Kurzrock1, and
  22. Michelle A. Fanale3
  1. 1Department of Investigational Cancer Therapeutics (Phase I Clinical Trials Program), Division of Cancer Medicine, The University of Texas MD Anderson Cancer Center, Houston, Texas.
  2. 2Department of Internal Medicine (Division of Oncology), Washington University School of Medicine, St. Louis, Missouri.
  3. 3Department of Lymphoma and Myeloma, The University of Texas MD Anderson Cancer Center, Houston, Texas.
  4. 4Department of Stem Cell Transplantation, The University of Texas MD Anderson Cancer Center, Houston, Texas.
  1. ↵*Corresponding Author:
    Filip Janku, The University of Texas MD Anderson Cancer Center, 1515 Holcombe Blvd, Unit 0455, Houston, TX 77030. Phone: 713-563-0308; Fax: 713-745-8056; E-mail: fjanku{at}mdanderson.org
  • Current address for Y. Oki: Jazz Pharmaceuticals, Palo Alto, California; current address for V.M. Velez-Bravo, Sylvester Cancer Center, Miami, Florida; current address for G.S. Falchook, Sarah Cannon Research Institute at HealthONE, Denver, Colorado; current address for J.J. Wheler, Bicara Therapeutics, Cambridge, Massachusetts; current address for Garrido-Laguna, Department of Internal Medicine (Division of Oncology), Huntsman Cancer Institute and University of Utah School of Medicine, Salt Lake City, Utah; current address for R. Kurzrock, Center for Personalized Cancer Therapy, University of California San Diego Moores Cancer Center, San Diego, California; and current address for M.A. Finale, Seattle Genetics, Seattle, Washington.

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Clinical Cancer Research: 26 (21)
November 2020
Volume 26, Issue 21
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Safety and Efficacy of Vorinostat Plus Sirolimus or Everolimus in Patients with Relapsed Refractory Hodgkin Lymphoma
Filip Janku, Haeseong Park, S. Greg Call, Kiran Madwani, Yasuhiro Oki, Vivek Subbiah, David S. Hong, Aung Naing, Vivianne M. Velez-Bravo, Tamara G. Barnes, Fredrick B. Hagemeister, Gerald S. Falchook, Daniel D. Karp, Jennifer J. Wheler, Sarina A. Piha-Paul, Ignacio Garrido-Laguna, Elizabeth J. Shpall, Luis E. Fayad, Sattva S. Neelapu, Funda Meric-Bernstam, Razelle Kurzrock and Michelle A. Fanale
Clin Cancer Res November 1 2020 (26) (21) 5579-5587; DOI: 10.1158/1078-0432.CCR-20-1215

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Safety and Efficacy of Vorinostat Plus Sirolimus or Everolimus in Patients with Relapsed Refractory Hodgkin Lymphoma
Filip Janku, Haeseong Park, S. Greg Call, Kiran Madwani, Yasuhiro Oki, Vivek Subbiah, David S. Hong, Aung Naing, Vivianne M. Velez-Bravo, Tamara G. Barnes, Fredrick B. Hagemeister, Gerald S. Falchook, Daniel D. Karp, Jennifer J. Wheler, Sarina A. Piha-Paul, Ignacio Garrido-Laguna, Elizabeth J. Shpall, Luis E. Fayad, Sattva S. Neelapu, Funda Meric-Bernstam, Razelle Kurzrock and Michelle A. Fanale
Clin Cancer Res November 1 2020 (26) (21) 5579-5587; DOI: 10.1158/1078-0432.CCR-20-1215
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