Immunomodulatory Activity of a Colony-stimulating Factor-1 Receptor Inhibitor in Patients with Advanced Refractory Breast or Prostate Cancer: A Phase I Study

Karen A. Autio; Christopher A. Klebanoff; David Schaer; John Sae Wook Kauh; Susan F. Slovin; Matthew Adamow; Victoria S. Blinder; Manisha Brahmachary; Michelle Carlsen; Elizabeth Comen; Daniel C. Danila; Thompson N. Doman; Jeremy C. Durack; Josef J. Fox; Jill S. Gluskin; David M. Hoffman; Suhyun Kang; Praneet Kang; Jonathan Landa; Philomena F. McAndrew; Shanu Modi; Michael J. Morris; Ruslan Novosiadly; Dana E. Rathkopf; Rachel Sanford; Sonya C. Chapman; Courtney M. Tate; Danni Yu; Phillip Wong; Heather L. McArthur

doi:10.1158/1078-0432.CCR-20-0855

Clinical Trials: Immunotherapy

Immunomodulatory Activity of a Colony-stimulating Factor-1 Receptor Inhibitor in Patients with Advanced Refractory Breast or Prostate Cancer: A Phase I Study

Karen A. Autio, Christopher A. Klebanoff, David Schaer, John Sae Wook Kauh, Susan F. Slovin, Matthew Adamow, Victoria S. Blinder, Manisha Brahmachary, Michelle Carlsen, Elizabeth Comen, Daniel C. Danila, Thompson N. Doman, Jeremy C. Durack, Josef J. Fox, Jill S. Gluskin, David M. Hoffman, Suhyun Kang, Praneet Kang, Jonathan Landa, Philomena F. McAndrew, Shanu Modi, Michael J. Morris, Ruslan Novosiadly, Dana E. Rathkopf, Rachel Sanford, Sonya C. Chapman, Courtney M. Tate, Danni Yu, Phillip Wong and Heather L. McArthur

Karen A. Autio

1Memorial Sloan Kettering Cancer Center, New York, New York.

2Weill Cornell Medical College, New York, New York.

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For correspondence: autiok@mskcc.org

Christopher A. Klebanoff

1Memorial Sloan Kettering Cancer Center, New York, New York.

2Weill Cornell Medical College, New York, New York.

3Parker Institute for Cancer Immunotherapy, New York, New York.

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David Schaer

4Pfizer WRD, Pearl River, New York.

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John Sae Wook Kauh

5Hutchison MediPharma International (US) Inc., Florham Park, New Jersey.

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ORCID record for John Sae Wook Kauh

Susan F. Slovin

1Memorial Sloan Kettering Cancer Center, New York, New York.

2Weill Cornell Medical College, New York, New York.

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Matthew Adamow

1Memorial Sloan Kettering Cancer Center, New York, New York.

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ORCID record for Matthew Adamow

Victoria S. Blinder

1Memorial Sloan Kettering Cancer Center, New York, New York.

2Weill Cornell Medical College, New York, New York.

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Manisha Brahmachary

6Eli Lilly and Company, New York, New York.

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Michelle Carlsen

7Eli Lilly and Company, Indianapolis, Indiana.

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Elizabeth Comen

1Memorial Sloan Kettering Cancer Center, New York, New York.

2Weill Cornell Medical College, New York, New York.

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Daniel C. Danila

1Memorial Sloan Kettering Cancer Center, New York, New York.

2Weill Cornell Medical College, New York, New York.

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Thompson N. Doman

7Eli Lilly and Company, Indianapolis, Indiana.

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Jeremy C. Durack

1Memorial Sloan Kettering Cancer Center, New York, New York.

2Weill Cornell Medical College, New York, New York.

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Josef J. Fox

1Memorial Sloan Kettering Cancer Center, New York, New York.

2Weill Cornell Medical College, New York, New York.

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Jill S. Gluskin

1Memorial Sloan Kettering Cancer Center, New York, New York.

2Weill Cornell Medical College, New York, New York.

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ORCID record for Jill S. Gluskin

David M. Hoffman

8Cedars-Sinai Medical Center, Los Angeles, California.

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Suhyun Kang

7Eli Lilly and Company, Indianapolis, Indiana.

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Praneet Kang

1Memorial Sloan Kettering Cancer Center, New York, New York.

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Jonathan Landa

1Memorial Sloan Kettering Cancer Center, New York, New York.

2Weill Cornell Medical College, New York, New York.

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Philomena F. McAndrew

8Cedars-Sinai Medical Center, Los Angeles, California.

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Shanu Modi

1Memorial Sloan Kettering Cancer Center, New York, New York.

2Weill Cornell Medical College, New York, New York.

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ORCID record for Shanu Modi

Michael J. Morris

1Memorial Sloan Kettering Cancer Center, New York, New York.

2Weill Cornell Medical College, New York, New York.

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Ruslan Novosiadly

6Eli Lilly and Company, New York, New York.

9Bristol-Myers Squibb, Princeton, New Jersey.

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Dana E. Rathkopf

1Memorial Sloan Kettering Cancer Center, New York, New York.

2Weill Cornell Medical College, New York, New York.

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Rachel Sanford

1Memorial Sloan Kettering Cancer Center, New York, New York.

2Weill Cornell Medical College, New York, New York.

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Sonya C. Chapman

10Eli Lilly and Company, Windlesham, United Kingdom.

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Courtney M. Tate

7Eli Lilly and Company, Indianapolis, Indiana.

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Danni Yu

7Eli Lilly and Company, Indianapolis, Indiana.

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Phillip Wong

1Memorial Sloan Kettering Cancer Center, New York, New York.

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Heather L. McArthur

8Cedars-Sinai Medical Center, Los Angeles, California.

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DOI: 10.1158/1078-0432.CCR-20-0855 Published November 2020

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November 2020
Volume 26, Issue 21

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Immunomodulatory Activity of a Colony-stimulating Factor-1 Receptor Inhibitor in Patients with Advanced Refractory Breast or Prostate Cancer: A Phase I Study

Clin Cancer Res November 1 2020 (26) (21) 5609-5620; DOI: 10.1158/1078-0432.CCR-20-0855

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Immunomodulatory Activity of a Colony-stimulating Factor-1 Receptor Inhibitor in Patients with Advanced Refractory Breast or Prostate Cancer: A Phase I Study