Integrative Analysis of Pleomorphic Dermal Sarcomas Reveals Fibroblastic Differentiation and Susceptibility to Immunotherapy

Sebastian Klein; Alexander Quaas; Ka-Won Noh; Maria Cartolano; Nima Abedpour; Cornelia Mauch; Jennifer Quantius; Hans Christian Reinhardt; Reinhard Buettner; Martin Peifer; Doris Helbig

doi:10.1158/1078-0432.CCR-20-1899

Precision Medicine and Imaging

Integrative Analysis of Pleomorphic Dermal Sarcomas Reveals Fibroblastic Differentiation and Susceptibility to Immunotherapy

Sebastian Klein, Alexander Quaas, Ka-Won Noh, Maria Cartolano, Nima Abedpour, Cornelia Mauch, Jennifer Quantius, Hans Christian Reinhardt, Reinhard Buettner, Martin Peifer and Doris Helbig

Sebastian Klein

1Institute for Pathology, University Hospital Cologne, Cologne, Germany.

2Else Kröner Forschungskolleg Clonal Evolution in Cancer, University Hospital Cologne, Cologne, Germany.

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For correspondence: mpeifer@uni-koeln.de sebastian.klein@uk-koeln.de doris.helbig@uk-koeln.de

Alexander Quaas

1Institute for Pathology, University Hospital Cologne, Cologne, Germany.

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Ka-Won Noh

1Institute for Pathology, University Hospital Cologne, Cologne, Germany.

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Maria Cartolano

3Department of Translational Genomics, Center of Integrated Oncology Cologne-Bonn, Medical Faculty, University of Cologne, Cologne, Germany.

4Center for Molecular Medicine, Medical Faculty, University Hospital Cologne, Cologne, Germany.

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Nima Abedpour

3Department of Translational Genomics, Center of Integrated Oncology Cologne-Bonn, Medical Faculty, University of Cologne, Cologne, Germany.

4Center for Molecular Medicine, Medical Faculty, University Hospital Cologne, Cologne, Germany.

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Cornelia Mauch

5Department of Dermatology, University Hospital Cologne, Cologne, Germany.

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Jennifer Quantius

1Institute for Pathology, University Hospital Cologne, Cologne, Germany.

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Hans Christian Reinhardt

6Clinic for Hematology, West German Cancer Center, University Hospital Essen, Essen, German Cancer Consortium (DKTK), Germany.

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ORCID record for Hans Christian Reinhardt

Reinhard Buettner

1Institute for Pathology, University Hospital Cologne, Cologne, Germany.

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Martin Peifer

3Department of Translational Genomics, Center of Integrated Oncology Cologne-Bonn, Medical Faculty, University of Cologne, Cologne, Germany.

4Center for Molecular Medicine, Medical Faculty, University Hospital Cologne, Cologne, Germany.

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For correspondence: mpeifer@uni-koeln.de sebastian.klein@uk-koeln.de doris.helbig@uk-koeln.de

Doris Helbig

5Department of Dermatology, University Hospital Cologne, Cologne, Germany.

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ORCID record for Doris Helbig
For correspondence: mpeifer@uni-koeln.de sebastian.klein@uk-koeln.de doris.helbig@uk-koeln.de

DOI: 10.1158/1078-0432.CCR-20-1899 Published November 2020

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November 2020
Volume 26, Issue 21

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Integrative Analysis of Pleomorphic Dermal Sarcomas Reveals Fibroblastic Differentiation and Susceptibility to Immunotherapy

Sebastian Klein, Alexander Quaas, Ka-Won Noh, Maria Cartolano, Nima Abedpour, Cornelia Mauch, Jennifer Quantius, Hans Christian Reinhardt, Reinhard Buettner, Martin Peifer and Doris Helbig

Clin Cancer Res November 1 2020 (26) (21) 5638-5645; DOI: 10.1158/1078-0432.CCR-20-1899

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Integrative Analysis of Pleomorphic Dermal Sarcomas Reveals Fibroblastic Differentiation and Susceptibility to Immunotherapy

Sebastian Klein, Alexander Quaas, Ka-Won Noh, Maria Cartolano, Nima Abedpour, Cornelia Mauch, Jennifer Quantius, Hans Christian Reinhardt, Reinhard Buettner, Martin Peifer and Doris Helbig

Clin Cancer Res November 1 2020 (26) (21) 5638-5645; DOI: 10.1158/1078-0432.CCR-20-1899

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