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Precision Medicine and Imaging

Serum IL6 as a Prognostic Biomarker and IL6R as a Therapeutic Target in Biliary Tract Cancers

Dan Høgdall, Colm J. O'Rourke, Christian Dehlendorff, Ole F. Larsen, Lars H. Jensen, Astrid Z. Johansen, Hien Dang, Valentina M. Factor, Mie Grunnet, Morten Mau-Sørensen, Douglas V.N.P. Oliveira, Dorte Linnemann, Mogens K. Boisen, Xin W. Wang, Julia S. Johansen and Jesper B. Andersen
Dan Høgdall
1Department of Oncology, Herlev and Gentofte Hospital, Copenhagen University Hospital, Herlev, Denmark.
2Biotech Research and Innovation Centre (BRIC), Department of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark.
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  • For correspondence: Danhog01@regionh.dk
Colm J. O'Rourke
2Biotech Research and Innovation Centre (BRIC), Department of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark.
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Christian Dehlendorff
3Danish Cancer Society Research Center, Danish Cancer Society, Copenhagen, Denmark.
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Ole F. Larsen
1Department of Oncology, Herlev and Gentofte Hospital, Copenhagen University Hospital, Herlev, Denmark.
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Lars H. Jensen
4Department of Oncology, University Hospital of Southern Denmark, Vejle, Denmark.
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Astrid Z. Johansen
1Department of Oncology, Herlev and Gentofte Hospital, Copenhagen University Hospital, Herlev, Denmark.
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Hien Dang
5Division of Surgical Research, Thomas Jefferson University, Philadelphia, Pennsylvania.
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Valentina M. Factor
6Laboratory of Molecular Pharmacology, Developmental Therapeutics Branch, Center for Cancer Research, NCI, NIH, Bethesda, Maryland, USA.
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Mie Grunnet
7Department of Oncology, Rigshospitalet, Copenhagen University Hospital, Copenhagen, Denmark.
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Morten Mau-Sørensen
7Department of Oncology, Rigshospitalet, Copenhagen University Hospital, Copenhagen, Denmark.
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Douglas V.N.P. Oliveira
2Biotech Research and Innovation Centre (BRIC), Department of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark.
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Dorte Linnemann
8Department of Pathology, Herlev and Gentofte Hospital, Copenhagen University Hospital, Herlev, Denmark.
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Mogens K. Boisen
1Department of Oncology, Herlev and Gentofte Hospital, Copenhagen University Hospital, Herlev, Denmark.
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Xin W. Wang
9Laboratory of Human Carcinogenesis, Center for Cancer Research, NCI, NIH, Bethesda, Maryland, USA.
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Julia S. Johansen
1Department of Oncology, Herlev and Gentofte Hospital, Copenhagen University Hospital, Herlev, Denmark.
10Department of Medicine, Herlev and Gentofte Hospital, Copenhagen University Hospital, Herlev, Denmark.
11Department of Clinical Medicine, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark.
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Jesper B. Andersen
2Biotech Research and Innovation Centre (BRIC), Department of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark.
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DOI: 10.1158/1078-0432.CCR-19-2700 Published November 2020
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Cited By

Article Information

Volume 26, Issue 21, pp. 5655-5667

DOI 
https://doi.org/10.1158/1078-0432.CCR-19-2700
PubMed 
32933994

Published By 
American Association for Cancer Research
Print ISSN 
1078-0432
Online ISSN 
1557-3265
History 
  • Received August 16, 2019
  • Revision received April 23, 2020
  • Accepted August 17, 2020
  • Published first September 15, 2020.

Article Versions

  • Previous version (September 15, 2020 - 00:05).
  • Previous version (September 18, 2020 - 04:54).
  • You are viewing the most recent version of this article.
Copyright & Usage 
©2020 American Association for Cancer Research.

Author Information

  1. Dan Høgdall1,2,*,
  2. Colm J. O'Rourke2,
  3. Christian Dehlendorff3,
  4. Ole F. Larsen1,
  5. Lars H. Jensen4,
  6. Astrid Z. Johansen1,
  7. Hien Dang5,
  8. Valentina M. Factor6,
  9. Mie Grunnet7,
  10. Morten Mau-Sørensen7,
  11. Douglas V.N.P. Oliveira2,
  12. Dorte Linnemann8,
  13. Mogens K. Boisen1,
  14. Xin W. Wang9,
  15. Julia S. Johansen1,10,11,#, and
  16. Jesper B. Andersen2,#
  1. 1Department of Oncology, Herlev and Gentofte Hospital, Copenhagen University Hospital, Herlev, Denmark.
  2. 2Biotech Research and Innovation Centre (BRIC), Department of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark.
  3. 3Danish Cancer Society Research Center, Danish Cancer Society, Copenhagen, Denmark.
  4. 4Department of Oncology, University Hospital of Southern Denmark, Vejle, Denmark.
  5. 5Division of Surgical Research, Thomas Jefferson University, Philadelphia, Pennsylvania.
  6. 6Laboratory of Molecular Pharmacology, Developmental Therapeutics Branch, Center for Cancer Research, NCI, NIH, Bethesda, Maryland, USA.
  7. 7Department of Oncology, Rigshospitalet, Copenhagen University Hospital, Copenhagen, Denmark.
  8. 8Department of Pathology, Herlev and Gentofte Hospital, Copenhagen University Hospital, Herlev, Denmark.
  9. 9Laboratory of Human Carcinogenesis, Center for Cancer Research, NCI, NIH, Bethesda, Maryland, USA.
  10. 10Department of Medicine, Herlev and Gentofte Hospital, Copenhagen University Hospital, Herlev, Denmark.
  11. 11Department of Clinical Medicine, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark.
  1. ↵*Corresponding Author:
    Dan Høgdall, Herlev and Gentofte Hospital, Borgmester Ib Juuls Vej 1, Herlev 2730, Denmark. Phone: +45 51200113; Fax: 0045 3868 3570; E-mail: Danhog01{at}regionh.dk
  1. ↵#J.S. Johansen and J.B. Andersen contributed equally to this article.

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Clinical Cancer Research: 26 (21)
November 2020
Volume 26, Issue 21
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Serum IL6 as a Prognostic Biomarker and IL6R as a Therapeutic Target in Biliary Tract Cancers
Dan Høgdall, Colm J. O'Rourke, Christian Dehlendorff, Ole F. Larsen, Lars H. Jensen, Astrid Z. Johansen, Hien Dang, Valentina M. Factor, Mie Grunnet, Morten Mau-Sørensen, Douglas V.N.P. Oliveira, Dorte Linnemann, Mogens K. Boisen, Xin W. Wang, Julia S. Johansen and Jesper B. Andersen
Clin Cancer Res November 1 2020 (26) (21) 5655-5667; DOI: 10.1158/1078-0432.CCR-19-2700

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Serum IL6 as a Prognostic Biomarker and IL6R as a Therapeutic Target in Biliary Tract Cancers
Dan Høgdall, Colm J. O'Rourke, Christian Dehlendorff, Ole F. Larsen, Lars H. Jensen, Astrid Z. Johansen, Hien Dang, Valentina M. Factor, Mie Grunnet, Morten Mau-Sørensen, Douglas V.N.P. Oliveira, Dorte Linnemann, Mogens K. Boisen, Xin W. Wang, Julia S. Johansen and Jesper B. Andersen
Clin Cancer Res November 1 2020 (26) (21) 5655-5667; DOI: 10.1158/1078-0432.CCR-19-2700
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