Serum IL6 as a Prognostic Biomarker and IL6R as a Therapeutic Target in Biliary Tract Cancers

Dan Høgdall; Colm J. O'Rourke; Christian Dehlendorff; Ole F. Larsen; Lars H. Jensen; Astrid Z. Johansen; Hien Dang; Valentina M. Factor; Mie Grunnet; Morten Mau-Sørensen; Douglas V.N.P. Oliveira; Dorte Linnemann; Mogens K. Boisen; Xin W. Wang; Julia S. Johansen; Jesper B. Andersen

doi:10.1158/1078-0432.CCR-19-2700

Precision Medicine and Imaging

Serum IL6 as a Prognostic Biomarker and IL6R as a Therapeutic Target in Biliary Tract Cancers

Dan Høgdall, Colm J. O'Rourke, Christian Dehlendorff, Ole F. Larsen, Lars H. Jensen, Astrid Z. Johansen, Hien Dang, Valentina M. Factor, Mie Grunnet, Morten Mau-Sørensen, Douglas V.N.P. Oliveira, Dorte Linnemann, Mogens K. Boisen, Xin W. Wang, Julia S. Johansen and Jesper B. Andersen

Dan Høgdall

1Department of Oncology, Herlev and Gentofte Hospital, Copenhagen University Hospital, Herlev, Denmark.

2Biotech Research and Innovation Centre (BRIC), Department of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark.

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For correspondence: Danhog01@regionh.dk

Colm J. O'Rourke

2Biotech Research and Innovation Centre (BRIC), Department of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark.

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Christian Dehlendorff

3Danish Cancer Society Research Center, Danish Cancer Society, Copenhagen, Denmark.

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Ole F. Larsen

1Department of Oncology, Herlev and Gentofte Hospital, Copenhagen University Hospital, Herlev, Denmark.

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Lars H. Jensen

4Department of Oncology, University Hospital of Southern Denmark, Vejle, Denmark.

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Astrid Z. Johansen

1Department of Oncology, Herlev and Gentofte Hospital, Copenhagen University Hospital, Herlev, Denmark.

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Hien Dang

5Division of Surgical Research, Thomas Jefferson University, Philadelphia, Pennsylvania.

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Valentina M. Factor

6Laboratory of Molecular Pharmacology, Developmental Therapeutics Branch, Center for Cancer Research, NCI, NIH, Bethesda, Maryland, USA.

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Mie Grunnet

7Department of Oncology, Rigshospitalet, Copenhagen University Hospital, Copenhagen, Denmark.

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Morten Mau-Sørensen

7Department of Oncology, Rigshospitalet, Copenhagen University Hospital, Copenhagen, Denmark.

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Douglas V.N.P. Oliveira

2Biotech Research and Innovation Centre (BRIC), Department of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark.

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Dorte Linnemann

8Department of Pathology, Herlev and Gentofte Hospital, Copenhagen University Hospital, Herlev, Denmark.

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Mogens K. Boisen

1Department of Oncology, Herlev and Gentofte Hospital, Copenhagen University Hospital, Herlev, Denmark.

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Xin W. Wang

9Laboratory of Human Carcinogenesis, Center for Cancer Research, NCI, NIH, Bethesda, Maryland, USA.

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Julia S. Johansen

1Department of Oncology, Herlev and Gentofte Hospital, Copenhagen University Hospital, Herlev, Denmark.

10Department of Medicine, Herlev and Gentofte Hospital, Copenhagen University Hospital, Herlev, Denmark.

11Department of Clinical Medicine, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark.

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Jesper B. Andersen

2Biotech Research and Innovation Centre (BRIC), Department of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark.

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DOI: 10.1158/1078-0432.CCR-19-2700 Published November 2020

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November 2020
Volume 26, Issue 21

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Serum IL6 as a Prognostic Biomarker and IL6R as a Therapeutic Target in Biliary Tract Cancers

Clin Cancer Res November 1 2020 (26) (21) 5655-5667; DOI: 10.1158/1078-0432.CCR-19-2700

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Serum IL6 as a Prognostic Biomarker and IL6R as a Therapeutic Target in Biliary Tract Cancers

Clin Cancer Res November 1 2020 (26) (21) 5655-5667; DOI: 10.1158/1078-0432.CCR-19-2700

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