Changes in Peripheral and Local Tumor Immunity after Neoadjuvant Chemotherapy Reshape Clinical Outcomes in Patients with Breast Cancer

Margaret L. Axelrod; Mellissa J. Nixon; Paula I. Gonzalez-Ericsson; Riley E. Bergman; Mark A. Pilkinton; Wyatt J. McDonnell; Violeta Sanchez; Susan R. Opalenik; Sherene Loi; Jing Zhou; Sean Mackay; Brent N. Rexer; Vandana G. Abramson; Valerie M. Jansen; Simon Mallal; Joshua Donaldson; Sara M. Tolaney; Ian E. Krop; Ana C. Garrido-Castro; Jonathan D. Marotti; Kevin Shee; Todd W. Miller; Melinda E. Sanders; Ingrid A. Mayer; Roberto Salgado; Justin M. Balko

doi:10.1158/1078-0432.CCR-19-3685

Translational Cancer Mechanisms and Therapy

Changes in Peripheral and Local Tumor Immunity after Neoadjuvant Chemotherapy Reshape Clinical Outcomes in Patients with Breast Cancer

Margaret L. Axelrod, Mellissa J. Nixon, Paula I. Gonzalez-Ericsson, Riley E. Bergman, Mark A. Pilkinton, Wyatt J. McDonnell, Violeta Sanchez, Susan R. Opalenik, Sherene Loi, Jing Zhou, Sean Mackay, Brent N. Rexer, Vandana G. Abramson, Valerie M. Jansen, Simon Mallal, Joshua Donaldson, Sara M. Tolaney, Ian E. Krop, Ana C. Garrido-Castro, Jonathan D. Marotti, Kevin Shee, Todd W. Miller, Melinda E. Sanders, Ingrid A. Mayer, Roberto Salgado and Justin M. Balko

Margaret L. Axelrod

1Department of Medicine, Vanderbilt University Medical Center, Nashville, Tennessee.

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Mellissa J. Nixon

1Department of Medicine, Vanderbilt University Medical Center, Nashville, Tennessee.

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Paula I. Gonzalez-Ericsson

2Breast Cancer Research Program, Vanderbilt University Medical Center, Nashville, Tennessee.

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Riley E. Bergman

1Department of Medicine, Vanderbilt University Medical Center, Nashville, Tennessee.

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Mark A. Pilkinton

3Department of Infectious Disease, Vanderbilt University Medical Center, Nashville, Tennessee.

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Wyatt J. McDonnell

3Department of Infectious Disease, Vanderbilt University Medical Center, Nashville, Tennessee.

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Violeta Sanchez

1Department of Medicine, Vanderbilt University Medical Center, Nashville, Tennessee.

2Breast Cancer Research Program, Vanderbilt University Medical Center, Nashville, Tennessee.

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Susan R. Opalenik

1Department of Medicine, Vanderbilt University Medical Center, Nashville, Tennessee.

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Sherene Loi

4Department of Oncology, University of Melbourne and Peter MacCallum Cancer Centre, Melbourne, Victoria, Australia.

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Jing Zhou

5IsoPlexis Corporation, Branford, Connecticut.

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Sean Mackay

5IsoPlexis Corporation, Branford, Connecticut.

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Brent N. Rexer

1Department of Medicine, Vanderbilt University Medical Center, Nashville, Tennessee.

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Vandana G. Abramson

1Department of Medicine, Vanderbilt University Medical Center, Nashville, Tennessee.

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Valerie M. Jansen

1Department of Medicine, Vanderbilt University Medical Center, Nashville, Tennessee.

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Simon Mallal

3Department of Infectious Disease, Vanderbilt University Medical Center, Nashville, Tennessee.

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Joshua Donaldson

1Department of Medicine, Vanderbilt University Medical Center, Nashville, Tennessee.

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Sara M. Tolaney

6Department of Medical Oncology, Dana-Farber Cancer Institute and Harvard Medical School, Boston, Massachusetts.

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Ian E. Krop

6Department of Medical Oncology, Dana-Farber Cancer Institute and Harvard Medical School, Boston, Massachusetts.

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Ana C. Garrido-Castro

6Department of Medical Oncology, Dana-Farber Cancer Institute and Harvard Medical School, Boston, Massachusetts.

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Jonathan D. Marotti

7Department of Pathology & Laboratory Medicine, Dartmouth-Hitchcock Medical Center, Lebanon, New Hampshire.

8Norris Cotton Cancer Center, Geisel School of Medicine at Dartmouth, Hanover, New Hampshire.

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Kevin Shee

9Department of Molecular & Systems Biology, Geisel School of Medicine at Dartmouth, Hanover, New Hampshire.

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Todd W. Miller

8Norris Cotton Cancer Center, Geisel School of Medicine at Dartmouth, Hanover, New Hampshire.

9Department of Molecular & Systems Biology, Geisel School of Medicine at Dartmouth, Hanover, New Hampshire.

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Melinda E. Sanders

2Breast Cancer Research Program, Vanderbilt University Medical Center, Nashville, Tennessee.

10Department of Pathology, Microbiology and Immunology, Vanderbilt University Medical Center, Nashville, Tennessee.

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Ingrid A. Mayer

1Department of Medicine, Vanderbilt University Medical Center, Nashville, Tennessee.

2Breast Cancer Research Program, Vanderbilt University Medical Center, Nashville, Tennessee.

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Roberto Salgado

4Department of Oncology, University of Melbourne and Peter MacCallum Cancer Centre, Melbourne, Victoria, Australia.

11Department of Pathology, GZA-ZNA Hospitals, Antwerp, Belgium.

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Justin M. Balko

1Department of Medicine, Vanderbilt University Medical Center, Nashville, Tennessee.

2Breast Cancer Research Program, Vanderbilt University Medical Center, Nashville, Tennessee.

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For correspondence: justin.balko@vumc.org

DOI: 10.1158/1078-0432.CCR-19-3685 Published November 2020

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November 2020
Volume 26, Issue 21

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Changes in Peripheral and Local Tumor Immunity after Neoadjuvant Chemotherapy Reshape Clinical Outcomes in Patients with Breast Cancer

Clin Cancer Res November 1 2020 (26) (21) 5668-5681; DOI: 10.1158/1078-0432.CCR-19-3685

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Changes in Peripheral and Local Tumor Immunity after Neoadjuvant Chemotherapy Reshape Clinical Outcomes in Patients with Breast Cancer

Clin Cancer Res November 1 2020 (26) (21) 5668-5681; DOI: 10.1158/1078-0432.CCR-19-3685

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