Sildenafil Potentiates the Therapeutic Efficacy of Docetaxel in Advanced Prostate Cancer by Stimulating NO-cGMP Signaling

Sakthivel Muniyan; Satyanarayana Rachagani; Seema Parte; Sushanta Halder; Parthasarathy Seshacharyulu; Prakash Kshirsagar; Jawed A. Siddiqui; Raghupathy Vengoji; Sanchita Rauth; Ridwan Islam; Kavita Mallya; Kaustubh Datta; Lei Xi; Anindita Das; Benjamin A. Teply; Rakesh C. Kukreja; Surinder K. Batra

doi:10.1158/1078-0432.CCR-20-1569

Translational Cancer Mechanisms and Therapy

Sildenafil Potentiates the Therapeutic Efficacy of Docetaxel in Advanced Prostate Cancer by Stimulating NO-cGMP Signaling

Sakthivel Muniyan, Satyanarayana Rachagani, Seema Parte, Sushanta Halder, Parthasarathy Seshacharyulu, Prakash Kshirsagar, Jawed A. Siddiqui, Raghupathy Vengoji, Sanchita Rauth, Ridwan Islam, Kavita Mallya, Kaustubh Datta, Lei Xi, Anindita Das, Benjamin A. Teply, Rakesh C. Kukreja and Surinder K. Batra

Sakthivel Muniyan

1Department of Biochemistry and Molecular Biology, University of Nebraska Medical Center, Omaha, Nebraska.

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For correspondence: sbatra@unmc.edu s.muniyan@unmc.edu

Satyanarayana Rachagani

1Department of Biochemistry and Molecular Biology, University of Nebraska Medical Center, Omaha, Nebraska.

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Seema Parte

1Department of Biochemistry and Molecular Biology, University of Nebraska Medical Center, Omaha, Nebraska.

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Sushanta Halder

1Department of Biochemistry and Molecular Biology, University of Nebraska Medical Center, Omaha, Nebraska.

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Parthasarathy Seshacharyulu

1Department of Biochemistry and Molecular Biology, University of Nebraska Medical Center, Omaha, Nebraska.

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Prakash Kshirsagar

1Department of Biochemistry and Molecular Biology, University of Nebraska Medical Center, Omaha, Nebraska.

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Jawed A. Siddiqui

1Department of Biochemistry and Molecular Biology, University of Nebraska Medical Center, Omaha, Nebraska.

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Raghupathy Vengoji

1Department of Biochemistry and Molecular Biology, University of Nebraska Medical Center, Omaha, Nebraska.

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Sanchita Rauth

1Department of Biochemistry and Molecular Biology, University of Nebraska Medical Center, Omaha, Nebraska.

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Ridwan Islam

1Department of Biochemistry and Molecular Biology, University of Nebraska Medical Center, Omaha, Nebraska.

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Kavita Mallya

1Department of Biochemistry and Molecular Biology, University of Nebraska Medical Center, Omaha, Nebraska.

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Kaustubh Datta

1Department of Biochemistry and Molecular Biology, University of Nebraska Medical Center, Omaha, Nebraska.

2Fred and Pamela Buffett Cancer Center, Eppley Institute for Research in Cancer and Allied Diseases, University of Nebraska Medical Center, Omaha, Nebraska.

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Lei Xi

3Pauley Heart Center, Department of Internal Medicine, Division of Cardiology, Virginia Commonwealth University, Richmond, Virginia.

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Anindita Das

3Pauley Heart Center, Department of Internal Medicine, Division of Cardiology, Virginia Commonwealth University, Richmond, Virginia.

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Benjamin A. Teply

2Fred and Pamela Buffett Cancer Center, Eppley Institute for Research in Cancer and Allied Diseases, University of Nebraska Medical Center, Omaha, Nebraska.

4Department of Internal Medicine, University of Nebraska Medical Center, Omaha, Nebraska.

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Rakesh C. Kukreja

3Pauley Heart Center, Department of Internal Medicine, Division of Cardiology, Virginia Commonwealth University, Richmond, Virginia.

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Surinder K. Batra

1Department of Biochemistry and Molecular Biology, University of Nebraska Medical Center, Omaha, Nebraska.

2Fred and Pamela Buffett Cancer Center, Eppley Institute for Research in Cancer and Allied Diseases, University of Nebraska Medical Center, Omaha, Nebraska.

5Department of Pathology and Microbiology, University of Nebraska Medical Center, Omaha, Nebraska.

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For correspondence: sbatra@unmc.edu s.muniyan@unmc.edu

DOI: 10.1158/1078-0432.CCR-20-1569 Published November 2020

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November 2020
Volume 26, Issue 21

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Sildenafil Potentiates the Therapeutic Efficacy of Docetaxel in Advanced Prostate Cancer by Stimulating NO-cGMP Signaling

Clin Cancer Res November 1 2020 (26) (21) 5720-5734; DOI: 10.1158/1078-0432.CCR-20-1569

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Sildenafil Potentiates the Therapeutic Efficacy of Docetaxel in Advanced Prostate Cancer by Stimulating NO-cGMP Signaling

Clin Cancer Res November 1 2020 (26) (21) 5720-5734; DOI: 10.1158/1078-0432.CCR-20-1569

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