The XPO1 Inhibitor KPT-8602 Synergizes with Dexamethasone in Acute Lymphoblastic Leukemia

Delphine Verbeke; Sofie Demeyer; Cristina Prieto; Charles E. de Bock; Jolien De Bie; Olga Gielen; Kris Jacobs; Nicole Mentens; Bronte Manouk Verhoeven; Anne Uyttebroeck; Nancy Boeckx; Kim De Keersmaecker; Johan Maertens; Heidi Segers; Jan Cools

doi:10.1158/1078-0432.CCR-20-1315

Translational Cancer Mechanisms and Therapy

The XPO1 Inhibitor KPT-8602 Synergizes with Dexamethasone in Acute Lymphoblastic Leukemia

Delphine Verbeke, Sofie Demeyer, Cristina Prieto, Charles E. de Bock, Jolien De Bie, Olga Gielen, Kris Jacobs, Nicole Mentens, Bronte Manouk Verhoeven, Anne Uyttebroeck, Nancy Boeckx, Kim De Keersmaecker, Johan Maertens, Heidi Segers and Jan Cools

Delphine Verbeke

1Center for Human Genetics, KU Leuven, Leuven, Belgium.

2Center for Cancer Biology, VIB, Leuven, Belgium.

3Leuvens Kanker Instituut (LKI), KU Leuven – UZ Leuven, Leuven, Belgium.

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Sofie Demeyer

1Center for Human Genetics, KU Leuven, Leuven, Belgium.

2Center for Cancer Biology, VIB, Leuven, Belgium.

3Leuvens Kanker Instituut (LKI), KU Leuven – UZ Leuven, Leuven, Belgium.

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Cristina Prieto

1Center for Human Genetics, KU Leuven, Leuven, Belgium.

2Center for Cancer Biology, VIB, Leuven, Belgium.

3Leuvens Kanker Instituut (LKI), KU Leuven – UZ Leuven, Leuven, Belgium.

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Charles E. de Bock

4Children's Cancer Institute, Lowy Cancer Research Centre, University of New South Wales, Randwick, New South Wales, Australia.

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ORCID record for Charles E. de Bock

Jolien De Bie

1Center for Human Genetics, KU Leuven, Leuven, Belgium.

2Center for Cancer Biology, VIB, Leuven, Belgium.

3Leuvens Kanker Instituut (LKI), KU Leuven – UZ Leuven, Leuven, Belgium.

5Department of Laboratory Medicine, UZ Leuven, Leuven, Belgium.

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Olga Gielen

1Center for Human Genetics, KU Leuven, Leuven, Belgium.

2Center for Cancer Biology, VIB, Leuven, Belgium.

3Leuvens Kanker Instituut (LKI), KU Leuven – UZ Leuven, Leuven, Belgium.

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Kris Jacobs

1Center for Human Genetics, KU Leuven, Leuven, Belgium.

2Center for Cancer Biology, VIB, Leuven, Belgium.

3Leuvens Kanker Instituut (LKI), KU Leuven – UZ Leuven, Leuven, Belgium.

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Nicole Mentens

1Center for Human Genetics, KU Leuven, Leuven, Belgium.

2Center for Cancer Biology, VIB, Leuven, Belgium.

3Leuvens Kanker Instituut (LKI), KU Leuven – UZ Leuven, Leuven, Belgium.

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Bronte Manouk Verhoeven

1Center for Human Genetics, KU Leuven, Leuven, Belgium.

2Center for Cancer Biology, VIB, Leuven, Belgium.

3Leuvens Kanker Instituut (LKI), KU Leuven – UZ Leuven, Leuven, Belgium.

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Anne Uyttebroeck

3Leuvens Kanker Instituut (LKI), KU Leuven – UZ Leuven, Leuven, Belgium.

6Department of Pediatric Oncology, UZ Leuven, Leuven, Belgium.

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Nancy Boeckx

5Department of Laboratory Medicine, UZ Leuven, Leuven, Belgium.

7Department of Oncology, KU Leuven, Leuven, Belgium.

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Kim De Keersmaecker

3Leuvens Kanker Instituut (LKI), KU Leuven – UZ Leuven, Leuven, Belgium.

7Department of Oncology, KU Leuven, Leuven, Belgium.

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Johan Maertens

3Leuvens Kanker Instituut (LKI), KU Leuven – UZ Leuven, Leuven, Belgium.

8Department of Hematology, UZ Leuven, Leuven, Belgium.

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Heidi Segers

3Leuvens Kanker Instituut (LKI), KU Leuven – UZ Leuven, Leuven, Belgium.

6Department of Pediatric Oncology, UZ Leuven, Leuven, Belgium.

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Jan Cools

1Center for Human Genetics, KU Leuven, Leuven, Belgium.

2Center for Cancer Biology, VIB, Leuven, Belgium.

3Leuvens Kanker Instituut (LKI), KU Leuven – UZ Leuven, Leuven, Belgium.

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ORCID record for Jan Cools
For correspondence: jan.cools@kuleuven.be

DOI: 10.1158/1078-0432.CCR-20-1315 Published November 2020

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November 2020
Volume 26, Issue 21

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The XPO1 Inhibitor KPT-8602 Synergizes with Dexamethasone in Acute Lymphoblastic Leukemia

Clin Cancer Res November 1 2020 (26) (21) 5747-5758; DOI: 10.1158/1078-0432.CCR-20-1315

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The XPO1 Inhibitor KPT-8602 Synergizes with Dexamethasone in Acute Lymphoblastic Leukemia

Clin Cancer Res November 1 2020 (26) (21) 5747-5758; DOI: 10.1158/1078-0432.CCR-20-1315

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