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Clinical Trials: Targeted Therapy

PIK3CA Mutation in the ShortHER Randomized Adjuvant Trial for Patients with Early HER2+ Breast Cancer: Association with Prognosis and Integration with PAM50 Subtype

Valentina Guarneri, Maria Vittoria Dieci, Giancarlo Bisagni, Alba A. Brandes, Antonio Frassoldati, Luigi Cavanna, Antonino Musolino, Francesco Giotta, Anita Rimanti, Ornella Garrone, Elena Bertone, Katia Cagossi, Oriana Nanni, Federico Piacentini, Enrico Orvieto, Gaia Griguolo, Matteo Curtarello, Loredana Urso, Laia Paré, Nuria Chic, Roberto D'Amico, Aleix Prat and Pierfranco Conte
Valentina Guarneri
1Department of Surgery, Oncology and Gastroenterology, University of Padova, Padova, Italy.
2Medical Oncology 2, Istituto Oncologico Veneto IOV-IRCCS, Padova, Italy.
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Maria Vittoria Dieci
1Department of Surgery, Oncology and Gastroenterology, University of Padova, Padova, Italy.
2Medical Oncology 2, Istituto Oncologico Veneto IOV-IRCCS, Padova, Italy.
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  • ORCID record for Maria Vittoria Dieci
  • For correspondence: mariavittoria.dieci@unipd.it
Giancarlo Bisagni
3Department of Oncology and Advanced Technologies, Reggio Emilia, Italy.
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Alba A. Brandes
4Medical Oncology, Azienda Unità Sanitaria Locale di Bologna-IRCCS Istituto delle Scienze Neurologiche, Bologna, Italy.
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Antonio Frassoldati
5Clinical Oncology, Department of Morphology, Surgery and Experimental Medicine, S Anna University Hospital, Ferrara, Italy.
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Luigi Cavanna
6Department of Oncology-Hematology, G. da Saliceto Hospital, Piacenza, Italy.
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  • ORCID record for Luigi Cavanna
Antonino Musolino
7Medical Oncology and Breast Unit, University Hospital of Parma, Parma, Italy.
8Department of Medicine and Surgery, University of Parma, Parma, Italy.
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  • ORCID record for Antonino Musolino
Francesco Giotta
9IRCCS Istituto Tumori “Giovanni Paolo II” di Bari, Parma, Italy.
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  • ORCID record for Francesco Giotta
Anita Rimanti
10Medical Oncology, Azienda Ospedaliera di Mantova, Mantova, Italy.
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Ornella Garrone
11Breast Unit, Medical Oncology, A.O.S. Croce and Carle Teaching Hospital, Cuneo, Italy.
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  • ORCID record for Ornella Garrone
Elena Bertone
12Department of Gynecology and Obstetrics, Ospedale S. Anna, Turin, Italy.
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Katia Cagossi
13Breast Unit Ausl Modena, Ramazzini Hospital, Carpi, Italy.
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Oriana Nanni
14Istituto Scientifico Romagnolo per lo Studio e la Cura dei Tumori (IRST) IRCCS, Meldola, Italy.
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Federico Piacentini
15Division of Medical Oncology, Department of Medical and Surgical Sciences for Children & Adults, University Hospital of Modena, Modena, Italy.
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  • ORCID record for Federico Piacentini
Enrico Orvieto
16Pathology Unit, Rovigo, Italy.
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Gaia Griguolo
1Department of Surgery, Oncology and Gastroenterology, University of Padova, Padova, Italy.
2Medical Oncology 2, Istituto Oncologico Veneto IOV-IRCCS, Padova, Italy.
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Matteo Curtarello
17Immunology and Molecular Oncology Unit, Istituto Oncologico Veneto IOV-IRCCS, Padova, Italy.
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Loredana Urso
1Department of Surgery, Oncology and Gastroenterology, University of Padova, Padova, Italy.
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  • ORCID record for Loredana Urso
Laia Paré
18SOLTI Breast Cancer Research Group, Barcelona, Spain.
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Nuria Chic
19Department of Medical Oncology, Hospital Clínic de Barcelona, Barcelona, Spain.
20Translational Genomics and Targeted Therapeutics in Solid Tumors, August Pi i Sunyer Biomedical Research Institute (IDIBAPS), Barcelona, Spain.
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Roberto D'Amico
21Department of Medical and Surgical Sciences for Children & Adults, University of Modena, Modena, Italy.
22Azienda Ospedaliero-Universitaria di Modena, Modena, Italy.
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Aleix Prat
18SOLTI Breast Cancer Research Group, Barcelona, Spain.
19Department of Medical Oncology, Hospital Clínic de Barcelona, Barcelona, Spain.
20Translational Genomics and Targeted Therapeutics in Solid Tumors, August Pi i Sunyer Biomedical Research Institute (IDIBAPS), Barcelona, Spain.
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Pierfranco Conte
1Department of Surgery, Oncology and Gastroenterology, University of Padova, Padova, Italy.
2Medical Oncology 2, Istituto Oncologico Veneto IOV-IRCCS, Padova, Italy.
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  • ORCID record for Pierfranco Conte
DOI: 10.1158/1078-0432.CCR-20-1731 Published November 2020
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ARTICLE USAGE: August 2020 to January 2021

AbstractFull-text HTMLPDF
Total2054498478

Cited By

Article Information

Volume 26, Issue 22, pp. 5843-5851

DOI 
https://doi.org/10.1158/1078-0432.CCR-20-1731
PubMed 
32843527

Published By 
American Association for Cancer Research
Print ISSN 
1078-0432
Online ISSN 
1557-3265
History 
  • Received May 5, 2020
  • Revision received June 22, 2020
  • Accepted August 14, 2020
  • Published first August 25, 2020.

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  • Previous version (August 25, 2020 - 05:56).
  • Previous version (October 8, 2020 - 06:49).
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Copyright & Usage 
©2020 American Association for Cancer Research.

Author Information

  1. Valentina Guarneri1,2,
  2. Maria Vittoria Dieci1,2,*,
  3. Giancarlo Bisagni3,
  4. Alba A. Brandes4,
  5. Antonio Frassoldati5,
  6. Luigi Cavanna6,
  7. Antonino Musolino7,8,
  8. Francesco Giotta9,
  9. Anita Rimanti10,
  10. Ornella Garrone11,
  11. Elena Bertone12,
  12. Katia Cagossi13,
  13. Oriana Nanni14,
  14. Federico Piacentini15,
  15. Enrico Orvieto16,
  16. Gaia Griguolo1,2,
  17. Matteo Curtarello17,
  18. Loredana Urso1,
  19. Laia Paré18,
  20. Nuria Chic19,20,
  21. Roberto D'Amico21,22,
  22. Aleix Prat18,19,20, and
  23. Pierfranco Conte1,2
  1. 1Department of Surgery, Oncology and Gastroenterology, University of Padova, Padova, Italy.
  2. 2Medical Oncology 2, Istituto Oncologico Veneto IOV-IRCCS, Padova, Italy.
  3. 3Department of Oncology and Advanced Technologies, Reggio Emilia, Italy.
  4. 4Medical Oncology, Azienda Unità Sanitaria Locale di Bologna-IRCCS Istituto delle Scienze Neurologiche, Bologna, Italy.
  5. 5Clinical Oncology, Department of Morphology, Surgery and Experimental Medicine, S Anna University Hospital, Ferrara, Italy.
  6. 6Department of Oncology-Hematology, G. da Saliceto Hospital, Piacenza, Italy.
  7. 7Medical Oncology and Breast Unit, University Hospital of Parma, Parma, Italy.
  8. 8Department of Medicine and Surgery, University of Parma, Parma, Italy.
  9. 9IRCCS Istituto Tumori “Giovanni Paolo II” di Bari, Parma, Italy.
  10. 10Medical Oncology, Azienda Ospedaliera di Mantova, Mantova, Italy.
  11. 11Breast Unit, Medical Oncology, A.O.S. Croce and Carle Teaching Hospital, Cuneo, Italy.
  12. 12Department of Gynecology and Obstetrics, Ospedale S. Anna, Turin, Italy.
  13. 13Breast Unit Ausl Modena, Ramazzini Hospital, Carpi, Italy.
  14. 14Istituto Scientifico Romagnolo per lo Studio e la Cura dei Tumori (IRST) IRCCS, Meldola, Italy.
  15. 15Division of Medical Oncology, Department of Medical and Surgical Sciences for Children & Adults, University Hospital of Modena, Modena, Italy.
  16. 16Pathology Unit, Rovigo, Italy.
  17. 17Immunology and Molecular Oncology Unit, Istituto Oncologico Veneto IOV-IRCCS, Padova, Italy.
  18. 18SOLTI Breast Cancer Research Group, Barcelona, Spain.
  19. 19Department of Medical Oncology, Hospital Clínic de Barcelona, Barcelona, Spain.
  20. 20Translational Genomics and Targeted Therapeutics in Solid Tumors, August Pi i Sunyer Biomedical Research Institute (IDIBAPS), Barcelona, Spain.
  21. 21Department of Medical and Surgical Sciences for Children & Adults, University of Modena, Modena, Italy.
  22. 22Azienda Ospedaliero-Universitaria di Modena, Modena, Italy.
  1. ↵*Corresponding Author:
    Maria Vittoria Dieci, University of Padova, Istituto Oncologico Veneto IRCCS, via Gattamelata 64, Padova 35128, Italy. Phone: 39 0498215295; Fax: 39 0498215932; E-mail: mariavittoria.dieci{at}unipd.it
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Clinical Cancer Research: 26 (22)
November 2020
Volume 26, Issue 22
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PIK3CA Mutation in the ShortHER Randomized Adjuvant Trial for Patients with Early HER2+ Breast Cancer: Association with Prognosis and Integration with PAM50 Subtype
Valentina Guarneri, Maria Vittoria Dieci, Giancarlo Bisagni, Alba A. Brandes, Antonio Frassoldati, Luigi Cavanna, Antonino Musolino, Francesco Giotta, Anita Rimanti, Ornella Garrone, Elena Bertone, Katia Cagossi, Oriana Nanni, Federico Piacentini, Enrico Orvieto, Gaia Griguolo, Matteo Curtarello, Loredana Urso, Laia Paré, Nuria Chic, Roberto D'Amico, Aleix Prat and Pierfranco Conte
Clin Cancer Res November 15 2020 (26) (22) 5843-5851; DOI: 10.1158/1078-0432.CCR-20-1731

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PIK3CA Mutation in the ShortHER Randomized Adjuvant Trial for Patients with Early HER2+ Breast Cancer: Association with Prognosis and Integration with PAM50 Subtype
Valentina Guarneri, Maria Vittoria Dieci, Giancarlo Bisagni, Alba A. Brandes, Antonio Frassoldati, Luigi Cavanna, Antonino Musolino, Francesco Giotta, Anita Rimanti, Ornella Garrone, Elena Bertone, Katia Cagossi, Oriana Nanni, Federico Piacentini, Enrico Orvieto, Gaia Griguolo, Matteo Curtarello, Loredana Urso, Laia Paré, Nuria Chic, Roberto D'Amico, Aleix Prat and Pierfranco Conte
Clin Cancer Res November 15 2020 (26) (22) 5843-5851; DOI: 10.1158/1078-0432.CCR-20-1731
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