Skip to main content
  • AACR Publications
    • Blood Cancer Discovery
    • Cancer Discovery
    • Cancer Epidemiology, Biomarkers & Prevention
    • Cancer Immunology Research
    • Cancer Prevention Research
    • Cancer Research
    • Clinical Cancer Research
    • Molecular Cancer Research
    • Molecular Cancer Therapeutics

AACR logo

  • Register
  • Log in
  • My Cart
Advertisement

Main menu

  • Home
  • About
    • The Journal
    • AACR Journals
    • Subscriptions
    • Permissions and Reprints
    • Reviewing
    • CME
  • Articles
    • OnlineFirst
    • Current Issue
    • Past Issues
    • CCR Focus Archive
    • Meeting Abstracts
    • Collections
      • COVID-19 & Cancer Resource Center
      • Breast Cancer
      • Clinical Trials
      • Immunotherapy: Facts and Hopes
      • Editors' Picks
      • "Best of" Collection
  • For Authors
    • Information for Authors
    • Author Services
    • Best of: Author Profiles
    • Submit
  • Alerts
    • Table of Contents
    • Editors' Picks
    • OnlineFirst
    • Citation
    • Author/Keyword
    • RSS Feeds
    • My Alert Summary & Preferences
  • News
    • Cancer Discovery News
  • COVID-19
  • Webinars
  • Search More

    Advanced Search

  • AACR Publications
    • Blood Cancer Discovery
    • Cancer Discovery
    • Cancer Epidemiology, Biomarkers & Prevention
    • Cancer Immunology Research
    • Cancer Prevention Research
    • Cancer Research
    • Clinical Cancer Research
    • Molecular Cancer Research
    • Molecular Cancer Therapeutics

User menu

  • Register
  • Log in
  • My Cart

Search

  • Advanced search
Clinical Cancer Research
Clinical Cancer Research
  • Home
  • About
    • The Journal
    • AACR Journals
    • Subscriptions
    • Permissions and Reprints
    • Reviewing
    • CME
  • Articles
    • OnlineFirst
    • Current Issue
    • Past Issues
    • CCR Focus Archive
    • Meeting Abstracts
    • Collections
      • COVID-19 & Cancer Resource Center
      • Breast Cancer
      • Clinical Trials
      • Immunotherapy: Facts and Hopes
      • Editors' Picks
      • "Best of" Collection
  • For Authors
    • Information for Authors
    • Author Services
    • Best of: Author Profiles
    • Submit
  • Alerts
    • Table of Contents
    • Editors' Picks
    • OnlineFirst
    • Citation
    • Author/Keyword
    • RSS Feeds
    • My Alert Summary & Preferences
  • News
    • Cancer Discovery News
  • COVID-19
  • Webinars
  • Search More

    Advanced Search

Translational Cancer Mechanisms and Therapy

Targeting Extracellular Matrix Remodeling Restores BRAF Inhibitor Sensitivity in BRAFi-resistant Melanoma

Charles Marusak, Varsha Thakur, Yuan Li, Juliano T. Freitas, Patrick M. Zmina, Vijay S. Thakur, Mayland Chang, Ming Gao, Jiufeng Tan, Min Xiao, Yiling Lu, Gordon B. Mills, Keith Flaherty, Dennie T. Frederick, Benchun Miao, Ryan J. Sullivan, Tabea Moll, Genevieve M. Boland, Meenhard Herlyn, Gao Zhang and Barbara Bedogni
Charles Marusak
1Department of Dermatology, University of Miami Miller School of Medicine, Miami, Florida.
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Varsha Thakur
1Department of Dermatology, University of Miami Miller School of Medicine, Miami, Florida.
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
  • ORCID record for Varsha Thakur
Yuan Li
1Department of Dermatology, University of Miami Miller School of Medicine, Miami, Florida.
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
  • ORCID record for Yuan Li
Juliano T. Freitas
1Department of Dermatology, University of Miami Miller School of Medicine, Miami, Florida.
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
  • ORCID record for Juliano T. Freitas
Patrick M. Zmina
1Department of Dermatology, University of Miami Miller School of Medicine, Miami, Florida.
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Vijay S. Thakur
2Department of Radiation Oncology, University of Miami Miller School of Medicine, Miami, Florida.
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
  • ORCID record for Vijay S. Thakur
Mayland Chang
3Department of Chemistry and Biochemistry, University of Notre Dame, Notre Dame, Indiana.
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Ming Gao
3Department of Chemistry and Biochemistry, University of Notre Dame, Notre Dame, Indiana.
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Jiufeng Tan
4The Wistar Institute, Philadelphia, Pennsylvania.
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
  • ORCID record for Jiufeng Tan
Min Xiao
4The Wistar Institute, Philadelphia, Pennsylvania.
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Yiling Lu
5Department of Genomic Medicine, Division of Cancer Medicine, MD Anderson Cancer Center, Houston, Texas.
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Gordon B. Mills
6The Knight Cancer Institute, Oregon Health Sciences University, Portland, Oregon.
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
  • ORCID record for Gordon B. Mills
Keith Flaherty
7Department of Medicine, Harvard Medical School, Massachusetts General Hospital Cancer Center, Boston, Massachusetts.
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Dennie T. Frederick
8Massachusetts General Hospital Cancer Center, Boston, Massachusetts.
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Benchun Miao
8Massachusetts General Hospital Cancer Center, Boston, Massachusetts.
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Ryan J. Sullivan
8Massachusetts General Hospital Cancer Center, Boston, Massachusetts.
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Tabea Moll
9Department of Surgery, Massachusetts General Hospital, Boston, Massachusetts.
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
  • ORCID record for Tabea Moll
Genevieve M. Boland
9Department of Surgery, Massachusetts General Hospital, Boston, Massachusetts.
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
  • ORCID record for Genevieve M. Boland
Meenhard Herlyn
4The Wistar Institute, Philadelphia, Pennsylvania.
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Gao Zhang
10Department of Neurosurgery, Duke University, Durham, North Carolina.
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
  • ORCID record for Gao Zhang
Barbara Bedogni
1Department of Dermatology, University of Miami Miller School of Medicine, Miami, Florida.
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
  • ORCID record for Barbara Bedogni
  • For correspondence: BXB602@MIAMI.EDU
DOI: 10.1158/1078-0432.CCR-19-2773 Published November 2020
  • Article
  • Figures & Data
  • Info & Metrics
  • PDF
Loading

Online Impact

Statistics from Altmetric.com

ARTICLE USAGE

ARTICLE USAGE: August 2020 to January 2021

AbstractFull-text HTMLPDF
Total260693291

Cited By

Article Information

Volume 26, Issue 22, pp. 6039-6050

DOI 
https://doi.org/10.1158/1078-0432.CCR-19-2773
PubMed 
32820016

Published By 
American Association for Cancer Research
Print ISSN 
1078-0432
Online ISSN 
1557-3265
History 
  • Received August 21, 2019
  • Revision received July 7, 2020
  • Accepted August 17, 2020
  • Published first August 20, 2020.

Article Versions

  • Previous version (August 20, 2020 - 05:55).
  • Previous version (August 25, 2020 - 05:56).
  • Previous version (October 6, 2020 - 05:38).
  • You are viewing the most recent version of this article.
Copyright & Usage 
©2020 American Association for Cancer Research.

Author Information

  1. Charles Marusak1,
  2. Varsha Thakur1,
  3. Yuan Li1,
  4. Juliano T. Freitas1,
  5. Patrick M. Zmina1,
  6. Vijay S. Thakur2,
  7. Mayland Chang3,
  8. Ming Gao3,
  9. Jiufeng Tan4,
  10. Min Xiao4,
  11. Yiling Lu5,
  12. Gordon B. Mills6,
  13. Keith Flaherty7,
  14. Dennie T. Frederick8,
  15. Benchun Miao8,
  16. Ryan J. Sullivan8,
  17. Tabea Moll9,
  18. Genevieve M. Boland9,
  19. Meenhard Herlyn4,
  20. Gao Zhang10, and
  21. Barbara Bedogni1,*
  1. 1Department of Dermatology, University of Miami Miller School of Medicine, Miami, Florida.
  2. 2Department of Radiation Oncology, University of Miami Miller School of Medicine, Miami, Florida.
  3. 3Department of Chemistry and Biochemistry, University of Notre Dame, Notre Dame, Indiana.
  4. 4The Wistar Institute, Philadelphia, Pennsylvania.
  5. 5Department of Genomic Medicine, Division of Cancer Medicine, MD Anderson Cancer Center, Houston, Texas.
  6. 6The Knight Cancer Institute, Oregon Health Sciences University, Portland, Oregon.
  7. 7Department of Medicine, Harvard Medical School, Massachusetts General Hospital Cancer Center, Boston, Massachusetts.
  8. 8Massachusetts General Hospital Cancer Center, Boston, Massachusetts.
  9. 9Department of Surgery, Massachusetts General Hospital, Boston, Massachusetts.
  10. 10Department of Neurosurgery, Duke University, Durham, North Carolina.
  1. ↵*Corresponding Author:
    Barbara Bedogni, University of Miami, 1600 NW 10th Ave., RMSB2067, Miami, FL 33136. Phone: 650-387-2993; E-mail: BXB602{at}MIAMI.EDU
View Full Text
PreviousNext
Back to top
Clinical Cancer Research: 26 (22)
November 2020
Volume 26, Issue 22
  • Table of Contents
  • Table of Contents (PDF)
  • About the Cover
  • Editorial Board (PDF)

Sign up for alerts

View this article with LENS

Open full page PDF
Article Alerts
Sign In to Email Alerts with your Email Address
Email Article

Thank you for sharing this Clinical Cancer Research article.

NOTE: We request your email address only to inform the recipient that it was you who recommended this article, and that it is not junk mail. We do not retain these email addresses.

Enter multiple addresses on separate lines or separate them with commas.
Targeting Extracellular Matrix Remodeling Restores BRAF Inhibitor Sensitivity in BRAFi-resistant Melanoma
(Your Name) has forwarded a page to you from Clinical Cancer Research
(Your Name) thought you would be interested in this article in Clinical Cancer Research.
CAPTCHA
This question is for testing whether or not you are a human visitor and to prevent automated spam submissions.
Citation Tools
Targeting Extracellular Matrix Remodeling Restores BRAF Inhibitor Sensitivity in BRAFi-resistant Melanoma
Charles Marusak, Varsha Thakur, Yuan Li, Juliano T. Freitas, Patrick M. Zmina, Vijay S. Thakur, Mayland Chang, Ming Gao, Jiufeng Tan, Min Xiao, Yiling Lu, Gordon B. Mills, Keith Flaherty, Dennie T. Frederick, Benchun Miao, Ryan J. Sullivan, Tabea Moll, Genevieve M. Boland, Meenhard Herlyn, Gao Zhang and Barbara Bedogni
Clin Cancer Res November 15 2020 (26) (22) 6039-6050; DOI: 10.1158/1078-0432.CCR-19-2773

Citation Manager Formats

  • BibTeX
  • Bookends
  • EasyBib
  • EndNote (tagged)
  • EndNote 8 (xml)
  • Medlars
  • Mendeley
  • Papers
  • RefWorks Tagged
  • Ref Manager
  • RIS
  • Zotero
Share
Targeting Extracellular Matrix Remodeling Restores BRAF Inhibitor Sensitivity in BRAFi-resistant Melanoma
Charles Marusak, Varsha Thakur, Yuan Li, Juliano T. Freitas, Patrick M. Zmina, Vijay S. Thakur, Mayland Chang, Ming Gao, Jiufeng Tan, Min Xiao, Yiling Lu, Gordon B. Mills, Keith Flaherty, Dennie T. Frederick, Benchun Miao, Ryan J. Sullivan, Tabea Moll, Genevieve M. Boland, Meenhard Herlyn, Gao Zhang and Barbara Bedogni
Clin Cancer Res November 15 2020 (26) (22) 6039-6050; DOI: 10.1158/1078-0432.CCR-19-2773
del.icio.us logo Digg logo Reddit logo Twitter logo CiteULike logo Facebook logo Google logo Mendeley logo
  • Tweet Widget
  • Facebook Like
  • Google Plus One

Jump to section

  • Article
    • Abstract
    • Introduction
    • Materials and Methods
    • Results
    • Discussion
    • Disclosure of Potential Conflicts of Interest
    • Authors' Contributions
    • Acknowledgments
    • Footnotes
    • References
  • Figures & Data
  • Info & Metrics
  • PDF
Advertisement

Related Articles

Cited By...

More in this TOC Section

  • Genomic and Epigenomic Profiling of FH-deficient RCC
  • Tarloxotinib Is a Hypoxia-Activated pan-HER Kinase Inhibitor
  • Characterization and Clinical Outcomes of MMR-D SBA
Show more Translational Cancer Mechanisms and Therapy
  • Home
  • Alerts
  • Feedback
  • Privacy Policy
Facebook  Twitter  LinkedIn  YouTube  RSS

Articles

  • Online First
  • Current Issue
  • Past Issues
  • CCR Focus Archive
  • Meeting Abstracts

Info for

  • Authors
  • Subscribers
  • Advertisers
  • Librarians

About Clinical Cancer Research

  • About the Journal
  • Editorial Board
  • Permissions
  • Submit a Manuscript
AACR logo

Copyright © 2021 by the American Association for Cancer Research.

Clinical Cancer Research
eISSN: 1557-3265
ISSN: 1078-0432

Advertisement