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Abstract
Genome-wide DNA methylation profiles of serous tubal intraepithelial carcinomas (STIC) resemble methylation profiles of high-grade serous ovarian carcinomas (HGSOC) more closely than normal fallopian tube epithelium. While STICs and HGSOCs share subsets of common hypermethylated regions, DNA methylation can distinguish STICs from HGSOCs to provide proof-of-principle that DNA methylation can identify HGSOC initiation.
See related article by Pisanic et al., p. 6310
Footnotes
Clin Cancer Res 2020;26:6083–5
- Received September 8, 2020.
- Revision received September 15, 2020.
- Accepted September 23, 2020.
- Published first September 28, 2020.
- ©2020 American Association for Cancer Research.
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December 2020
Volume 26, Issue 23
Volume 26, Issue 23
DNA Methylation Profiling of Premalignant Lesions as a Path to Ovarian Cancer Early Detection
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