The cover shows a trans-iliac bone marrow biopsy of a patient with hormone-naïve metastatic prostate cancer. The hematoxylin and eosin stained section reveals bony trabecula lined by osteoblasts and foci of prostatic adenocarcinoma in an edematous stromal background, lacking hematopoiesis. For details, see the article by Corn and colleagues on page 990 of this issue.