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Table of Contents

Highlights

  • Highlights
    Selected Articles from This Issue
    Clin Cancer Res January 1 2021 27 (1) 1-1;

CCR Translations

  • CCR Translations
    New Drug for Chronic Myeloid Leukemia Might Stimulate the Market
    Martin C. Müller
    Clin Cancer Res January 1 2021 27 (1) 3-4; DOI:10.1158/1078-0432.CCR-20-3684

  • CCR Translations
    Checking the Hippo in Sarcomatoid Renal Cell Carcinoma with Immunotherapy
    Joyce K. Hwang, Neeraj Agarwal, James Brugarolas and Tian Zhang
    Clin Cancer Res January 1 2021 27 (1) 5-7; DOI:10.1158/1078-0432.CCR-20-3506

  • CCR Translations
    Age is in the Eye of the Beholder: Distinguishing Molecular Signatures in Early-onset Pancreatic Adenocarcinomas
    Emil Lou
    Clin Cancer Res January 1 2021 27 (1) 8-10; DOI:10.1158/1078-0432.CCR-20-3683

CCR Perspectives in Regulatory Science and Policy

  • CCR Perspectives in Regulatory Science and Policy
    U.S. Food and Drug Administration: Initial Experience with the Real-Time Oncology Review Program
    R. Angelo de Claro, Jennifer J. Gao, Tamy Kim, Paul G. Kluetz, Marc R. Theoret, Julia A. Beaver and Richard Pazdur
    Clin Cancer Res January 1 2021 27 (1) 11-14; DOI:10.1158/1078-0432.CCR-20-2220

Review

  • Review
    Designing Evolutionary-based Interception Strategies to Block the Transition from Precursor Phases to Multiple Myeloma
    Francesco Maura, Ola Landgren and Gareth J. Morgan
    Clin Cancer Res January 1 2021 27 (1) 15-23; DOI:10.1158/1078-0432.CCR-20-1395

Perspectives

  • Perspectives | Free Article
    Similarities in Risk for COVID-19 and Cancer Disparities
    Lisa A. Newman, Robert A. Winn and John M. Carethers
    Clin Cancer Res January 1 2021 27 (1) 24-27; DOI:10.1158/1078-0432.CCR-20-3421

Special Report

  • Special Report | AuthorChoice
    The Latest on Uveal Melanoma Research and Clinical Trials: Updates from the Cure Ocular Melanoma (CURE OM) Science Meeting (2019)
    Vivian Chua, Jane Mattei, Anna Han, Lauren Johnston, Kyleigh LiPira, Sara M. Selig, Richard D. Carvajal, Andrew E. Aplin and Sapna P. Patel
    Clin Cancer Res January 1 2021 27 (1) 28-33; DOI:10.1158/1078-0432.CCR-20-2536

Research Briefs: Clinical Trial Brief Report

  • Research Briefs: Clinical Trial Brief Report | AuthorChoice
    Overcoming MET-Dependent Resistance to Selective RET Inhibition in Patients with RET Fusion–Positive Lung Cancer by Combining Selpercatinib with Crizotinib
    Ezra Y. Rosen, Melissa L. Johnson, Sarah E. Clifford, Romel Somwar, Jennifer F. Kherani, Jieun Son, Arrien A. Bertram, Monika A. Davare, Eric Gladstone, Elena V. Ivanova, Dahlia N. Henry, Elaine M. Kelley, Mika Lin, Marina S.D. Milan, Binoj C. Nair, Elizabeth A. Olek, Jenna E. Scanlon, Morana Vojnic, Kevin Ebata, Jaclyn F. Hechtman, Bob T. Li, Lynette M. Sholl, Barry S. Taylor, Marc Ladanyi, Pasi A. Jänne, S. Michael Rothenberg, Alexander Drilon and Geoffrey R. Oxnard
    Clin Cancer Res January 1 2021 27 (1) 34-42; DOI:10.1158/1078-0432.CCR-20-2278

Clinical Trials: Targeted Therapy

  • Clinical Trials: Targeted Therapy | AuthorChoice
    Open-label, Multicenter, Phase II Study of RC48-ADC, a HER2-Targeting Antibody–Drug Conjugate, in Patients with Locally Advanced or Metastatic Urothelial Carcinoma
    Xinan Sheng, Xieqiao Yan, Lin Wang, Yanxia Shi, Xin Yao, Hong Luo, Benkang Shi, Jiyan Liu, Zhisong He, Guohua Yu, Jianming Ying, Weiqing Han, Changlu Hu, Yun Ling, Zhihong Chi, Chuanliang Cui, Lu Si, Jianmin Fang, Aiping Zhou and Jun Guo
    Clin Cancer Res January 1 2021 27 (1) 43-51; DOI:10.1158/1078-0432.CCR-20-2488

  • Clinical Trials: Targeted Therapy
    Expanded Low Allele Frequency RAS and BRAF V600E Testing in Metastatic Colorectal Cancer as Predictive Biomarkers for Cetuximab in the Randomized CO.17 Trial
    Jonathan M. Loree, Anthony Dowers, Dongsheng Tu, Derek J. Jonker, Daniel L. Edelstein, Hannah Quinn, Frank Holtrup, Timothy Price, John R. Zalcberg, Malcolm J. Moore, Christos S. Karapetis, Chris J. O'Callaghan, Paul Waring, Hagen F. Kennecke, Stanley R. Hamilton and Scott Kopetz
    Clin Cancer Res January 1 2021 27 (1) 52-59; DOI:10.1158/1078-0432.CCR-20-2710

  • Clinical Trials: Targeted Therapy | AuthorChoice
    Phase I Study of Alvocidib Followed by 7+3 (Cytarabine + Daunorubicin) in Newly Diagnosed Acute Myeloid Leukemia
    Joshua F. Zeidner, Daniel J. Lee, Mark Frattini, Gil D. Fine, Judy Costas, Kathryn Kolibaba, Stephen P. Anthony, David Bearss and B. Douglas Smith
    Clin Cancer Res January 1 2021 27 (1) 60-69; DOI:10.1158/1078-0432.CCR-20-2649

  • Clinical Trials: Targeted Therapy
    Flumatinib versus Imatinib for Newly Diagnosed Chronic Phase Chronic Myeloid Leukemia: A Phase III, Randomized, Open-label, Multi-center FESTnd Study
    Li Zhang, Li Meng, Bingcheng Liu, Yanli Zhang, Huanling Zhu, Jiuwei Cui, Aining Sun, Yu Hu, Jie Jin, Hao Jiang, Xi Zhang, Yan Li, Li Liu, Wanggang Zhang, Xiaoli Liu, Jian Gu, Jianhui Qiao, Guifang Ouyang, Xin Liu, Jianmin Luo, Ming Jiang, Xiaobao Xie, Jianyong Li, Chunting Zhao, Mei Zhang, Tonghua Yang and Jianxiang Wang
    Clin Cancer Res January 1 2021 27 (1) 70-77; DOI:10.1158/1078-0432.CCR-20-1600

Clinical Trials: Immunotherapy

  • Clinical Trials: Immunotherapy
    Efficacy and Safety of Nivolumab Plus Ipilimumab versus Sunitinib in First-line Treatment of Patients with Advanced Sarcomatoid Renal Cell Carcinoma
    Nizar M. Tannir, Sabina Signoretti, Toni K. Choueiri, David F. McDermott, Robert J. Motzer, Abdallah Flaifel, Jean-Christophe Pignon, Miriam Ficial, Osvaldo Arén Frontera, Saby George, Thomas Powles, Frede Donskov, Michael R. Harrison, Philippe Barthélémy, Scott S. Tykodi, Judit Kocsis, Alain Ravaud, Jeronimo R. Rodriguez-Cid, Sumanta K. Pal, Andre M. Murad, Yuko Ishii, Shruti Shally Saggi, M. Brent McHenry and Brian I. Rini
    Clin Cancer Res January 1 2021 27 (1) 78-86; DOI:10.1158/1078-0432.CCR-20-2063

  • Clinical Trials: Immunotherapy
    Phase I Clinical Trial of Combination Propranolol and Pembrolizumab in Locally Advanced and Metastatic Melanoma: Safety, Tolerability, and Preliminary Evidence of Antitumor Activity
    Shipra Gandhi, Manu R. Pandey, Kristopher Attwood, Wenyan Ji, Agnieszka K. Witkiewicz, Erik S. Knudsen, Cheryl Allen, Joseph D. Tario, Paul K. Wallace, Carlos D. Cedeno, Maria Levis, Suzanne Stack, Pauline Funchain, Joseph J. Drabick, Mark J. Bucsek, Igor Puzanov, Hemn Mohammadpour, Elizabeth A. Repasky and Marc S. Ernstoff
    Clin Cancer Res January 1 2021 27 (1) 87-95; DOI:10.1158/1078-0432.CCR-20-2381

  • Clinical Trials: Immunotherapy
    Intratumoral Injection of Clostridium novyi-NT Spores in Patients with Treatment-refractory Advanced Solid Tumors
    Filip Janku, Halle Huihong Zhang, Abdulmohammad Pezeshki, Sanjay Goel, Ravi Murthy, Andrea Wang-Gillam, Dale R. Shepard, Thorunn Helgason, Tyler Masters, David S. Hong, Sarina A. Piha-Paul, Daniel D. Karp, Mark Klang, Steven Y. Huang, Divya Sakamuri, Anjali Raina, Jean Torrisi, Stephen B. Solomon, Alice Weissfeld, Ernest Trevino, Gary DeCrescenzo, Amanda Collins, Maria Miller, Jennifer L. Salstrom, Ronald L. Korn, Linping Zhang, Saurabh Saha, Alexey A. Leontovich, David Tung, Brent Kreider, Mary Varterasian, Khashayarsha Khazaie and Mrinal M. Gounder
    Clin Cancer Res January 1 2021 27 (1) 96-106; DOI:10.1158/1078-0432.CCR-20-2065

Precision Medicine and Imaging

  • Precision Medicine and Imaging
    Three Distinct Stroma Types in Human Pancreatic Cancer Identified by Image Analysis of Fibroblast Subpopulations and Collagen
    Yurina Ogawa, Yohei Masugi, Tokiya Abe, Ken Yamazaki, Akihisa Ueno, Yoko Fujii-Nishimura, Shutaro Hori, Hiroshi Yagi, Yuta Abe, Minoru Kitago and Michiie Sakamoto
    Clin Cancer Res January 1 2021 27 (1) 107-119; DOI:10.1158/1078-0432.CCR-20-2298

  • Precision Medicine and Imaging | AuthorChoice
    Development and Validation of a Gene Signature Classifier for Consensus Molecular Subtyping of Colorectal Carcinoma in a CLIA-Certified Setting
    Jeffrey S. Morris, Rajyalakshmi Luthra, Yusha Liu, Dzifa Y. Duose, Wonyul Lee, Neelima G. Reddy, Justin Windham, Huiqin Chen, Zhimin Tong, Baili Zhang, Wei Wei, Manyam Ganiraju, Bradley M. Broom, Hector A. Alvarez, Alicia Mejia, Omkara Veeranki, Mark J. Routbort, Van K. Morris, Michael J. Overman, David Menter, Riham Katkhuda, Ignacio I. Wistuba, Jennifer S. Davis, Scott Kopetz and Dipen M. Maru
    Clin Cancer Res January 1 2021 27 (1) 120-130; DOI:10.1158/1078-0432.CCR-20-2403

  • Precision Medicine and Imaging | AuthorChoice
    Using Machine Learning Algorithms to Predict Immunotherapy Response in Patients with Advanced Melanoma
    Paul Johannet, Nicolas Coudray, Douglas M. Donnelly, George Jour, Irineu Illa-Bochaca, Yuhe Xia, Douglas B. Johnson, Lee Wheless, James R. Patrinely, Sofia Nomikou, David L. Rimm, Anna C. Pavlick, Jeffrey S. Weber, Judy Zhong, Aristotelis Tsirigos and Iman Osman
    Clin Cancer Res January 1 2021 27 (1) 131-140; DOI:10.1158/1078-0432.CCR-20-2415

  • Precision Medicine and Imaging | AuthorChoice
    Novel Methylated DNA Markers in the Surveillance of Colorectal Cancer Recurrence
    Hao Xie, Douglas W. Mahoney, Patrick H. Foote, Kelli N. Burger, Karen A. Doering, William R. Taylor, Sara S. Then, Xiaoming Cao, Maria McGlinch, Calise K. Berger, Tsung-Teh Wu, Joleen M. Hubbard, Hatim T. Allawi, Michael W. Kaiser, Graham P. Lidgard, David A. Ahlquist and John B. Kisiel
    Clin Cancer Res January 1 2021 27 (1) 141-149; DOI:10.1158/1078-0432.CCR-20-2589

  • Precision Medicine and Imaging
    Subtype-Discordant Pancreatic Ductal Adenocarcinoma Tumors Show Intermediate Clinical and Molecular Characteristics
    James T. Topham, Joanna M. Karasinska, Michael K.C. Lee, Veronika Csizmok, Laura M. Williamson, Gun Ho Jang, Robert E. Denroche, Erica S. Tsang, Steve E. Kalloger, Hui-li Wong, Grainne M. O'Kane, Richard A. Moore, Andrew J. Mungall, Faiyaz Notta, Jonathan M. Loree, Julie M. Wilson, Oliver Bathe, Patricia A. Tang, Rachel Goodwin, Jennifer J. Knox, Steven Gallinger, Janessa Laskin, Marco A. Marra, Steven J.M. Jones, Daniel J. Renouf and David F. Schaeffer
    Clin Cancer Res January 1 2021 27 (1) 150-157; DOI:10.1158/1078-0432.CCR-20-2831

  • Precision Medicine and Imaging
    International Consensus Definition of DNA Methylation Subgroups in Juvenile Myelomonocytic Leukemia
    Maximilian Schönung, Julia Meyer, Peter Nöllke, Adam B. Olshen, Mark Hartmann, Norihiro Murakami, Manabu Wakamatsu, Yusuke Okuno, Christoph Plass, Mignon L. Loh, Charlotte M. Niemeyer, Hideki Muramatsu, Christian Flotho, Elliot Stieglitz and Daniel B. Lipka
    Clin Cancer Res January 1 2021 27 (1) 158-168; DOI:10.1158/1078-0432.CCR-20-3184

  • Precision Medicine and Imaging
    TERT Promoter Mutation Analysis for Blood-Based Diagnosis and Monitoring of Gliomas
    Koushik Muralidharan, Anudeep Yekula, Julia L. Small, Zachary S. Rosh, Keiko M. Kang, Lan Wang, Spencer Lau, Hui Zhang, Hakho Lee, Chetan Bettegowda, Michael R. Chicoine, Steven N. Kalkanis, Ganesh M. Shankar, Brian V. Nahed, William T. Curry, Pamela S. Jones, Daniel P. Cahill, Leonora Balaj and Bob S. Carter
    Clin Cancer Res January 1 2021 27 (1) 169-178; DOI:10.1158/1078-0432.CCR-20-3083

  • Precision Medicine and Imaging
    MRI and 18FET-PET Predict Survival Benefit from Bevacizumab Plus Radiotherapy in Patients with Isocitrate Dehydrogenase Wild-type Glioblastoma: Results from the Randomized ARTE Trial
    Hans-Georg Wirsching, Ulrich Roelcke, Jonathan Weller, Thomas Hundsberger, Andreas F. Hottinger, Roger von Moos, Francesca Caparrotti, Katrin Conen, Luca Remonda, Patrick Roth, Adrian Ochsenbein, Ghazaleh Tabatabai and Michael Weller
    Clin Cancer Res January 1 2021 27 (1) 179-188; DOI:10.1158/1078-0432.CCR-20-2096

  • Precision Medicine and Imaging
    Preclinical Comparison of the Blood–brain barrier Permeability of Osimertinib with Other EGFR TKIs
    Nicola Colclough, Kan Chen, Peter Johnström, Nicole Strittmatter, Yumei Yan, Gail L. Wrigley, Magnus Schou, Richard Goodwin, Katarina Varnäs, Sally J. Adua, Minghui Zhao, Don X. Nguyen, Gareth Maglennon, Peter Barton, James Atkinson, Lin Zhang, Annika Janefeldt, Joanne Wilson, Aaron Smith, Akihiro Takano, Ryosuke Arakawa, Mikhail Kondrashov, Jonas Malmquist, Evgeny Revunov, Ana Vazquez-Romero, Mohammad Mahdi Moein, Albert D. Windhorst, Natasha A. Karp, M. Raymond V. Finlay, Richard A. Ward, James W.T. Yates, Paul D. Smith, Lars Farde, Zack Cheng and Darren A.E. Cross
    Clin Cancer Res January 1 2021 27 (1) 189-201; DOI:10.1158/1078-0432.CCR-19-1871

  • Precision Medicine and Imaging | AuthorChoice
    Genome and Transcriptome Biomarkers of Response to Immune Checkpoint Inhibitors in Advanced Solid Tumors
    Alexandra Pender, Emma Titmuss, Erin D. Pleasance, Kevin Y. Fan, Hillary Pearson, Scott D. Brown, Cameron J. Grisdale, James T. Topham, Yaoqing Shen, Melika Bonakdar, Gregory A. Taylor, Laura M. Williamson, Karen L. Mungall, Eric Chuah, Andrew J. Mungall, Richard A. Moore, Jean-Michel Lavoie, Stephen Yip, Howard Lim, Daniel J. Renouf, Sophie Sun, Robert A. Holt, Steven J.M. Jones, Marco A. Marra and Janessa Laskin
    Clin Cancer Res January 1 2021 27 (1) 202-212; DOI:10.1158/1078-0432.CCR-20-1163

  • Precision Medicine and Imaging
    A Cyclin D1–Dependent Transcriptional Program Predicts Clinical Outcome in Mantle Cell Lymphoma
    Santiago Demajo, Robert Albero, Guillem Clot, Giancarlo Castellano, Alba Navarro, Cristina Capdevila, Anna Enjuanes, Ferran Nadeu, Eva Giné, Magda Pinyol, Elaine S. Jaffe, German Ott, Louis M. Staudt, Andreas Rosenwald, David W. Scott, Lisa M. Rimsza, Armando López-Guillermo, Sílvia Beà, Elias Campo and Pedro Jares
    Clin Cancer Res January 1 2021 27 (1) 213-225; DOI:10.1158/1078-0432.CCR-20-2868

  • Precision Medicine and Imaging
    Detection of Chemotherapy-resistant Pancreatic Cancer Using a Glycan Biomarker, sTRA
    ChongFeng Gao, Luke Wisniewski, Ying Liu, Ben Staal, Ian Beddows, Dennis Plenker, Mohammed Aldakkak, Johnathan Hall, Daniel Barnett, Mirna Kheir Gouda, Peter Allen, Richard Drake, Amer Zureikat, Ying Huang, Douglas Evans, Aatur Singhi, Randall E. Brand, David A. Tuveson, Susan Tsai and Brian B. Haab
    Clin Cancer Res January 1 2021 27 (1) 226-236; DOI:10.1158/1078-0432.CCR-20-2475

  • Precision Medicine and Imaging
    Spatiotemporal Heterogeneity in Multiparametric Physiologic MRI Is Associated with Patient Outcomes in IDH-Wildtype Glioblastoma
    Ji Eun Park, Ho Sung Kim, NakYoung Kim, Seo Young Park, Young-Hoon Kim and Jeong Hoon Kim
    Clin Cancer Res January 1 2021 27 (1) 237-245; DOI:10.1158/1078-0432.CCR-20-2156

  • Precision Medicine and Imaging
    Delving into Early-onset Pancreatic Ductal Adenocarcinoma: How Does Age Fit In?
    Erica S. Tsang, James T. Topham, Joanna M. Karasinska, Michael K.C. Lee, Laura M. Williamson, Shehara Mendis, Robert E. Denroche, Gun Ho Jang, Steve E. Kalloger, Richard A. Moore, Andrew J. Mungall, Oliver F. Bathe, Patricia A. Tang, Faiyaz Notta, Julie M. Wilson, Janessa Laskin, Grainne M. O'Kane, Jennifer J. Knox, Rachel A. Goodwin, Jonathan M. Loree, Steven J.M. Jones, Marco A. Marra, Steven Gallinger, David F. Schaeffer and Daniel J. Renouf
    Clin Cancer Res January 1 2021 27 (1) 246-254; DOI:10.1158/1078-0432.CCR-20-1042

  • Precision Medicine and Imaging
    An Immune Risk Score Predicts Survival of Patients with Acute Myeloid Leukemia Receiving Chemotherapy
    Yun Wang, Yan-yu Cai, Tobias Herold, Run-cong Nie, Yu Zhang, Robert Peter Gale, Klaus H. Metzeler, Yun Zeng, Shun-qing Wang, Xue-yi Pan, Tong-hua Yang, Yuan-bin Wu, Qing Zhang, Zhi-jun Wuxiao, Xin Du, Zhi-wei Liang, Yong-zhong Su, Jing-bo Xu, Yong-qing Wang, Ze-lin Liu, Jian-wei Wu, Xiong Zhang, Bing-yi Wu, Ruo-zhi Xiao, San-bin Wang, Jin-yuan Li, Pei-dong Chi, Qian-yi Zhang, Si-liang Chen, Zhe-yuan Qin, Xin-mei Zhang, Na Zhong, Wolfgang Hiddemann, Qi-fa Liu, Bei Zhang and Yang Liang
    Clin Cancer Res January 1 2021 27 (1) 255-266; DOI:10.1158/1078-0432.CCR-20-3417

Translational Cancer Mechanisms and Therapy

  • Translational Cancer Mechanisms and Therapy
    Genomic Analysis of Germline Variation Associated with Survival of Patients with Colorectal Cancer Treated with Chemotherapy Plus Biologics in CALGB/SWOG 80405 (Alliance)
    Federico Innocenti, Alexander B. Sibley, Sushant A. Patil, Amy S. Etheridge, Chen Jiang, Fang-Shu Ou, Stefanie D. Howell, Sarah J. Plummer, Graham Casey, Monica M. Bertagnolli, Howard L. McLeod, James T. Auman, Charles D. Blanke, Yoichi Furukawa, Alan P. Venook, Michiaki Kubo, Heinz-Josef Lenz, Joel S. Parker, Mark J. Ratain and Kouros Owzar
    Clin Cancer Res January 1 2021 27 (1) 267-275; DOI:10.1158/1078-0432.CCR-20-2021

  • Translational Cancer Mechanisms and Therapy
    Concurrent Dexamethasone Limits the Clinical Benefit of Immune Checkpoint Blockade in Glioblastoma
    J. Bryan Iorgulescu, Prafulla C. Gokhale, Maria C. Speranza, Benjamin K. Eschle, Michael J. Poitras, Margaret K. Wilkens, Kara M. Soroko, Chhayheng Chhoeu, Aine Knott, Yan Gao, Mary Jane Lim-Fat, Gregory J. Baker, Dennis M. Bonal, Quang-Dé Nguyen, Gareth R. L. Grant, Keith L. Ligon, Peter K. Sorger, E. Antonio Chiocca, Ana C. Anderson, Paul T. Kirschmeier, Arlene H. Sharpe, Gordon J. Freeman and David A. Reardon
    Clin Cancer Res January 1 2021 27 (1) 276-287; DOI:10.1158/1078-0432.CCR-20-2291

  • Translational Cancer Mechanisms and Therapy | AuthorChoice
    In-depth Clinical and Biological Exploration of DNA Damage Immune Response as a Biomarker for Oxaliplatin Use in Colorectal Cancer
    Sudhir B. Malla, David J. Fisher, Enric Domingo, Andrew Blake, Sylvana Hassanieh, Keara L. Redmond, Susan D. Richman, Michael Youdell, Steven M. Walker, Gemma E. Logan, Aikaterina Chatzipli, Raheleh Amirkhah, Matthew P. Humphries, Stephanie G. Craig, Ultan McDermott, Matthew T. Seymour, Dion G. Morton, Philip Quirke, Nicholas P. West, Manuel Salto-Tellez, Richard D. Kennedy, Patrick G. Johnston, Ian Tomlinson, Viktor H. Koelzer, Letitia Campo, Richard S. Kaplan, Daniel B. Longley, Mark Lawler, Timothy S. Maughan, Louise C. Brown and Philip D. Dunne; on behalf of the S:CORT consortium
    Clin Cancer Res January 1 2021 27 (1) 288-300; DOI:10.1158/1078-0432.CCR-20-3237

  • Translational Cancer Mechanisms and Therapy | AuthorChoice
    Serial Circulating Tumor DNA in Predicting and Monitoring the Effect of Neoadjuvant Chemoradiotherapy in Patients with Rectal Cancer: A Prospective Multicenter Study
    Jiaolin Zhou, Changxi Wang, Guole Lin, Yi Xiao, Wenzhuo Jia, Gang Xiao, Qian Liu, Bin Wu, Aiwen Wu, Huizhong Qiu, Fuquan Zhang, Ke Hu, Huadan Xue, Zhanlong Shen, Zhenjun Wang, Jiagang Han, Beizhan Niu, Yaping Xu, Zicheng Yu and Ling Yang
    Clin Cancer Res January 1 2021 27 (1) 301-310; DOI:10.1158/1078-0432.CCR-20-2299

  • Translational Cancer Mechanisms and Therapy | AuthorChoice
    Breast Cancer Index Predicts Extended Endocrine Benefit to Individualize Selection of Patients with HR+ Early-stage Breast Cancer for 10 Years of Endocrine Therapy
    Iris Noordhoek, Kai Treuner, Hein Putter, Yi Zhang, Jenna Wong, Elma Meershoek-Klein Kranenbarg, Marjolijn Duijm-de Carpentier, Cornelis J.H. van de Velde, Catherine A. Schnabel and Gerrit-Jan Liefers
    Clin Cancer Res January 1 2021 27 (1) 311-319; DOI:10.1158/1078-0432.CCR-20-2737

  • Translational Cancer Mechanisms and Therapy
    Comparative Genomics Reveals Distinct Immune-oncologic Pathways in African American Men with Prostate Cancer
    Shivanshu Awasthi, Anders Berglund, Julieta Abraham-Miranda, Robert J. Rounbehler, Kevin Kensler, Amparo Serna, Adriana Vidal, Sungyong You, Michael R. Freeman, Elai Davicioni, Yang Liu, R. Jeffrey Karnes, Eric A. Klein, Robert B. Den, Bruce J. Trock, Joshua D. Campbell, David J. Einstein, Raavi Gupta, Steven Balk, Priti Lal, Jong Y. Park, John L. Cleveland, Timothy R. Rebbeck, Stephen J. Freedland and Kosj Yamoah
    Clin Cancer Res January 1 2021 27 (1) 320-329; DOI:10.1158/1078-0432.CCR-20-2925

  • Translational Cancer Mechanisms and Therapy
    An Immune-Related Gene Prognostic Index for Head and Neck Squamous Cell Carcinoma
    Yue Chen, Zhi-Yong Li, Guan-Qun Zhou and Ying Sun
    Clin Cancer Res January 1 2021 27 (1) 330-341; DOI:10.1158/1078-0432.CCR-20-2166

  • Translational Cancer Mechanisms and Therapy
    Combinations with Allosteric SHP2 Inhibitor TNO155 to Block Receptor Tyrosine Kinase Signaling
    Chen Liu, Hengyu Lu, Hongyun Wang, Alice Loo, Xiamei Zhang, Guizhi Yang, Colleen Kowal, Scott Delach, Ye Wang, Silvia Goldoni, William D. Hastings, Karrie Wong, Hui Gao, Matthew J. Meyer, Susan E. Moody, Matthew J. LaMarche, Jeffrey A. Engelman, Juliet A. Williams, Peter S. Hammerman, Tinya J. Abrams, Morvarid Mohseni, Giordano Caponigro and Huai-Xiang Hao
    Clin Cancer Res January 1 2021 27 (1) 342-354; DOI:10.1158/1078-0432.CCR-20-2718

Letters to the Editor

  • Letters to the Editor
    Drug–Radiotherapy Combination Trial Developments—Letter
    Joseph R. Evans, Kyle C. Cuneo and Theodore S. Lawrence
    Clin Cancer Res January 1 2021 27 (1) 355-355; DOI:10.1158/1078-0432.CCR-20-4003

  • Letters to the Editor
    Drug–Radiotherapy Combination Trial Developments—Response
    Eric Deutsch, Cyrus Chargari, Ralph R. Weichselbaum and Antonin Levy
    Clin Cancer Res January 1 2021 27 (1) 356-356; DOI:10.1158/1078-0432.CCR-20-4163

Corrections

  • Corrections | Free Article
    Correction: Neoadjuvant and Adjuvant Pembrolizumab in Resectable Locally Advanced, Human Papillomavirus–unrelated Head and Neck Cancer: A Multicenter, Phase II Trial
    Ravindra Uppaluri, Katie M. Campbell, Ann Marie Egloff, Paul Zolkind, Zachary L. Skidmore, Brian Nussenbaum, Randal C. Paniello, Jason T. Rich, Ryan Jackson, Patrik Pipkorn, Loren S. Michel, Jessica Ley, Peter Oppelt, Gavin P. Dunn, Erica K. Barnell, Nicholas C. Spies, Tianxiang Lin, Tiantian Li, David T. Mulder, Youstina Hanna, Iulia Cirlan, Trevor J. Pugh, Tenny Mudianto, Rachel Riley, Liye Zhou, Vickie Y. Jo, Matthew D. Stachler, Glenn J. Hanna, Jason Kass, Robert Haddad, Jonathan D. Schoenfeld, Evisa Gjini, Ana Lako, Wade Thorstad, Hiram A. Gay, Mackenzie Daly, Scott J. Rodig, Ian S. Hagemann, Dorina Kallogjeri, Jay F. Piccirillo, Rebecca D. Chernock, Malachi Griffith, Obi L. Griffith and Douglas R. Adkins
    Clin Cancer Res January 1 2021 27 (1) 357-357; DOI:10.1158/1078-0432.CCR-20-4484

  • Corrections | Free Article
    Correction: Immune Checkpoint Blockade in Combination with Stereotactic Body Radiotherapy in Patients with Metastatic Pancreatic Ductal Adenocarcinoma
    Changqing Xie, Austin G. Duffy, Gagandeep Brar, Suzanne Fioravanti, Donna Mabry-Hrones, Melissa Walker, Cecilia Monge Bonilla, Bradford J. Wood, Deborah E. Citrin, Elizabeth M. Gil Ramirez, Freddy E. Escorcia, Bernadette Redd, Jonathan M. Hernandez, Jeremy L. Davis, Billel Gasmi, David Kleiner, Seth M. Steinberg, Jennifer C. Jones and Tim F. Greten
    Clin Cancer Res January 1 2021 27 (1) 358-358; DOI:10.1158/1078-0432.CCR-20-4640

Acknowledgment to Reviewers

  • Acknowledgment to Reviewers | Free Article
    Acknowledgment to Reviewers
    Clin Cancer Res January 1 2021 27 (1) 359-367; DOI:10.1158/1078-0432.CCR-27-1-Reviewers

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Clinical Cancer Research: 27 (1)
January 2021
Volume 27, Issue 1
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  • Table of Contents (PDF)
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Issue Highlights

  • Expanded Low Allele Frequency RAS and BRAF V600E Testing in Metastatic Colorectal Cancer as Predictive Biomarkers for Cetuximab in the Randomized CO.17 Trial
  • Efficacy and Safety of Nivolumab Plus Ipilimumab versus Sunitinib in First-line Treatment of Patients with Advanced Sarcomatoid Renal Cell Carcinoma
  • Three Distinct Stroma Types in Human Pancreatic Cancer Identified by Image Analysis of Fibroblast Subpopulations and Collagen
  • Concurrent Dexamethasone Limits the Clinical Benefit of Immune Checkpoint Blockade in Glioblastoma

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  • Immune Checkpoint Blockade Requires Macrophage CXCL9/CXCL10
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Clinical Cancer Research
eISSN: 1557-3265
ISSN: 1078-0432

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