Table of Contents

Translational Cancer Mechanisms and Therapy

• Translational Cancer Mechanisms and Therapy

  Exploiting B-cell Receptor Stereotypy to Design Tailored Immunotherapy in Chronic Lymphocytic Leukemia

  Alessandra Rovida, Cristina Maccalli, Lydia Scarfò, Paolo Dellabona, Kostas Stamatopoulos and Paolo Ghia

  Clin Cancer Res February 1 2021 27 (3) 729-739; DOI:10.1158/1078-0432.CCR-20-1632

  
  
• Translational Cancer Mechanisms and Therapy

  Improved Assessment of Response Status in Patients with Pancreatic Cancer Treated with Neoadjuvant Therapy using Somatic Mutations and Liquid Biopsy Analysis

  Lingdi Yin, Ning Pu, Elizabeth Thompson, Yi Miao, Christopher Wolfgang and Jun Yu

  Clin Cancer Res February 1 2021 27 (3) 740-748; DOI:10.1158/1078-0432.CCR-20-1746

  
  
• Translational Cancer Mechanisms and Therapy

  Immune Infiltrate in the Primary Tumor Predicts Effect of Adjuvant Radiotherapy in Breast Cancer; Results from the Randomized SweBCG91RT Trial

  Axel Stenmark Tullberg, Henri A.J. Puttonen, Martin Sjöström, Erik Holmberg, S. Laura Chang, Felix Y. Feng, Corey Speers, Lori J. Pierce, Dan Lundstedt, Fredrika Killander, Emma Niméus, Anikó Kovács and Per Karlsson

  Clin Cancer Res February 1 2021 27 (3) 749-758; DOI:10.1158/1078-0432.CCR-20-3299

  
  
• Translational Cancer Mechanisms and Therapy | AuthorChoice

  Regulation of CEACAM5 and Therapeutic Efficacy of an Anti-CEACAM5–SN38 Antibody–drug Conjugate in Neuroendocrine Prostate Cancer

  Diana C. DeLucia, Thomas M. Cardillo, Lisa Ang, Mark P. Labrecque, Ailin Zhang, James E. Hopkins, Navonil De Sarkar, Ilsa Coleman, Rui M. Gil da Costa, Eva Corey, Lawrence D. True, Michael C. Haffner, Michael T. Schweizer, Colm Morrissey, Peter S. Nelson and John K. Lee

  Clin Cancer Res February 1 2021 27 (3) 759-774; DOI:10.1158/1078-0432.CCR-20-3396

  
  
• Translational Cancer Mechanisms and Therapy | AuthorChoice

  Hypofractionated FLASH-RT as an Effective Treatment against Glioblastoma that Reduces Neurocognitive Side Effects in Mice

  Pierre Montay-Gruel, Munjal M. Acharya, Patrik Gonçalves Jorge, Benoît Petit, Ioannis G. Petridis, Philippe Fuchs, Ron Leavitt, Kristoffer Petersson, Maude Gondré, Jonathan Ollivier, Raphael Moeckli, François Bochud, Claude Bailat, Jean Bourhis, Jean-François Germond, Charles L. Limoli and Marie-Catherine Vozenin

  Clin Cancer Res February 1 2021 27 (3) 775-784; DOI:10.1158/1078-0432.CCR-20-0894

  
  
• Translational Cancer Mechanisms and Therapy

  A Novel Neoplastic Fusion Transcript, RAD51AP1-DYRK4, Confers Sensitivity to the MEK Inhibitor Trametinib in Aggressive Breast Cancers

  Chia-Chia Liu, Jamunarani Veeraraghavan, Ying Tan, Jin-Ah Kim, Xian Wang, Suet Kee Loo, Sanghoon Lee, Yiheng Hu and Xiao-Song Wang

  Clin Cancer Res February 1 2021 27 (3) 785-798; DOI:10.1158/1078-0432.CCR-20-2769

  
  
• Translational Cancer Mechanisms and Therapy

  MET Exon 14–altered Lung Cancers and MET Inhibitor Resistance

  Robin Guo, Michael Offin, A. Rose Brannon, Jason Chang, Andrew Chow, Lukas Delasos, Jeffrey Girshman, Olivia Wilkins, Caroline G. McCarthy, Alex Makhnin, Christina Falcon, Kerry Scott, Yuan Tian, Fabiola Cecchi, Todd Hembrough, Deepu Alex, Ronglai Shen, Ryma Benayed, Bob T. Li, Charles M. Rudin, Mark G. Kris, Maria E. Arcila, Natasha Rekhtman, Paul Paik, Ahmet Zehir and Alexander Drilon

  Clin Cancer Res February 1 2021 27 (3) 799-806; DOI:10.1158/1078-0432.CCR-20-2861

  
  
• Translational Cancer Mechanisms and Therapy

  Effects of HER Family–targeting Tyrosine Kinase Inhibitors on Antibody-dependent Cell-mediated Cytotoxicity in HER2-expressing Breast Cancer

  Denis M. Collins, Stephen F. Madden, Nicola Gaynor, Dalal AlSultan, Marion Le Gal, Alex J. Eustace, Kathy A. Gately, Clare Hughes, Anthony M. Davies, Thamir Mahgoub, Jo Ballot, Sinead Toomey, Darran P. O'Connor, William M. Gallagher, Frankie A. Holmes, Virginia Espina, Lance Liotta, Bryan T. Hennessy, Kenneth J. O'Byrne, Max Hasmann, Birgit Bossenmaier, Norma O'Donovan and John Crown

  Clin Cancer Res February 1 2021 27 (3) 807-818; DOI:10.1158/1078-0432.CCR-20-2007

  
  
• Translational Cancer Mechanisms and Therapy

  Exploiting Protein Translation Dependence in Multiple Myeloma with Omacetaxine-Based Therapy

  Zachary J. Walker, Beau M. Idler, Lorraine N. Davis, Brett M. Stevens, Michael J. VanWyngarden, Denis Ohlstrom, Shelby C. Bearrows, Andrew Hammes, Clayton A. Smith, Craig T. Jordan, Tomer M. Mark, Peter A. Forsberg and Daniel W. Sherbenou

  Clin Cancer Res February 1 2021 27 (3) 819-830; DOI:10.1158/1078-0432.CCR-20-2246

  
  
• Translational Cancer Mechanisms and Therapy

  Integrative Analysis of miRNAs Identifies Clinically Relevant Epithelial and Stromal Subtypes of Head and Neck Squamous Cell Carcinoma

  Jeremiah Holt, Vonn Walter, Xiaoying Yin, David Marron, Matthew D. Wilkerson, Hyo Young Choi, Xiaobei Zhao, Heejoon Jo, David Neil Hayes and Yoon Ho Ko

  Clin Cancer Res February 1 2021 27 (3) 831-842; DOI:10.1158/1078-0432.CCR-20-0557

  
  
• Translational Cancer Mechanisms and Therapy

  Comparison of Haploidentical Bone Marrow versus Matched Unrelated Donor Peripheral Blood Stem Cell Transplantation with Posttransplant Cyclophosphamide in Patients with Acute Leukemia

  Arnon Nagler, Myriam Labopin, Bhagirathbhai Dholaria, Emanuele Angelucci, Boris Afanasyev, Jan J. Cornelissen, Simona Sica, Ellen Meijer, Fabio Ciceri, Gwendolyn Van Gorkom, Nicolaus Kröger, Hans Martin, Pietro Pioltelli, Antonio Risitano, Jonathan Canaani, Bipin N. Savani, Jaime Sanz and Mohamad Mohty

  Clin Cancer Res February 1 2021 27 (3) 843-851; DOI:10.1158/1078-0432.CCR-20-2809

  
  
• Translational Cancer Mechanisms and Therapy | AuthorChoice

  Proteogenomic Analysis of Salivary Adenoid Cystic Carcinomas Defines Molecular Subtypes and Identifies Therapeutic Targets

  Renata Ferrarotto, Yoshitsugu Mitani, Daniel J. McGrail, Kaiyi Li, Tatiana V. Karpinets, Diana Bell, Steven J. Frank, Xingzhi Song, Michael E. Kupferman, Bin Liu, J. Jack Lee, Bonnie S. Glisson, Jianhua Zhang, Jon C. Aster, Shiaw-Yih Lin, P. Andrew Futreal, John V. Heymach and Adel K. El-Naggar

  Clin Cancer Res February 1 2021 27 (3) 852-864; DOI:10.1158/1078-0432.CCR-20-1192

  
  
• Translational Cancer Mechanisms and Therapy

  Oncolytic Reovirus (pelareorep) Induces Autophagy in KRAS-mutated Colorectal Cancer

  Jeeshan Jiffry, Thongthai Thavornwatanayong, Devika Rao, Elisha J. Fogel, Durvanand Saytoo, Rishika Nahata, Hillary Guzik, Imran Chaudhary, Titto Augustine, Sanjay Goel and Radhashree Maitra

  Clin Cancer Res February 1 2021 27 (3) 865-876; DOI:10.1158/1078-0432.CCR-20-2385

  
  
• Translational Cancer Mechanisms and Therapy

  NRF2 Activation Promotes Aggressive Lung Cancer and Associates with Poor Clinical Outcomes

  Anju Singh, Anneleen Daemen, Dorothee Nickles, Sang-Min Jeon, Oded Foreman, Kuladeep Sudini, Florian Gnad, Stephane Lajoie, Naina Gour, Wayne Mitzner, Samit Chatterjee, Eun-Ji Choi, Buvana Ravishankar, Amy Rappaport, Namrata Patil, Mark McCleland, Leisa Johnson, George Acquaah-Mensah, Edward Gabrielson, Shyam Biswal and Georgia Hatzivassiliou

  Clin Cancer Res February 1 2021 27 (3) 877-888; DOI:10.1158/1078-0432.CCR-20-1985

  
  
• Translational Cancer Mechanisms and Therapy

  Modification of Extracellular Matrix Enhances Oncolytic Adenovirus Immunotherapy in Glioblastoma

  Juri Kiyokawa, Yoichiro Kawamura, Shanawaz M. Ghouse, Simge Acar, Erinç Barçın, Jordi Martínez-Quintanilla, Robert L. Martuza, Ramon Alemany, Samuel D. Rabkin, Khalid Shah and Hiroaki Wakimoto

  Clin Cancer Res February 1 2021 27 (3) 889-902; DOI:10.1158/1078-0432.CCR-20-2400