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Clinical Cancer Research
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Clinical Trials: Immunotherapy

Combining Nivolumab and Ipilimumab with Infliximab or Certolizumab in Patients with Advanced Melanoma: First Results of a Phase Ib Clinical Trial

Anne Montfort, Thomas Filleron, Mathieu Virazels, Carine Dufau, Jean Milhès, Cécile Pagès, Pascale Olivier, Maha Ayyoub, Muriel Mounier, Amélie Lusque, Stéphanie Brayer, Jean-Pierre Delord, Nathalie Andrieu-Abadie, Thierry Levade, Céline Colacios, Bruno Ségui and Nicolas Meyer
Anne Montfort
1INSERM UMR 1037, Cancer Research Center of Toulouse (CRCT), Toulouse, France.
2Equipe Labellisée Fondation ARC pour la recherche sur le cancer, Toulouse, France.
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Thomas Filleron
3Methodology, biostatistics and clinical operations, Institut Claudius Regaud, IUCT-O, Toulouse, France.
4Institut Universitaire du Cancer (IUCT-O), Toulouse, France.
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  • ORCID record for Thomas Filleron
Mathieu Virazels
1INSERM UMR 1037, Cancer Research Center of Toulouse (CRCT), Toulouse, France.
2Equipe Labellisée Fondation ARC pour la recherche sur le cancer, Toulouse, France.
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  • ORCID record for Mathieu Virazels
Carine Dufau
1INSERM UMR 1037, Cancer Research Center of Toulouse (CRCT), Toulouse, France.
2Equipe Labellisée Fondation ARC pour la recherche sur le cancer, Toulouse, France.
5Université Toulouse III - Paul Sabatier, Toulouse, France.
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Jean Milhès
1INSERM UMR 1037, Cancer Research Center of Toulouse (CRCT), Toulouse, France.
2Equipe Labellisée Fondation ARC pour la recherche sur le cancer, Toulouse, France.
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Cécile Pagès
4Institut Universitaire du Cancer (IUCT-O), Toulouse, France.
6Service d'Oncodermatologie, IUCT-O, CHU de Toulouse, Toulouse, France.
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Pascale Olivier
7Service de Pharmacologie médicale et clinique, Centre Régional de Pharmacovigilance, de Pharmacoépidémiologie et d'information sur le médicament du CHU de Toulouse, Toulouse, France.
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Maha Ayyoub
1INSERM UMR 1037, Cancer Research Center of Toulouse (CRCT), Toulouse, France.
4Institut Universitaire du Cancer (IUCT-O), Toulouse, France.
5Université Toulouse III - Paul Sabatier, Toulouse, France.
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Muriel Mounier
3Methodology, biostatistics and clinical operations, Institut Claudius Regaud, IUCT-O, Toulouse, France.
4Institut Universitaire du Cancer (IUCT-O), Toulouse, France.
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Amélie Lusque
3Methodology, biostatistics and clinical operations, Institut Claudius Regaud, IUCT-O, Toulouse, France.
4Institut Universitaire du Cancer (IUCT-O), Toulouse, France.
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Stéphanie Brayer
1INSERM UMR 1037, Cancer Research Center of Toulouse (CRCT), Toulouse, France.
2Equipe Labellisée Fondation ARC pour la recherche sur le cancer, Toulouse, France.
6Service d'Oncodermatologie, IUCT-O, CHU de Toulouse, Toulouse, France.
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Jean-Pierre Delord
1INSERM UMR 1037, Cancer Research Center of Toulouse (CRCT), Toulouse, France.
4Institut Universitaire du Cancer (IUCT-O), Toulouse, France.
5Université Toulouse III - Paul Sabatier, Toulouse, France.
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Nathalie Andrieu-Abadie
1INSERM UMR 1037, Cancer Research Center of Toulouse (CRCT), Toulouse, France.
2Equipe Labellisée Fondation ARC pour la recherche sur le cancer, Toulouse, France.
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Thierry Levade
1INSERM UMR 1037, Cancer Research Center of Toulouse (CRCT), Toulouse, France.
2Equipe Labellisée Fondation ARC pour la recherche sur le cancer, Toulouse, France.
5Université Toulouse III - Paul Sabatier, Toulouse, France.
8Laboratoire de Biochimie, Institut Fédératif de Biologie, CHU Purpan, Toulouse, France.
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Céline Colacios
1INSERM UMR 1037, Cancer Research Center of Toulouse (CRCT), Toulouse, France.
2Equipe Labellisée Fondation ARC pour la recherche sur le cancer, Toulouse, France.
5Université Toulouse III - Paul Sabatier, Toulouse, France.
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Bruno Ségui
1INSERM UMR 1037, Cancer Research Center of Toulouse (CRCT), Toulouse, France.
2Equipe Labellisée Fondation ARC pour la recherche sur le cancer, Toulouse, France.
5Université Toulouse III - Paul Sabatier, Toulouse, France.
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  • For correspondence: bruno.segui@inserm.fr meyer.n@chu-toulouse.fr
Nicolas Meyer
1INSERM UMR 1037, Cancer Research Center of Toulouse (CRCT), Toulouse, France.
2Equipe Labellisée Fondation ARC pour la recherche sur le cancer, Toulouse, France.
4Institut Universitaire du Cancer (IUCT-O), Toulouse, France.
5Université Toulouse III - Paul Sabatier, Toulouse, France.
6Service d'Oncodermatologie, IUCT-O, CHU de Toulouse, Toulouse, France.
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  • For correspondence: bruno.segui@inserm.fr meyer.n@chu-toulouse.fr
DOI: 10.1158/1078-0432.CCR-20-3449 Published February 2021
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Article Information

Volume 27, Issue 4, pp. 1037-1047

DOI 
https://doi.org/10.1158/1078-0432.CCR-20-3449
PubMed 
33272982

Published By 
American Association for Cancer Research
Print ISSN 
1078-0432
Online ISSN 
1557-3265
History 
  • Received September 2, 2020
  • Revision received October 27, 2020
  • Accepted November 30, 2020
  • Published first December 3, 2020.

Article Versions

  • Previous version (December 3, 2020 - 06:43).
  • Previous version (January 5, 2021 - 05:33).
  • You are viewing the most recent version of this article.
Copyright & Usage 
©2020 American Association for Cancer Research.

Author Information

  1. Anne Montfort1,2,
  2. Thomas Filleron3,4,
  3. Mathieu Virazels1,2,
  4. Carine Dufau1,2,5,
  5. Jean Milhès1,2,
  6. Cécile Pagès4,6,
  7. Pascale Olivier7,
  8. Maha Ayyoub1,4,5,
  9. Muriel Mounier3,4,
  10. Amélie Lusque3,4,
  11. Stéphanie Brayer1,2,6,
  12. Jean-Pierre Delord1,4,5,
  13. Nathalie Andrieu-Abadie1,2,
  14. Thierry Levade1,2,5,8,
  15. Céline Colacios1,2,5,
  16. Bruno Ségui1,2,5,#,*, and
  17. Nicolas Meyer1,2,4,5,6,#,*
  1. 1INSERM UMR 1037, Cancer Research Center of Toulouse (CRCT), Toulouse, France.
  2. 2Equipe Labellisée Fondation ARC pour la recherche sur le cancer, Toulouse, France.
  3. 3Methodology, biostatistics and clinical operations, Institut Claudius Regaud, IUCT-O, Toulouse, France.
  4. 4Institut Universitaire du Cancer (IUCT-O), Toulouse, France.
  5. 5Université Toulouse III - Paul Sabatier, Toulouse, France.
  6. 6Service d'Oncodermatologie, IUCT-O, CHU de Toulouse, Toulouse, France.
  7. 7Service de Pharmacologie médicale et clinique, Centre Régional de Pharmacovigilance, de Pharmacoépidémiologie et d'information sur le médicament du CHU de Toulouse, Toulouse, France.
  8. 8Laboratoire de Biochimie, Institut Fédératif de Biologie, CHU Purpan, Toulouse, France.
  1. ↵*Corresponding Authors:
    Bruno Ségui, Cancer Research Center of Toulouse, 2 avenue Hubert Curien, CS 53717, Toulouse Cedex 1 31037, France. Phone: 33 5-8274-1621; Fax: 335-8274-1685; E-mail: bruno.segui{at}inserm.fr; and Nicolas Meyer, Skin Cancer Unit, Institut Universitaire du Cancer and CHU, 1 rue Irène Joliot-Curie, 31059 Toulouse Cedex 09, France. Phone: 33 5-3115-6034; Fax: 33 5-3115-6033; E-mail: meyer.n{at}chu-toulouse.fr
  1. ↵#B. Ségui and N. Meyer contributed equally to this article.

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Clinical Cancer Research: 27 (4)
February 2021
Volume 27, Issue 4
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Combining Nivolumab and Ipilimumab with Infliximab or Certolizumab in Patients with Advanced Melanoma: First Results of a Phase Ib Clinical Trial
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Combining Nivolumab and Ipilimumab with Infliximab or Certolizumab in Patients with Advanced Melanoma: First Results of a Phase Ib Clinical Trial
Anne Montfort, Thomas Filleron, Mathieu Virazels, Carine Dufau, Jean Milhès, Cécile Pagès, Pascale Olivier, Maha Ayyoub, Muriel Mounier, Amélie Lusque, Stéphanie Brayer, Jean-Pierre Delord, Nathalie Andrieu-Abadie, Thierry Levade, Céline Colacios, Bruno Ségui and Nicolas Meyer
Clin Cancer Res February 15 2021 (27) (4) 1037-1047; DOI: 10.1158/1078-0432.CCR-20-3449

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Combining Nivolumab and Ipilimumab with Infliximab or Certolizumab in Patients with Advanced Melanoma: First Results of a Phase Ib Clinical Trial
Anne Montfort, Thomas Filleron, Mathieu Virazels, Carine Dufau, Jean Milhès, Cécile Pagès, Pascale Olivier, Maha Ayyoub, Muriel Mounier, Amélie Lusque, Stéphanie Brayer, Jean-Pierre Delord, Nathalie Andrieu-Abadie, Thierry Levade, Céline Colacios, Bruno Ségui and Nicolas Meyer
Clin Cancer Res February 15 2021 (27) (4) 1037-1047; DOI: 10.1158/1078-0432.CCR-20-3449
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