Skip to main content
  • AACR Publications
    • Blood Cancer Discovery
    • Cancer Discovery
    • Cancer Epidemiology, Biomarkers & Prevention
    • Cancer Immunology Research
    • Cancer Prevention Research
    • Cancer Research
    • Clinical Cancer Research
    • Molecular Cancer Research
    • Molecular Cancer Therapeutics

AACR logo

  • Register
  • Log in
  • My Cart
Advertisement

Main menu

  • Home
  • About
    • The Journal
    • AACR Journals
    • Subscriptions
    • Permissions and Reprints
  • Articles
    • OnlineFirst
    • Current Issue
    • Past Issues
    • CCR Focus Archive
    • Meeting Abstracts
    • Collections
      • COVID-19 & Cancer Resource Center
      • Breast Cancer
      • Clinical Trials
      • Immunotherapy: Facts and Hopes
      • Editors' Picks
      • "Best of" Collection
  • For Authors
    • Information for Authors
    • Author Services
    • Best of: Author Profiles
    • Submit
  • Alerts
    • Table of Contents
    • Editors' Picks
    • OnlineFirst
    • Citation
    • Author/Keyword
    • RSS Feeds
    • My Alert Summary & Preferences
  • News
    • Cancer Discovery News
  • COVID-19
  • Webinars
  • Search More

    Advanced Search

  • AACR Publications
    • Blood Cancer Discovery
    • Cancer Discovery
    • Cancer Epidemiology, Biomarkers & Prevention
    • Cancer Immunology Research
    • Cancer Prevention Research
    • Cancer Research
    • Clinical Cancer Research
    • Molecular Cancer Research
    • Molecular Cancer Therapeutics

User menu

  • Register
  • Log in
  • My Cart

Search

  • Advanced search
Clinical Cancer Research
Clinical Cancer Research
  • Home
  • About
    • The Journal
    • AACR Journals
    • Subscriptions
    • Permissions and Reprints
  • Articles
    • OnlineFirst
    • Current Issue
    • Past Issues
    • CCR Focus Archive
    • Meeting Abstracts
    • Collections
      • COVID-19 & Cancer Resource Center
      • Breast Cancer
      • Clinical Trials
      • Immunotherapy: Facts and Hopes
      • Editors' Picks
      • "Best of" Collection
  • For Authors
    • Information for Authors
    • Author Services
    • Best of: Author Profiles
    • Submit
  • Alerts
    • Table of Contents
    • Editors' Picks
    • OnlineFirst
    • Citation
    • Author/Keyword
    • RSS Feeds
    • My Alert Summary & Preferences
  • News
    • Cancer Discovery News
  • COVID-19
  • Webinars
  • Search More

    Advanced Search

Translational Cancer Mechanisms and Therapy

Identification of a Synthetic Lethal Relationship between Nucleotide Excision Repair Deficiency and Irofulven Sensitivity in Urothelial Cancer

Judit Börcsök, Zsofia Sztupinszki, Raie Bekele, Sizhi P. Gao, Miklos Diossy, Amruta S. Samant, Kasia M. Dillon, Viktoria Tisza, Sándor Spisák, Orsolya Rusz, Istvan Csabai, Helle Pappot, Zoë J. Frazier, David J. Konieczkowski, David Liu, Naresh Vasani, James A. Rodrigues, David B. Solit, Jean H. Hoffman-Censits, Elizabeth R. Plimack, Jonathan E. Rosenberg, Jean-Bernard Lazaro, Mary-Ellen Taplin, Gopa Iyer, Søren Brunak, Rita Lozsa, Eliezer M. Van Allen, Dávid Szüts, Kent W. Mouw and Zoltan Szallasi
Judit Börcsök
1Danish Cancer Society Research Center, Copenhagen, Denmark.
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
  • ORCID record for Judit Börcsök
Zsofia Sztupinszki
1Danish Cancer Society Research Center, Copenhagen, Denmark.
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
  • ORCID record for Zsofia Sztupinszki
Raie Bekele
2Department of Radiation Oncology, Dana-Farber Cancer Institute, Boston, Massachusetts.
18Harvard Medical School, Boston, Massachusetts.
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Sizhi P. Gao
3Human Oncology and Pathogenesis Program, Memorial Sloan Kettering Cancer Center, New York, New York.
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Miklos Diossy
1Danish Cancer Society Research Center, Copenhagen, Denmark.
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
  • ORCID record for Miklos Diossy
Amruta S. Samant
2Department of Radiation Oncology, Dana-Farber Cancer Institute, Boston, Massachusetts.
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Kasia M. Dillon
2Department of Radiation Oncology, Dana-Farber Cancer Institute, Boston, Massachusetts.
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Viktoria Tisza
4Computational Health Informatics Program, Boston Children's Hospital, Boston, Massachusetts.
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Sándor Spisák
5Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, Massachusetts.
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Orsolya Rusz
62nd Department of Pathology, SE NAP, Brain Metastasis Research Group, Semmelweis University, Budapest, Hungary.
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Istvan Csabai
7Department of Physics of Complex Systems, Eötvös Loránd University, Budapest, Hungary.
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
  • ORCID record for Istvan Csabai
Helle Pappot
8Department of Oncology, Rigshospitalet, University of Copenhagen, Copenhagen, Denmark.
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
  • ORCID record for Helle Pappot
Zoë J. Frazier
2Department of Radiation Oncology, Dana-Farber Cancer Institute, Boston, Massachusetts.
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
David J. Konieczkowski
9Department of Radiation Oncology, Arthur G. James Cancer Hospital and Richard J. Solove Research Institute, The Ohio State University, Columbus, Ohio.
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
David Liu
5Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, Massachusetts.
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
  • ORCID record for David Liu
Naresh Vasani
3Human Oncology and Pathogenesis Program, Memorial Sloan Kettering Cancer Center, New York, New York.
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
James A. Rodrigues
3Human Oncology and Pathogenesis Program, Memorial Sloan Kettering Cancer Center, New York, New York.
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
David B. Solit
3Human Oncology and Pathogenesis Program, Memorial Sloan Kettering Cancer Center, New York, New York.
10Genitourinary Oncology Service, Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, New York.
11Marie-Josee and Henry R. Kravis Center for Molecular Oncology, Memorial Sloan Kettering Cancer Center, New York, New York.
12Weill Cornell Medical College, New York, New York.
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Jean H. Hoffman-Censits
13Department of Oncology, Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins University, Baltimore, Maryland.
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Elizabeth R. Plimack
14Department of Hematology/Oncology, Fox Chase Cancer Center, Philadelphia, Pennsylvania.
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Jonathan E. Rosenberg
10Genitourinary Oncology Service, Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, New York.
12Weill Cornell Medical College, New York, New York.
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Jean-Bernard Lazaro
2Department of Radiation Oncology, Dana-Farber Cancer Institute, Boston, Massachusetts.
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Mary-Ellen Taplin
5Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, Massachusetts.
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Gopa Iyer
10Genitourinary Oncology Service, Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, New York.
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Søren Brunak
15Novo Nordisk Foundation Center for Protein Research, University of Copenhagen, Copenhagen, Denmark.
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Rita Lozsa
16Institute of Enzymology, Research Centre for Natural Sciences, Budapest, Hungary.
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Eliezer M. Van Allen
5Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, Massachusetts.
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Dávid Szüts
16Institute of Enzymology, Research Centre for Natural Sciences, Budapest, Hungary.
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Kent W. Mouw
2Department of Radiation Oncology, Dana-Farber Cancer Institute, Boston, Massachusetts.
17Department of Radiation Oncology, Brigham & Women's Hospital, Boston, Massachusetts.
18Harvard Medical School, Boston, Massachusetts.
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
  • For correspondence: zoltan.szallasi@childrens.harvard.edu kent_mouw@dfci.harvard.edu
Zoltan Szallasi
1Danish Cancer Society Research Center, Copenhagen, Denmark.
4Computational Health Informatics Program, Boston Children's Hospital, Boston, Massachusetts.
62nd Department of Pathology, SE NAP, Brain Metastasis Research Group, Semmelweis University, Budapest, Hungary.
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
  • ORCID record for Zoltan Szallasi
  • For correspondence: zoltan.szallasi@childrens.harvard.edu kent_mouw@dfci.harvard.edu
DOI: 10.1158/1078-0432.CCR-20-3316 Published April 2021
  • Article
  • Figures & Data
  • Info & Metrics
  • PDF
Loading

Online Impact

Statistics from Altmetric.com

ARTICLE USAGE

ARTICLE USAGE: November 2020 to April 2021

AbstractFull-text HTMLPDF
Total4185193447

Cited By

Article Information

Volume 27, Issue 7, pp. 2011-2022

DOI 
https://doi.org/10.1158/1078-0432.CCR-20-3316
PubMed 
33208343

Published By 
American Association for Cancer Research
Print ISSN 
1078-0432
Online ISSN 
1557-3265
History 
  • Received August 21, 2020
  • Revision received October 16, 2020
  • Accepted November 4, 2020
  • Published first November 18, 2020.

Article Versions

  • Previous version (November 18, 2020 - 07:03).
  • Previous version (March 8, 2021 - 04:49).
  • You are viewing the most recent version of this article.
Copyright & Usage 
©2020 American Association for Cancer Research.

Author Information

  1. Judit Börcsök1,#,
  2. Zsofia Sztupinszki1,#,
  3. Raie Bekele2,18,#,
  4. Sizhi P. Gao3,#,
  5. Miklos Diossy1,
  6. Amruta S. Samant2,
  7. Kasia M. Dillon2,
  8. Viktoria Tisza4,
  9. Sándor Spisák5,
  10. Orsolya Rusz6,
  11. Istvan Csabai7,
  12. Helle Pappot8,
  13. Zoë J. Frazier2,
  14. David J. Konieczkowski9,
  15. David Liu5,
  16. Naresh Vasani3,
  17. James A. Rodrigues3,
  18. David B. Solit3,10,11,12,
  19. Jean H. Hoffman-Censits13,
  20. Elizabeth R. Plimack14,
  21. Jonathan E. Rosenberg10,12,
  22. Jean-Bernard Lazaro2,
  23. Mary-Ellen Taplin5,
  24. Gopa Iyer10,
  25. Søren Brunak15,
  26. Rita Lozsa16,
  27. Eliezer M. Van Allen5,
  28. Dávid Szüts16,
  29. Kent W. Mouw2,17,18,*, and
  30. Zoltan Szallasi1,4,6,*
  1. 1Danish Cancer Society Research Center, Copenhagen, Denmark.
  2. 2Department of Radiation Oncology, Dana-Farber Cancer Institute, Boston, Massachusetts.
  3. 3Human Oncology and Pathogenesis Program, Memorial Sloan Kettering Cancer Center, New York, New York.
  4. 4Computational Health Informatics Program, Boston Children's Hospital, Boston, Massachusetts.
  5. 5Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, Massachusetts.
  6. 62nd Department of Pathology, SE NAP, Brain Metastasis Research Group, Semmelweis University, Budapest, Hungary.
  7. 7Department of Physics of Complex Systems, Eötvös Loránd University, Budapest, Hungary.
  8. 8Department of Oncology, Rigshospitalet, University of Copenhagen, Copenhagen, Denmark.
  9. 9Department of Radiation Oncology, Arthur G. James Cancer Hospital and Richard J. Solove Research Institute, The Ohio State University, Columbus, Ohio.
  10. 10Genitourinary Oncology Service, Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, New York.
  11. 11Marie-Josee and Henry R. Kravis Center for Molecular Oncology, Memorial Sloan Kettering Cancer Center, New York, New York.
  12. 12Weill Cornell Medical College, New York, New York.
  13. 13Department of Oncology, Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins University, Baltimore, Maryland.
  14. 14Department of Hematology/Oncology, Fox Chase Cancer Center, Philadelphia, Pennsylvania.
  15. 15Novo Nordisk Foundation Center for Protein Research, University of Copenhagen, Copenhagen, Denmark.
  16. 16Institute of Enzymology, Research Centre for Natural Sciences, Budapest, Hungary.
  17. 17Department of Radiation Oncology, Brigham & Women's Hospital, Boston, Massachusetts.
  18. 18Harvard Medical School, Boston, Massachusetts.
  1. ↵*Corresponding Authors:
    Zoltan Szallasi, Harvard Medical School, 300 Longwood Ave., Boston, MA 02215. Phone: 617-355-2179; E-mail: zoltan.szallasi{at}childrens.harvard.edu; and Kent W. Mouw, Department of Radiation Oncology, Dana-Farber Cancer Institute, 450 Brookline Ave., HIM 350, Boston, MA 02215. Phone: 617-582-9356; E-mail: kent_mouw{at}dfci.harvard.edu
  1. ↵#J. Börcsök, Z. Sztupinszki, R. Bekele, and S.P. Gao contributed equally to this article.

View Full Text
PreviousNext
Back to top
Clinical Cancer Research: 27 (7)
April 2021
Volume 27, Issue 7
  • Table of Contents
  • Table of Contents (PDF)
  • About the Cover
  • Editorial Board (PDF)

Sign up for alerts

View this article with LENS

Open full page PDF
Article Alerts
Sign In to Email Alerts with your Email Address
Email Article

Thank you for sharing this Clinical Cancer Research article.

NOTE: We request your email address only to inform the recipient that it was you who recommended this article, and that it is not junk mail. We do not retain these email addresses.

Enter multiple addresses on separate lines or separate them with commas.
Identification of a Synthetic Lethal Relationship between Nucleotide Excision Repair Deficiency and Irofulven Sensitivity in Urothelial Cancer
(Your Name) has forwarded a page to you from Clinical Cancer Research
(Your Name) thought you would be interested in this article in Clinical Cancer Research.
CAPTCHA
This question is for testing whether or not you are a human visitor and to prevent automated spam submissions.
Citation Tools
Identification of a Synthetic Lethal Relationship between Nucleotide Excision Repair Deficiency and Irofulven Sensitivity in Urothelial Cancer
Judit Börcsök, Zsofia Sztupinszki, Raie Bekele, Sizhi P. Gao, Miklos Diossy, Amruta S. Samant, Kasia M. Dillon, Viktoria Tisza, Sándor Spisák, Orsolya Rusz, Istvan Csabai, Helle Pappot, Zoë J. Frazier, David J. Konieczkowski, David Liu, Naresh Vasani, James A. Rodrigues, David B. Solit, Jean H. Hoffman-Censits, Elizabeth R. Plimack, Jonathan E. Rosenberg, Jean-Bernard Lazaro, Mary-Ellen Taplin, Gopa Iyer, Søren Brunak, Rita Lozsa, Eliezer M. Van Allen, Dávid Szüts, Kent W. Mouw and Zoltan Szallasi
Clin Cancer Res April 1 2021 (27) (7) 2011-2022; DOI: 10.1158/1078-0432.CCR-20-3316

Citation Manager Formats

  • BibTeX
  • Bookends
  • EasyBib
  • EndNote (tagged)
  • EndNote 8 (xml)
  • Medlars
  • Mendeley
  • Papers
  • RefWorks Tagged
  • Ref Manager
  • RIS
  • Zotero
Share
Identification of a Synthetic Lethal Relationship between Nucleotide Excision Repair Deficiency and Irofulven Sensitivity in Urothelial Cancer
Judit Börcsök, Zsofia Sztupinszki, Raie Bekele, Sizhi P. Gao, Miklos Diossy, Amruta S. Samant, Kasia M. Dillon, Viktoria Tisza, Sándor Spisák, Orsolya Rusz, Istvan Csabai, Helle Pappot, Zoë J. Frazier, David J. Konieczkowski, David Liu, Naresh Vasani, James A. Rodrigues, David B. Solit, Jean H. Hoffman-Censits, Elizabeth R. Plimack, Jonathan E. Rosenberg, Jean-Bernard Lazaro, Mary-Ellen Taplin, Gopa Iyer, Søren Brunak, Rita Lozsa, Eliezer M. Van Allen, Dávid Szüts, Kent W. Mouw and Zoltan Szallasi
Clin Cancer Res April 1 2021 (27) (7) 2011-2022; DOI: 10.1158/1078-0432.CCR-20-3316
del.icio.us logo Digg logo Reddit logo Twitter logo CiteULike logo Facebook logo Google logo Mendeley logo
  • Tweet Widget
  • Facebook Like
  • Google Plus One

Jump to section

  • Article
    • Abstract
    • Introduction
    • Materials and Methods
    • Results
    • Discussion
    • Authors' Disclosures
    • Authors' Contributions
    • Acknowledgments
    • Footnotes
    • References
  • Figures & Data
  • Info & Metrics
  • PDF
Advertisement

Related Articles

Cited By...

More in this TOC Section

  • Preclinical Evaluation of AMG 160 in mCRPC Models
  • Molecular Profiling of Metastatic Breast Cancer
  • Therapeutic Targeting NRG1 Fusion Cancers with Seribantumab
Show more Translational Cancer Mechanisms and Therapy
  • Home
  • Alerts
  • Feedback
  • Privacy Policy
Facebook  Twitter  LinkedIn  YouTube  RSS

Articles

  • Online First
  • Current Issue
  • Past Issues
  • CCR Focus Archive
  • Meeting Abstracts

Info for

  • Authors
  • Subscribers
  • Advertisers
  • Librarians

About Clinical Cancer Research

  • About the Journal
  • Editorial Board
  • Permissions
  • Submit a Manuscript
AACR logo

Copyright © 2021 by the American Association for Cancer Research.

Clinical Cancer Research
eISSN: 1557-3265
ISSN: 1078-0432

Advertisement