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Prediction of response to neoadjuvant chemoendocrine therapy in primary breast carcinomas.

A Makris, T J Powles, M Dowsett, C K Osborne, P A Trott, I N Fernando, S E Ashley, M G Ormerod, J C Titley, R K Gregory and D C Allred
A Makris
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T J Powles
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M Dowsett
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C K Osborne
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P A Trott
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I N Fernando
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S E Ashley
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M G Ormerod
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J C Titley
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R K Gregory
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D C Allred
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DOI:  Published April 1997
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Abstract

Our aim was to determine whether biological molecular markers can predict response to neoadjuvant chemoendocrine therapy in patients with early breast cancer. Ninety patients (median age 56 years; range, 28-69 years) with primary operable breast carcinoma were studied. They were treated with four 3-weekly cycles of chemotherapy with mitozantrone, methotrexate (+/- mitomycin C), and tamoxifen prior to surgery. Fine-needle aspiration was used to obtain samples from patients prior to therapy, and the following parameters were assessed: estrogen receptor (ER), progesterone receptor (PgR), p53, Ki67, Bcl-2, and c-erbB-2 measured by immunocytochemistry, and ploidy and S-phase fraction (SPF) by flow cytometry. The tumors of 78% of the subjects responded (complete response, 9%; partial response, 69%) and 22% did not (no change, 20%; progressive disease, 2%). Response rates according to disease stage and patient age were as follows: T1, 74%; T2, 79%; T3/T4, 78%; age </=50 years, 76%; >50, 79% (P = not significant). Response rates for other parameters were as follows: ER-positive, 82%, and -negative, 70%; PgR-positive, 86%, and -negative, 71%; p53-positive, 74%, and -negative, 81%; Bcl-2-positive, 85%, and -negative 61%; c-erbB-2-positive, 57%, and -negative, 93%; Ki67 high, 77%, and low, 81%; SPF high, 77%, and low, 77%; aneuploid, 71%; and diploid, 85%. Only the difference for c-erbB-2 was statistically significant (P = 0.007). A trend for higher response rates to neoadjuvant chemoendocrine therapy for tumors that were positive for ER, PgR, and Bcl-2 was observed but did not reach statistical significance. Tumors negative for c-erbB-2 had a higher response rate, which was statistically significant. In contrast, Ki67, ploidy, SPF, and p53 failed to predict for response.

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April 1997
Volume 3, Issue 4
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Prediction of response to neoadjuvant chemoendocrine therapy in primary breast carcinomas.
A Makris, T J Powles, M Dowsett, C K Osborne, P A Trott, I N Fernando, S E Ashley, M G Ormerod, J C Titley, R K Gregory and D C Allred
Clin Cancer Res April 1 1997 (3) (4) 593-600;

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Prediction of response to neoadjuvant chemoendocrine therapy in primary breast carcinomas.
A Makris, T J Powles, M Dowsett, C K Osborne, P A Trott, I N Fernando, S E Ashley, M G Ormerod, J C Titley, R K Gregory and D C Allred
Clin Cancer Res April 1 1997 (3) (4) 593-600;
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Clinical Cancer Research
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