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Evaluation of epidermal growth factor-related growth factors and receptors and of neoangiogenesis in completely resected stage I-IIIA non-small-cell lung cancer: amphiregulin and microvessel count are independent prognostic indicators of survival.

G Fontanini, M De Laurentiis, S Vignati, S Chinè, M Lucchi, V Silvestri, A Mussi, S De Placido, G Tortora, A R Bianco, W Gullick, C A Angeletti, G Bevilacqua and F Ciardiello
G Fontanini
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M De Laurentiis
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S Vignati
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S Chinè
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M Lucchi
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V Silvestri
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A Mussi
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S De Placido
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G Tortora
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A R Bianco
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W Gullick
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C A Angeletti
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G Bevilacqua
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F Ciardiello
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DOI:  Published January 1998
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Abstract

We have determined the expression of transforming growth factor alpha (TGF alpha), amphiregulin (AR), CRIPTO, the epidermal growth factor receptor (EGFR), erbB-2, erbB-3, and tumor angiogenesis in a series of 195 patients with stage I-IIIA non-small cell lung cancer (NSCLC) treated with radical surgery to define their usefulness as prognostic indicators of survival. A variable degree of specific staining in cancer cells was observed for the three growth factors and for the three growth factor receptors in the majority of NSCLC patients. A statistically significant association between overexpression of TGF alpha, AR, and CRIPTO was observed. Enhanced expression of AR was significantly correlated with enhanced expression of erbB-2 and advanced T-stage. A direct association was also detected for overexpression of TGF alpha and of erbB-2 or erbB-3, respectively. Sex, tumor size, nodal status, stage, microvessel count, as a measure of neovascularization, and AR overexpression significantly correlated with overall survival at univariate analysis. In a Cox multivariate analysis, the only characteristics with an independent prognostic effect on OAS were microvessel count [relative hazard (RH), 6.61; P < 0.00001), nodal status (RH, 1.59; P = 0.0013), and AR overexpression (RH, 1.72; P = 0.02). These results suggest that evaluation of neoangiogenesis and of certain growth factors, such as AR, can be useful in addition to conventional pathological staging to select high-risk NSCLC patients who may benefit from post-surgical systemic therapies.

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January 1998
Volume 4, Issue 1
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Evaluation of epidermal growth factor-related growth factors and receptors and of neoangiogenesis in completely resected stage I-IIIA non-small-cell lung cancer: amphiregulin and microvessel count are independent prognostic indicators of survival.
G Fontanini, M De Laurentiis, S Vignati, S Chinè, M Lucchi, V Silvestri, A Mussi, S De Placido, G Tortora, A R Bianco, W Gullick, C A Angeletti, G Bevilacqua and F Ciardiello
Clin Cancer Res January 1 1998 (4) (1) 241-249;

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Evaluation of epidermal growth factor-related growth factors and receptors and of neoangiogenesis in completely resected stage I-IIIA non-small-cell lung cancer: amphiregulin and microvessel count are independent prognostic indicators of survival.
G Fontanini, M De Laurentiis, S Vignati, S Chinè, M Lucchi, V Silvestri, A Mussi, S De Placido, G Tortora, A R Bianco, W Gullick, C A Angeletti, G Bevilacqua and F Ciardiello
Clin Cancer Res January 1 1998 (4) (1) 241-249;
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Clinical Cancer Research
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